The Treg/Th17 cell ratio is reduced in the skin lesions of patients with pyoderma gangrenosum

British Journal of Dermatology

Volumn 173, Issue 1, 2015, Pages 275-278

  Caproni, M ^a   Antiga, E ^a   Volpi, W ^a   Verdelli, A ^a   Venegoni, L ^b   Quaglino, P ^c   Fabbri, P ^a   Marzano, A V ^b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD161 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 17; STEROID; TRANSFORMING GROWTH FACTOR BETA; BIOLOGICAL MARKER; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; LEUKOCYTE ANTIGEN;

CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; DERMATITIS; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATION; LETTER; NEUTROPHIL; PRIORITY JOURNAL; PYODERMA GANGRENOSUM; REGULATORY T LYMPHOCYTE; SKIN DEFECT; STEROID THERAPY; TH17 CELL; ADULT; FEMALE; IMMUNOLOGY; LYMPHOCYTE COUNT; MALE; METABOLISM; MIDDLE AGED;

ADULT; ANTIGENS, CD; BIOMARKERS; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-10; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; PYODERMA GANGRENOSUM; T-LYMPHOCYTES, REGULATORY; TH17 CELLS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84941602120     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/bjd.13670     Document Type: Letter

References (15)

1. Marzano AV, Ishak RS, Saibeni S, et al,. Autoinflammatory skin disorders in inflammatory bowel diseases, pyoderma gangrenosum and Sweet's syndrome: a comprehensive review and disease classification criteria. Clin Rev Allergy Immunol 2013; 45: 202-10.
2. Butler D, Shinkai K,. What do autoinflammatory syndromes teach about common cutaneous diseases such as pyoderma gangrenosum? A commentary. Dermatol Clin 2013; 31: 427-35.
3. Marzano AV, Cugno M, Trevisan V, et al,. Role of inflammatory cells, cytokines and matrix metalloproteinases in neutrophil-mediated skin diseases. Clin Exp Immunol 2010; 162: 100-7.
4. Guenova E, Teske A, Fehrenbacher B, et al,. Interleukin 23 expression in pyoderma gangrenosum and targeted therapy with ustekinumab. Arch Dermatol 2011; 147: 1203-5.
5. + regulatory T cells in human autoimmune diseases. Nat Rev Immunol 2010; 10: 849-59.
6. Niu YH, Yin DL, Liu HL, et al,. Restoring the Treg cell to Th17 cell ratio may alleviate HBV-related acute-on-chronic liver failure. World J Gastroenterol 2013; 19: 4146-54.
7. Caproni M, Torchia D, Antiga E, et al,. The comparative effects of tacrolimus and hydrocortisone in adult atopic dermatitis: an immunohistochemical study. Br J Dermatol 2007; 156: 312-19.
8. Caproni M, Torchia D, Antiga E, et al,. The effects of tacrolimus ointment on regulatory T lymphocytes in atopic dermatitis. J Clin Immunol 2006; 26: 370-5.
9. Antiga E, Quaglino P, Bellandi S, et al,. Regulatory T cells in the skin lesions and blood of patients with systemic sclerosis and morphoea. Br J Dermatol 2010; 162: 1056-63.
10. Glocker EO, Kotlarz D, Boztug K, et al,. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med 2009; 361: 2033-45.
11. Demidowich AP, Freeman AF, Kuhns DB, et al,. Brief report: genotype, phenotype, and clinical course in five patients with PAPA syndrome (pyogenic sterile arthritis, pyoderma gangrenosum, and acne). Arthritis Rheum 2012; 64: 2022-7.
12. Marzano AV, Fanoni D, Antiga E, et al,. Expression of cytokines, chemokines and other effector molecules in two prototypic autoinflammatory skin diseases, pyoderma gangrenosum and Sweet's syndrome. Clin Exp Immunol 2014; 178: 48-56.
13. Agarwal S, Misra R, Aggarwal A,. Interleukin 17 levels are increased in juvenile idiopathic arthritis synovial fluid and induce synovial fibroblasts to produce proinflammatory cytokines and matrix metalloproteinases. J Rheumatol 2008; 35: 515-19.
14. Goldminz AM, Botto NC, Gottlieb AB,. Severely recalcitrant pyoderma gangrenosum successfully treated with ustekinumab. J Am Acad Dermatol 2012; 67: e237-8.
15. Eastaff-Leung N, Mabarrack N, Barbour A, et al,. Foxp3+ regulatory T cells, Th17 effector cells, and cytokine environment in inflammatory bowel disease. J Clin Immunol 2010; 30: 80-9.