Effect of multi-nutrient insufficiency on markers of one carbon metabolism in young women: Response to a methionine load

European Journal of Clinical Nutrition

Volumn 70, Issue 6, 2016, Pages 687-693

  Katre, P ^a   Joshi, S ^a   Bhat, D S ^a   Deshmukh, M ^a   Gurav, N ^a   Pandit, S ^a   Lubree, H ^a   Marczewski, S ^b   Bennett, C ^b   Gruca, L ^b   Kalyanaraman, K ^a   Naik, S S ^a   Yajnik, C S ^a   Kalhan, S C ^b  

^a Kamalnayan Bajaj Diabetology Research Centre   (India)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BIOLOGICAL MARKER; CYANOCOBALAMIN; CYSTEINE; FOLIC ACID; GLUTATHIONE; GLYCINE; HOMOCYSTEINE; METHIONINE; PYRIDOXINE; SERINE; CARBON; VITAMIN B COMPLEX;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; BLOOD SAMPLING; CARBON METABOLISM; CONTROLLED STUDY; DESCRIPTIVE RESEARCH; FEMALE; FOLIC ACID BLOOD LEVEL; HUMAN; INDIA; NUTRIENT LOADING; NUTRITIONAL DEFICIENCY; ONE CARBON METABOLISM; ORANGE JUICE; PROTEIN BLOOD LEVEL; RACE DIFFERENCE; UNITED STATES; VITAMIN BLOOD LEVEL; BLOOD; BODY HEIGHT; FOOD; MALNUTRITION; METABOLISM; OHIO; PATHOPHYSIOLOGY;

ADULT; AMINO ACIDS; BIOMARKERS; BODY HEIGHT; CARBON; FEMALE; FOLIC ACID; FOOD; GLUTATHIONE; HOMOCYSTEINE; HUMANS; INDIA; MALNUTRITION; METHIONINE; OHIO; VITAMIN B 12; VITAMIN B COMPLEX;

EID: 84941711954     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/ejcn.2015.155     Document Type: Article

References (43)

1. Mason JB. Biomarkers of nutrient exposure and status in one-carbon (methyl) metabolism. J Nutr 2003; 133: 941s-947s.
2. King WD, Ho V, Dodds L, Perkins SL, Casson RI, Massey TE. Relationships among biomarkers of one-carbon metabolism. Mol Biol Rep 2012; 39: 7805-7812.
3. Lamers Y. Indicators and methods for folate, vitamin B-12, and vitamin B-6 status assessment in humans. Curr Opin Clin Nutr Metab Care 2011; 14: 445-454.
4. Selhub J, Jacques PF, Dallal G, Choumenkovitch S, Rogers G. The use of blood concentrations of vitamins and their respective functional indicators to define folate and vitamin B 12 status. Food Nutr Bull 2008; 29: S67-S73.
5. Vogiatzoglou A, Oulhaj A, Smith AD, Nurk E, Drevon CA, Ueland PM et al. Determinants of plasma methylmalonic acid in a large population: implications for assessment of vitamin B 12 status. Clin Chem 2009; 55: 2198-2206.
6. Bhardwaj A, Kumar D, Raina SK, Bansal P, Bhushan S, Chander V. Rapid assessment for coexistence of vitamin B12 and iron deficiency anemia among adolescent males and females in Northern Himalayan state of India. Anemia 2013; 2013: 959605.
7. Folate and vitamin B12 deficiencies. Proceedings of a WHO technical consultation held 18-21 October, 2005, in Geneva, Switzerland. Food Nutr Bull 2008; 29: S1-S246.
8. Sukla KK, Nagar R, Raman R. Vitamin-B12 and folate deficiency, major contributing factors for anemia: A population based study. e-SPEN Journal 2014; 9: e45-e48.
9. Kalhan SC, Uppal SO, Moorman JL, Bennett C, Gruca LL, Parimi PS et al. Metabolic and genomic response to dietary isocaloric protein restriction in the rat. J Biol Chem 2011; 286: 5266-5277.
10. Ingenbleek Y, Hardilliera E, Jung L. Subclinical protein malnutrition is a determinant of hyperhomocysteinemia. Nutrition 2002; 18: 40-46.
11. Ingenbleek Y, McCully KS. Vegetrainism produces subclinical malnutrition, hyperhomocysteinemia and atherogenesis. Nutrition 2012; 28: 148-153.
12. Chambers JC, Ueland PM, Wright M, Dore CJ, Refsum H, Kooner JS. Investigation of relationship between reduced, oxidized, and protein-bound homocysteine and vascular endothelial function in healthy human subjects. Circ Res 2001; 89: 187-192.
13. Chambers JC, Obeid OA, Kooner JS. Physiological increments in plasma homocysteine induce vascular endothelial dysfunction in normal human subjects. Arterioscler Thromb Vasc Biol 1999; 19: 2922-2927.
14. Sassi S, Cosmi B, Palareti G, Legnani C, Grossi G, Musolesi S et al. Influence of age, sex and vitamin status on fasting and post-methionine load plasma homocysteine levels. Haematologica 2002; 87: 957-964.
15. De JR, Griffioen PH, van Zelst B, Brouns RM, Visser W, Lindemans J. Evaluation of a shorter methionine loading test. Clin Chem Lab Med 2004; 42: 1027-1031.
16. Kalhan SC, Gruca LL, Parimi PS, O'Brien A, Dierker L, Burkett E. Serine metabolism in human pregnancy. Am J Physiol Endocrinol Metab 2003; 284: E733-E740.
17. Garcia AJ, Apitz-Castro R. Plasma total homocysteine quantification: an improvement of the classical high-performance liquid chromatographic method with fluorescence detection of the thiol-SBD derivatives. J Chromatogr B Analyt Technol Biomed Life Sci 2002; 779: 359-363.
18. Lammarre SG, MacMillan L, Morrow GP, Randell E, Pongnopparat T, Brosnan M et al. An isotope-dilution, GC-MS assay for formate and its application to human and animal metabolism. Amino acids 2014; 46: 1885-1891.
19. Kelleher BP, Broin SD. Microbiological assay for vitamin B12 performed in 96-well microtitre plates. J Clin Pathol 1991; 44: 13.
20. Tamura T, Freeberg LE, Cornwell PE. Inhibition by EDTA of Growth of Lactobacillus casei in the folate microbiologic assay and its reversal by added manganese or Iron. Clin Chem 1990; 36: 11.
21. Bergstrom J, Furst P, Vinnars E. Effect of a test meal, without and with protein, on muscle and plasma free amino acids. Clin Sci 1990; 79: 331-337.
22. Rao S, Yajnik CS, Kanade, Fall CH, Margetts BM, Jackson AA et al. Intake of micronutrient-rich foods in rural Indian mothers is associated with the size of their babies at birth: Pune Maternal Nutrition Study. J Nutr 2001; 131: 1217-1224.
23. Hermann W, Schorr H, Obeid R, Geisel J. Vitamin B-12 status, particularly holotranscobalamin II and methylmalonic acid concentrations, and hyperhomocysteinemia in vegetarians. Am J Clin Nutr 2003; 78: 131-136.
24. Antony AC. Vegetarianism and B-12 (cobalamin) deficiency. Am J Clin Nutr 2003; 78: 3-6.
25. Pawlak R, Lester SE, Babatunde T. The prevalence of cobalamin deficiency among vegetarians assessed by serum vitamin B12: a review of literature. Eur J Clin Nutr 2014; 68: 541-548.
26. Quinlivan EP, Gregory JF. Effect of food fortification on folic acid intake in the United States. Am J Clin Nutr 2003; 77: 221-225.
27. Gaine PC, Pikosky MA, Martin WF, Bolster DR, Maresh CM, Rodriguez NR. Level of dietary protein impacts whole body protein turnover in trained males at rest. Metabolism 2006; 55: 501-507.
28. Lariviere F, Kupranycz DA, Chiasson J-L, Hoffer. J. Plasma leucine kinetics and urinary nitrogen excretion in intensively treated diabetes mellitus. Am J Physiol 1992; 263: E173-E179.
29. Sketcher RD, James WP. Branched-chain amino acid oxidation in relation to catabolic enzyme activities in rats given a protein-free diet at different stages of development. Br J Nutr 1974; 32: 615-623.
30. Adibi S. Influence of dietary deprivation on plasma concentration of free amino acids of man. J Appl Physiol 1968; 25: 52-57.
31. Adibi SA, Modesto TA, Morse EL, Amin PM. Amino acid levels in plasma, liver, and skeletal muscle during protein deprivation. Am J Physiol 1973; 225: 408-414.
32. Nagao K, Bannai M, Seki S, Mori M, Takahashi M. Adaptational modification of serine and threonine metabolism in the liver to essential amino acid deficiency in rats. Amino Acids 2009; 36: 555-562.
33. Noguchi Y, Shikata N, Furuhata Y, Kimura T, Takahashi M. Characterization of dietary protein-dependent anibo acid metabolism by linking free amino acids with transcriptional profiles through analysis of correlation. Physiol Genomics 2008; 34: 315-326.
34. Gibson NR, Jahoor F, Ware L, Jackson AA. Endogenous glycine and tyrosine production is maintained in adults consuming a marginal-protein diet. Am J Clin Nutr 2002; 75: 511-518.
35. Sheikh K, Camejo G, Lanne B, Halvarsson T, Landergren MR, Oakes. ND. Beyond lipids, pharmacological PPARa activation has important effects on amino acid metabolism as studied in the rat. Am J Physiol Endocrinol Metab 2007; 292: E1157-E1185.
36. Motil KJ, Matthews DE, Bier DM, Burke JF, Munro HN, Young VR. Whole-body leucine and lysine metabolism: response to dietary protein intake in young men. Am J Physiol 1981; 240: E712-E721.
37. Kalhan SC, Hanson RW. Resurgence of serine: an often neglected but indispensable amino acid. J Biol Chem 2012; 287: 19786-19791.
38. Lamarre SG, Molloy AM, Reinke SN, Sykes BD, Brosnan ME, Brosnan JT. Formate can differentiate between hyperhomocysteinemia due to impaired remethylation and impaired transsulfuration. Am J Physiol Endocrinol Metab 2012; 302: E61-E67.
39. Refsum H, Yajnik CS, Gadkari M, Schneede J, Vollset SE, Orning L et al. Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians. Am J Clin Nutr 2001; 74: 233-241.
40. Lu SC. Regulation of hepatic glutathione synthesis: current concepts and controversies. FASEB J 13: 1169-1183.
41. Finkelstein JD, Martin JJ. Methionine metabolism in mammals. Adaptation to methionine excess. J Biol Chem 1986; 261: 1582-1587.
42. Selhub J, Miller JW. The pathogenesis of homocysteinemia: interruption of the coordinate regulation by s-adenosylmethionine of the remethylation and transsulfuration of homocysteine. Am J Clin Nutr 1992; 55: 131-138.
43. Grillo MA, Colombatto S. S-adenosylmethionine and its products. Amino Acids 2008; 34: 187-193.