The benefits of exercise for patients with non-alcoholic fatty liver disease

Expert Review of Gastroenterology and Hepatology

Volumn 9, Issue 10, 2015, Pages 1247-1250

  Keating, Shelley E ^a   George, Jacob ^b   Johnson, Nathan A ^b,c  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

aerobic training; exercise; hepatic steatosis; non alcoholic fatty liver disease; resistance training

Indexed keywords

AEROBIC EXERCISE; COMORBIDITY; DISEASE COURSE; EXERCISE INTENSITY; FITNESS; HUMAN; KINESIOTHERAPY; MUSCLE STRENGTH; NONALCOHOLIC FATTY LIVER; PHYSICAL ACTIVITY; RESISTANCE TRAINING; REVIEW; RISK BENEFIT ANALYSIS; SAFETY; THERAPY EFFECT; TREATMENT DURATION; EXERCISE; NON-ALCOHOLIC FATTY LIVER DISEASE; PHYSIOLOGY; PRACTICE GUIDELINE;

EXERCISE; EXERCISE THERAPY; HUMANS; NON-ALCOHOLIC FATTY LIVER DISEASE; PHYSICAL EXERTION; PRACTICE GUIDELINES AS TOPIC; RESISTANCE TRAINING;

EID: 84941880262     PISSN: 17474124     EISSN: 17474132     Source Type: Journal    
DOI: 10.1586/17474124.2015.1075392     Document Type: Review

References (28)

1. Bellentani S, Scaglioni F, Marino M, Bedogni G. Epidemiology of non-alcoholic fatty liver disease. Dig Dis 2010;28(1): 155-61
2. Suzuki A, Lindor K, Saver JS, et al. Effect of changes on body weight and lifestyle in nonalcoholic fatty liver disease. J Hepatol 2005;43(6):1060-6
3. Musso G, Gambino R, Cassader M, Pagano G. A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease. Hepatology 2011;52(1):79-104
4. Keating S, Hackett D, George J, Johnson N. Exercise and non-alcoholic fatty liver disease: a systematic review and meta-analysis. J Hepatol 2012;57:157-66
5. Bacchi E, Negri C, Targher G, et al. Both resistance training and aerobic training reduce hepatic fat content in type 2 diabetic subjects with nonalcoholic fatty liver disease (the RAED2 randomized trial). Hepatology 2013;58(4):1287-95
6. Sullivan S, Kirk EP, Mittendorfer B, et al. Randomized trial of exercise effect on intrahepatic triglyceride content and lipid kinetics in nonalcoholic fatty liver disease. Hepatology 2012;55(6):1738-45
7. Slentz CA, Duscha BD, Johnson JL, et al. Effects of the amount of exercise on body weight, body composition, and measures of central obesity: STRRIDE-a randomized controlled study. Arch Intern Med 2004; 164(1):31-9
8. Magkos F. Exercise and fat accumulation in the human liver. Curr Opin Lipidol 2010; 21(6):507-17
9. Garber CE, Blissmer B, Deschenes MR, et al. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sport Exerc 2011;43(7):1334-59
10. World Health Organisation. Global recommendations on physical activity for health. World Health Organisation; Geneva, Switzerland: 2010
11. Johnson NA, Sachinwalla T, Walton DW, et al. Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss. Hepatology 2009;50(4):1105-12
12. Lee S, Deldin AR, White D, et al. Aerobic exercise but not resistance exercise reduces intrahepatic lipid content and visceral fat and improves insulin sensitivity in obese adolescent girls: a randomized controlled trial. Am J Physiol Endocrinol Metab 2013; 305(10):E1222-9
13. Lee S, Bacha F, Hannon T, et al. Effects of aerobic versus resistance exercise without caloric restriction on abdominal fat, intrahepatic lipid, and insulin sensitivity in obese adolescent boys: a randomized, controlled trial. Diabetes 2012;61(11): 2787-95
14. Keating SE, Hackett DA, Parker HM, et al. Effect of aerobic exercise training dose on liver fat and visceral adiposity. J Hepatol 2015;63:174-82
15. van der Heijden G-J, Wang ZJ, Chu ZD, et al. A 12-week aerobic exercise program reduces hepatic fat accumulation and insulin resistance in obese, Hispanic adolescents. Obesity 2010;18(2):384-90
16. Pugh CJ, Cuthbertson DJ, Sprung VS, et al. Exercise training improves cutaneous microvascular function in nonalcoholic fatty liver disease. Am J Physiol Endocrinol Metab 2013;305(1):E50-8
17. Damor K, Mittal K, Bhalla AS, et al. Effect of progressive resistance exercise training on hepatic Fat in Asian Indians with non-alcoholic fatty liver disease. BJMMR 2014;1:114-24
18. Zelber-Sagi S, Buch A, Yeshua H, et al. Effect of resistance training on non-alcoholic fatty-liver disease a randomized-clinical trial. World J Gastroenterol 2014;20(15):4382-92
19. Hallsworth K, Fattakhova G, Hollingsworth KG, et al. Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss. Gut 2011;60(9):1278-83
20. Slentz CA, Bateman LA, Willis LH, et al. Effects of aerobic vs resistance training on visceral and liver fat stores, liver enzymes, and insulin resistance by HOMA in overweight adults from STRRIDE AT/RT. Am J Physiol Endocrinol Metab 2011; 301(5):E1033-9
21. Van Der Heijden GJ, Wang ZJ, Chu Z, et al. Strength exercise improves muscle mass and hepatic insulin sensitivity in obese youth. Med Sci Sports Exerc 2010;42(11): 1973-80
22. Hickman IJ, Byrne NM, Croci I, et al. A pilot randomised study of the metabolic and histological effects of exercise in non-alcoholic steatohepatitis. J Diabetes Metab 2013;4:8
23. Kistler KD, Brunt EM, Clark JM, et al. Physical activity recommendations, exercise intensity, and histological severity of nonalcoholic fatty liver disease. Am J Gastroenterol 2011;106(3):460-8
24. Cho J, Kim S, Lee S, Kang H. Effect of training intensity on nonalcoholic fatty liver disease. Med Sci Sports Exerc 2014;47(8): 1624-34
25. Rognmo O, Moholdt T, Bakken H, et al. Cardiovascular risk of high-versus moderate-intensity aerobic exercise in coronary heart disease patients. Circulation 2012;126(12):1436-40
26. Pugh CJ, Spring VS, Kemp GJ, et al. Exercise training reverses endothelial dysfunction in nonalcoholic fatty liver disease. Am J Physiol-Heart C 2014; 307(9):H1298-306
27. Kodama S, Saito K, Tanaka S, et al. Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis. JAMA 2009; 301(19):2024-35
28. Bellentani S, Dalle Grave R, Suppini A, Marchesini G. Behavior therapy for nonalcoholic fatty liver disease: The need for a multidisciplinary approach. Hepatology 2008;47(2):746-54