메뉴 건너뛰기




Volumn 38, Issue 4, 2015, Pages 437-445

Pentoxifylline alleviates hypertension in metabolic syndrome: Effect on low-grade inflammation and angiotensin system

Author keywords

Hypertension; Insulin resistance; Pentoxifylline; Vascular

Indexed keywords

ADIPONECTIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; FRUCTOSAMINE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; PENTOXIFYLLINE; TUMOR NECROSIS FACTOR ALPHA; VASODILATOR AGENT;

EID: 84941791474     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.1007/s40618-014-0209-z     Document Type: Article
Times cited : (23)

References (40)
  • 1
    • 20644449050 scopus 로고    scopus 로고
    • Pathophysiology of dyslipidaemia in the metabolic syndrome
    • 1743285 1:STN:280:DC%2BD2M3ptFOhsg%3D%3D 15937200
    • Kolovou GD, Anagnostopoulou KK, Cokkinos DV (2005) Pathophysiology of dyslipidaemia in the metabolic syndrome. Postgrad Med J 81:358-366
    • (2005) Postgrad Med J , vol.81 , pp. 358-366
    • Kolovou, G.D.1    Anagnostopoulou, K.K.2    Cokkinos, D.V.3
  • 2
    • 0348222671 scopus 로고    scopus 로고
    • Inflammation: The link between insulin resistance, obesity and diabetes
    • 1:CAS:528:DC%2BD3sXhtVSjtL7N 14698276
    • Dandona P, Aljada A, Bandyopadhyay A (2004) Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol 25:4-7
    • (2004) Trends Immunol , vol.25 , pp. 4-7
    • Dandona, P.1    Aljada, A.2    Bandyopadhyay, A.3
  • 4
    • 84887614586 scopus 로고    scopus 로고
    • The renin-angiotensin system in adipose tissue and its metabolic consequences during obesity
    • 1:CAS:528:DC%2BC3sXhs1SrsrfF 24120291
    • Frigolet ME, Torres N, Tovar AR (2013) The renin-angiotensin system in adipose tissue and its metabolic consequences during obesity. J Nutr Biochem 24:2003-2015
    • (2013) J Nutr Biochem , vol.24 , pp. 2003-2015
    • Frigolet, M.E.1    Torres, N.2    Tovar, A.R.3
  • 5
    • 0023587988 scopus 로고
    • A controlled trial of pentoxifylline (Trental 400) in intermittent claudication: Clinical, haemostatic and rheological effects
    • 1:STN:280:DyaL1c3jtlCmtg%3D%3D 3330188
    • Reilly DT, Quinton DN, Barrie WW (1987) A controlled trial of pentoxifylline (Trental 400) in intermittent claudication: clinical, haemostatic and rheological effects. N Z Med J 100:445-447
    • (1987) N Z Med J , vol.100 , pp. 445-447
    • Reilly, D.T.1    Quinton, D.N.2    Barrie, W.W.3
  • 6
    • 0027231850 scopus 로고
    • Inhibition of endogenous TNF formation by pentoxifylline
    • 1:CAS:528:DyaK2cXhvVantrs%3D 8330908
    • Zabel P, Schade FU, Schlaak M (1993) Inhibition of endogenous TNF formation by pentoxifylline. Immunobiology 187:447-463
    • (1993) Immunobiology , vol.187 , pp. 447-463
    • Zabel, P.1    Schade, F.U.2    Schlaak, M.3
  • 7
    • 80054945074 scopus 로고    scopus 로고
    • Pentoxifylline alleviates vascular impairment in insulin resistance via TNF-α inhibition
    • 1:CAS:528:DC%2BC3MXhtVegur3F 21800096
    • El-Bassossy HM, El-Moselhy MA, Mahmoud MF (2011) Pentoxifylline alleviates vascular impairment in insulin resistance via TNF-α inhibition. Naunyn Schmiedebergs Arch Pharmacol 384:277-285
    • (2011) Naunyn Schmiedebergs Arch Pharmacol , vol.384 , pp. 277-285
    • El-Bassossy, H.M.1    El-Moselhy, M.A.2    Mahmoud, M.F.3
  • 8
    • 84902187978 scopus 로고    scopus 로고
    • Pentoxifylline alleviates cardiac ischemia and dysfunction following experimental angina in insulin resistance
    • 4038549 24874295
    • Azhar A, El-Bassossy HM (2014) Pentoxifylline alleviates cardiac ischemia and dysfunction following experimental angina in insulin resistance. PLoS One 9:e98281
    • (2014) PLoS One , vol.9 , pp. e98281
    • Azhar, A.1    El-Bassossy, H.M.2
  • 9
    • 0026113344 scopus 로고
    • Comparison of in vitro platelet aggregation and its inhibition by three antithrombotic drugs between human and Guinea pig
    • 1:STN:280:DyaK38%2Flt1Olsg%3D%3D 1946813
    • Huang ZS, Lee TK (1991) Comparison of in vitro platelet aggregation and its inhibition by three antithrombotic drugs between human and guinea pig. Proc Natl Sci Counc Repub China B 15:8-14
    • (1991) Proc Natl Sci Counc Repub China B , vol.15 , pp. 8-14
    • Huang, Z.S.1    Lee, T.K.2
  • 10
    • 0024853153 scopus 로고
    • Stimulatory effects of vascular prostaglandins on the antiaggregatory activities of pentoxifylline acetylsalicylic acid combinations in vitro
    • 1:STN:280:DyaK3c7hvVeitA%3D%3D 2514520
    • Weithmann KU, Just M, Schlotte V, Seiffge D (1989) Stimulatory effects of vascular prostaglandins on the antiaggregatory activities of pentoxifylline acetylsalicylic acid combinations in vitro. Vasa 18:273-276
    • (1989) Vasa , vol.18 , pp. 273-276
    • Weithmann, K.U.1    Just, M.2    Schlotte, V.3    Seiffge, D.4
  • 11
    • 0024582402 scopus 로고
    • New aspects of the pharmacology of pentoxifylline
    • Lenoble G (1989) New aspects of the pharmacology of pentoxifylline. J Mal Vasc 14 (Suppl A):35-41
    • (1989) J Mal Vasc , vol.14 , pp. 35-41
    • Lenoble, G.1
  • 12
    • 0021933238 scopus 로고
    • Preventive treatment of cerebral transient ischemia: Comparative randomized trial of pentoxifylline versus conventional antiaggregants
    • 1:STN:280:DyaL2M7gtFGlsQ%3D%3D 3881263
    • Herskovits E, Famulari A, Tamaroff L, Gonzalez AM, Vazquez A, Dominguez R, Fraiman H, Vila J (1985) Preventive treatment of cerebral transient ischemia: comparative randomized trial of pentoxifylline versus conventional antiaggregants. Eur Neurol 24:73-81
    • (1985) Eur Neurol , vol.24 , pp. 73-81
    • Herskovits, E.1    Famulari, A.2    Tamaroff, L.3    Gonzalez, A.M.4    Vazquez, A.5    Dominguez, R.6    Fraiman, H.7    Vila, J.8
  • 13
    • 0021346128 scopus 로고
    • Antithrombotic effects of pentoxifylline on laser-induced thrombi in rat mesenteric arteries
    • 1:CAS:528:DyaL2cXhtlagsbo%3D
    • Seiffge D, Kremer E (1984) Antithrombotic effects of pentoxifylline on laser-induced thrombi in rat mesenteric arteries. IRCS Med Sci 12:91-92
    • (1984) IRCS Med Sci , vol.12 , pp. 91-92
    • Seiffge, D.1    Kremer, E.2
  • 15
    • 84907940280 scopus 로고    scopus 로고
    • Characterization of vascular complications in experimental model of fructose induced metabolic syndrome
    • El-Bassossy H, Dsokey N, Fahmy A (2014) Characterization of vascular complications in experimental model of fructose induced metabolic syndrome. Toxicol Mech Methods, pp 1-8. doi: 10.3109/15376516.2014.945109
    • (2014) Toxicol Mech Methods , pp. 1-8
    • El-Bassossy, H.1    Dsokey, N.2    Fahmy, A.3
  • 16
    • 0027268731 scopus 로고
    • Anaesthetic effects of chloral hydrate, pentobarbitone and urethane in adult male rats
    • 1:CAS:528:DyaK3sXlslCjs7c%3D 8366672
    • Field KJ, White WJ, Lang CM (1993) Anaesthetic effects of chloral hydrate, pentobarbitone and urethane in adult male rats. Lab Anim 27:258-269
    • (1993) Lab Anim , vol.27 , pp. 258-269
    • Field, K.J.1    White, W.J.2    Lang, C.M.3
  • 18
    • 84878350506 scopus 로고    scopus 로고
    • Heme oxygenase-1 induction protects against hypertension associated with diabetes: Effect on exaggerated vascular contractility
    • 1:CAS:528:DC%2BC3sXitlCnur4%3D 23254361
    • Hassan N, El-Bassossy HM, Zakaria MNM (2013) Heme oxygenase-1 induction protects against hypertension associated with diabetes: effect on exaggerated vascular contractility. Naunyn Schmiedebergs Arch Pharmacol 386:217-226
    • (2013) Naunyn Schmiedebergs Arch Pharmacol , vol.386 , pp. 217-226
    • Hassan, N.1    El-Bassossy, H.M.2    Zakaria, M.N.M.3
  • 19
    • 84896738346 scopus 로고    scopus 로고
    • Caffeic acid phenethyl ester, a 5-lipoxygenase enzyme inhibitor, alleviates diabetic atherosclerotic manifestations: Effect on vascular reactivity and stiffness
    • 1:CAS:528:DC%2BC2cXlt1eqsLg%3D 24508943
    • Hassan NA, El-Bassossy HM, Mahmoud MF, Fahmy A (2014) Caffeic acid phenethyl ester, a 5-lipoxygenase enzyme inhibitor, alleviates diabetic atherosclerotic manifestations: effect on vascular reactivity and stiffness. Chem Biol Interact 213:28-36
    • (2014) Chem Biol Interact , vol.213 , pp. 28-36
    • Hassan, N.A.1    El-Bassossy, H.M.2    Mahmoud, M.F.3    Fahmy, A.4
  • 20
    • 84878083345 scopus 로고    scopus 로고
    • Quercetin protects against diabetes-induced exaggerated vasoconstriction in rats: Effect on low grade inflammation
    • Mahmoud MF, Hassan NA, El Bassossy HM, Fahmy A (2013) Quercetin protects against diabetes-induced exaggerated vasoconstriction in rats: effect on low grade inflammation. PLoS One 8:1-11
    • (2013) PLoS One , vol.8 , pp. 1-11
    • Mahmoud, M.F.1    Hassan, N.A.2    El Bassossy, H.M.3    Fahmy, A.4
  • 21
    • 80053562178 scopus 로고    scopus 로고
    • Cinnamaldehyde protects from the hypertension associated with diabetes
    • 1:CAS:528:DC%2BC3MXht12gsrjJ 21840367
    • El-Bassossy HM, Fahmy A, Badawy D (2011) Cinnamaldehyde protects from the hypertension associated with diabetes. Food Chem Toxicol 49:3007-3012
    • (2011) Food Chem Toxicol , vol.49 , pp. 3007-3012
    • El-Bassossy, H.M.1    Fahmy, A.2    Badawy, D.3
  • 22
    • 84877824517 scopus 로고    scopus 로고
    • Arginase inhibition alleviates hypertension in the metabolic syndrome
    • 3682715 1:CAS:528:DC%2BC3sXptlOhtro%3D 23441715
    • El-Bassossy HM, El-Fawal R, Fahmy A, Watson ML (2013) Arginase inhibition alleviates hypertension in the metabolic syndrome. Br J Pharmacol 169:693-703
    • (2013) Br J Pharmacol , vol.169 , pp. 693-703
    • El-Bassossy, H.M.1    El-Fawal, R.2    Fahmy, A.3    Watson, M.L.4
  • 25
    • 0037614819 scopus 로고    scopus 로고
    • What is the most important component of blood pressure: Systolic, diastolic or pulse pressure?
    • 12698068
    • Strandberg TE, Pitkala K (2003) What is the most important component of blood pressure: systolic, diastolic or pulse pressure? Curr Opin Nephrol Hypertens 12:293-297
    • (2003) Curr Opin Nephrol Hypertens , vol.12 , pp. 293-297
    • Strandberg, T.E.1    Pitkala, K.2
  • 26
    • 0023232148 scopus 로고
    • 24-h blood glucose pattern in type i and type II diabetics after oral treatment with pentoxifylline as assessed by artificial endocrine pancreas
    • 1:STN:280:DyaL1c%2Fnt12ksw%3D%3D 3687311
    • Raptis S, Mitrakou A, Hadjidakis D, Diamantopoulos E, Anastasiou C, Fountas A, Muller R (1987) 24-h blood glucose pattern in type I and type II diabetics after oral treatment with pentoxifylline as assessed by artificial endocrine pancreas. Acta Diabetol Lat 24:181-192
    • (1987) Acta Diabetol Lat , vol.24 , pp. 181-192
    • Raptis, S.1    Mitrakou, A.2    Hadjidakis, D.3    Diamantopoulos, E.4    Anastasiou, C.5    Fountas, A.6    Muller, R.7
  • 27
    • 0034570446 scopus 로고    scopus 로고
    • Pentoxifylline effects on nerve conduction velocity and blood flow in diabetic rats
    • 2477753 1:STN:280:DC%2BD3MvhvFKqsw%3D%3D 11469390
    • Flint H, Cotter MA, Cameron NE (2000) Pentoxifylline effects on nerve conduction velocity and blood flow in diabetic rats. Int J Exp Diabetes Res 1:49-58
    • (2000) Int J Exp Diabetes Res , vol.1 , pp. 49-58
    • Flint, H.1    Cotter, M.A.2    Cameron, N.E.3
  • 28
    • 1442275317 scopus 로고    scopus 로고
    • Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes
    • 14988310
    • Pickup JC (2004) Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care 27:813-823
    • (2004) Diabetes Care , vol.27 , pp. 813-823
    • Pickup, J.C.1
  • 29
    • 84856874824 scopus 로고    scopus 로고
    • Anti-inflammatory effect of atorvastatin on vascular reactivity and insulin resistance in fructose fed rats
    • 1:CAS:528:DC%2BC38XhvVSht7c%3D 22297754
    • Mahmoud MF, El-Nagar M, El-Bassossy HM (2012) Anti-inflammatory effect of atorvastatin on vascular reactivity and insulin resistance in fructose fed rats. Arch Pharm Res 35:155-162
    • (2012) Arch Pharm Res , vol.35 , pp. 155-162
    • Mahmoud, M.F.1    El-Nagar, M.2    El-Bassossy, H.M.3
  • 32
    • 84866534289 scopus 로고    scopus 로고
    • Pentoxifylline decreases serum levels of tumor necrosis factor alpha, interleukin 6 and C-reactive protein in hemodialysis patients: Results of a randomized double-blind, controlled clinical trial
    • 1:CAS:528:DC%2BC38XmvVejtbs%3D
    • Gonzalez-Espinoza L, Rojas-Campos E, Medina-Perez M, Pena-Quintero P, Gomez-Navarro B, Cueto-Manzano AM (2012) Pentoxifylline decreases serum levels of tumor necrosis factor alpha, interleukin 6 and C-reactive protein in hemodialysis patients: results of a randomized double-blind, controlled clinical trial. Nephrol Dial Transpl 27:2023-2028
    • (2012) Nephrol Dial Transpl , vol.27 , pp. 2023-2028
    • Gonzalez-Espinoza, L.1    Rojas-Campos, E.2    Medina-Perez, M.3    Pena-Quintero, P.4    Gomez-Navarro, B.5    Cueto-Manzano, A.M.6
  • 33
    • 34447650212 scopus 로고    scopus 로고
    • Effect of pentoxifylline on inflammatory burden, oxidative stress and platelet aggregability in hypertensive type 2 diabetes mellitus patients
    • 1:CAS:528:DC%2BD2sXot1ymu7Y%3D
    • Maiti R, Agrawal NK, Dash D, Pandey BL (2007) Effect of pentoxifylline on inflammatory burden, oxidative stress and platelet aggregability in hypertensive type 2 diabetes mellitus patients. Vasc Pharmacol 47:118-124
    • (2007) Vasc Pharmacol , vol.47 , pp. 118-124
    • Maiti, R.1    Agrawal, N.K.2    Dash, D.3    Pandey, B.L.4
  • 34
    • 38049079202 scopus 로고    scopus 로고
    • Pentoxifylline reduces pro-inflammatory and increases anti-inflammatory activity in patients with coronary artery disease - A randomized placebo-controlled study
    • 1:CAS:528:DC%2BD1cXpt12htA%3D%3D 17196208
    • Fernandes JL, de Oliveira RT, Mamoni RL, Coelho OR, Nicolau JC, Blotta MH, Serrano CV (2008) Pentoxifylline reduces pro-inflammatory and increases anti-inflammatory activity in patients with coronary artery disease - a randomized placebo-controlled study. Atherosclerosis 196:434-442
    • (2008) Atherosclerosis , vol.196 , pp. 434-442
    • Fernandes, J.L.1    De Oliveira, R.T.2    Mamoni, R.L.3    Coelho, O.R.4    Nicolau, J.C.5    Blotta, M.H.6    Serrano, C.V.7
  • 35
    • 84873717637 scopus 로고    scopus 로고
    • The effect of pentoxifylline on reduction of proteinuria among patients with type 2 diabetes under blockade of angiotensin system: A double blind and randomized clinical trial
    • 23169362
    • Ghorbani A, Omidvar B, Beladi-Mousavi SS, Lak E, Vaziri S (2012) The effect of pentoxifylline on reduction of proteinuria among patients with type 2 diabetes under blockade of angiotensin system: a double blind and randomized clinical trial. Nefrologia 32:790-796
    • (2012) Nefrologia , vol.32 , pp. 790-796
    • Ghorbani, A.1    Omidvar, B.2    Beladi-Mousavi, S.S.3    Lak, E.4    Vaziri, S.5
  • 36
    • 78650049718 scopus 로고    scopus 로고
    • TNF-α in hypothalamic paraventricular nucleus contributes to sympathoexcitation in heart failure by modulating AT1 receptor and neurotransmitters
    • 1:CAS:528:DC%2BC3MXovVejtA%3D%3D 21135513
    • Kang YM, Wang Y, Yang LM, Elks C, Cardinale J, Yu XJ, Zhao XF, Zhang J, Zhang LH, Yang ZM, Francis J (2010) TNF-α in hypothalamic paraventricular nucleus contributes to sympathoexcitation in heart failure by modulating AT1 receptor and neurotransmitters. Tohoku J Exp Med 222:251-263
    • (2010) Tohoku J Exp Med , vol.222 , pp. 251-263
    • Kang, Y.M.1    Wang, Y.2    Yang, L.M.3    Elks, C.4    Cardinale, J.5    Yu, X.J.6    Zhao, X.F.7    Zhang, J.8    Zhang, L.H.9    Yang, Z.M.10    Francis, J.11
  • 37
    • 46149092954 scopus 로고    scopus 로고
    • Cytokine blockade attenuates sympathoexcitation in heart failure: Cross-talk between nNOS, AT-1R and cytokines in the hypothalamic paraventricular nucleus
    • 2593148 1:CAS:528:DC%2BD1cXotlOjtLo%3D 18550427
    • Guggilam A, Patel KP, Haque M, Ebenezer PJ, Kapusta DR, Francis J (2008) Cytokine blockade attenuates sympathoexcitation in heart failure: cross-talk between nNOS, AT-1R and cytokines in the hypothalamic paraventricular nucleus. Eur J Heart Fail 10:625-634
    • (2008) Eur J Heart Fail , vol.10 , pp. 625-634
    • Guggilam, A.1    Patel, K.P.2    Haque, M.3    Ebenezer, P.J.4    Kapusta, D.R.5    Francis, J.6
  • 40
    • 0021325327 scopus 로고
    • Severe theophylline toxicity. Role of conservative measures, antiarrhythmic agents, and charcoal hemoperfusion
    • 1:CAS:528:DyaL2cXltVeru7Y%3D 6720731
    • Greenberg A, Piraino BH, Kroboth PD, Weiss J (1984) Severe theophylline toxicity. Role of conservative measures, antiarrhythmic agents, and charcoal hemoperfusion. Am J Med 76:854-860
    • (1984) Am J Med , vol.76 , pp. 854-860
    • Greenberg, A.1    Piraino, B.H.2    Kroboth, P.D.3    Weiss, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.