Basket trials: Just the end of the first quarter

Journal of Clinical Oncology

Volumn 33, Issue 25, 2015, Pages 2823-2824

  Stenzinger, Albrecht ^a   Weichert, Wilko ^a   Lennerz, Jochen K ^b   Klauschen, Frederick ^c  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; B RAF KINASE; ERLOTINIB; LAPATINIB; PROTEOME; SELUMETINIB; SUNITINIB; TRANSCRIPTOME; TUMOR MARKER;

ADVANCED CANCER; COLON POLYP; COLORECTAL CANCER; HUMAN; LETTER; MELANOMA; MUTATION; NON SMALL CELL LUNG CANCER; PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROTEIN EXPRESSION; SMALL CELL LUNG CANCER; THORAX CANCER; THYMOMA; THYMUS CANCER; CARCINOMA, NON-SMALL-CELL LUNG; FEMALE; LUNG NEOPLASMS; MALE; METABOLISM; MOLECULARLY TARGETED THERAPY; SMALL CELL LUNG CARCINOMA; THYMUS NEOPLASMS;

BIOMARKERS, TUMOR; CARCINOMA, NON-SMALL-CELL LUNG; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MOLECULAR TARGETED THERAPY; SMALL CELL LUNG CARCINOMA; THYMUS NEOPLASMS;

EID: 84941355262     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2015.62.1516     Document Type: Letter

References (10)

1. Lopez-Chavez A., Thomas A, Rajan A., et al: Molecular profiling and targeted therapy for advanced thoracic malignancies: A biomarker-derived, multiarm, multihistology phase II basket trial. J Clin Oncol 33:1000-1007, 2015
2. Marino-Enriquez A., Fletcher CD: Shouldn't we care about the biology of benign tumours? Nat Rev Cancer 14:701-702, 2014
3. Hu-Lieskovan S., Robert L, Homet Moreno B, et al: Combining targeted therapy with immunotherapy in BRAF-mutant melanoma: Promise and challenges. J Clin Oncol 32:2248-2254, 2014
4. Spring KJ, Zhao ZZ, Karamatic R, et al High prevalence of sessile serrated adenomas with BRAF mutations: A prospective study of patients undergoing colonoscopy. Gastroenterology 131: 1400-1407, 2006
5. Prahallad A, Sun C, Huang S., et al: Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature 483:100-103, 2012
6. Shaw AT, Yeap BY, Mino-Kenudson M, et al: Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol 27:4247-4253, 2009
7. Klauschen F, Andreeff M, Keilholz U., et al: The combinatorial complexity of cancer precision medicine. Oncoscience 1:504-509, 2014
8. Heim D, Budczies J, Stenzinger A., et al: Cancer beyond organ and tissue specificity: Next-generation-sequencing gene mutation data reveal complex genetic similarities across major cancers. Int J Cancer 135:2362-2369, 2014
9. Budczies J, Bockmayr M, Denkert C., et al: Classical pathology and mutational load of breast cancer: Integration of two worlds. J Pathol Clin Res doi: 10.1002/cjp2.25
10. Klauschen F, Heim D, Stenzinger A: Histological tumor typing in the age of molecular profiling. Pathol Res Pract, 2015