Novel antimalarial antibodies highlight the importance of the antibody Fc region in mediating protection

Blood

Volumn 102, Issue 13, 2003, Pages 4424-4430

  Pleass, Richard J ^a   Ogun, Solabomi A ^b   McGuinness, David H ^b   Van De Winkel, Jan G J ^b   Holder, Anthony A ^b   Woof, Jenny M ^b  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A1; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G2B; MALARIA ANTIBODY; MEROZOITE SURFACE PROTEIN 1; NEUTRALIZING ANTIBODY; PROTOZOON ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN BINDING; ANTIGEN FUNCTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL PROTECTION; CHO CELL; CONTROLLED STUDY; FEMALE; IMMUNE RESPONSE; IMMUNOPATHOLOGY; IN VIVO STUDY; MALARIA; MEROZOITE; MOUSE; NONHUMAN; PASSIVE IMMUNIZATION; PHAGOCYTOSIS; PLASMODIUM YOELII; PRIORITY JOURNAL;

EID: 0345599934     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-02-0583     Document Type: Article

References (45)

1. Breman JG, Egan A, Keusch GT. The ears of the hippopotamus: manifestations, determinants, and estimates of the malaria burden. Am J Trop Med Hyg. 2001;64:1-11.
2. Cohen S, McGregor A, Carrington S. Gamma globulin and acquired immunity to malaria. Nature. 1961;192:733-737.
3. Good MF, Kaslow DC, Miller LH. Pathways and strategies for developing a malaria blood-stage vaccine. Annu Rev Immunol. 1998;16:57-87.
4. Holder AA, Blackman MJ, Burghaus PA, et al. A malaria merozoite surface protein (MSP1)-structure, processing and function. Mem Inst Oswaldo Cruz. 1992;87:37-42.
5. Florens L, Washburn MP, Raine JD, et al. A proteomic view of the Plasmodium falciparum life cycle. Nature. 2002;419:520-526.
6. 19 are a major component of the invasion-inhibitory response in individuals immune to malaria. J Exp Med. 2001;193:1403-1412.
7. Pleass RJ, Woof JM. Fc receptors and immunity to parasites. Trends Parasitol. 2001;17:545-551.
8. Rotman HL, Daly TM, Clynes R, Long CA. Fc receptors are not required for antibody-mediated protection against lethal malaria challenge in a mouse model. J Immunol. 1998;161:1908-1912.
9. Bouharoun-Tayoun H, Oeuvray C, Lunel F, Druilhe P. Mechanisms underlying the monocyte mediated antibody-dependent killing of Plasmodium falciparum asexual blood stages. J Exp Med. 1995;182:409-418.
10. Bouharoun-Tayoun H, Attanath P, Sabchareon A, Chongsuphajaisiddi T, Druilhe P. Antibodies that protect humans against Plasmodium falciparum blood stages do not on their own inhibit parasite growth and invasion in vitro, but act in cooperation with monocytes. J Exp Med. 1990;172:1633-1641.
11. Wang Z, Raifu M, Howard M, et al. Universal PCR amplification of mouse immunoglobulin gene variable regions: the design of degenerate primers and an assessment of the effect of DNA polymerase 3′ to 5′ exonuclease activity. J Immunol Methods. 2000;233:167-177.
12. Pope AR, Embleton MJ, Menaugh R. Construction and use of antibody gene repertoires. In: McCafferty J, Hoogenboom H, Chiswell D, eds. Antibody Engineering, A Practical Approach. Oxford, United Kingdom: IRL Press; 1996:1-40.
13. Batten MR, Senior BW, Kilian M, Woof JM. Amino-acid sequence requirements in the hinge of human immunoglobulin A1 (IgA1) for cleavage by streptococcal IgA1 proteases. Infect Immun. 2003;71:1462-1469.
14. Persic L, Roberts A, Wilton J, Cattaneo A, Bradbury A, Hoogenboom HR. An integrated vector system for the eukaryotic expression of antibodies or their fragments after selection from phage display libraries. Gene. 1997;187:9-18.
15. Volkel T, Korn T, Bach M, Muller R, Kontermann RE. Optimized linker sequences for the expression of monomeric and dimeric bispecific single-chain diabodies. Prot Engineering. 2001;14:815-823.
16. Perisic O, Webb PA, Holliger P, Winter G, Williams RL. Crystal structure of a diabody, a bivalent antibody fragment. Structure. 1994;2:1217-1226.
17. Morton HC, Atkin JD, Owens RJ, Woof JM. Purification and characterization of chimeric human IgA1 and IgA2 expressed in COS and Chinese hamster ovary cells. J Immunol. 1993;151:4743-4752.
18. Pleass RJ, Dunlop JI, Anderson CM, Woof JM. Identification of residues in the CH2/CH3 domain interface of IgA essential for interaction with the human Fcα receptor (FcαR) CD89. J Biol Chem. 1999:274:23508-23514.
19. Schlichtherle M, Wahlgren M, Perlmann H, Scherf A. Methods in Malaria Research. Manassas, Virginia: 2000.
20. Spencer Valero LM, Ogun SA, Fleck SL, et al. Passive immunization with antibodies against three distinct epitopes on Plasmodium yoelii merozoite surface protein 1 suppresses parasitemia. Infect Immun. 1998;66:3925-3930.
21. Carlton JM, Angiroli SV, Suh BB, et al. Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii. Nature. 2002;419:512-519.
22. van Egmond M, van Garderen E, van Spriel AB, et al. FcalphaRI-positive liver Kupffer cells: reappraisal of the function of immunoglobulin A in immunity. Nature Med. 2000;6:680-685.
23. van Spriel AB, van Ojik HH, van de Winkel JGJ. Immunotherapeutic perspective for bispecific antibodies. Trends Immunol. 2000;21:391-397.
24. Kumaratilake LM, Ferrante A, Jaeger T, Rzeptzyk CM. Effects of cytokine and complement and antibody on the neutrophils respiratory burst and phagocytic response to P falciparum merozoites. Infect Immun. 1992;60:3731-3738.
25. Geissmann F, Launay P, Pasquier B, et al. A subset of human dendritic cells expresses IgA Fc receptor (CD89), which mediates internalization and activation upon cross-linking by IgA complexes. J Immunol. 2001;166:346-352.
26. Wolf HM, Hauber I, Gulle H, et al. Anti-inflammatory properties of human serum IgA: induction of IL-1 receptor antagonist and FcαR (CD89) mediated down regulation of tumour necrosis factor-alpha (TNF-α) and IL-6 in human monocytes. Clin Exp Immunol. 1996;105:537-543.
27. Miller LH, Good MF, Milon G. Malaria pathology. Science. 1994;264:1878-1883.
28. Biswas S, Saxena QB, Roy A, Kubilan L. Naturally occurring Plasmodium specific IgA antibodies in humans from a malaria endemic area. J Biosci. 1995;20:453-460.
29. Leke RG, Ndansi R, Southerland NJ, Quakyi IA, Taylor DW. Identification of anti-Plasmodium falciparum antibodies in human breast milk. Scand J Immunol. 1992;11:17-22.
30. Kumaratilake LM, Ferrante A, Jaeger T, Morris-Jones SD. The role of complement, antibody, and TNF-α in the killing of Plasmodium falciparum by the monocytic cell line THP-1. Infect Immun. 1997;65:5342-5345.
31. Salmon D, Vilde JL, Andrien B, Simonovic R, Lebras J. Role of immune serum and complement in stimulation of the metabolic burst of human neutrophils by Plasmodium falciparum. Infect Immun. 1986;51:801-806.
32. Saeland EG, Vidarsson JHW, Leusen E, et al. Central role for complement in passive protection by human IgG1 and IgG2 anti-pneumococcal antibodies in mice. J Immunol. 2003;170:6158-6164.
33. Hulett MD, Hogarth PM. Molecular basis of Fc receptor function. Adv Immunol. 1994;57:1-127.
34. 1, I: the binding of homologous and heterologous immunoglobulin G. J Immunol. 1979;123:1905-1913.
35. Vukovic P, Chen K, Qin Liu X, et al. Single-chain antibodies produced by phage display against the C-terminal 19 kDa region of merozoite surface protein-1 of Plasmodium yoelii reduce parasite growth following challenge. Vaccine. 2002;20:2826-2835.
36. Thomas AW, Deans JA, Mitchell GH, Alderson T, Cohen S. The Fab fragments of monoclonal IgG to a merozoite surface antigen inhibit Plasmodium knowlesi invasion of erythrocytes. Mol Biochem Parasitol. 1984;13:187-199.
37. Guevara Patino JA, Holder AA, McBride JS, Brackman MJ. Antibodies that inhibit malaria merozoite surface protein-1 processing and erythrocyte invasion are blocked by naturally acquired human antibodies. J Exp Med. 1997;186:1-11.
38. Stockmeyer B, Elasser D, Dechant M, et al. Mechanisms of G-CSF or GM-CSF-stimulated tumor cell killing by Fc receptor directed bispecific antibodies. J Immunol Methods. 2001;248:103-111.
39. Saul A, Miller LH. A robust neutralization test for Plasmodium falciparum malaria. J Exp Med. 2001;193:51-54.
40. Clynes RA, Towers TL, Presta LG, Ravetch JV. Inhibitory Fc receptors modulate in vivo cytotoxicity against tumour targets. Nature Med. 2000;6:443-446.
41. 2+ response in human neutrophils. J Biol Chem. 1995;270:10671-10679.
42. Underhill DM, Ozinsky A. Phagocytosis of microbes: complexity in action. Annu Rev Immunol. 2002;20:825-852.
43. Wallace PK, Valone FH, Fanger MW. Myeloid cell-targeted cytotoxicity of tumor cells. In: Fanger MW, ed. Bispecific Antibodies. Austin, Texas: Springer-Verlag, R.G. Landes Company; 1995:43-76.
44. Ho M, White NJ, Looareesuwan S, et al. Splenic Fc receptor function in host defence and anemia in acute Plasmodium falciparum malaria. J Infect Dis. 1990;161:555-561.
45. Yoshida S, Kobayashi T, Matsuoka H, et al. T cell activation and cytokine production via a bispecific single-chain antibody fragment targeted to blood-stage malaria parasites. Blood. 2002;101:2300-2306.