Pulsatile GnRH is superior to HCG in therapeutic efficacy in adolescent boys with hypogonadotropic hypogonadodism

Journal of Clinical Endocrinology and Metabolism

Volumn 100, Issue 7, 2015, Pages 2793-2799

  Gong, Chunxiu ^a   Liu, Ying ^a   Qin, Miao ^a   Wu, Di ^a   Wang, Xiaoling ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; FOLLITROPIN; GONADORELIN; LUTEINIZING HORMONE; TAMOXIFEN; TESTOSTERONE;

ACNE; ADOLESCENT; ADVERSE DRUG REACTION; ARTICLE; BONE AGE; BONE RADIOGRAPHY; BREAST DISEASE; CHILD; CHINA; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG SAFETY; FOLLITROPIN BLOOD LEVEL; FOLLOW UP; HUMAN; HUMAN CELL; HYPOGONADOTROPIC HYPOGONADISM; IDIOPATHIC DISEASE; KALLMANN SYNDROME; LUTEINIZING HORMONE BLOOD LEVEL; MALE; MULTIPLE CYCLE TREATMENT; ORCHIDOMETER; OUTCOME ASSESSMENT; PEDIATRIC HOSPITAL; PENIS; PENIS ERECTION; PRIORITY JOURNAL; SCHOOL CHILD; SCROTAL PAIN; SIDE EFFECT; TESTIS SIZE; TESTOSTERONE BLOOD LEVEL; TREATMENT RESPONSE; BLOOD; CLINICAL TRIAL; COMPARATIVE STUDY; DRUG EFFECTS; HYPOGONADISM; INFUSION PUMP; PUBERTY; PULSATILE FLOW; SPERMATOGENESIS; SUBCUTANEOUS DRUG ADMINISTRATION; TREATMENT OUTCOME;

ADOLESCENT; CHILD; CHORIONIC GONADOTROPIN; GONADOTROPIN-RELEASING HORMONE; HUMANS; HYPOGONADISM; INFUSION PUMPS, IMPLANTABLE; INFUSIONS, SUBCUTANEOUS; KALLMANN SYNDROME; MALE; PUBERTY; PULSATILE FLOW; SPERMATOGENESIS; TREATMENT OUTCOME;

EID: 84941721083     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2015-1343     Document Type: Article

References (26)

1. Bianco SD, Kaiser UB. The genetic and molecular basis of idiopathic hypogonadotropic hypogonadism. Nat Rev Endocrinol. 2009;5: 569-576.
2. Silveira LF, MacColl GS, Bouloux PM. Hypogonadotropic hypogonadism. Semin Reprod Med. 2002;20:327-338.
3. Sykiotis GP, Hoang XH, Avbelj M, et al. Congenital idiopathic hypogonadotropic hypogonadism: evidence of defects in the hypothalamus, pituitary, and testes. J Clin Endocrinol Metab. 2010;95: 3019-3027.
4. Ge Q. Clinical Reproductive Endocrinology. 1st ed. Beijing: Science and Technology Literature Press; 2001.
5. Mitchell AL, Dwyer A, Pitteloud N, Quinton R. Genetic basis and variable phenotypic expression of Kallmann syndrome: towards a unifying theory. Trends Endocrinol Metab. 2011;22:249-258.
6. Silveira LF, Trarbach EB, Latronico AC. Genetics basis for GnRHdependent pubertal disorders in humans. Mol Cell Endocrinol. 2010;324:30-38.
7. Young J, Metay C, Bouligand J, et al. SEMA3A deletion in a family with Kallmann syndrome validates the role of semaphorin 3A in human puberty and olfactory system development. Hum Reprod. 2012;27:1460-1465.
8. Semple RK, Topaloglu AK. The recent genetics of hypogonadotrophic hypogonadism-novel insights and new questions. Clin Endocrinol (Oxf). 2010;72:427-435.
9. Bhasin S, Cunningham GR, Hayes FJ, et al. Testosterone therapy in menwith androgen deficiency syndromes: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2010;95:2536-2559.
10. Liu PY, Baker HW, Jayadev V, Zacharin M, Conway AJ, Handelsman DJ. Induction of spermatogenesis and fertility during gonadotropin treatment of gonadotropin-deficient infertile men: predictors of fertility outcome. J Clin Endocrinol Metab. 2009;94:801-808.
11. Zhang G, Jia M, Zhao J. Normal men and patients with idiopathic low gonadal hormone function reduction reactions to automatic LHRH pulse injection. Chin J Endocrinol Metab. 1987;3:76-79.
12. Delemarre-van de Waal HA. Application of gonadotropin releasing hormone in hypogonadotropic hypogonadism-diagnostic and therapeutic aspects. Eur J Endocrinol. 2004;151(suppl 3):U89-U94.
13. Miyagawa Y, Tsujimura A, Matsumiya K, et al. Outcome of gonadotropin therapy for male hypogonadotropic hypogonadism at university affiliated male infertility centers: a 30-year retrospective study. J Urol. 2005;173:2072-2075.
14. Buchter D, Behre HM, Kliesch S, Nieschlag E. Pulsatile GnRH or human chorionic gonadotropin/human menopausal gonadotropin as effective treatment for men with hypogonadotropic hypogonadism: a review of 42 cases. Eur J Endocrinol. 1998;139:298-303.
15. Yu C, Songxian L. Practical Gynecological Endocrinology. Shanghai, China: Fudan University Press; 2004.
16. Zacharin M, Sabin MA, Nair VV, Dabadghao P. Addition of recombinant follicle-stimulating hormone to human chorionic gonadotropin treatment in adolescents and young adults with hypogonadotropic hypogonadism promotes normal testicular growth and may promote early spermatogenesis. Fertil Steril. 2012;98:836-842.
17. Hayes FJ, Seminara SB, Crowley WF Jr. Hypogonadotropic hypogonadism. Endocrinol Metab Clin North Am 1998;27:739-763, vii.
18. Seminara SB, Hayes FJ, Crowley WF Jr. Gonadotropin-releasing hormone deficiency in the human (idiopathic hypogonadotropic hypogonadism and Kallmann's syndrome): pathophysiological and genetic considerations. Endocr Rev. 1998;19:521-539.
19. Fraietta R, Zylberstejn DS, Esteves SC. Hypogonadotropic hypogonadism revisited. Clinics (Sao Paulo). 2013;68(1):81-88.
20. Raivio T, Wikstrom AM, Dunkel L. Treatment of gonadotropindeficient boys with recombinanthumanFSH: long-term observation and outcome. Eur J Endocrinol. 2007;156:105-111.
21. WalkerWH. Testosterone signaling and the regulation of spermatogenesis. Spermatogenesis. 2011;1:116-120.
22. Willems A, Batlouni SR, Esnal A, et al. Selective ablation of the androgen receptor in mouse Sertoli cells affects sertoli cell maturation, barrier formation and cytoskeletal development. PLoS One. 2010;5:e14168.
23. Han TS, Bouloux PM. What is the optimal therapy for young males with hypogonadotropic hypogonadism? Clin Endocrinol (Oxf). 2010;72:731-7371.
24. Xu H. Hypogonadotropic Hypogonadism Patients Succeeded in Spermatogenesis With Combined Treatment of HCG and HMG: Clinical Characteristics and Influence Factors. Beijing: Peking Union Medical College; 2013.
25. Liu L, Chaudhari N, Corle D, et al. Comparison of pulsatile subcutaneous gonadotropins in the treatment of men with isolated hypogonadotropic hypogonadism. Fertil Steril. 1988;49:302-308.
26. Pitteloud N, Hayes FJ, Dwyer A, et al. Predictors of outcome of long-termGnRHtherapy in men with idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2002;87:4128-4136.