Abnormal social reward responses in anorexia nervosa: An fmri study

PLoS ONE

Volumn 10, Issue 7, 2015, Pages

  Via, Esther ^a,b,c   Soriano Mas, Carles ^a,d,e   Sánchez, Isabel ^a   Forcano, Laura ^a,f,g   Harrison, Ben J ^c   Davey, Christopher G ^c,h   Pujol, Jesús ^f   Martínez Zalacaín, Ignacio ^a   Menchón, José M ^a,b,d   Fernández Aranda, Fernando ^a,b,g   Cardoner, Narcís ^a,b,d  

^a HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d INSTITUTO DE SALUD CARLOS III   (Spain)

^e UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^f HOSPITAL DEL MAR   (Spain)

^g Instituto de Salud Carlos III   (Spain)

^h National Centre of Excellence in Youth Mental Health Orygen ^*  (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTATION; ADULT; ANOREXIA NERVOSA; ANTERIOR INSULA; ARTICLE; BEHAVIOR ASSESSMENT; BEHAVIOR DISORDER ASSESSMENT; BRAIN FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE SEVERITY; DORSOLATERAL PREFRONTAL CORTEX; DORSOMEDIAL PREFRONTAL CORTEX; EATING DISORDER INVENTORY 2; FEMALE; FRONTAL OPERCULUM; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; IMAGE ANALYSIS; MONTE CARLO METHOD; MOTIVATION; NUCLEAR MAGNETIC RESONANCE SCANNER; PERSONALITY; REWARD; SOCIAL ACCEPTANCE; SOCIAL BEHAVIOR; SOCIAL COGNITION; SOCIAL PSYCHOLOGY; SOCIAL STRESS; THE SENSITIVITY TO PUNISHMENT AND SENSITIVITY TO REWARD QUESTIONNAIRE; ADOLESCENT; BRAIN; CASE CONTROL STUDY; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADOLESCENT; ADULT; ANOREXIA NERVOSA; BRAIN; CASE-CONTROL STUDIES; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MIDDLE AGED; REWARD; SOCIAL BEHAVIOR;

EID: 84941309177     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0133539     Document Type: Article

References (91)

1. Treasure J, Corfield F, Cardi V. A three-phase model of the social emotional functioning in eating disorders. Eur Eat Disord Rev. 2012; 20: 431-8. doi:10.1002/erv.2181 PMID: 22539368.
2. National Collaborating Centre or Mental Health commissioned by the National Institute for Clinical Excellence. National Clinical Practice Guideline Number CG9 (NICE Guidelines). Eating Disorders Core interventions in the treatment and management of anorexia nervosa, bulimia nervosa and related eating disorders. [Internet]. The British Psychological Society & The Royal College of Psychiatists; 2004. Available:http://www.nice.org.uk/guidance/cg9.
3. Harrison A, Tchanturia K, Naumann U, Treasure J. Social emotional functioning and cognitive styles in eating disorders. Br J Clin Psychol. 2012; 51: 261-79. doi:10.1111/j.2044-8260.2011.02026.x PMID: 22803934.
4. Krug I, Penelo E, Fernandez-Aranda F, Anderluh M, Bellodi L, Cellini E, et al. Low social interactions in eating disorder patients in childhood and adulthood: A multi-centre European case control study. J Health Psychol. 2013; 18: 26-37. doi:10.1177/1359105311435946 PMID: 22491496.
5. Park RJ, Dunn BD, Barnard PJ. Schematic Models and Modes of Mind in Anorexia Nervosa I : A Novel Process Account. 2011; 4: 415-437.
6. Chavez M, Insel TR. Eating disorders: National Institute of Mental Health's perspective. Am Psychol. 2007; 62: 159-66. doi:10.1037/0003-066X.62.3.159 PMID: 17469895.
7. Karwautz AFK, Wagner G, Waldherr K, Nader IW, Fernandez-Aranda F, Estivill X, et al. Gene-environment interaction in anorexia nervosa: Relevance of non-shared environment and the serotonin transporter gene. Mol Psychiatry. 2011; 16: 590-2. doi:10.1038/mp.2010.125 PMID: 21135854.
8. Krug I, Villarejo C, Jiménez-Murcia S, Perpiñá C, Vilarrasa N, Granero R, et al. Eating-related environmental factors in underweight eating disorders and obesity: Are there common vulnerabilities during childhood and early adolescence? Eur Eat Disord Rev. 2013; 21: 202-8. doi:10.1002/erv.2204 PMID: 23172786.
9. Zink CF, Weinberger DR. Cracking the moody brain: The rewards of self starvation. Nat Med. 2010; 16: 1382-3. doi:10.1038/nm1210-1382 PMID: 21135849.
10. Zucker NL, Losh M, Bulik CM, LaBar KS, Piven J, Pelphrey KA. Anorexia nervosa and autism spectrum disorders: guided investigation of social cognitive endophenotypes. Psychol Bull. 2007; 133: 976- 1006. doi:10.1037/0033-2909.133.6.976 PMID: 17967091.
11. Kaye WH, Bulik CM, Thornton L, Barbarich N, Masters K. Comorbidity of anxiety disorders with anorexia and bulimia nervosa. Am J Psychiatry. 2004; 161: 2215-21. doi:10.1176/appi.ajp.161.12.2215 PMID: 15569892.
12. Behrens TEJ, Hunt LT, Woolrich MW, Fs M. Associative learning of social value. 2009; 456: 245-249. doi:10.1038/nature07538.
13. Kennedy DP, Adolphs R. The social brain in psychiatric and neurological disorders. Trends Cogn Sci. 2012; 16: 559-72. doi:10.1016/j.tics.2012.09.006 PMID: 23047070.
14. Daniel R, Pollmann S. A universal role of the ventral striatum in reward-based learning: Evidence from human studies. Neurobiol Learn Mem. 2014; 114: 90-100. PMID: 24825620.
15. Krach S, Paulus FM, Bodden M, Kircher T. The rewarding nature of social interactions. Front Behav Neurosci. 2010; 4: 22. doi:10.3389/fnbeh.2010.00022 PMID: 20577590.
16. Fareri DS, Delgado MR. Social Rewards and Social Networks in the Human Brain. Neuroscientist. 2014; 20: 387-402. doi:10.1177/1073858414521869 PMID: 24561513.
17. Knutson B, Cooper JC. Functional magnetic resonance imaging of reward prediction. Curr Opin Neurol. 2005; 18: 411-7. PMID: 16003117.
18. Ivanov I, Liu X, Clerkin S, Schulz K, Fan J, Friston K, et al. Methylphenidate and brain activity in a reward/conflict paradigm: Role of the insula in task performance. Eur Neuropsychopharmacol. 2014; 24: 897-906. PMID: 24491951.
19. Izuma K, Saito DN, Sadato N. Processing of social and monetary rewards in the human striatum. Neuron. 2008; 58: 284-94doi:10.1016/j.neuron.2008.03.020 PMID: 18439412.
20. Davey CG, Allen NB, Harrison BJ, Dwyer DB, Yücel M. Being liked activates primary reward and midline self-related brain regions. Hum Brain Mapp. 2010; 31: 660-8. doi:10.1002/hbm.20895 PMID: 19823984.
21. Lin A, Adolphs R, Rangel A. Social and monetary reward learning engage overlapping neural substrates. Soc Cogn Affect Neurosci. 2012; 7: 274-81. doi:10.1093/scan/nsr006 PMID: 21427193.
22. Ochsner KN. The social-emotional processing stream: five core constructs and their translational potential for schizophrenia and beyond. Biol Psychiatry. 2008; 64: 48-61. doi:10.1016/j.biopsych.2008.04.024 PMID: 18549876.
23. Bergh C, Södersten P. Anorexia nervosa, self-starvation and the reward of stress. Nat Med. 1996; 2: 21-2. PMID: 8564826.
24. Kim SF. Animal models of eating disorders. Neuroscience. 2012; 211: 2-12. PMID: 22465439.
25. Södersten P, Nergårdh R, Bergh C, Zandian M, Scheurink A. Behavioral neuroendocrinology and treatment of anorexia nervosa. Front Neuroendocrinol. 2008; 29: 445-62doi:10.1016/j.yfrne.2008.06.001 PMID: 18602416.
26. Keating C. Theoretical perspective on anorexia nervosa: The conflict of reward. Neurosci Biobehav Rev. 2010; 34: 73-9. doi:10.1016/j.neubiorev.2009.07.004 PMID: 19619579.
27. Frank GKW. Altered brain reward circuits in eating disorders: chicken or egg? Curr Psychiatry Rep. 2013; 15: 396. doi:10.1007/s11920-013-0396-x PMID: 23963630.
28. Kontis D, Theochari E. Dopamine in anorexia nervosa: A systematic review. Behav Pharmacol. Unit for the Study of Cognition in Psychosis, Psychiatric Hospital of Attica, Athens, Greece. dimkontis@gmail. com; 2012; 23: 496-515.
29. Keating C, Tilbrook AJ, Rossell SL, Enticott PG, Fitzgerald PB. Reward processing in anorexia nervosa. Neuropsychologia. 2012; 50: 567-75. doi:10.1016/j.neuropsychologia.2012.01.036PMID: 22349445.
30. Kaye WH, Wierenga CE, Bailer UF, Simmons AN, Bischoff-Grethe A. Nothing tastes as good as skinny feels: The neurobiology of anorexia nervosa. Trends Neurosci. 2013; 36: 110-20. doi:10.1016/j.tins.2013.01.003 PMID: 23333342.
31. Fladung A-K, Grön G, Grammer K, Herrnberger B, Schilly E, Grasteit S, et al. A neural signature of anorexia nervosa in the ventral striatal reward system. Am J Psychiatry. 2010; 167: 206-12. doi:10.1176/appi.ajp.2009.09010071PMID: 19833790.
32. Cowdrey FA, Park RJ, Harmer CJ, McCabe C. Increased neural processing of rewarding and aversive food stimuli in recovered anorexia nervosa. Biol Psychiatry. 2011; 70: 736-43. doi:10.1016/j.biopsych.2011.05.028 PMID: 21714958.
33. Frank GKW, Reynolds JR, Shott ME, Jappe L, Yang TT, Tregellas JR, et al. Anorexia nervosa and obesity are associated with opposite brain reward response. Neuropsychopharmacology. 2012; 37: 2031- 46. doi:10.1038/npp.2012.51PMID: 22549118.
34. Wagner A, Aizenstein H, Mazurkewicz L, Fudge J, Frank GK, Putnam K, et al. Altered insula response to taste stimuli in individuals recovered from restricting-type anorexia nervosa. Neuropsychopharmacology. 2008; 33: 513-23. doi:10.1038/sj.npp.1301443 PMID: 17487228.
35. Wagner A, Aizenstein H, Venkatraman VK, Fudge J, May JC, Mazurkewicz L, et al. Altered reward processing in women recovered from anorexia nervosa. Am J Psychiatry. 2007; 164: 1842-9. doi:10.1176/appi.ajp.2007.07040575 PMID: 18056239.
36. Schmidt U, Treasure J. Anorexia nervosa: valued and visible. A cognitive-interpersonal maintenance model and its implications for research and practice. Br J Clin Psychol. 2006; 45: 343-66. PMID: 17147101.
37. Cardi V, Matteo R Di, Corfield F, Treasure J. Social reward and rejection sensitivity in eating disorders: An investigation of attentional bias and early experiences. World J Biol Psychiatry. 2013; 14: 622-33. doi:10.3109/15622975.2012.665479PMID: 22424288.
38. Watson KK, Werling DM, Zucker NL, Platt ML. Altered social reward and attention in anorexia nervosa. Front Psychol. 2010; 1: 36. doi:10.3389/fpsyg.2010.00036 PMID: 21887145.
39. Rieger E, Van Buren DJ, Bishop M, Tanofsky-Kraff M, Welch R, Wilfley DE. An eating disorder-specific model of interpersonal psychotherapy (IPT-ED): causal pathways and treatment implications. Clin Psychol Rev. 2010; 30: 400-10. PMID: 20227151.
40. Cardi V, Corfield F, Leppanen J, Rhind C, Deriziotis S, Hadjimichalis A, et al. Emotional processing of infants displays in eating disorders. PLoS One. 2014; 9: E113191. doi:10.1371/journal.pone.0113191 PMID: 25463051.
41. Cloninger CR. A systematic method for clinical description and classification of personality variants. A proposal. Arch Gen Psychiatry. 1987; 44: 573-88. PMID: 3579504.
42. Gray J. Neural systems of motivation, emotion and affect. In: Maden J, editor. Neurobiology of learning, emotion and affect. New York, NY: Raven Press; 1991. pp. 273-306.
43. Harrison A, Treasure J, Smillie LD. Approach and avoidance motivation in eating disorders. Psychiatry Res. 2011; 188: 396-401. doi:10.1016/j.psychres.2011.04.022 PMID: 21645929.
44. Glashouwer KA, Bloot L, Veenstra EM, Franken IHA, de Jong PJ. Heightened sensitivity to punishment and reward in anorexia nervosa. Appetite. 2014; 75: 97-102. doi:10.1016/j.appet.2013.12.019 PMID: 24389241.
45. Matton A, Goossens L, Braet C, Vervaet M. Punishment and reward sensitivity: Are naturally occurring clusters in these traits related to eating and weight problems in adolescents? Eur Eat Disord Rev. 2013; 21: 184-94. doi:10.1002/erv.2226 PMID: 23426856.
46. Harrison A, O'Brien N, Lopez C, Treasure J. Sensitivity to reward and punishment in eating disorders. Psychiatry Res. 2010; 177: 1-11. doi:10.1016/j.psychres.2009.06.010 PMID: 20381877.
47. Davey CG, Allen NB, Harrison BJ, Yücel M. Increased amygdala response to positive social feedback in young people with major depressive disorder. Biol Psychiatry. 2011; 69: 734-41. doi:10.1016/j.biopsych.2010.12.004 PMID: 21257158.
48. Eisenberger NI. The neural bases of social pain: Evidence for shared representations with physical pain. Psychosom Med. 2012; 74: 126-35. PMID: 22286852.
49. American Psychiatric Association, Association AP. Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR). Washington, DC: American Psychiatric Association; 2000.
50. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition. (SCID-I/P). New York: Biometrics Research;New York State Psychiatric Institute; 2002.
51. Via E, Zalesky A, Sánchez I, Forcano L, Harrison BJ, Pujol J, et al. Disruption of brain white matter microstructure in women with anorexia nervosa. J Psychiatry Neurosci. 2014; 39: 130135.
52. Lobo A, Perez-Echeverria MJ, Artal J. Validity of the scaled version of the General Health Questionnaire (GHQ-28) in a Spanish population. Psychol Med. ENGLAND; 1986; 16: 135-140.
53. First MB, Spitzer RL, Gibbon M, Williams JB. Structured Clinical Interview for DSM-IV-RS Axis 1 Disorders- Non-patient edition (SCID-I/NP). New York: Biometrics Research, New York State Psychiatric Institute; 2007.
54. Garner DM. Eating Disorder Inventory -2 professional manual. Odessa, FL: Psychological Assessment Resources.; 1991.
55. Torrubia R, Avila C, Molto J, & Caseras X. The Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSRQ) as a measure of Gray's anxiety and impulsivity dimensions. Pers Individ Dif. 2001; 31: 834-862.
56. Liebowitz MR. Social phobia. Mod Probl Pharmacopsychiatry. 1987; 22: 141-73. PMID: 2885745.
57. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960; 23: 56-62. PMID: 14399272.
58. Hamilton M. The assessment of anxiety states by rating. Br J Med Psychol. Not Available; 1959; 32: 50-55. PMID: 13638508.
59. Martinez AM, Benavente R. The AR Face Database CVC Tech. Report #24 [Internet]. 1998. Available: http://www2.ece.ohio-state.edu/aleix/ARdatabase.html.
60. Ward B. Simultaneous Inference for FMRI Data. NIMH. [Internet]. NIMH; 2000. Available: http://afni.nimh.nih.gov/pub/dist/doc/manual/AlphaSim.pdf. Last accessed 1 July 2015.
61. Pelloux Y, Everitt BJ, Dickinson A. Compulsive drug seeking by rats under punishment: Effects of drug taking history. Psychopharmacology (Berl). 2007; 194: 127-37. doi:10.1007/s00213-007-0805-0.
62. Schmitz TW, Johnson SC. Relevance to self: A brief review and framework of neural systems underlying appraisal. Neurosci Biobehav Rev. 2007; 31: 585-96. doi:10.1016/j.neubiorev.2006.12.003 PMID: 17418416.
63. Fornito A, Zalesky A, Pantelis C, Bullmore ET. Schizophrenia, neuroimaging and connectomics. Neuroimage. 2012; 62: 2296-314. doi:10.1016/j.neuroimage.2011.12.090 PMID: 22387165.
64. Ochsner KN, Beer JS, Robertson ER, Cooper JC, Gabrieli JDE, Kihsltrom JF, et al. The neural correlates of direct and reflected self-knowledge. Neuroimage. 2005; 28: 797-814. doi:10.1016/j.neuroimage.2005.06.069 PMID: 16290016.
65. Gunther Moor B, van Leijenhorst L, Rombouts SARB, Crone EA, Van der Molen MW. Do you like me? Neural correlates of social evaluation and developmental trajectories. Soc Neurosci. 2010; 5: 461-82. doi:10.1080/17470910903526155 PMID: 20721813.
66. Mitchell JP, Cloutier J, Banaji MR, Macrae CN. Medial prefrontal dissociations during processing of trait diagnostic and nondiagnostic person information. Soc Cogn Affect Neurosci. 2006; 1: 49-55. doi:10.1093/scan/nsl007 PMID: 18985100.
67. Amodio DM, Frith CD. Meeting of minds: The medial frontal cortex and social cognition. Nat Rev Neurosci. 2006; 7: 268-77doi:10.1038/nrn1884 PMID: 16552413.
68. Isoda M, Noritake A. What makes the dorsomedial frontal cortex active during reading the mental states of others? Front Neurosci. Frontiers; 2013; 7: 232. doi:10.3389/fnins.2013.00232.
69. Schulte-Rüther M, Mainz V, Fink GR, Herpertz-Dahlmann B, Konrad K. Theory of mind and the brain in anorexia nervosa: Relation to treatment outcome. J Am Acad Child Adolesc Psychiatry. 2012; 51: 832- 841.e11. doi:10.1016/j.jaac.2012.06.007 PMID: 22840554.
70. McAdams CJ, Krawczyk DC. Who am I? How do I look? Neural differences in self-identity in anorexia nervosa. Soc Cogn Affect Neurosci. 2014; 9: 12-21. doi:10.1093/scan/nss093PMID: 22956668.
71. Schienle A, Köchel A, Ebner F, Reishofer G, Schäfer A. Neural correlates of intolerance of uncertainty. Neurosci Lett. 2010; 479: 272-6. doi:10.1016/j.neulet.2010.05.078PMID: 20570602.
72. Volz KG, Schubotz RI, von Cramon DY. Predicting events of varying probability: uncertainty investigated by fMRI. Neuroimage. 2003; 19: 271-80. PMID: 12814578.
73. Sternheim L, Konstantellou A, Startup H, Schmidt U. What does uncertainty mean to women with anorexia nervosa? An interpretative phenomenological analysis. Eur Eat Disord Rev. 19: 12-24. doi:10.1002/erv.1029PMID: 20669152.
74. Harrison a, Sullivan S, Tchanturia K, Treasure J. Emotional functioning in eating disorders: Attentional bias, emotion recognition and emotion regulation. Psychol Med. 2010; 40: 1887-97. doi:10.1017/S0033291710000036PMID: 20102669.
75. Renwick B, Campbell IC, Schmidt U. Review of attentional bias modification: A brain-directed treatment for eating disorders. Eur Eat Disord Rev. 2013; 21: 464-74. doi:10.1002/erv.2248 PMID: 24002738.
76. Beck I, Smits DJM, Claes L, Vandereycken W, Bijttebier P. Psychometric evaluation of the behavioral inhibition/behavioral activation system scales and the sensitivity to punishment and sensitivity to reward questionnaire in a sample of eating disordered patients. Pers Individ Dif. 2009; 47: 407-412. doi:10.1016/j.paid.2009.04.007.
77. Avila C, Parcet MA, Barrós-Loscertales A. A cognitive neuroscience approach to individual differences in sensitivity to reward. Neurotox Res. 2008; 14: 191-203. doi:10.1007/BF03033810 PMID: 19073426.
78. Chase HW, Kumar P, Eickhoff SB, Dombrovski AY. Reinforcement learning models and their neural correlates: An activation likelihood estimation meta-analysis. Cogn Affect Behav Neurosci. 2015; doi:10.3758/s13415-015-0338-7.
79. Kaye WH, Fudge JL, Paulus M. New insights into symptoms and neurocircuit function of anorexia nervosa. Nat Rev Neurosci. 2009; 10: 573-84. doi:10.1038/nrn2682 PMID: 19603056.
80. Vocks S, Herpertz S, Rosenberger C, Senf W, Gizewski ER. Effects of gustatory stimulation on brain activity during hunger and satiety in females with restricting-type anorexia nervosa: An fMRI study. J Psychiatr Res. 2011; 45: 395-403. doi:10.1016/j.jpsychires.2010.07.012 PMID: 20709330.
81. Oberndorfer TA, Frank GKW, Simmons AN, Wagner A, McCurdy D, Fudge JL, et al. Altered insula response to sweet taste processing after recovery from anorexia and bulimia nervosa. Am J Psychiatry. 2013; 170: 1143-51. PMID: 23732817.
82. Costumero V, Barrós-Loscertales A, Bustamante JC, Ventura-Campos N, Fuentes P, Rosell-Negre P, et al. Reward sensitivity is associated with brain activity during erotic stimulus processing. PLoS One. 2013; 8: E66940. doi:10.1371/journal.pone.0066940PMID: 23840558.
83. Hsu DT, Sanford BJ, Meyers KK, Love TM, Hazlett KE, Wang H, et al. Response of the μ-opioid system to social rejection and acceptance. Mol Psychiatry. 2013; 18: 1211-7. doi:10.1038/mp.2013.96 PMID: 23958960.
84. Jiang T, Soussignan R, Rigaud D, Schaal B. Pleasure for visual and olfactory stimuli evoking energydense foods is decreased in anorexia nervosa. Psychiatry Res. 2010; 180: 42-7. doi:10.1016/j.psychres.2010.04.041PMID: 20488559.
85. Berridge KC. "Liking" and "wanting" food rewards: brain substrates and roles in eating disorders. Physiol Behav. 2009; 97: 537-50. PMID: 19336238.
86. Delgado MR. Reward-related responses in the human striatum. Ann N Y Acad Sci. 2007; 1104: 70-88. doi:10.1196/annals.1390.002 PMID: 17344522.
87. Scott DJ, Stohler CS, Egnatuk CM, Wang H, Koeppe RA, Zubieta J-K. Individual differences in reward responding explain placebo-induced expectations and effects. Neuron. 2007; 55: 325-36. doi:10.1016/j.neuron.2007.06.028 PMID: 17640532.
88. Rolls ET. Taste, olfactory, and food reward value processing in the brain. Prog Neurobiol. 2015; doi:10.1016/j.pneurobio.2015.03.002.
89. Brühl AB. Making Sense of Real-Time Functional Magnetic Resonance Imaging (rtfMRI) and rtfMRI Neurofeedback. Int J Neuropsychopharmacol. 2015; doi: 10.1093/ijnp/pyv020.
90. Caria A, de Falco S. Anterior insular cortex regulation in autism spectrum disorders. Front Behav Neurosci. 2015; 9: 38. doi:10.3389/fnbeh.2015.00038 PMID: 25798096.
91. Kim Y-R, Kim C-H, Park JH, Pyo J, Treasure J. The impact of intranasal oxytocin on attention to social emotional stimuli in patients with anorexia nervosa: A double blind within-subject cross-over experiment. PLoS One. 2014; 9: E90721. doi:10.1371/journal.pone.0090721 PMID: 24603863.