Randomized sham controlled double-blind trial of repetitive transcranial magnetic stimulation for adults with severe Tourette syndrome

Brain Stimulation

Volumn 8, Issue 3, 2015, Pages 574-581

  Landeros Weisenberger, Angeli ^a   Mantovani, Antonio ^b,c   Motlagh, Maria G ^a,d   De Alvarenga, Pedro Gomes ^e   Katsovich, Liliya ^a   Leckman, James F ^a   Lisanby, Sarah H ^f  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CITY UNIVERSITY OF NEW YORK MEDICAL SCHOOL   (United States)

^c NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF SÃO PAULO   (Brazil)

^f DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Magnetic stimulation; Randomized controlled trial; Tourette syndrome; Transcranial

Indexed keywords

CLOMIPRAMINE; CLONAZEPAM; CLONIDINE; HALOPERIDOL; OXCARBAZEPINE; PAROXETINE; QUETIAPINE; RISPERIDONE; VALPROIC ACID;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL EXAMINATION; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; FEMALE; GILLES DE LA TOURETTE SYNDROME; HEADACHE; HUMAN; MALE; MUSCLE SPRAIN; NECK PAIN; OPEN STUDY; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION; SHAM PROCEDURE; SINGLE BLIND PROCEDURE; TRANSCRANIAL MAGNETIC STIMULATION; TREATMENT DURATION; MIDDLE AGED; MOTOR CORTEX; PATHOPHYSIOLOGY; PROCEDURES; TOURETTE SYNDROME; TREATMENT OUTCOME; YOUNG ADULT;

ADULT; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; MOTOR CORTEX; TOURETTE SYNDROME; TRANSCRANIAL MAGNETIC STIMULATION; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84941599216     PISSN: 1935861X     EISSN: 18764754     Source Type: Journal    
DOI: 10.1016/j.brs.2014.11.015     Document Type: Article

References (58)

1. Leckman JF, Bloch MH, Sukhodolsky DG, et al. Phenomenology of tics and sensory urges: the self under siege. In: Martino D, Leckman JF, editors. Tourette syndrome. New York: Oxford Unity Press; 2013. p. 3e25.
2. Bloch MH, Peterson BS, Scahill L, et al. Adulthood outcome of tic and obsessive-compulsive symptom severity in children with Tourette syndrome. Arch Pediatr Adolesc Med 2006;160(1):65e9.
3. Wiesendanger M. Eccles' perspective of the forebrain, its role in skilled movements, and the mind-brain problem. Prog Neurobiol 2006;78(3e5):304e21.
4. Cunnington R, Windischberger C, Moser E. Premovement activity of the presupplementary motor area and the readiness for action: studies of timeresolved event-related functional MRI. Hum Mov Sci 2005;24(5e6):644e56.
5. Bohlhalter S, Goldfine A, Matteson S, et al. Neural correlates of tic generation in Tourette syndrome: an event-related functional MRI study. Brain 2006;129:2029e37.
6. Hampson M, Tokoglu F, King RA, et al. Brain areas coactivating with motor cortex during chronic motor tics and intentional movements. Biol Psychiatry 2009;65(7):594e9.
7. Roessner V, Rothenberger A, Rickards H, Hoekstra PJ. European clinical guidelines for Tourette syndrome and other tic disorders. Eur Child Adolesc Psychiatry 2011;20(4):153e4.
8. McGuire JF, Piacentini J, Brennan EA, et al. A meta-analysis of behavior therapy for Tourette Syndrome. J Psychiatr Res 2014;50:106e12.
9. Robertson MM, Stern JS. Gilles de la Tourette syndrome: symptomatic treatment based on evidence. Eur Child Adolesc Psychiatry 2000;9(1):60e75.
10. Roessner V, Rothenberger A. Pharmacological treatment of tics. In: Martino D, Leckman JF, editors. Tourette syndrome. New York: Oxford Unity Press; 2013. p. 524e52.
11. Mller-Vahl KR, Cath DC, Cavanna AE, et al, ESSTS Guidelines Group. European clinical guidelines for Tourette syndrome and other tic disorders. Part IV: deep brain stimulation. Eur Child Adolesc Psychiatry 2011;20(4):209e17.
12. Mller-Vahl KR. Surgical treatment of Tourette syndrome. Neurosci Biobehav Rev 2013;37(6):1178e85.
13. Servello D, Sassi M, Gaeta M, et al. Tourette syndrome bears a higher rate of inflammatory complications at the implanted hardware in deep brain stimulation. Acta Neurochir (Wien) 2011;153(3):629e32.
14. Orth M. Transcranial magnetic stimulation in Gilles de la Tourette syndrome. J Psychosom Res 2009;67(6):591e8.
15. Munchau A, Bloem BR, Thilo KV, et al. Repetitive transcranial magnetic stimulation for Tourette syndrome. Neurology 2002;59(11):1789e91.
16. Chae JH, Nahas Z, Wassermann E, et al. A pilot safety study of repetitive transcranial magnetic stimulation in Tourette's syndrome. Cogn Behav Neurol 2004;17(2):109e17.
17. Orth M, Kirby R, Richardson MP, et al. Subthreshold rTMS over pre-motor cortex has no effect on tics in patients with Gilles de la Tourette syndrome. Clin Neurophysiol 2005;116(4):764e8.
18. Mantovani A, Lisanby SH, Pieraccini F, et al. Repetitive transcranial magnetic stimulation in the treatment of obsessive-compulsive disorder and Tourette's syndrome. Int J Neuropsychopharmacol 2006;9(1):95e100.
19. Mantovani A, Leckman JF, Grantz H, et al. Repetitive transcranial magnetic stimulation of the supplementary motor area in the treatment of Tourette syndrome: report of two cases. Clin Neurophysiol 2007;118(10):2314e5.
20. Kwon HJ, Lim WS, Lim MH, et al. 1-Hz low frequency repetitive transcranial magnetic stimulation in children with Tourette's syndrome. Neurosci Lett 2011;492(1):1e4.
21. Le K, Liu L, Sun M, et al. Transcranial magnetic stimulation at 1 Hertz improves clinical symptoms in children with Tourette syndrome for at least 6 months. J Clin Neurosci 2013;20(2):257e62.
22. Salatino A, Momo E, Nobili M, et al. Awareness of symptoms amelioration following low-frequency repetitive transcranial magnetic stimulation in a patient with Tourette syndrome and comorbid obsessive-compulsive disorder. Brain Stimul 2014;7(2):341e3.
23. Wu SW, Maloney T, Gilbert DL, et al. Functional MRI-navigated repetitive transcranial magnetic stimulation over supplementary motor area in chronic tic disorders. Brain Stimul 2014;7(2):212e8.
24. Guy W. ECDEU assessment manual for psychopharmacology. Rockville, MD: Department of Health, Education, and Welfare Public Health Service Alcohol, Drug Abuse, and Mental Health Administration; 1976.
25. Leckman JF, Riddle MA, Hardin MT, et al. The Yale Global Tic Severity Scale: initial testing of a clinician-rated scale of tic severity. J Am Acad Child Adolesc Psychiatry 1989;28:566e73.
26. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:56e62.
27. Lin H, Yeh CB, Peterson BS, et al. Assessment of symptom exacerbations in a longitudinal study of children with Tourette's syndrome or obsessivecompulsive disorder. J Am Acad Child Adolesc Psychiatry 2002;41(9):1070e7.
28. Woods DW, Piacentini J, Himle MB, Chang S. Premonitory urge for Tics Scale: initial psychometric results and examination of the premonitory urge phenomenon in youths with Tic disorders. J Dev Behav Pediatr 2005;26(6):397e403.
29. Scahill L, Chappell PB, Kim YS, et al. A placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorder. Am J Psychiatry 2001;158(7):1067e74.
30. Scahill L, Leckman JF, Schultz RT, et al. A placebo-controlled trial of risperidone in Tourette syndrome. Neurology 2003;60(7):1130e5.
31. Goodman WK, Price LH, Rasmussen SA, et al. The Yale-Brown obsessive compulsive scale: development, use, and reliability. Arch Gen Psychiatry 1989;46(11):1006e101.
32. Adler LA, Faraone SV, Spencer TJ, et al. The reliability and validity of self- and investigator ratings of ADHD in adults. J Atten Disord 2008;11(6):711e9.
33. Adler LA, Shaw DM, Spencer TJ, et al. Preliminary examination of the reliability and concurrent validity of the attention-deficit/hyperactivity disorder selfreport scale v1.1 symptom checklist to rate symptoms of attention- deficit/hyperactivity disorder in adolescents. J Child Adolesc Psychopharmacol 2012;22(3):238e44.
34. Hamilton M. The assessment of anxiety states by rating. Br J Med Psychol 1959;32:50e6.
35. Keel JC, Smith MJ, Wassermann EM. A safety screening questionnaire for transcranial magnetic stimulation. Clin Neurophysiol 2001;12(4):720.
36. Jeon S, Walkup JT, Woods DW, et al. Detecting a clinically meaningful change in tic severity in Tourette syndrome: a comparison of three methods. Contemp Clin Trials 2013;36(2):414e20.
37. Rossi S, Ferro M, Cincotta M, et al. A real electro-magnetic placebo device for sham transcranial magnetic stimulation. Clin Neurophysiol 2007;118(3): 709e16.
38. Levine J, Schooler NR. SAFETEE: a technique for the systematic assessment of side effects in clinical trials. Psychopharmacol Bull 1986;22:343e81.
39. Suppa A, Belvisi D, Bologna M, et al. Abnormal cortical and brain stem plasticity in Gilles de la Tourette syndrome. Mov Disord 2011;26(9): 1703e10.
40. Wu SW, Gilbert DL. Altered neurophysiologic response to intermittent theta burst stimulation in Tourette syndrome. Brain Stimul 2012;5(3):315e9.
41. Cui Y, Jin Z, Chen X, et al. Abnormal baseline brain activity in drug-nave patients with Tourette syndrome: a resting-state fMRI study. Front Hum Neurosci 2014;7:913.
42. Liu Y, Miao W, Wang J, et al. Structural abnormalities in early Tourette syndrome children: a combined voxel-based morphometry and tract-based spatial statistics study. PLoS One 2013;8(9):e76105.
43. Ziemann U, Paulus W, Rothenberger A. Decreased motor inhibition in Tourette's disorder: evidence from transcranial magnetic stimulation. Am J Psychiatry 1997;154(9):1277e84.
44. Berardelli A, Curr A, Fabbrini G, Gilio F, Manfredi M. Pathophysiology of tics and Tourette syndrome. J Neurol 2003;250(7):781e7.
45. Orth J. Electrophysiology of Tourette syndrome. In: Martino D, Leckman JF, editors. Tourette syndrome. New York: Oxford Unity Press; 2013. p. 221e37.
46. Franzkowiak S, Pollok B, Biermann-Ruben K, et al. Altered pattern of motor cortical activation-inhibition during voluntary movements in Tourette syndrome. Mov Disord 2010;25(12):1960e6.
47. Jung J, Jackson SR, Parkinson A, Jackson GM. Cognitive control over motor output in Tourette syndrome. Neurosci Biobehav Rev 2013;37(6): 1016e25.
48. Fitzgerald PB, Brown TL, Daskalakis ZJ, et al. Intensity-dependent effects of 1 Hz rTMS on human corticospinal excitability. Clin Neurophysiol 2002;113(7):1136e41.
49. Siniatchkin M, Kröner-Herwig B, Kocabiyik E, Rothenberger A. Intracortical inhibition and facilitation in migraineea transcranial magnetic stimulation study. Headache 2007;47(3):364e70.
50. Teepker M, Hötzel J, Timmesfeld N, et al. Low-frequency rTMS of the vertex in the prophylactic treatment of migraine. Cephalalgia 2010;30(2):137e44.
51. Fierro B, Ricci R, Piazza A, et al. 1Hz rTMS enhances extrastriate cortex activity in migraine: evidence of a reduced inhibition? Neurology 2003;61(10):1446e8.
52. Brighina F, Giglia G, Scalia S, et al. Facilitatory effects of 1 Hz rTMS in motor cortex of patients affected by migraine with aura. Exp Brain Res 2005;161(1):34e8.
53. Speer AM, Willis MW, Herscovitch P, et al. Intensity-dependent regional cerebral blood flow during 1-Hz repetitive transcranial magnetic stimulation in healthy volunteers studied with H215O positron emission tomography: I. Effects of primary motor cortex rTMS. Biol Psychiatry 2003;54(8):818e25.
54. Caparelli E, Backus W, Telang F, et al. Is 1 Hz rTMS always inhibitory in healthy individuals? Open Neuroimag J 2012;6:69e74.
55. Obeso I, Cho SS, Antonelli F, et al. Stimulation of the pre-SMA influences cerebral blood flow in frontal areas involved with inhibitory control of action. Brain Stimul 2013;6(5):769e76.
56. Peterchev A, Goetz SM, Westin GG, et al. Pulse width dependence of motor threshold and input-output curve characterized with controllable pulse parameter transcranial magnetic stimulation. Clin Neurophysiol 2013;124(7):1364e72.
57. Goetz S, Luber B, Lisanby SH, et al. Enhancement of rTMS neuromodulatory effects with novel waveforms demonstrated via controllable pulse parameter TMS (cTMS). Neuropsychopharmacology 2013;38:S246.
58. Paulus W, Classen J, Cohen LG, et al. State of the art: pharmacologic effects on cortical excitability measures tested by transcranial magnetic stimulation. Brain Stimul 2008;1(3):151e63.