Secreted mucins and airway bacterial colonization in non-CF bronchiectasis

Respirology

Volumn 20, Issue 7, 2015, Pages 1082-1088

  Sibila, Oriol ^a,b   Suarez Cuartin, Guillermo ^a,b   Rodrigo Troyano, Ana ^a,b   Fardon, Thomas C ^b   Finch, Simon ^b   Mateus, Eder Freddy ^b   Garcia Bellmunt, Laia ^a,b   Castillo, Diego ^a,b   Vidal, Silvia ^b   Sanchez Reus, Ferran ^b,c   Restrepo, Marcos I ^d   Chalmers, James D ^b  

^a HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

^d UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

bronchial colonization; bronchiectasis; lung defense mechanism; mucin

Indexed keywords

MUCIN 2; MUCIN 5AC; MUCIN 5B; MUCIN;

ADULT; ARTICLE; BACTERIAL COLONIZATION; BACTERIUM CULTURE; BRONCHIECTASIS; BRONCHIECTASIS SEVERITY INDEX; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE SEVERITY; DISEASE SEVERITY ASSESSMENT; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HAEMOPHILUS INFLUENZAE; HUMAN; MALE; MEASUREMENT; NON CYSTIC FIBROSIS BRONCHIECTASIS; PATHOGENESIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; PSEUDOMONAS AERUGINOSA; RESPIRATORY TRACT INFECTION; SPUTUM ANALYSIS; SPUTUM CULTURE; SUPERNATANT; AGED; BACTERIAL COUNT; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; MIDDLE AGED; RESPIRATORY SYSTEM; SECRETION (PROCESS); SEVERITY OF ILLNESS INDEX; SPUTUM; STATISTICS;

AGED; BRONCHIECTASIS; COLONY COUNT, MICROBIAL; CROSS-SECTIONAL STUDIES; FEMALE; HAEMOPHILUS INFLUENZAE; HUMANS; MALE; MIDDLE AGED; MUCINS; PROSPECTIVE STUDIES; PSEUDOMONAS AERUGINOSA; RESPIRATORY SYSTEM; SEVERITY OF ILLNESS INDEX; SPUTUM; STATISTICS AS TOPIC;

EID: 84941588369     PISSN: 13237799     EISSN: 14401843     Source Type: Journal    
DOI: 10.1111/resp.12595     Document Type: Article

References (33)

1. McShane PJ, Naureckas ET, Tino G, Strek ME,. Non-cystic fibrosis bronchiectasis. Am. J. Respir. Crit. Care Med. 2013; 188: 647-656.
2. Fuschillo S, De Felice A, Balzano G,. Mucosal inflammation in idiopatic bronchiectasis; cellular and molecular mechanisms. Eur. Respir. J. 2008; 31: 396-406.
3. Chalmers JD, Hill AT,. Mechanisms of immune dysfunction and bacterial persistence in non-cystic fibrosis bronchiectasis. Mol. Immunol. 2013; 55: 27-34.
4. Angrill J, Agusti C, de Celis R, Raño A, Gonzalez J, Sole T, Xaubet A, Rodriguez-Roisin R, Torres A,. Bacterial colonization in patients with bronchiectasis. Microbiological pattern and risk factors. Thorax 2002; 57: 15-19.
5. Cole PJ,. A new look at the pathogenesis, management of persistent bronchial sepsis: a 'vicious circle' hypothesis and its logical therapeutic connotations. In:, Davies RJ, (ed) Strategies for the Management of Chronic Bacterial Sepsis. Medicine Publishing Foundation, Oxford, 1984; 1-20.
6. Kaliner M, Marom Z, Patow C, Shelhamer J,. Human respiratory mucus. J. Allergy Clin. Immunol. 1984; 73: 318-323.
7. Rose MC, Voynow JA,. Respiratory tract mucin genes and mucin glycoproteins in health and disease. Physiol. Rev. 2006; 86: 245-278.
8. Thornton DJ, Carlstedt I, Howard M, Devine PL, Price MR, Sheehan JK,. Respiratory mucins: identification of core proteins and glycoforms. Biochem. J. 1996; 316: 967-975.
9. Rose MC, Nickola TJ, Voynow JA,. Airway mucus obstruction: mucin glycoproteins, MUC gene regulation and globet cell hyperplasia. Am. J. Respir. Cell Mol. Biol. 2001; 24: 533-537.
10. Voynow JA, Rubin BK,. Mucins, mucus and sputum. Chest 2009; 135: 505-512.
11. Kirham S, Seehan JK, Knight D, Richardson PS, Thornton DJ,. Heterogeneity of airway mucus: variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B. Biochem. J. 2002; 361: 537-546.
12. Rose MC, Brown CF, Jacoby JZ, Lynn WS, Kaufman B,. Biochemical properties of tracheobronchial mucins from cystic fibrosis and non-cystic fibrosis individuals. Pediatr. Res. 1987; 22: 545-551.
13. Henke MO, Renner A, Huber RM, Seeds MC, Rubin BK,. MUC5AC and MUC5B mucins are decreased in cystic fibrosis airway secretions. Am J Respir Cell Moll Biol. 2004; 31: 86-89.
14. Henke MO, John G, Germann M, Lindemann H, Rubin BK,. MUC5AC and MUC5B mucins increase in cystic fibrosis airway secretions during pulmonary exacerbations. Am. J. Respir. Crit. Care Med. 2007; 175: 816-821.
15. Roy MG, Livraghi-Butrico A, Fletcher AA, McElwee MM, Evans SE, Boerner RM, Alexander SN, Bellinghausen LK, Song AS, Petrova YM, et al., MUC5B is required for airway defense. Nature 2014; 505: 412-416.
16. Vendrell M, de Gracia J, Olveira C, Martínez MA, Giron R, Maiz L, Cantõn R, Coll R, Escribano A, Sole A,. Diagnosis and treatment of bronchiectasis. Spanish Society of Pneumology and Thoracic Surgery. Arch. Bronconeumol. 2008; 44: 629-640.
17. Pasteur MC, Bilton D, Hill AT,. British Thoracic Society guideline for non-CF bronchiectasis. Thorax 2010; 65 (Suppl. 1): i1-58.
18. Chalmers JD, Goeminne P, Aliberti S, McDonnell MJ, Lonni S, Davidson J, Poppelwell L, Salih W, Pesci A, Dupont LJ, et al., The Bronchiectasis Severity Index: an international derivation and validation study. Am. J. Respir. Crit. Care Med. 2014; 189: 576-585.
19. Chalmers JD, Smith PM, McHugh BJ, Coherty C, Govan JR, Hill AT,. Short-and long-term antibiotic treatment reduces airway and systemic inflammation in non-cystic fibrosis bronchiectasis. Am. J. Respir. Crit. Care Med. 2012; 186: 657-665.
20. Ballows A, Hauser WJ, Hermann KL, Isenberg HD, Shadomy HJ,. Manual of clinical microbiology, 5th edn. American Society of Microbiology, Washington, DC, 1991.
21. Thornton DJ, Rousseau K, McGuckin MA,. Structure and function of the polymeric mucins in airways mucus. Annu. Rev. Physiol. 2008; 70: 459-486.
22. Busine MP, Devisme L, Copin MC, Durand-Reville M, Gosselin B, Aubert PJ, Porchet N,. Developmental mucin gene expression in the human respiratory tract. Am. J. Respir. Cell Mol. Biol. 1999; 20: 209-218.
23. Vinall LE, Fowler JC, Jones AL, Kirkbride HJ, de Bolos C, Laine A, Porchet N, Gum JR, Kim YS, Moss FM, et al., Polymorphisms of human mucin genes in chest disease: possible significance of MUC2. Am. J. Respir. Cell Mol. Biol. 2000; 23: 678-686.
24. Kirkham S, Kolsum U, Rousseau K, Singh D, Vestbo J, Thornton DJ,. MUC5B is the major mucin in the gel phase of sputum in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2008; 178: 1033-1039.
25. Cole PJ,. Inflammation: a two-edged sword-the model of bronchiectasis. Eur. J. Respir. Dis. Suppl. 1986; 147: 6-15.
26. Watt AP, Brown V, Courtney J, Kelly M, Garske L, Elborn JS, Ennis M,. Neutrophil apoptosis, proinflammatory mediators and cell counts in bronchiectasis. Thorax 2004; 59: 232-236.
27. Loebinger MR, Wells AU, Hansell DM, Chinyanganya N, Devaraj A, Meister M, Wilson R,. Mortality in bronchiectasis: a long-term study assessing the factors influencing survival. Eur. Respir. J. 2009; 34: 843-849.
28. Kawakubo M, Ito Y, Okimura Y, Kobayashi M, Sakura K, Kasama S, Fukuda MN, Fukuda M, Katsuyama T, Nakayama J,. Natural antibiotic function of a human gastric mucin against Helicobacter pylori infection. Science 2004; 305: 1003-1006.
29. Fischer BM, Rochelle LG, Voynow JA, Akley NJ, Adler KB,. Tumor necrosis factor-alfa stimulates mucin secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro. Am. J. Respir. Cell Mol. Biol. 1999; 20: 413-422.
30. Park JA, He F, Martin LD, Li Y, Chorley BN, Adler KB,. Human neutrophil elastase induces hypersecretion of mucin from well-differentiated human bronchial epithelial cells in vitro via a protein kinase C-mediated mechanism. Am. J. Pathol. 2005; 167: 651-661.
31. Klinger JD, Tandler B, Liedtke CM, Boat TF,. Proteinases of Pseudomonas aeruginosa evoke mucin release by tracheal epithelium. J. Clin. Invest. 1984; 74: 1669-1678.
32. Fujisawa T, Chang MM, Velichko S, Thai P, Hung LY, Huang F, Phuong N, Chen Y, Wu R,. NF-kB mediates IL-1B adn IL-17A-induced MUC5B expression in airway epithelial cells. Am. J. Respir. Cell Mol. Biol. 2011; 45: 246-252.
33. Murray MP1, Govan JR, Doherty CJ, Simpson AJ, Wilkinson TS, Chalmers JD, Greening AP, Haslett C, Hill AT,. A randomized controlled trial of nebulized gentamicin in non-cystic fibrosis bronchiectasis. Am. J. Respir. Crit. Care Med. 2011; 183: 491-499.