Flot-2 expression correlates with EGFR levels and poor prognosis in surgically resected non-small cell lung cancer

PLoS ONE

Volumn 10, Issue 7, 2015, Pages

  Wen, Qiuyuan ^a   Wang, Weiyuan ^a   Chu, Shuzhou ^a   Luo, Jiadi ^a   Chen, Lingjiao ^a   Xie, Guiyuan ^a   Xu, Lina ^a   Li, Meirong ^a   Fan, Songqing ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; FLOTILLIN 2; FLOTILLINS; MEMBRANE PROTEIN;

ADULT; ADVANCED CANCER; ARTICLE; CANCER PROGNOSIS; CANCER STAGING; CANCER SURGERY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG CANCER CELL LINE; MAJOR CLINICAL STUDY; MALE; NON SMALL CELL LUNG CANCER; OVERALL SURVIVAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; ADENOCARCINOMA; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SQUAMOUS CELL; KAPLAN MEIER METHOD; LUNG NEOPLASMS; METABOLISM; MIDDLE AGED; MULTIVARIATE ANALYSIS; PATHOLOGY; PROGNOSIS; PROPORTIONAL HAZARDS MODEL;

ADENOCARCINOMA; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SQUAMOUS CELL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; LUNG NEOPLASMS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 84941334646     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0132190     Document Type: Article

References (26)

1. Little AG, Gay EG, Gaspar LE, Stewart AK. National survey of non-small cell lung cancer in the United States: epidemiology, pathology and patterns of care. Lung Cancer. 2007; 57: 253-260. doi: 10.1016/j. lungcan.2007.03.012 PMID: 17451842
2. Bickel PE, Scherer PE, Schnitzer JE, Oh P, Lisanti MP, Lodish HF. Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins. J Biol Chem. 1997; 272: 13793-13802. PMID: 9153235
3. Neumann-Giesen C, Falkenbach B, Beicht P, Claasen S, Luers G, Stuermer CA, et al. Membrane and raft association of reggie-1/flotillin-2: role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpression. Biochem J. 2004; 378: 509-518. PMID: 14599293
4. Neumann-Giesen C, Fernow I, Amaddii M, Tikkanen R. Role of EGF-induced tyrosine phosphorylation of reggie-1/flotillin-2 in cell spreading and signaling to the actin cytoskeleton. J Cell Sci. 2007; 120: 395-406. doi: 10.1242/jcs.03336 PMID: 17213334
5. Banning A, Kurrle N, Meister M, Tikkanen R. Flotillins in receptor tyrosine kinase signaling and cancer. Cells. 2014; 3: 129-149. doi: 10.3390/cells3010129 PMID: 24709906
6. Solis GP, Hoegg M, Munderloh C, Schrock Y, Malaga-Trillo E, Rivera-Milla E, et al. Reggie/flotillin proteins are organized into stable tetramers in membrane microdomains. Biochem J. 2007; 403: 313-322. PMID: 17206938
7. Hazarika P, McCarty MF, Prieto VG, George S, Babu D, Koul D, et al. Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1. Cancer Res. 2004; 64: 7361-7369. doi: 10.1158/0008-5472.CAN-04-0823 PMID: 15492257
8. Doherty SD, Prieto VG, George S, Hazarika P, Duvic M. High flotillin-2 expression is associated with lymph node metastasis and Breslow depth in melanoma. Melanoma Res. 2006; 16: 461-463. PMID: 17013097
9. Yang XY, Ren CP, Wang L, Li H, Jiang CJ, Zhang HB, et al. Identification of differentially expressed genes in metastatic and non-metastatic nasopharyngeal carcinoma cells by suppression subtractive hybridization. Cell Oncol. 2005; 27: 215-223. PMID: 16308470
10. Wen Q, Li J, Wang W, Xie G, Xu L, Luo J, et al. Increased expression of flotillin-2 protein as a novel biomarker for lymph node metastasis in nasopharyngeal carcinoma. PLoS One. 2014; 9: e101676. doi: 10.1371/journal.pone.0101676 PMID: 25014228
11. Wang X, Yang Q, Guo L, Li XH, Zhao XH, Song LB, et al. Flotillin-2 is associated with breast cancer progression and poor survival outcomes. J Transl Med. 2013; 11: 190. doi: 10.1186/1479-5876-11-190 PMID: 23945257
12. Zhu Z, Wang J, Sun Z, Sun X, Wang Z, Xu H. Flotillin2 expression correlates with HER2 levels and poor prognosis in gastric cancer. PLoS One. 2013; 8: e62365. doi: 10.1371/journal.pone.0062365 PMID: 23658725
13. Liu Y, Lin L, Huang Z, Ji B, Mei S, Lin Y, et al. High expression of flotillin-2 is associated with poor clinical survival in cervical carcinoma. Int J Clin Exp Pathol. 2015; 8: 622-628. PMID: 25755754
14. Liang Z, Zhang J, Zeng X, Gao J, Wu S, Liu T. Relationship between EGFR expression, copy number and mutation in lung adenocarcinomas. BMC Cancer. 2010; 10: 376. doi: 10.1186/1471-2407-10-376 PMID: 20637128
15. Goffin JR, Zbuk K. Epidermal growth factor receptor: pathway, therapies, and pipeline. Clin Ther. 2013; 35: 1282-1303. doi: 10.1016/j.clinthera.2013.08.007 PMID: 24054705
16. Normanno N, De Luca A, Bianco C, Strizzi L, Mancino M, Maiello MR, et al. Epidermal growth factor receptor (EGFR) signaling in cancer. Gene. 2006; 366: 2-16. doi: 10.1016/j.gene.2005.10.018 PMID: 16377102
17. Amaddii M, Meister M, Banning A, Tomasovic A, Mooz J, Rajalingam K, et al. Flotillin-1/reggie-2 protein plays dual role in activation of receptor-tyrosine kinase/mitogen-activated protein kinase signaling. J Biol Chem. 2012; 287: 7265-7278. doi: 10.1074/jbc.M111.287599 PMID: 22232557
18. Arkhipova KA, Sheyderman AN, Laktionov KK, Mochalnikova VV, Zborovskaya IB. Simultaneous expression of flotillin-1, flotillin-2, stomatin and caveolin-1 in non-small cell lung cancer and soft tissue sarcomas. BMC Cancer. 2014; 14: 100. doi: 10.1186/1471-2407-14-100 PMID: 24533441
19. Wang YL, Yao WJ, Guo L, Xi HF, Li SY, Wang ZM. Expression of flotillin-2 in human non-small cell lung cancer and its correlation with tumor progression and patient survival. Int J Clin Exp Pathol. 2015; 8: 601-607. PMID: 25755751
20. Babuke T, Ruonala M, Meister M, Amaddii M, Genzler C, Esposito A, et al. Hetero-oligomerization of reggie-1/flotillin-2 and reggie-2/flotillin-1 is required for their endocytosis. Cell Signal. 2009; 21: 1287-1297. doi: 10.1016/j.cellsig.2009.03.012 PMID: 19318123
21. Solis GP, Schrock Y, Hulsbusch N, Wiechers M, Plattner H, Stuermer CA. Reggies/flotillins regulate E-cadherin-mediated cell contact formation by affecting EGFR trafficking. Mol Biol Cell. 2012; 23: 1812-1825. doi: 10.1091/mbc.E11-12-1006 PMID: 22438585
22. Chansky K, Sculier JP, Crowley JJ, Giroux D, Van Meerbeeck J, Goldstraw P. The International Association for the Study of Lung Cancer Staging Project: prognostic factors and pathologic TNM stage in surgically managed non-small cell lung cancer. J Thorac Oncol. 2009; 4: 792-801. PMID: 19458556
23. Jiang A, Gao X, Zhang D, Zhang L, Lu H. Expression and clinical significance of the Trop-2 gene in advanced non-small cell lung carcinoma. Oncol Lett. 2013; 6: 375-380. doi: 10.3892/ol.2013.1368 PMID: 24137332
24. Sasaki Y, Oshima Y, Koyama R, Maruyama R, Akashi H, Mita H, et al. Identification of flotillin-2, a major protein on lipid rafts, as a novel target of p53 family members. Mol Cancer Res. 2008; 6: 395-406. doi: 10.1158/1541-7786.MCR-07-0108 PMID: 18296650
25. Al Zobair AA, Al Obeidy BF, Yang L, Yang C, Hui Y, Yu H, et al. Concomitant overexpression of EGFR and CXCR4 is associated with worse prognosis in a new molecular subtype of non-small cell lung cancer. Oncol Rep. 2013; 29: 1524-1532. doi: 10.3892/or.2013.2254 PMID: 23443279
26. Gately K, Forde L, Cuffe S, Cummins R, Kay EW, Feuerhake F, et al. High coexpression of both EGFR and IGF1R correlates with poor patient prognosis in resected non-small-cell lung cancer. Clin Lung Cancer. 2014; 15: 58-66. doi: 10.1016/j.cllc.2013.08.005 PMID: 24210543