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Volumn 5, Issue , 2015, Pages

Standardization of the antibody-dependent respiratory burst assay with human neutrophils and Plasmodium falciparum malaria

Author keywords

[No Author keywords available]

Indexed keywords

FC RECEPTOR; MALARIA VACCINE; PROTOZOON ANTIBODY;

EID: 84941770213     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep14081     Document Type: Article
Times cited : (23)

References (57)
  • 1
    • 79957703902 scopus 로고    scopus 로고
    • A Research Agenda for Malaria Eradication: Vaccines
    • The malERA Consultative Group on Vaccines. A Research Agenda for Malaria Eradication: Vaccines. PLoS Med 8, e1000398 (2011).
    • (2011) PLoS Med , vol.8
  • 2
    • 84856679687 scopus 로고    scopus 로고
    • Global malaria mortality between 1980 and 2010: A systematic analysis
    • Murray, C. J. L. et al. Global malaria mortality between 1980 and 2010: a systematic analysis. Lancet 379, 413-431 (2012).
    • (2012) Lancet , vol.379 , pp. 413-431
    • Murray, C.J.L.1
  • 4
    • 45549097494 scopus 로고    scopus 로고
    • Immunity to malaria: More questions than answers
    • Langhorne, J., Ndungu, F. M., Sponaas, A.-M. & Marsh, K. Immunity to malaria: more questions than answers. Nat Imm 9, 725-732 (2008).
    • (2008) Nat Imm , vol.9 , pp. 725-732
    • Langhorne, J.1    Ndungu, F.M.2    Sponaas, A.-M.3    Marsh, K.4
  • 5
    • 84897450410 scopus 로고    scopus 로고
    • Plasmodium falciparum erythrocyte invasion: Combining function with immune evasion
    • Wright, G. J. & Rayner, J. C. Plasmodium falciparum erythrocyte invasion: combining function with immune evasion. PLoS Path 10, e1003943 (2014).
    • (2014) PLoS Path , vol.10
    • Wright, G.J.1    Rayner, J.C.2
  • 6
    • 77952862926 scopus 로고    scopus 로고
    • Blood-stage malaria vaccines - Recent progress and future challenges
    • Goodman, A. L. & Draper, S. J. Blood-stage malaria vaccines - recent progress and future challenges. Ann Trop Med Parasitol 104, 189-211 (2010).
    • (2010) Ann Trop Med Parasitol , vol.104 , pp. 189-211
    • Goodman, A.L.1    Draper, S.J.2
  • 7
    • 84928210228 scopus 로고    scopus 로고
    • Recent developments in malaria vaccinology
    • Halbroth, B. R. & Draper, S. J. Recent developments in malaria vaccinology. Adv Parasitol 88, 1-49 (2015).
    • (2015) Adv Parasitol , vol.88 , pp. 1-49
    • Halbroth, B.R.1    Draper, S.J.2
  • 8
    • 79960671082 scopus 로고    scopus 로고
    • Impact on malaria parasite multiplication rates in infected volunteers of the protein-in-adjuvant vaccine AMA1-C1/Alhydrogel+CPG 7909
    • Duncan, C. J. A. et al. Impact on malaria parasite multiplication rates in infected volunteers of the protein-in-adjuvant vaccine AMA1-C1/Alhydrogel+CPG 7909. PLoS ONE 6, e22271 (2011).
    • (2011) PLoS ONE , vol.6
    • Duncan, C.J.A.1
  • 9
    • 84863683912 scopus 로고    scopus 로고
    • Can growth inhibition assays (GIA) predict blood-stage malaria vaccine efficacy?
    • Duncan, C., Hill, A. V. S. & Ellis, R. Can growth inhibition assays (GIA) predict blood-stage malaria vaccine efficacy? Hum Vaccin Immunother 8, 706-714 (2012).
    • (2012) Hum Vaccin Immunother , vol.8 , pp. 706-714
    • Duncan, C.1    Hill, A.V.S.2    Ellis, R.3
  • 10
    • 84871570852 scopus 로고    scopus 로고
    • Efficient measurement of opsonising antibodies to Plasmodium falciparum merozoites
    • Hill, D. L. et al. Efficient measurement of opsonising antibodies to Plasmodium falciparum merozoites. PLoS ONE 7, e51692 (2012).
    • (2012) PLoS ONE , vol.7
    • Hill, D.L.1
  • 11
    • 84904305506 scopus 로고    scopus 로고
    • Opsonic phagocytosis of Plasmodium falciparum merozoites: Mechanism in human immunity and a correlate of protection against malaria
    • Osier, F. H. et al. Opsonic phagocytosis of Plasmodium falciparum merozoites: mechanism in human immunity and a correlate of protection against malaria. BMC Medicine 12, 108 (2014).
    • (2014) BMC Medicine , vol.12 , pp. 108
    • Osier, F.H.1
  • 12
    • 0026688902 scopus 로고
    • Phagocytosis of Plasmodium falciparum-infected human red blood cells by human monocytes: Involvement of immune and nonimmune determinants and dependence on parasite developmental stage
    • Turrini, F. et al. Phagocytosis of Plasmodium falciparum-infected human red blood cells by human monocytes: involvement of immune and nonimmune determinants and dependence on parasite developmental stage. Blood 80, 801-808 (1992).
    • (1992) Blood , vol.80 , pp. 801-808
    • Turrini, F.1
  • 13
    • 0020664118 scopus 로고
    • Phagocytosis of Plasmodium falciparum-parasitized erythrocytes by human polymorphonuclear leukocytes
    • Celada, A., Cruchaud, A. & Perrin, L. H. Phagocytosis of Plasmodium falciparum-parasitized erythrocytes by human polymorphonuclear leukocytes. J Parasitol 69, 49-53 (1983).
    • (1983) J Parasitol , vol.69 , pp. 49-53
    • Celada, A.1    Cruchaud, A.2    Perrin, L.H.3
  • 14
    • 84861908387 scopus 로고    scopus 로고
    • A simplified, sensitive phagocytic assay for malaria cultures facilitated by flow cytometry of differentially-stained cell populations
    • Chan, C. L., Rénia, L. & Tan, K. S. W. A simplified, sensitive phagocytic assay for malaria cultures facilitated by flow cytometry of differentially-stained cell populations. PLoS ONE 7, e38523 (2012).
    • (2012) PLoS ONE , vol.7
    • Chan, C.L.1    Rénia, L.2    Tan, K.S.W.3
  • 15
    • 84925004026 scopus 로고    scopus 로고
    • Human antibodies fix complement to inhibit Plasmodium falciparum invasion of erythrocytes and are associated with protection against malaria
    • Boyle, M. J. et al. Human antibodies fix complement to inhibit Plasmodium falciparum invasion of erythrocytes and are associated with protection against malaria. Immunity 42, 580-590 (2015).
    • (2015) Immunity , vol.42 , pp. 580-590
    • Boyle, M.J.1
  • 16
    • 0024360303 scopus 로고
    • Effector cells involved in nonspecific and antibody-dependent mechanisms directed against Plasmodium falciparum blood stages in vitro
    • Lunel, F. & Druilhe, P. Effector cells involved in nonspecific and antibody-dependent mechanisms directed against Plasmodium falciparum blood stages in vitro. Infect Immun 57, 2043-2049 (1989).
    • (1989) Infect Immun , vol.57 , pp. 2043-2049
    • Lunel, F.1    Druilhe, P.2
  • 17
    • 0025606095 scopus 로고
    • Antibodies that protect humans against Plasmodium falciparum blood stages do not on their own inhibit parasite growth and invasion in vitro, but act in cooperation with monocytes
    • Bouharoun-Tayoun, H., Attanath, P., Sabchareon, A., Chongsuphajaisiddhi, T. & Druilhe, P. Antibodies that protect humans against Plasmodium falciparum blood stages do not on their own inhibit parasite growth and invasion in vitro, but act in cooperation with monocytes. J Exp Med 172, 1633-1641 (1990).
    • (1990) J Exp Med , vol.172 , pp. 1633-1641
    • Bouharoun-Tayoun, H.1    Attanath, P.2    Sabchareon, A.3    Chongsuphajaisiddhi, T.4    Druilhe, P.5
  • 18
    • 84880225221 scopus 로고    scopus 로고
    • The malaria vaccine candidate GMZ2 elicits functional antibodies in individuals from malaria endemic and non-endemic areas
    • Jepsen, M. P. G. et al. The malaria vaccine candidate GMZ2 elicits functional antibodies in individuals from malaria endemic and non-endemic areas. J Infect Dis 208, 479-488 (2013).
    • (2013) J Infect Dis , vol.208 , pp. 479-488
    • Jepsen, M.P.G.1
  • 19
    • 77957784634 scopus 로고    scopus 로고
    • Clinical protection from falciparum malaria correlates with neutrophil respiratory bursts induced by merozoites opsonized with human serum antibodies
    • Joos, C. et al. Clinical protection from falciparum malaria correlates with neutrophil respiratory bursts induced by merozoites opsonized with human serum antibodies. PLoS ONE 5, e9871 (2010).
    • (2010) PLoS ONE , vol.5
    • Joos, C.1
  • 20
    • 84914170307 scopus 로고    scopus 로고
    • Assessment of the neutrophilic antibody-dependent respiratory burst (ADRB) response to Plasmodium falciparum
    • Kapelski, S., Klockenbring, T., Fischer, R., Barth, S. & Fendel, R. Assessment of the neutrophilic antibody-dependent respiratory burst (ADRB) response to Plasmodium falciparum. J Leuk Biol 96, 1-12 (2014).
    • (2014) J Leuk Biol , vol.96 , pp. 1-12
    • Kapelski, S.1    Klockenbring, T.2    Fischer, R.3    Barth, S.4    Fendel, R.5
  • 21
    • 0345599934 scopus 로고    scopus 로고
    • Novel antimalarial antibodies highlight the importance of the antibody Fc region in mediating protection
    • Pleass, R. J. et al. Novel antimalarial antibodies highlight the importance of the antibody Fc region in mediating protection. Blood 102, 4424-4430 (2003).
    • (2003) Blood , vol.102 , pp. 4424-4430
    • Pleass, R.J.1
  • 22
    • 0033967836 scopus 로고    scopus 로고
    • Opsonization and phagocytosis of Plasmodium falciparum merozoites measured by flow cytometry
    • Kumaratilake, L. M. & Ferrante, A. Opsonization and phagocytosis of Plasmodium falciparum merozoites measured by flow cytometry. Clin Diagn Lab Immunol 7, 9-13 (2000).
    • (2000) Clin Diagn Lab Immunol , vol.7 , pp. 9-13
    • Kumaratilake, L.M.1    Ferrante, A.2
  • 23
    • 0022341794 scopus 로고
    • Schizonts, merozoites, and phagocytosis in falciparum malaria
    • Sun, T. & Chakrabarti, C. Schizonts, merozoites, and phagocytosis in falciparum malaria. Ann Clin Lab Sci 15, 465-469 (1985).
    • (1985) Ann Clin Lab Sci , vol.15 , pp. 465-469
    • Sun, T.1    Chakrabarti, C.2
  • 24
    • 84897026073 scopus 로고    scopus 로고
    • Assessment of antibody-dependent respiratory burst activity from mouse neutrophils on Plasmodium yoelii malaria challenge outcome
    • Llewellyn, D. et al. Assessment of antibody-dependent respiratory burst activity from mouse neutrophils on Plasmodium yoelii malaria challenge outcome. J Leuk Biol 95, 369-382 (2014).
    • (2014) J Leuk Biol , vol.95 , pp. 369-382
    • Llewellyn, D.1
  • 25
    • 0020696254 scopus 로고
    • Evidence for reactive oxygen intermediates causing hemolysis and parasite death in malaria
    • Clark, I. A. & Hunt, N. H. Evidence for reactive oxygen intermediates causing hemolysis and parasite death in malaria. Infect Immun 39, 1-6 (1983).
    • (1983) Infect Immun , vol.39 , pp. 1-6
    • Clark, I.A.1    Hunt, N.H.2
  • 26
    • 0019471126 scopus 로고
    • Susceptibility of leishmania to oxygen intermediates and killing by normal macrophages
    • Murray, H. Susceptibility of leishmania to oxygen intermediates and killing by normal macrophages. J Exp Med 153, 1302-1315 (1981).
    • (1981) J Exp Med , vol.153 , pp. 1302-1315
    • Murray, H.1
  • 27
    • 0018675769 scopus 로고
    • Macrophage oxygen-dependent antimicrobial activity. I. Susceptibility of Toxoplasma gondii to oxygen intermediates
    • Murray, H. W. & Cohn, Z. A. Macrophage oxygen-dependent antimicrobial activity. I. Susceptibility of Toxoplasma gondii to oxygen intermediates. J Exp Med 150, 938-949 (1979).
    • (1979) J Exp Med , vol.150 , pp. 938-949
    • Murray, H.W.1    Cohn, Z.A.2
  • 28
    • 0018410383 scopus 로고
    • Oxidant damage mediates variant red cell resistance to malaria
    • Friedman, M. J. Oxidant damage mediates variant red cell resistance to malaria. Nature 280, 245-247 (1979).
    • (1979) Nature , vol.280 , pp. 245-247
    • Friedman, M.J.1
  • 29
    • 0032992577 scopus 로고    scopus 로고
    • High oxygen radical production is associated with fast parasite clearance in children with Plasmodium falciparum malaria
    • Greve, B. et al. High oxygen radical production is associated with fast parasite clearance in children with Plasmodium falciparum malaria. J Infect Dis 179, 1584-1586 (1999).
    • (1999) J Infect Dis , vol.179 , pp. 1584-1586
    • Greve, B.1
  • 30
    • 0032929623 scopus 로고    scopus 로고
    • Are reactive oxygen species involved in the pathogenesis of murine cerebral malaria?
    • Sanni, L. A. et al. Are reactive oxygen species involved in the pathogenesis of murine cerebral malaria? J Infect Dis 179, 217-222 (1999).
    • (1999) J Infect Dis , vol.179 , pp. 217-222
    • Sanni, L.A.1
  • 31
    • 84870602529 scopus 로고    scopus 로고
    • ChAd63-MVA-vectored blood-stage malaria vaccines targeting MSP1 and AMA1: Assessment of efficacy against mosquito bite challenge in humans
    • Sheehy, S. H. et al. ChAd63-MVA-vectored blood-stage malaria vaccines targeting MSP1 and AMA1: assessment of efficacy against mosquito bite challenge in humans. Mol Ther 20, 2355-2368 (2012).
    • (2012) Mol Ther , vol.20 , pp. 2355-2368
    • Sheehy, S.H.1
  • 33
    • 34249703970 scopus 로고    scopus 로고
    • The importance of human FcgRI in mediating protection to malaria
    • McIntosh, R. S. et al. The importance of human FcgRI in mediating protection to malaria. PLoS Path 3, e72 (2007).
    • (2007) PLoS Path , vol.3
    • McIntosh, R.S.1
  • 35
    • 79251544880 scopus 로고    scopus 로고
    • Complement alternative pathway acts as a positive feedback amplification of neutrophil activation
    • Camous, L. et al. Complement alternative pathway acts as a positive feedback amplification of neutrophil activation. Blood 117, 1340-1349 (2011).
    • (2011) Blood , vol.117 , pp. 1340-1349
    • Camous, L.1
  • 36
    • 0024425302 scopus 로고
    • Complement membrane attack on nucleated cells: Resistance, recovery and non lethal effects
    • Morgan, B. P. Complement membrane attack on nucleated cells: resistance, recovery and non lethal effects. Biochem J 264, 1-14 (1989).
    • (1989) Biochem J , vol.264 , pp. 1-14
    • Morgan, B.P.1
  • 37
    • 0030657786 scopus 로고    scopus 로고
    • Neutrophil Fcγ and complement receptors involved in binding soluble IgG immune complexes and in specific granule release induced by soluble IgG immune complexes
    • Voice, J. K. & Lachmann, P. J. Neutrophil Fcγ and complement receptors involved in binding soluble IgG immune complexes and in specific granule release induced by soluble IgG immune complexes. Eur J Immunol 27, 2514-2523 (1997).
    • (1997) Eur J Immunol , vol.27 , pp. 2514-2523
    • Voice, J.K.1    Lachmann, P.J.2
  • 38
    • 84907463083 scopus 로고    scopus 로고
    • Assessment of humoral immune responses to blood-stage malaria antigens following ChAd63-MVA immunization, controlled human malaria infection and natural exposure
    • Biswas, S. et al. Assessment of humoral immune responses to blood-stage malaria antigens following ChAd63-MVA immunization, controlled human malaria infection and natural exposure. PLoS One 9, e107903 (2014).
    • (2014) PLoS One , vol.9
    • Biswas, S.1
  • 40
    • 37249043123 scopus 로고    scopus 로고
    • Development and characterization of a standardized ELISA including a reference serum on each plate to detect antibodies induced by experimental malaria vaccines
    • Miura, K. et al. Development and characterization of a standardized ELISA including a reference serum on each plate to detect antibodies induced by experimental malaria vaccines. Vaccine 26, 193-200 (2008).
    • (2008) Vaccine , vol.26 , pp. 193-200
    • Miura, K.1
  • 41
    • 0031595604 scopus 로고    scopus 로고
    • Detection of Fcg receptors on human endothelial cells stimulated with cytokines tumour necrosis factor-alpha (TNF-a) and interferon-gamma (IFN-g)
    • Pan, L., Kreisle, R. & Shi, Y. Detection of Fcg receptors on human endothelial cells stimulated with cytokines tumour necrosis factor-alpha (TNF-a) and interferon-gamma (IFN-g). Clin Exp Immunol 112, 533-538 (1998).
    • (1998) Clin Exp Immunol , vol.112 , pp. 533-538
    • Pan, L.1    Kreisle, R.2    Shi, Y.3
  • 42
    • 0036882321 scopus 로고    scopus 로고
    • Fcγ receptor IIA and IIIB polymorphisms are associated with susceptibility to cerebral malaria
    • Omi, K. et al. Fcγ receptor IIA and IIIB polymorphisms are associated with susceptibility to cerebral malaria. Parasitol Int 51, 361-366 (2002).
    • (2002) Parasitol Int , vol.51 , pp. 361-366
    • Omi, K.1
  • 43
    • 1342310914 scopus 로고    scopus 로고
    • Association of Fcg receptor Ila (CD32) polymorphism with severe malaria in West Africa
    • Cooke, G. S. et al. Association of Fcg receptor Ila (CD32) polymorphism with severe malaria in West Africa. Am J Trop Med Hyg 69, 565-568 (2003).
    • (2003) Am J Trop Med Hyg , vol.69 , pp. 565-568
    • Cooke, G.S.1
  • 44
    • 0035399821 scopus 로고    scopus 로고
    • Fcγ receptor IIa (CD32) polymorphism is associated with protection of infants against high-density Plasmodium falciparum infection. VII. Asembo Bay Cohort Project
    • Shi, Y. P. et al. Fcγ receptor IIa (CD32) polymorphism is associated with protection of infants against high-density Plasmodium falciparum infection. VII. Asembo Bay Cohort Project. J Infect Dis 184, 107-111 (2001).
    • (2001) J Infect Dis , vol.184 , pp. 107-111
    • Shi, Y.P.1
  • 45
    • 84856749596 scopus 로고    scopus 로고
    • Functional haplotypes of Fc gamma (Fcγ) receptor (FcγRIIA and FcγRIIIB) predict risk to repeated episodes of severe malarial anemia and mortality in Kenyan children
    • Ouma, C. et al. Functional haplotypes of Fc gamma (Fcγ) receptor (FcγRIIA and FcγRIIIB) predict risk to repeated episodes of severe malarial anemia and mortality in Kenyan children. Hum Genet, 131, 289-299 (2012).
    • (2012) Hum Genet , vol.131 , pp. 289-299
    • Ouma, C.1
  • 46
    • 34247355050 scopus 로고    scopus 로고
    • Phase I dose escalation safety and immunogenicity trial of Plasmodium falciparum apical membrane protein (AMA-1) FMP2.1, adjuvanted with AS02A, in malaria-naïve adults at the Walter Reed Army Institute of Research
    • Polhemus, M. E. et al. Phase I dose escalation safety and immunogenicity trial of Plasmodium falciparum apical membrane protein (AMA-1) FMP2.1, adjuvanted with AS02A, in malaria-naïve adults at the Walter Reed Army Institute of Research. Vaccine 25, 4203-4212 (2007).
    • (2007) Vaccine , vol.25 , pp. 4203-4212
    • Polhemus, M.E.1
  • 47
    • 0037033084 scopus 로고    scopus 로고
    • Serine repeat antigen (SERA5) is predominantly expressed among the SERA multigene family of Plasmodium falciparum, and the acquired antibody titers correlate with serum inhibition of the parasite growth
    • Aoki, S. et al. Serine repeat antigen (SERA5) is predominantly expressed among the SERA multigene family of Plasmodium falciparum, and the acquired antibody titers correlate with serum inhibition of the parasite growth. J Biol Chem 277, 47533-47540 (2002).
    • (2002) J Biol Chem , vol.277 , pp. 47533-47540
    • Aoki, S.1
  • 48
    • 84857399087 scopus 로고    scopus 로고
    • Phase Ia clinical evaluation of the safety and immunogenicity of the Plasmodium falciparum blood-stage antigen AMA1 in ChAd63 and MVA vaccine vectors
    • Sheehy, S. H. et al. Phase Ia clinical evaluation of the safety and immunogenicity of the Plasmodium falciparum blood-stage antigen AMA1 in ChAd63 and MVA vaccine vectors. PLoS One 7, e31208 (2012).
    • (2012) PLoS One , vol.7
    • Sheehy, S.H.1
  • 49
    • 33644871833 scopus 로고    scopus 로고
    • Immune effector mechanisms in malaria
    • Marsh, K. & Kinyanjui, S. Immune effector mechanisms in malaria. Parasite Immunol 28, 51-60 (2006).
    • (2006) Parasite Immunol , vol.28 , pp. 51-60
    • Marsh, K.1    Kinyanjui, S.2
  • 50
    • 84870778753 scopus 로고    scopus 로고
    • Enhancing blockade of Plasmodium falciparum erythrocyte invasion: Assessing combinations of antibodies against PfRH5 and other merozoite antigens
    • Williams, A. R. et al. Enhancing blockade of Plasmodium falciparum erythrocyte invasion: assessing combinations of antibodies against PfRH5 and other merozoite antigens. PLoS Path 8, e1002991 (2012).
    • (2012) PLoS Path , vol.8
    • Williams, A.R.1
  • 51
    • 0018704491 scopus 로고
    • Synchronization of Plasmodium falciparum erythrocytic stages in culture
    • Lambros, C. & Vanderberg, J. P. Synchronization of Plasmodium falciparum erythrocytic stages in culture. J Parasitol 65, 418-420 (1979).
    • (1979) J Parasitol , vol.65 , pp. 418-420
    • Lambros, C.1    Vanderberg, J.P.2
  • 52
    • 0023597795 scopus 로고
    • Identification of three stage-specific proteinases of Plasmodium falciparum
    • Rosenthal, P. J., Kim, K., McKerrow, J. H. & Leech, J. H. Identification of three stage-specific proteinases of Plasmodium falciparum. J Exp Med 166, 816-821 (1987).
    • (1987) J Exp Med , vol.166 , pp. 816-821
    • Rosenthal, P.J.1    Kim, K.2    McKerrow, J.H.3    Leech, J.H.4
  • 53
    • 0035793051 scopus 로고    scopus 로고
    • Malaria parasite exit from the host erythrocyte: A two-step process requiring extraerythrocytic proteolysis
    • Salmon, B. L., Oksman, A. & Goldberg, D. E. Malaria parasite exit from the host erythrocyte: A two-step process requiring extraerythrocytic proteolysis. PNAS 98, 271-276 (2001).
    • (2001) PNAS , vol.98 , pp. 271-276
    • Salmon, B.L.1    Oksman, A.2    Goldberg, D.E.3
  • 54
    • 45549104352 scopus 로고    scopus 로고
    • Neutrophil isolation from nonhuman species
    • (eds. Quinn, M. T., DeLeo, F. R. & Bokoch, G. M.) Humana Press, Totowa
    • Siemsen, D. W., Schepetkin, I. A., Kirpotina, L. N., Lei, B. & Quinn, M. T. Neutrophil isolation from nonhuman species. in Neutrophil Methods and Protocols, Vol. 412 (eds. Quinn, M. T., DeLeo, F. R. & Bokoch, G. M.) 21-34 (Humana Press, Totowa, 2007).
    • (2007) Neutrophil Methods and Protocols , vol.412 , pp. 21-34
    • Siemsen, D.W.1    Schepetkin, I.A.2    Kirpotina, L.N.3    Lei, B.4    Quinn, M.T.5
  • 55
    • 84860390192 scopus 로고    scopus 로고
    • Phase Ia clinical evaluation of the Plasmodium falciparum blood-stage antigen MSP1 in ChAd63 and MVA vaccine vectors
    • Sheehy, S. H. et al. Phase Ia clinical evaluation of the Plasmodium falciparum blood-stage antigen MSP1 in ChAd63 and MVA vaccine vectors. Mol Ther 19, 2269-2276 (2011).
    • (2011) Mol Ther , vol.19 , pp. 2269-2276
    • Sheehy, S.H.1
  • 56
    • 33845390102 scopus 로고
    • Hierarchical partitioning
    • Chevan, A. & Sutherland, M. Hierarchical partitioning. Am Stat 45, 90-96 (1991).
    • (1991) Am Stat , vol.45 , pp. 90-96
    • Chevan, A.1    Sutherland, M.2


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