Serum uric acid level as a risk factor for acute kidney injury in hospitalized patients: a retrospective database analysis using the integrated medical information system at Kochi Medical School hospital

Clinical and Experimental Nephrology

Volumn 20, Issue 2, 2016, Pages 235-243

  Otomo, Kazunori ^a   Horino, Taro ^a   Miki, Takeo ^a   Kataoka, Hiromi ^a   Hatakeyama, Yutaka ^a   Matsumoto, Tatsuki ^a   Hamada Ode, Kazu ^a   Shimamura, Yoshiko ^a   Ogata, Koji ^a   Inoue, Kosuke ^a   Taniguchi, Yoshinori ^a   Terada, Yoshio ^a   Okuhara, Yoshiyasu ^a  

^a KOCHI UNIVERSITY   (Japan)

Author keywords

Acute kidney injury; AKI; Hyperuricemia; Hypouricemia; Medical database analysis

Indexed keywords

NITROGEN; UREA; URIC ACID; BIOLOGICAL MARKER;

ACUTE KIDNEY FAILURE; ADULT; ARTICLE; COMORBIDITY; DIABETES MELLITUS; DISEASE ASSOCIATION; FEMALE; HEART MUSCLE ISCHEMIA; HOSPITAL PATIENT; HUMAN; HYPERTENSION; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NEOPLASM; RISK ASSESSMENT; SEX DIFFERENCE; UREA NITROGEN BLOOD LEVEL; URIC ACID BLOOD LEVEL; URINE VOLUME; ACUTE KIDNEY INJURY; AGED; BLOOD; JAPAN; MEDICAL INFORMATION SYSTEM; RETROSPECTIVE STUDY; RISK FACTOR; STATISTICS AND NUMERICAL DATA;

ACUTE KIDNEY INJURY; ADULT; AGED; BIOMARKERS; FEMALE; HEALTH INFORMATION EXCHANGE; HUMANS; INPATIENTS; JAPAN; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; RISK FACTORS; URIC ACID;

EID: 84941348950     PISSN: 13421751     EISSN: 14377799     Source Type: Journal    
DOI: 10.1007/s10157-015-1156-5     Document Type: Article

References (21)

1. Cerda J, Lameire N, Eggers P. Diagnosis, epidemiology and outcomes of acute kidney injury. Clin J Am Soc Nephrol. 2008;3:844–61.
2. Hoste EA, Schurgers M. Epidemiology of acute kidney injury: how big is the problem? Crit Care Med. 2008;36:S146–51.
3. Matheny ME, Miller RA, Ikizler TA, Waitman LR, Denny JC, Schildcrout JS, Dittus RS, Peterson JF. Development of inpatient risk stratification models of acute kidney injury for use in electronic health records. Med Decis Mak. 2010;30:639–50.
4. Goldberg A, Kogan E, Hammerman H, Markiewicz W, Aronson D. The impact of transient and persistent acute kidney injury on long-term outcomes after acute myocardial infarction. Kidney Int. 2009;76:900–6.
5. Korkeila M, Ruokonen E, Takala J. Costs of care, long-term prognosis and quality of life in patients requiring renal replacement therapy during intensive care. Intensive Care Med. 2000;26:1824–31.
6. Ahlstrom A, Tallgren M, Peltonen S, Rasanen P, Pettila V. Survival and quality of life of patients requiring acute renal replacement therapy. Intensive Care Med. 2005;31:1222–8.
7. Coca SG, Singanamala S, Parikh CR. Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis. Kidney Int. 2012;81:442–8.
8. Kidney Disease Improving Global Outcomes (KDIGO). KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl. 2012;2:124–38.
9. Feig DI, Kang DH, Johnson RJ. Uric acid and cardiovascular risk. N Engl J Med. 2008;359:1811–21.
10. Obermayr RP, Temml C, Gutjahr G, Knechtelsdorfer M, Oberbauer R, Klauser-Braun R. Elevated uric acid increases the risk for kidney disease. J Am Soc Nephrol. 2008;19:2407–13.
11. Johnson RJ, Lanaspa MA, Gaucher EA. Uric acid: a danger signal from the RNA world that may have a role in the epidemic of obesity, metabolic syndrome, and cardiorenal disease: evolutionary considerations. Semin Nephrol. 2011;31:394–9.
12. Lapsia V, Johnson RJ, Dass B, Shimada M, Kambhampati G, Ejaz NI, Arif AA, Ejaz AA. Elevated uric acid increases the risk for acute kidney injury. Am J Med. 2012;125:302.e9–17.
13. Ejaz AA, Dass B, Kambhampati G, Ejaz NI, Maroz N, Dhatt GS, Arif AA, Faldu C, Lanaspa MA, Shah G, Johnson RJ. Lowering serum uric acid to prevent acute kidney injury. Med Hypotheses. 2012;78:796–9.
14. Barrantes F, Tian J, Vazquez R, Amoateng-Adjepong Y, Manthous CA. Acute kidney injury criteria predict outcomes of critically ill patients. Crit Care Med. 2008;36:1397–403.
15. Ejaz AA, Mu W, Kang DH, Roncal C, Sautin YY, Henderson G, Tabah-Fisch I, Keller B, Beaver TM, Nakagawa T, Johnson RJ. Could uric acid have a role in acute renal failure? Clin J Am Soc Nephrol. 2007;2:16–21.
16. Shimada M, Dass B, Ejaz AA. Paradigm shift in the role of uric acid in acute kidney injury. Semin Nephrol. 2011;31:453–8.
17. Shimada M, Johnson RJ, May WS Jr, Lingegowda V, Sood P, Nakagawa T, Van QC, Dass B, Ejaz AA. A novel role for uric acid in acute kidney injury associated with tumour lysis syndrome. Nephrol Dial Transplant. 2009;24:2960–4.
18. Fathallah-Shaykh SA, Cramer MT. Uric acid and the kidney. Pediatr Nephrol. 2014;29:999–1008.
19. Döring A, Gieger C, Mehta D, et al. SLC2A9 influences uric acid concentrations with pronounced sex-specific effects. Nat Genet. 2008;40:430–6.
20. Dehghan A, Köttgen A, Yang Q, et al. Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet. 2008;372:1953–61.
21. Kolz M, Johnson T, Sanna S, et al. Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet. 2009;5:e1000504.