Systems Biology Approach Reveals a Calcium-Dependent Mechanism for Basal Toxicity in Daphnia magna

Environmental Science and Technology

Volumn 49, Issue 18, 2015, Pages 11132-11140

  Antczak, Philipp ^a   White, Thomas A ^b   Giri, Anirudha ^c   Michelangeli, Francesco ^b   Viant, Mark R ^b   Cronin, Mark T D ^d   Vulpe, Chris ^e   Falciani, Francesco ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c ASSAM UNIVERSITY   (India)

^d LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL HAZARDS; CHEMICALS; HEALTH HAZARDS; RISK ASSESSMENT; TOXICITY;

BIOLOGICAL PATHWAYS; CALCIUM HOMEOSTASIS; CALCIUM MOBILIZATION; INTRACELLULAR CALCIUM MOBILIZATION; LIPOPHILIC COMPOUNDS; METABOLOME ANALYSIS; SUB-LETHAL EFFECTS; TRANSCRIPTIONAL CHANGES;

CALCIUM;

ADENOSINE TRIPHOSPHATASE (CALCIUM); CALCIUM; POLLUTANT; THAPSIGARGIN;

BIOCHEMICAL COMPOSITION; CALCIUM; CRUSTACEAN; DOSE-RESPONSE RELATIONSHIP; GENE EXPRESSION; GENETIC ANALYSIS; PHENOTYPE; PHYSIOLOGICAL RESPONSE; RISK ASSESSMENT; TOXICITY TEST; ZOOPLANKTON;

ADVERSE OUTCOME; AMINO ACID METABOLISM; ANESTHESIA; ARTICLE; BASAL TOXICITY; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM MOBILIZATION; CHEMICAL INTERACTION; CHEMICAL STRUCTURE; DAPHNIA MAGNA; DNA REPAIR; DNA REPLICATION; ENERGY METABOLISM; GENE EXPRESSION; HAZARD ASSESSMENT; HEART BEAT; HEART RATE; LC50; LIPID METABOLISM; LIPOPHILICITY; NONHUMAN; PREDICTION; PROCEDURES; PROTEIN DEGRADATION; PROTON NUCLEAR MAGNETIC RESONANCE; RANDOM FOREST; RISK ASSESSMENT; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY; TOXICITY; ANIMAL; DAPHNIA; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; POLLUTANT; STATISTICAL MODEL; TOXICITY TESTING;

DAPHNIA MAGNA;

ANIMALS; CALCIUM; DAPHNIA; ENVIRONMENTAL POLLUTANTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; MODELS, STATISTICAL; SYSTEMS BIOLOGY; THAPSIGARGIN; TOXICITY TESTS; TRANSCRIPTION, GENETIC;

EID: 84941712025     PISSN: 0013936X     EISSN: 15205851     Source Type: Journal    
DOI: 10.1021/acs.est.5b02707     Document Type: Article

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