Humanized thymidine kinase-NOG mice can be used to identify drugs that cause animal-specific hepatotoxicity: A case study with furosemide

Journal of Pharmacology and Experimental Therapeutics

Volumn 354, Issue 1, 2015, Pages 73-78

  Xu, Dan ^a   Michie, Sara A ^a   Zheng, Ming ^a   Takeda, Saori ^b   Wu, Manhong ^a   Peltz, Gary ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b In Vivo Sciences International   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID; DRUG METABOLITE; FUROSEMIDE; GAMMA KETOCARBOXYLIC ACID; GLUCURONIDE; GLUTATHIONE; UNCLASSIFIED DRUG; THYMIDINE KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEALKYLATION; DOSE RESPONSE; DRUG DISPOSITION; DRUG MEGADOSE; DRUG METABOLISM; DRUG SAFETY; HUMAN; HUMAN CELL; LIVER TOXICITY; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; SPECIES DIFFERENCE; SURVIVAL RATE; THYMIDINE KINASE NOG MOUSE; TOXICITY TESTING; ANIMAL; DRUG EFFECTS; DRUG SCREENING; GENETICS; LIVER; LIVER CELL; NECROSIS; PATHOLOGY; PROCEDURES; TISSUE DISTRIBUTION; TRANSPLANTATION;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; FUROSEMIDE; HEPATOCYTES; HUMANS; LIVER; MALE; MICE; NECROSIS; SPECIES SPECIFICITY; THYMIDINE KINASE; TISSUE DISTRIBUTION;

EID: 84941570150     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.115.224493     Document Type: Article

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