Shouldn't we care about the biology of benign tumours?

Nature Reviews Cancer

Volumn 14, Issue 11, 2014, Pages 701-702

  Marino Enriquez, Adrian ^a   Fletcher, Christopher D M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

ADENOMA; APOPTOSIS; BENIGN TUMOR; CARCINOGENESIS; CELL ENERGY; CELL LINEAGE; CRANIOPHARYNGIOMA; EPITHELIAL MESENCHYMAL TRANSITION; GENE MUTATION; GENOTYPE PHENOTYPE CORRELATION; HEMANGIOMA; HUMAN; KIDNEY CARCINOMA; LANGERHANS CELL HISTIOCYTOSIS; LEIOMYOMA; LOSS OF FUNCTION MUTATION; MELANOCYTIC NEVUS; METASTASIS; MOLECULAR BIOLOGY; NEUROBLASTOMA; PHENOTYPE; REVIEW; THYROID CARCINOMA; TUMOR MICROENVIRONMENT; CELL TRANSFORMATION; GENETICS; NEOPLASM; PATHOLOGY; TUMOR INVASION;

CELL TRANSFORMATION, NEOPLASTIC; HUMANS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASMS;

EID: 84908164045     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc3845     Document Type: Review

References (11)

1. Fearon, E. R. & Vogelstein, B. A genetic model for colorectal tumorigenesis. Cell. 61, 759-767 (1990).
2. Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell. 144, 646-674 (2011).
3. Mehine, M. et al. Characterization of uterine leiomyomas by whole-genome sequencing. N. Engl. J. Med. 369, 43-53 (2013).
4. Dankort, D. et al. BrafV600E cooperates with Pten loss to induce metastatic melanoma. Nature Genet. 41, 544-552 (2009).
5. Bernards, R. & Weinberg, R. A. A progression puzzle. Nature. 418, 823 (2002).
6. Nguyen, D. X. & Massagué, J. Genetic determinants of cancer metastasis. Nature Rev. Genet. 8, 341-352 (2007).
7. Sethi, N. & Kang, Y. Unravelling the complexity of metastasis-molecular understanding and targeted therapies. Nature Rev. Cancer. 11, 735-748 (2011).
8. Wang, Y. et al. Dystrophin is a tumor suppressor in human cancers with myogenic programs. Nature Genet. 46, 601-606 (2014).
9. Vogelstein, B. et al. Cancer genome landscapes. Science. 339, 1546-1558 (2013).
10. Egeblad, M. et al. Tumors as organs: complex tissues that interface with the entire organism. Dev. Cell. 18, 884-901 (2010).
11. Doyle, L. A. & Fletcher, C. D. Metastasizing "benign" cutaneous fibrous histiocytoma: a clinicopathologic analysis of 16 cases. Am. J. Surg. Pathol. 37, 484-495 (2013).