Synaptic changes in GABAA receptor expression in the thalamus of the stargazer mouse model of absence epilepsy

Neuroscience

Volumn 306, Issue , 2015, Pages 28-38

  Seo, S ^a   Leitch, B ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Absence epilepsy; GABAA receptors; Immunogold; Stargazer mouse; Thalamocortical network; Ventral posterior nucleus

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA4; 4 AMINOBUTYRIC ACID A RECEPTOR BETA2; 4 AMINOBUTYRIC ACID A RECEPTOR DELTA; UNCLASSIFIED DRUG; CACNG2 PROTEIN, MOUSE; CALCIUM CHANNEL; PROTEIN SUBUNIT;

ABSENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOCHEMISTRY; ELECTRON MICROSCOPY; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOGOLD STAINING; MALE; MOUSE; MOUSE MODEL; NERVE CELL; NONHUMAN; POSTEMBEDDING IMMUNOGOLD CYTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; STARGAZER MOUSE; SYNAPSE; THALAMIC RELAY NEURON; THALAMOCORTICAL TRACT; THALAMUS; THALAMUS VENTRAL NUCLEUS; WESTERN BLOTTING; ANIMAL; DISEASE MODEL; GENETICS; METABOLISM; NERVE CELL INHIBITION; PROTEIN SUBUNIT; TRANSGENIC MOUSE; ULTRASTRUCTURE;

ANIMALS; CALCIUM CHANNELS; DISEASE MODELS, ANIMAL; EPILEPSY, ABSENCE; MALE; MICE; MICE, TRANSGENIC; NEURAL INHIBITION; NEURONS; PROTEIN SUBUNITS; RECEPTORS, GABA-A; SYNAPSES; VENTRAL THALAMIC NUCLEI;

EID: 84941286255     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2015.08.021     Document Type: Article

References (51)

1. Bal T., von Krosigk M., McCormick D.A. Synaptic and membrane mechanisms underlying synchronized oscillations in the ferret lateral geniculate nucleus in vitro. J Physiol 1995, 483:641-663.
2. Baldy-Moulinier M. Sleep architecture and childhood absence epilepsy. Epilepsy Res Suppl 1992, 6:195-198.
3. Barad Z., Shevtsova O., Arbuthnott G.W., Leitch B. Selective loss of AMPA receptors at corticothalamic synapses in the epileptic stargazer mouse. Neuroscience 2012, 217:19-31.
4. Barbaresi P., Spreafico R., Frassoni C., Rustioni A. GABAergic neurons are present in the dorsal column nuclei but not in the ventroposterior complex of rats. Brain Res 1986, 382:305-326.
5. Beenhakker M.P., Huguenard J.R. Neurons that fire together also conspire together: is normal sleep circuitry hijacked to generate epilepsy?. Neuron 2009, 62:612-632.
6. Bessaïh T., Bourgeais L., Badiu C.I., Carter D.A., Toth T.I., Ruano D., et al. Nucleus-specific abnormalities of GABAergic synaptic transmission in a genetic model of absence seizures. J Neurophysiol 2006, 96:3074-3081.
7. Castro-Alamancos M.A. Neocortical synchronized oscillations induced by thalamic disinhibition in vivo. J Neurosci 1999, 19:RC27.
8. Chaves J., Sander J.W. Seizure aggravation in idiopathic generalized epilepsies. Epilepsia 2005, 46(Suppl 9):133-139.
9. Chen L., Chetkovich D.M., Petralia R.S., Sweeney N.T., Kawasaki Y., Wenthold R.J., et al. Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms. Nature 2000, 408:936-943.
10. A inhibition in typical absence epilepsy. Nat Med 2009, 15:1392-1399.
11. Cossette P., Lachance-Touchette P., Rouleau G.A. Mutated GABAA receptor subunits in idiopathic generalized epilepsy. Jasper's basic mechanisms of the epilepsies 2012, National Center for Biotechnology Information (US), Bethesda, MD. 4th ed. J.L. Noebels, M. Avoli, M.A. Rogawski, R.W. Olsen, A.V. Delgado-Escueta (Eds.).
12. Crunelli V., Leresche N. Childhood absence epilepsy: genes, channels, neurons and networks. Nat Rev Neurosci 2002, 3:371-382.
13. Crunelli V., Leresche N., Cope D.W. GABA-A receptor function in typical absence seizures. Jasper's basic mechanisms of the epilepsies 2012, National Center for Biotechnology Information (US), Bethesda (MD). 4th edition. J.L. Noebels, M. Avoli, M.A. Rogawski, R.W. Olsen, A.V. Delgado-Escueta (Eds.).
14. Errington A.C., Gibson K.M., Crunelli V., Cope D.W. Aberrant GABAA receptor-mediated inhibition in cortico-thalamic networks of succinic semialdehyde dehydrogenase deficient mice. PLoS One 2011, 6:e19021.
15. Farrant M., Nusser Z. Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors. Nat Rev Neurosci 2005, 6:215-229.
16. Gervasi N., Monnier Z., Vincent P., Paupardin-Tritsch D., Hughes S.W., Crunelli V., et al. Pathway-specific activation of gamma-hydroxybutyric acid in sensory thalamus and its relevance to absence seizures. J Neurosci 2003, 23:11469-11478.
17. Glauser T.A., Cnaan A., Shinnar S., Hirtz D.G., Dlugos D., Masur D., et al. Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy: initial monotherapy outcomes at 12months. Epilepsia 2013, 54:141-155.
18. Gylterud Owe S., Bogen I.L., Walaas S.I., Storm-Mathisen J., Bergersen L.H. Ultrastructural quantification of glutamate receptors at excitatory synapses in hippocampus of synapsin I+II double knock-out mice. Neuroscience 2005, 136:769-777.
19. Harris K.M., Weinberg R.J. Ultrastructure of synapses in the mammalian brain. Cold Spring Harb Perspect Biol 2012, 4:a005587.
20. Horita H. Epileptic seizures and sleep-wake rhythm. Psychiatry Clin Neurosci 2001, 55:171-172.
21. A receptors in thalamic nuclei in lh/lh model of absence seizures. Epilepsy Res 1997, 27:55-65.
22. Huguenard J.R., McCormick D.A. Thalamic synchrony and dynamic regulation of global forebrain oscillations. Trends Neurosci 2007, 30:350-356.
23. Huguenard J.R., Prince D.A. Intrathalamic rhythmicity studied in vitro: nominal T-current modulation causes robust antioscillatory effects. J Neurosci 1994, 14:5485-5502.
24. Huntsman M.M., Porcello D.M., Homanics G.E., DeLorey T.M., Huguenard J.R. Reciprocal inhibitory connections and network synchrony in the mammalian thalamus. Science 1999, 283:541-543.
25. Jallon P., Loiseau P., Loiseau J. Newly diagnosed unprovoked epileptic seizures: presentation at diagnosis in CAROLE study. Epilepsia 2001, 42:464-475.
26. Jones E.G. Synchrony in the interconnected circuitry of the thalamus and cerebral cortex. Disorders of consciousness. Ann NY Acad Sci 2009, 1157:10-23.
27. Jones E.G., Powell T.P.S. An electron microscopic study of the mode of termination of cortico-thalamic fibres within the sensory relay nuclei of the thalamus. Proc Soc London B 1969, 172:173-185.
28. Jones E.G., Powell T.P.S. Connexions of the somatic sensory cortex of the Rhesus monkey. III. Thalamic connexions. Brain 1970, 93:37-56.
29. Letts V.A. Stargazer - A mouse to seize. Epilepsy Curr 2005, 5:161-165.
30. Letts V.A., Kang M.G., Mahaffey C.L., Beyer B., Tenbrink H., Campbell K.P., et al. Phenotypic heterogeneity in the stargazin allelic series. Mamm Genome 2003, 14:506-513.
31. Liu X.-B., Coble J., van Luijtelaar G., Jones E.G. Reticular nucleus-specific changes in a3 subunit protein at GABA synapses in genetically epilepsy-prone rats. PNAS 2007, 104:12512-12517.
32. McCormick D.A., Contreras D. On the cellular and network bases of epileptic seizures. Annu Rev Physiol 2001, 63:815-846.
33. Menuz K., Nicoll R.A. Loss of inhibitory neuron AMPA receptors contributes to ataxia and epilepsy in stargazer mice. J Neurosci 2008, 28:10599-10603.
34. Mody I., Pearce R.A. Diversity of inhibitory neurotransmission through GABAA receptors. Trends Neurosci 2004, 27:569-575.
35. Noebels J.L., Qiao X., Bronson R.T., Spencer C., Davisson M.T. Stargazer: a new neurological mutant on chromosome 15 in the mouse with prolonged cortical seizures. Epilepsy Res 1990, 7:129-135.
36. Nusser Z., Hajos N., Somogyi P., Mody I. Increased number of synaptic GABA(A) receptors underlies potentiation at hippocampal inhibitory synapses. Nature 1998, 395:172-177.
37. Payne H.L., Donoghue P.S., Connelly W.M., Hinterreiter S., Tiwari P., Ives J.H., Hann V., Sieghart W., Lees G., Thompson C.L. Aberrant GABA(A) receptor expression in the dentate gyrus of the epileptic mutant mouse stargazer. J Neurosci 2006, 26:8600-8608.
38. Paz J.T., Bryant A.S., Peng K., Fenno L., Yizhar O., Frankel W.N., Deisseroth K., Huguenard J.R. A new mode of corticothalamic transmission revealed in the Gria4(-/-) model of absence epilepsy. Nat Neurosci 2011, 14:1167-1173.
39. Pirker S., Schwarzer C., Wieselthaler A., Sieghart W., Sperk G. GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience 2000, 101:815-850.
40. Ralston H.J. The synaptic organization of lemniscal projections to the ventrobasal thalamus of the cat. Brain Res 1969, 14:99-115.
41. Rigby M., Cull-Candy S.G., Farrant M. Transmembrane AMPAR regulatory protein γ2 is required for the modulation of GABA release by presynaptic AMPARs. J Neurosci 2015, 35:4203-4214.
42. Sanchez-Vives M.V., McCormick M.V. Functional properties of perigeniculate inhibition of dorsal lateral geniculate nucleus thalamocortical neurons in vitro. J Neurosci 1997, 17:8880-8893.
43. Seo S., Liu P., Leitch B. Spatial learning-induced accumulation of agmatine and glutamate at hippocampal CA1 synaptic terminals. Neuroscience 2011, 192:28-36.
44. A-receptor subunit expression in the stargazer mouse model of absence epilepsy. Epilepsia 2014, 55:224-232.
45. Shevtsova O., Leitch B. Selective loss of AMPA receptor subunits at inhibitory neuron synapses in the cerebellum of the ataxic stargazer mouse. Brain Res 2012, 1427:54-64.
46. Tan H.O., Reid C.A., Single F.N., Davies P.J., Chiu C., Murphy S., et al. Reduced cortical inhibition in a mouse model of familial childhood absence epilepsy. PNAS 2007, 104:17536-17541.
47. Tan H.O., Reid C.A., Chiu C., Jones M.V., Petrou S. Increased thalamic inhibition in the absence seizure prone DBA/2J mouse. Epilepsia 2008, 49:921-925.
48. Thomas P., Valton L., Genton P. Absence and myoclonic status epilepticus precipitated by antiepileptic drugs in idiopathic generalized epilepsy. Brain 2006, 129(Pt5):1281-1292.
49. A receptor trafficking and its role in regulating the plasticity of inhibitory synapses. Physiol Rev 2011, 91:1009-1022.
50. von Krosigk M., Bal T., McCormick D.A. Cellular mechanisms of a synchronized oscillation in the thalamus. Science 1993, 261:361-364.
51. Wirrell E.C. Accidental injury is a serious risk in children with typical absence epilepsy. Arch Neurol 1996, 53:929-932.