Productive life cycle of adeno-associated virus serotype 2 in the complete absence of a conventional polyadenylation signal

Journal of General Virology

Volumn 96, Issue 9, 2015, Pages 2780-2787

  Wang, Lina ^a,b   Yin, Zifei ^a,b   Wang, Yuan ^a,b   Lu, Yuan ^b   Zhang, Daniel ^b   Srivastava, Arun ^b,c   Ling, Changquan ^a,d   Aslanidi, George V ^b   Ling, Chen ^b,c  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

^d Shanghai Municipal Education Commission   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADENO ASSOCIATED VIRUS REPLICATION PROTEIN; HUMAN GROWTH HORMONE; MESSENGER RNA; PARVOVIRUS VECTOR; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS RNA;

ADENO ASSOCIATED VIRUS 2; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; INVERTED TERMINAL REPEAT; LIFE CYCLE; NONHUMAN; POLYADENYLATION; PRIORITY JOURNAL; PROGENY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENE; VIRAL LIFE CYCLE; VIRION; VIRUS GENOME; VIRUS REPLICATION; VIRUS VIRULENCE; DEPENDOPARVOVIRUS; DNA REPLICATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; LONG TERMINAL REPEAT; METABOLISM; PARVOVIRUS INFECTION; PHYSIOLOGY; VIROLOGY;

DEPENDOVIRUS; DNA REPLICATION; GENOME, VIRAL; HUMANS; PARVOVIRIDAE INFECTIONS; POLYADENYLATION; RNA, VIRAL; TERMINAL REPEAT SEQUENCES; VIRAL PROTEINS; VIRION; VIRUS REPLICATION;

EID: 84941595458     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/jgv.0.000229     Document Type: Article

References (35)

1. Ashktorab, H. & Srivastava, A. (1989). Identification of nuclear proteins that specifically interact with adeno-associated virus type 2 inverted terminal repeat hairpin DNA. J Virol 63, 3034–3039.
2. Atchison, R. W., Casto, B. C. & Hammon, W. M. (1965). Adenovirusassociated defective virus particles. Science 149, 754–755.
3. Buller, R. M., Janik, J. E., Sebring, E. D. & Rose, J. A. (1981). Herpes simplex virus types 1 and 2 completely help adenovirus-associated virus replication. J Virol 40, 241–247.
4. Cao, M., Zhu, H., Bandyopadhyay, S., You, H. & Hermonat, P. L. (2012). HPV-16 E1, E2 and E6 each complement the Ad5 helper gene set, increasing rAAV2 and wt AAV2 production. Gene Ther 19, 418–424.
5. Carter, B. J. & Rose, J. A. (1974). Transcription in vivo of a defective parvovirus: sedimentation and electrophoretic analysis of RNA synthesized by adenovirus-associated virus and its helper adenovirus. Virology 61, 182–199.
6. Cheng, B., Ling, C., Dai, Y., Lu, Y., Glushakova, L. G., Gee, S. W., McGoogan, K. E., Aslanidi, G. V., Park, M. & other authors (2012). Development of optimized AAV3 serotype vectors: mechanism of high-efficiency transduction of human liver cancer cells. Gene Ther 19, 375–384.
7. Fasina, O. & Pintel, D. J. (2013). The adeno-associated virus type 5 small Rep proteins expressed via internal translation initiation are functional. J Virol 87, 296–303.
8. Georg-Fries, B., Biederlack, S., Wolf, J. & zur Hausen, H. (1984). Analysis of proteins, helper dependence, and seroepidemiology of a new human parvovirus. Virology 134, 64–71.
9. Han, Z., Banworth, M. J., Makkia, R., Conley, S. M., Al-Ubaidi, M. R., Cooper, M. J. & Naash, M. I. (2015). Genomic DNA nanoparticles rescue rhodopsin-associated retinitis pigmentosa phenotype. FASEB J 29, 2535–2544.
10. Hoggan, M. D., Blacklow, N. R. & Rowe, W. P. (1966). Studies of small DNA viruses found in various adenovirus preparations: physical, biological, and immunological characteristics. Proc Natl Acad Sci USA 55, 1467–1474.
11. Im, D. S. & Muzyczka, N. (1989). Factors that bind to adenoassociated virus terminal repeats. J Virol 63, 3095–3104.
12. Laughlin, C. A., Westphal, H. & Carter, B. J. (1979). Spliced adenovirusassociated virus RNA. Proc Natl Acad Sci USA 76, 5567–5571.
13. Li, X., Miao, H., Zhang, Y., Li, W., Li, Z., Zhou, Y., Zhao, L. & Guo, Q. (2015). Bone marrow microenvironment confers imatinib resistance to chronic myelogenous leukemia and oroxylin A reverses the resistance by suppressing Stat3 pathway. Arch Toxicol 89, 121–136.
14. Lin, S., Shen, H., Li, J. L., Tang, S., Gu, Y., Chen, Z., Hu, C., Rice, J. C., Lu, J. & Wu, L. (2013a). Proteomic and functional analyses reveal the role of chromatin reader SFMBT1 in regulating epigenetic silencing and the myogenic gene program. J Biol Chem 288, 6238–6247.
15. Lin, S., Tian, L., Shen, H., Gu, Y., Li, J.-L., Chen, Z., Sun, X., You, M. J. & Wu, L. (2013b).DDX5 is a positive regulator of oncogenicNOTCH1 signaling in T cell acute lymphoblastic leukemia. Oncogene 32, 4845–4853.
16. Ling, C. Q., Wang, L. N., Wang, Y., Zhang, Y. H., Yin, Z. F., Wang, M. & Ling, C. (2014). The roles of traditional Chinese medicine in gene therapy. J Integr Med 12, 67–75.
17. Ling, C., Wang, Y., Lu, Y., Wang, L., Jayandharan, G. R., Aslanidi, G. V., Li, B., Cheng, B., Ma, W. & other authors (2015). Enhanced transgene expression from recombinant single-stranded D-sequence-substituted adeno-associated virus vectors in human cell lines in vitro and in murine hepatocytes in vivo. J Virol 89, 952–961.
18. Liu, B., Behura, S. K., Clem, R. J., Schneemann, A., Becnel, J., Severson, D. W. & Zhou, L. (2013a). P53-mediated rapid induction of apoptosis conveys resistance to viral infection in Drosophila melanogaster. PLoS Pathog 9, e1003137.
19. Liu, Y., Fang, Y., Zhou, Y., Zandi, E., Lee, C. L., Joo, K. I. & Wang, P. (2013b). Site-specific modification of adeno-associated viruses via a genetically engineered aldehyde tag. Small 9, 421–429.
20. Liu, Y., Joo, K. I. & Wang, P. (2013c). Endocytic processing of adenoassociated virus type 8 vectors for transduction of target cells. Gene Ther 20, 308–317.
21. McLaughlin, S. K., Collis, P., Hermonat, P. L. & Muzyczka, N. (1988). Adeno-associated virus general transduction vectors: analysis of proviral structures. J Virol 62, 1963–1973.
22. McPherson, R. A., Rosenthal, L. J. & Rose, J. A. (1985). Human cytomegalovirus completely helps adeno-associated virus replication. Virology 147, 217–222.
23. Mondal, J., Bishayee, K., Panigrahi, A. K. & Khuda-Bukhsh, A. R. (2014). Low doses of ethanolic extract of Boldo (Peumus boldus) can ameliorate toxicity generated by cisplatin in normal liver cells of mice in vivo and in WRL-68 cells in vitro, but not in cancer cells in vivo or in vitro. J Integr Med 12, 425–438.
24. Nash, K., Chen, W., Salganik, M. & Muzyczka, N. (2009). Identification of cellular proteins that interact with the adenoassociated virus Rep protein. J Virol 83, 454–469.
25. Nonnenmacher, M. & Weber, T. (2012). Intracellular transport of recombinant adeno-associated virus vectors. Gene Ther 19, 649–658.
26. Qiu, J. & Pintel, D. J. (2002). The adeno-associated virus type 2 Rep protein regulates RNA processing via interaction with the transcription template. Mol Cell Biol 22, 3639–3652.
27. Qiu, J. & Pintel, D. J. (2004). Alternative polyadenylation of adenoassociated virus type 5 RNA within an internal intron is governed by the distance between the promoter and the intron and is inhibited by U1 small nuclear RNP binding to the intervening donor. J Biol Chem 279, 14889–14898.
28. Qiu, J., Nayak, R. & Pintel, D. J. (2004). Alternative polyadenylation of adeno-associated virus type 5 RNA within an internal intron is governed by both a downstream element within the intron 39 splice acceptor and an element upstream of the P41 initiation site. J Virol 78, 83–93.
29. Samulski, R. J., Chang, L. S. & Shenk, T. (1987). A recombinant plasmid from which an infectious adeno-associated virus genome can be excised in vitro and its use to study viral replication. J Virol 61, 3096–3101.
30. Schlehofer, J. R., Ehrbar, M. & zur Hausen, H. (1986). Vaccinia virus, herpes simplex virus, and carcinogens induce DNA amplification in a human cell line and support replication of a helpervirus dependent parvovirus. Virology 152, 110–117.
31. Srivastava, A., Lusby, E. W. & Berns, K. I. (1983). Nucleotide sequence and organization of the adeno-associated virus 2 genome. J Virol 45, 555–564.
32. Wang, Y., Ling, C., Song, L., Wang, L., Aslanidi, G. V., Tan, M., Ling, C. & Srivastava, A. (2012). Limitations of encapsidation of recombinant self-complementary adeno-associated viral genomes in different serotype capsids and their quantitation. Hum Gene Ther Methods 23, 225–233.
33. Wang, Y., Miao, H., Li, W., Yao, J., Sun, Y., Li, Z., Zhao, L. & Guo, Q. (2014). CXCL12/CXCR4 axis confers adriamycin resistance to human chronic myelogenous leukemia and oroxylin A improves the sensitivity of K562/ADM cells. Biochem Pharmacol 90, 212–225.
34. Zhang, X. F., Zhu, J., Geng, W. Y., Zhao, S. J., Jiang, C. W., Cai, S. R., Cheng, M., Zhou, C. Y. & Liu, Z. B. (2014a). Electroacupuncture at Feishu (BL13) and Zusanli (ST36) down-regulates the expression of orexins and their receptors in rats with chronic obstructive pulmonary disease. J Integr Med 12, 417–424.
35. Zhang, Y. H., Wang, Y., Yusufali, A. H., Ashby, F., Zhang, D., Yin, Z. F., Aslanidi, G. V., Srivastava, A., Ling, C. Q. & Ling, C. (2014b). Cytotoxic genes from traditional Chinese medicine inhibit tumor growth both in vitro and in vivo. J Integr Med 12, 483–494.