Intranasal microemulsion for targeted nose to brain delivery in neurocysticercosis: Role of docosahexaenoic acid

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 96, Issue , 2015, Pages 363-379

  Shinde, Rajshree L ^a   Bharkad, Gopal P ^b   Devarajan, Padma V ^a  

^a INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b BOMBAY VETERINARY COLLEGE   (India)

Author keywords

Albendazole sulfoxide; Curcumin; Direct nose to brain transport (DTP); Docosahexaenoic acid (DHA); Drug targeting efficiency (DTE); Ex vivo permeation; Intranasal microemulsions; Neurocysticercosis; Nose to brain delivery; Taenia solium cyst

Indexed keywords

ALBENDAZOLE SULFOXIDE; CURCUMIN; DOCOSAHEXAENOIC ACID; OCTANOIN; ALBENDAZOLE; ANTHELMINTIC AGENT; DRUG COMBINATION; DRUG VEHICLE; EMULSION; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG PENETRATION; DRUG SOLUBILITY; HISTOPATHOLOGY; MALE; MICROEMULSION; NEUROCYSTICERCOSIS; NONHUMAN; NOSE; RAT; TAENIA SOLIUM; ZETA POTENTIAL; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; BLOOD BRAIN BARRIER; CHEMISTRY; DOMESTIC SHEEP; DRUG ABSORPTION; DRUG COMBINATION; DRUG EFFECTS; DRUG STABILITY; EMULSION; FEMALE; IN VITRO STUDY; INTRANASAL DRUG ADMINISTRATION; METABOLISM; NERVE CELL; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION; ULTRASTRUCTURE;

ADMINISTRATION, INTRANASAL; ALBENDAZOLE; ANIMALS; ANTHELMINTICS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BLOOD-BRAIN BARRIER; BRAIN; CURCUMIN; DOCOSAHEXAENOIC ACIDS; DRUG COMBINATIONS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; DRUG STABILITY; EMULSIONS; FEMALE; IN VITRO TECHNIQUES; MALE; NASAL ABSORPTION; NEUROCYSTICERCOSIS; NEURONS; PHARMACEUTICAL VEHICLES; RATS, SPRAGUE-DAWLEY; SHEEP, DOMESTIC; TISSUE DISTRIBUTION;

EID: 84941896498     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2015.08.008     Document Type: Article

References (53)

1. L. Illum Nasal drug delivery: problems, possibilities and solutions J. Control. Rel. 87 2003 187 198 10.1016/S0168-3659(02)00363-2
2. H.R. Costantino, L. Illum, G. Brandt, P.H. Johnson, and S.C. Quay Intranasal delivery: physicochemical and therapeutic aspects Int. J. Pharm. 337 2007 1 24 10.1016/j.ijpharm.2007.03.025
3. P.V. Devarajan, and R.L. Shinde Advances in microemulsions and nanoemulsions for improved therapy in brain cancer E. Souto, Advanced Anticancer Approaches with Multifunctional Lipid Nanocarriers 2011 i Smithers - Creative Publishing Solutions UK 347 394
4. J. Piazza, T. Hoare, L. Molinaro, K. Terpstra, J. Bhandari, P.R. Selvaganapathy, B. Gupta, and R.K. Mishra Haloperidol-loaded intranasally administered lectin functionalized poly (ethylene glycol)-block-poly (d,l)-lactic-co-glycolic acid (PEG-PLGA) nanoparticles for the treatment of schizophrenia Eur. J. Pharm. Biopharm. 87 2014 30 39 10.1016/j.ejpb.2014.02.007
5. V.V. Jogani, P.J. Shah, P. Mishra, A.K. Mishra, and A.R. Misra Intranasal mucoadhesive microemulsion of tacrine to improve brain targeting Alzheimer Dis. Assoc. Disord. 22 2008 116 124 10.1097/WAD.0b013e318157205b
6. Y.H. Lee, K.H. Kim, I.K. Yoon, K.E. Lee, I.K. Chun, J.Y. Rhie, and H.S. Gwak Pharmacokinetic evaluation of formulated levodopa methyl ester nasal delivery systems Eur. J. Drug Metabo. Pharmacokinet. 39 2014 237 242 10.1007/s13318-013-0171-8
7. E. Gavini, G. Rassu, L. Ferraro, S. Beggiato, A. Alhalaweh, S. Velaga, N. Marchetti, P. Bandiera, P. Giunchedi, and A. Dalpiaz Influence of polymeric microcarriers on the in vivo intranasal uptake of an anti-migraine drug for brain targeting Eur. J. Pharm. Biopharm. 83 2013 174 183 10.1016/j.ejpb.2012.10.010
8. X. Zhuang, X. Xiang, W. Grizzle, D. Sun, S. Zhang, R.C. Axtell, S. Ju, J. Mu, L. Zhang, L. Steinman, D. Miller, and H.G. Zhang Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain Mol. Ther. 19 2011 1769 1779 10.1038/mt.2011.164
9. T.E. Nash, G. Singh, A.C. White, V. Rajshekhar, J.A. Loeb, J.V. Proano, O.M. Takayanagui, A.E. Gonzalez, J.A. Butman, C. DeGiorgio, O.H. Del Brutto, A. Delgado-Escueta, C.A.W. Evans, R.H. Gilman, S.M. Martinez, M.T. Medina, E.J. Pretell, J. Teale, and H.H. Garcia Treatment of neurocysticercosis current status and future research needs Neurology 67 2006 1120 1127 10.1212/01.wnl.0000238514.51747.3a
10. K.E. Mwape, I.K. Phiri, N. Praet, N. Speybroeck, J.B. Muma, P. Dorny, and S. Gabriël The incidence of human cysticercosis in a rural community of Eastern Zambia PLoS Negl. Trop. Dis. 7 2013 e2142 10.1371/journal.pntd.0002142
11. S. Mahanty, A. Paredes, M. Marzal, E. Gonzalez, S. Rodriguez, P. Dorny, C. Guerra-Giraldez, H.H. Garcia, and T. Nash Sensitive in vitro system to assess morphological and biochemical effects of praziquantel and albendazole on Taenia solium cysts Antimicrob. Agents Chemother. 55 2011 211 217 10.1128/AAC.00761-10
12. F. Palomares, G. Palencia, J.R. Ambrosio, A. Ortiz, and H. Jung-Cook Evaluation of the efficacy of albendazole sulphoxide and praziquantel in combination on Taenia crassiceps cysts: in vitro studies J. Antimicrob. Chemother. 57 2006 482 488 10.1093/jac/dki484
13. P. Venkatesan Albendazole J. Antimicrob. Chemother. 41 1998 145 147 10.1093/jac/41.2.145
14. M.J. Lawrence, and G.D. Rees Microemulsion-based media as novel drug delivery systems Adv. Drug Deliv. Rev. 45 2000 89 121 10.1016/S0169-409X(00)00103-4
15. R.L. Shinde, A.B. Jindal, and P.V. Devarajan Microemulsions and nanoemulsions for targeted drug delivery to the brain Curr. Nanosci. 7 2011 119 133 10.2174/157341311794480282
16. T.K. Vyas, A.K. Babbar, R.K. Sharma, S. Singh, and A. Misra Preliminary brain-targeting studies on intranasal mucoadhesive microemulsions of sumatriptan AAPS PharmSciTech. 7 2006 E49 E57 10.1208/pt070108
17. T.K. Vyas, A.K. Babbar, R.K. Sharma, S. Singh, and A. Misra Intranasal mucoadhesive microemulsions of clonazepam: preliminary studies on brain targeting J. Pharm. Sci. 95 2006 570 580 10.1002/jps.20480
18. M. Kumar, A. Misra, A.K. Mishra, P. Mishra, and K. Pathak Mucoadhesive nanoemulsion-based intranasal drug delivery system of olanzapine for brain targeting J. Drug Target. 16 2008 806 814 10.1080/10611860802476504
19. M. Kumar, A. Misra, A.K. Babbar, A.K. Mishra, P. Mishra, and K. Pathak Intranasal nanoemulsion based brain targeting drug delivery system of risperidone Int. J. Pharm. 358 2008 285 291 10.1016/j.ijpharm.2008.03.029
20. T.K. Vyas, A.K. Babbar, R.K. Sharma, and A. Misra Intranasal mucoadhesive microemulsions of zolmitriptan: preliminary studies on brain-targeting J. Drug Target. 13 2005 317 324 10.1080/10611860500246217
21. Q. Zhang, X. Jiang, W. Jiang, W. Lu, L. Su, and Z. Shi Preparation of nimodipine-loaded microemulsion for intranasal delivery and evaluation on the targeting efficiency to the brain Int. J. Pharm. 275 2004 85 96 10.1016/j.ijpharm.2004.01.039
22. T.K. Vyas, A. Shahiwala, and M.M. Amiji Improved oral bioavailability and brain transport of Saquinavir upon administration in novel nanoemulsion formulations Int. J. Pharm. 347 2008 93 101 10.1016/j.ijpharm.2007.06.016
23. W.J. Lukiw, and N.G. Bazan Docosahexaenoic acid and the aging brain J. Nutr. 138 2008 2510 2514 10.3945/jn.108.096016
24. G. Virkel, A. Lifschitz, J. Sallovitz, A. Pis, and C. Lanusse Comparative hepatic and extrahepatic enantioselective sulfoxidation of albendazole and fenbendazole in sheep and cattle Drug Metab. Dispos. 32 2004 536 544 10.1124/dmd.32.5.536
25. N. Chainani-Wu Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa) J. Altern. Complement. Med. 9 2003 161 168 10.1089/107555303321223035
26. M.J. Patel, N.M. Patel, R.B. Patel, and R.P. Patel Formulation and evaluation of self-microemulsifying drug delivery system of lovastatin Asian J. Pharm. Sci. 5 2010 266 275
27. S. Setthacheewakul, S. Mahattanadul, N. Phadoongsombut, W. Pichayakorn, and R. Wiwattanapatapee Development and evaluation of self-microemulsifying liquid and pellet formulations of curcumin, and absorption studies in rats Eur. J. Pharm. Biopham. 76 2010 475 485 10.1016/j.ejpb.2010.07.011
28. R. Jain, S. Nabar, P. Dandekar, P. Hassan, V. Aswal, Y. Talmon, T. Shet, L. Borde, K. Ray, and V. Patravale Formulation and evaluation of novel micellar nanocarrier for nasal delivery of sumatriptan Nanomedicine 5 2010 575 587 10.2217/nnm.10.28
29. M.J. Pastoriza-Gallego, L. Lugo, J.L. Legido, and M.M. Piñeiro Rheological non-Newtonian behaviour of ethylene glycol-based Fe2O3 nanofluids Nanoscale Res. Lett. 6 2011 1 7 10.1186/1556-276X-6-560
30. N. Thirawong, J. Nunthanid, S. Puttipipatkhachorn, and P. Sriamornsak Mucoadhesive properties of various pectins on gastrointestinal mucosa: an in vitro evaluation using texture analyzer Eur. J. Pharm. Biopharm. 67 2007 132 140 10.1016/j.ejpb.2007.01.010
31. T.K. Bock, and B.W. Müller A novel assay to determine the hemolytic activity of drugs incorporated in colloidal carrier systems Pharm. Res. 11 1994 589 591 10.1023/A:1018987120738
32. H.D. Han, B.C. Shin, and H.S. Choi Doxorubicin-encapsulated thermosensitive liposomes modified with poly (N-isopropylacrylamide-co-acrylamide): drug release behavior and stability in the presence of serum Eur. J. Pharm. Biopharm. 62 2006 110 116 10.1016/j.ejpb.2005.07.006
33. H.S. Mahajan, V.K. Tyagi, R.R. Patil, and S.B. Dusunge Thiolated xyloglucan: synthesis, characterization and evaluation as mucoadhesive in situ gelling agent Carbohydr. Polym. 91 2013 618 625 10.1016/j.carbpol.2012.08.077
34. L. Kozlovskaya, M. Abou-Kaoud, and D. Stepensky Quantitative analysis of drug delivery to the brain via nasal route J. Control. Rel. 189 2014 133 140 10.1016/j.jconrel.2014.06.053
35. Z. Dong, H. Katsumi, T. Sakane, and A. Yamamoto Effects of polyamidoamine (PAMAM) dendrimers on the nasal absorption of poorly absorbable drugs in rats Int. J. Pharm. 393 2010 245 253 10.1016/j.ijpharm.2010.04.021
36. D. Dunston, S. Ashby, K. Krosnowski, T. Ogura, and W. Lin An effective manual deboning method to prepare intact mouse nasal tissue with preserved anatomical organization J. Vis. Exp. 78 2013 10 10.3791/50538
37. C.L. Saw, Y. Huang, and A.N. Kong Synergistic anti-inflammatory effects of low doses of curcumin in combination with polyunsaturated fatty acids: docosahexaenoic acid or eicosapentaenoic acid Biochem. Pharmacol. 79 2010 421 430 10.1016/j.bcp.2009.08.030
38. G. Corace, C. Angeloni, M. Malaguti, S. Hrelia, P.C. Stein, M. Brandl, R. Gotti, and B. Luppi Multifunctional liposomes for nasal delivery of the anti-Alzheimer drug tacrine hydrochloride J. Liposome Res. 24 2014 323 335 10.3109/08982104.2014.899369
39. K. Dae-Duk In vitro cellular models for nasal drug absorption studies E. Carsten, K. Kwang-Jin, Drug Absorption Studies: In Situ, In Vitro and In Silico Models 2007 Springer USA 216 234 10.1007/978-0-387-74901-3-9
40. M.A. Dobrovolskaia, J.D. Clogston, B.D. Neun, J.B. Hall, A.K. Patri, and S.E. McNeil Method for analysis of nanoparticle hemolytic properties in vitro Nano Lett. 8 2008 2180 2187 10.1021/nl0805615
41. Z. Hossain, H. Kurihara, M. Hosokawa, and K. Takahashi Docosahexaenoic acid and eicosapentaenoic acid-enriched phosphatidylcholine liposomes enhance the permeability, transportation and uptake of phospholipids in Caco-2 cells Mol. Cell. Biochem. 285 2006 155 163 10.1007/s-11010-005-9074-6
42. M. Usami, T. Komurasaki, A. Hanada, K. Kinoshita, and A. Ohata Effect of γ-linolenic acid or docosahexaenoic acid on tight junction permeability in intestinal monolayer cells and their mechanism by protein kinase C activation and/or eicosanoid formation Nutrition 19 2003 150 156 10.1016/S0899-9007(02)00927-9
43. S. Roig-Pérez, N. Cortadellas, M. Moretó, and R. Ferrer Intracellular mechanisms involved in docosahexaenoic acid-induced increases in tight junction permeability in Caco-2 cell monolayers J. Nutr. 140 2010 1557 1563 10.3945/jn.109.120469
44. F. Buyukozturk, J.C. Benneyan, and R.L. Carrier Impact of emulsion-based drug delivery systems on intestinal permeability and drug release kinetics J. Control. Rel. 142 2010 22 30 10.1016/j.jconrel.2009.10.005
45. R.A. Siddiqui, K. Harvey, E. Bammerlin, and N. Ikhlaque Docosahexaenoic acid: a potential modulator of brain tumors and metastasis J. Biomol. Res. Ther. 2 2013 3 10.4172/2167-7956.1000e119
46. M. Picq, P. Chen, M. Perez, M. Michaud, E. Véricel, M. Guichardant, M. Lagarde, and D.H.A. Metabolism Targeting the brain and lipoxygenation Mol. Neurobiol. 42 2010 48 51 10.1007/s12035-010-8131-7
47. S. Tamilvanan Formulation of multifunctional oil-in-water nanosized emulsions for active and passive targeting of drugs to otherwise inaccessible internal organs of the human body Int. J. Pharm. 381 2009 62 76 10.1016/j.ijpharm.2009.08.001
48. L.N. Nguyen, D. Ma, G. Shui, P. Wong, A. Cazenave-Gassiot, X. Zhang, M.R. Wenk, E.L. Goh, and D.L. Silver Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid Nature 509 2014 503 506 10.1038/nature13241
49. J. Kreuter, D. Shamenkov, V. Petrov, P. Ramge, K. Cychutek, C. Koch-Brandt, and R. Alyautdin Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier J. Drug Target. 10 2002 317 325 10.1080/10611860290031877
50. J. Kreuter, P. Ramge, V. Petrov, S. Hamm, S.E. Gelprina, B. Engelhardt, R. Alyautdin, H. von Briesen, and D.J. Begley Direct evidence that polysorbate-80-coated poly(butyl cyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of the drug to the nanoparticles Pharm. Res. 20 2003 409 416
51. T.M. Goppert, and R.H. Müller Polysorbate-stabilized solid lipid nanoparticles as colloidal carriers for intravenous targeting of drugs to the brain: comparison of plasma protein adsorption patterns J. Drug Target. 13 2005 179 187 10.1080/10611860500071292
52. A. Swargiary, B. Roy, and B. Ronghang B., Partial characterisation of alkaline phosphatase in Fasciolopsis buski - an intestinal fluke treated with crude extract of Alpinia nigra (Zingiberaceae) J. Pharm. Technol. Drug Res. 2 2013 5 10.7243/2050-120X-2-5
53. M. Coetzee, M. Haag, and M.C. Kruger Effects of arachidonic acid and docosahexaenoic acid on differentiation and mineralization of MC3T3-E1 osteoblast-like cells Cell Biochem. Funct. 27 2009 3 11 10.1002/cbf.1526