Acellular Hydrogels for Regenerative Burn Wound Healing: Translation from a Porcine Model

Journal of Investigative Dermatology

Volumn 135, Issue 10, 2015, Pages 2519-2529

  Shen, Yu I ^a   Song, Hyun Ho G ^a   Papa, Arianne E ^b   Burke, Jacqueline A ^b   Volk, Susan W ^c   Gerecht, Sharon ^a  

^a Johns Hopkins University   (United States)

^b Johns Hopkins University   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXTRAN; HYDROGEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BURN; CONTROLLED STUDY; EPITHELIZATION; EXPERIMENTAL PIG; EXTRACELLULAR MATRIX; GRANULATION TISSUE; HYDROGEL; INFLAMMATION; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PRIORITY JOURNAL; WOUND CLOSURE; WOUND HEALING; ANIMAL; ARTIFICIAL SKIN; BURNS; DISEASE MODEL; DRUG EFFECTS; HUMAN; IMMUNOHISTOCHEMISTRY; NEEDLE BIOPSY; PATHOLOGY; PHARMACOLOGY; PIG; PROCEDURES; RANDOMIZATION; REGENERATION; SENSITIVITY AND SPECIFICITY; SKIN CARE; SKIN TRANSPLANTATION;

ANIMALS; BIOPSY, NEEDLE; BURNS; DISEASE MODELS, ANIMAL; HUMANS; HYDROGELS; IMMUNOHISTOCHEMISTRY; RANDOM ALLOCATION; REGENERATION; SENSITIVITY AND SPECIFICITY; SKIN CARE; SKIN TRANSPLANTATION; SKIN, ARTIFICIAL; SUS SCROFA; SWINE; WOUND HEALING;

EID: 84941424093     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2015.182     Document Type: Article

References (37)

1. Ashcroft GS, Yang X, Glick AB et al. (1999) Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nat Cell Biol 1: 260-6
2. Blais M, Grenier M, Berthod F (2009) Improvement of nerve regeneration in tissue-engineered skin enriched with schwann cells. J InvestDermatol 129: 2895-900
3. Blais M, Parenteau-Bareil R, Cadau S et al. (2013) Concise review: tissueengineered skin and nerve regeneration in burn treatment. Stem Cells Transl Med 2: 545-51
4. Boateng JS, Matthews KH, Stevens HN et al. (2008) Wound healing dressings and drug delivery systems: a review. J Pharmaceut Sci 97: 2892-923
5. Branski LK, Mittermayr R, Herndon DN et al. (2008) A porcine model of fullthickness burn, excision and skin autografting. Burns 34: 1119-27
6. Cope O, Langohr JL, Moore FD et al. (1947) Expeditious care of full-thickness burn wounds by surgical excision and grafting. Ann Surg 125: 1
7. DiPietro LA (2013) Angiogenesis and scar formation in healing wounds. Curr Opin Rheumatol 25: 87-91
8. Eming SA, Krieg T, Davidson JM (2007) Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol 127: 514-25
9. Gaines C, Poranki D, DuWet al. (2013) Development of a porcine deep partial thickness burn model. Burns 39: 311-9
10. Guo R, Teng J, Xu S et al. (2014) Comparison studies of the in vivo treatment of full-thickness excisional wounds and burns by an artificial bilayer dermal equivalent and J-1 acellular dermal matrix. Wound Rep Regen 22: 390-8
11. Gurtner GC, Werner S, Barrandon Y et al. (2008) Wound repair and regeneration. Nature 453: 314-21
12. Hanjaya-Putra D, Shen Y-I, Wilson A et al. (2013) Integration and regression of implanted engineered human vascular networks during deep wound healing. Stem Cells Transl Med 2: 297-306
13. Hop MJ, Polinder S, van der Vlies CH et al. (2014) Costs of burn care: a systematic review. Wound Rep Regen 22: 436-50
14. Jeschke MG, Finnerty CC, Suman OE et al. (2007) The effect of oxandrolone on the endocrinologic, inflammatory, and hypermetabolic responses during the acute phase postburn. Ann Surg 246: 351-60
15. Jeschke MG, Kamolz L, Shahrokhi S (2013) Burn Care and Treatment: A Practical Guide. Springer: Vienna, Austria
16. Kiwanuka E, Hackl F, Philip J et al. (2011) Comparison of healing parameters in porcine full-thickness wounds transplanted with skin micrografts, splitthickness skin grafts, and cultured keratinocytes. J Am Coll Surg 213: 728-35
17. Koh TJ, DiPietro LA (2011) Inflammation and wound healing: the role of the macrophage. Expert Rev Mol Med 13: e23
18. Lamme EN, de Vries HJ, van Veen H et al. (1996) Extracellular matrix characterization during healing of full-thickness wounds treated with a collagen/elastin dermal substitute shows improved skin regeneration in pigs. J Histochem Cytochem 44: 1311-22
19. Malenfant A, Forget R, Papillon J et al. (1996) Prevalence and characteristics of chronic sensory problems in burn patients. Pain 67: 493-500
20. Martin P, D'Souza D, Martin J et al. (2003) Wound healing in the PU. 1 null mouse-tissue repair is not dependent on inflammatory cells. Curr Biol 13: 1122-8
21. Middelkoop E, van den Bogaerdt AJ, Lamme EN et al. (2004) Porcine wound models for skin substitution and burn treatment. Biomaterials 25: 1559-67
22. Nanney LB, Wenczak BA, Lynch JB (1996) Progressive burn injury documented with vimentin immunostaining. J Burn Care Res 17: 191-8
23. Orgill DP (2009) Excision and skin grafting of thermal burns. N Engl J Med 360: 893-901
24. Papp A, Kiraly K, Härmä M et al. (2004) The progression of burn depth in experimental burns: a histological and methodological study. Burns 30: 684-90
25. Sheridan RL (2012) Burns: A Practical Approach to Immediate Treatment and Long-Term Care. Manson Publishing: London, UK
26. Singer AJ, McClain SA (2003) A Porcine Burn Model. In: Wound Healing: Methods and Protocols 78: 107-19
27. Stoddard FJ Jr. , Ryan CM, Schneider JC (2014) Physical and psychiatric recovery from burns. Surg Clin N Am 94: 863-78
28. Sullivan TP, Eaglstein WH, Davis SC et al. (2001) The pig as a model for human wound healing. Wound Rep Regen 9: 66-76
29. Sun G, Shen YI, Ho CC et al. (2010) Functional groups affect physical and biological properties of dextran-based hydrogels. J Biomed Mater Res Part A 93: 1080-90
30. Sun G, Zhang X, Shen YI et al. (2011) Dextran hydrogel scaffolds enhance angiogenic responses and promote complete skin regeneration during burn wound healing. Proc Natl Acad Sci USA 108: 20976-81
31. Supp DM (2011) Skin substitutes for burn wound healing: current and future approaches. Informa Healthcare 6: 217-27
32. Swift ME, Burns AL, Gray KL et al. (2001) Age-related alterations in the inflammatory response to dermal injury. J Invest Dermatol 117: 1027-35
33. Tengara S, Tominaga M, Kamo A et al. (2010) Keratinocyte-derived anosmin-1, an extracellular glycoprotein encoded by the X-linked Kallmann syndrome gene, is involved in modulation of epidermal nerve density in atopic dermatitis. J Dermatol Sci 58: 64-71
34. Ward RS, Saffle JR, Schnebly WA et al. (1989) Sensory loss over grafted areas in patients with burns. J Burn Care Rehabil 10: 536-8
35. Ward RS, Tuckett RP (1991) Quantitative threshold changes in cutaneous sensation of patients with burns. J Burn Care Rehabil 12: 569-75
36. Williams FN, Jeschke MG, Chinkes DL et al. (2009) Modulation of the hypermetabolic response to trauma: temperature, nutrition, and drugs. J Am Coll Surg 208: 489-502
37. Zhang X, Wei X, Liu L et al. (2010) Association of increasing burn severity in mice with delayed mobilization of circulating angiogenic cells. Archiv Surg 145: 259-66