Bile acids and FGF receptors: Orchestrators of optimal liver regeneration

Gut

Volumn 64, Issue 9, 2015, Pages 1351-1352

  Gilgenkrantz, Hélène ^a   Tordjmann, Thierry ^b  

^a INSTITUT COCHIN   (France)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; CHOLESTEROL 7ALPHA MONOOXYGENASE; FARNESOID X RECEPTOR; FIBROBLAST GROWTH FACTOR 19; FIBROBLAST GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 4; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SCATTER FACTOR RECEPTOR; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; BIOLOGICAL MARKER;

CELL CYCLE G1 PHASE; CELL DIVISION; CELL PROLIFERATION; DOWN REGULATION; ENDOTHELIUM CELL; HUMAN; LIGAND BINDING; LIVER CELL; LIVER REGENERATION; MACROPHAGE; NONHUMAN; NOTE; PARTIAL HEPATECTOMY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; ANIMAL; CONVALESCENCE; CYTOLOGY; GENETICS; LIVER RESECTION; METABOLISM; MOUSE; PHYSIOLOGY; PROCEDURES; SENSITIVITY AND SPECIFICITY;

ANIMALS; BILE ACIDS AND SALTS; BIOLOGICAL MARKERS; CELL PROLIFERATION; HEPATECTOMY; HEPATOCYTES; HUMANS; LIVER REGENERATION; MICE; RECEPTORS, FIBROBLAST GROWTH FACTOR; RECOVERY OF FUNCTION; SENSITIVITY AND SPECIFICITY;

EID: 84941270138     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2014-308746     Document Type: Note

References (13)

1. Michalopoulos GK, DeFrances MC. Liver regeneration. Science 1997;276:60-6.
2. Doignon I, Julien B, Serrière-Lanneau V, et al. Immediate neuroendocrine signaling after partial hepatectomy through acute portal hyperpressure and cholestasis. J Hepatol 2011;54:481-8.
3. Péan N, Doignon I, Garcin I, et al. The receptor TGR5 protects the liver from bile acid overlead during liver regeneration in mice. Hepatology 2013;58:1451-60.
4. Barone M, Francavilla A, Polimeno L, et al. Modulation of rat hépatocyte prolifération by bile salts: in vitro and in vivo studies. Hepatology 1996;23:1159-66.
5. Huang W, Ma K, Zhang J, et al. Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration. Science 2006;312: 233-6.
6. Zhang L, Wang YD, Chen WD, et al. Promotion of liver regeneration/repair by farnesoid X receptor in both liver and intetine in mice. Hepatology 2012;56:2336-43.
7. Uriarte I, Fernandez-Barrena MG, Monte MJ, et al. Identification of fibroblast growth factor 15 as a novel mediator of liver regeneration and its application in the prevention of post-resection liver failure in mice. Gut 2013;62:899-1.
8. Inagaki T, Choi M, Moschetta A, et al. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metabol 2005;2:217-25.
9. Yu C, Wang F, Kan M, et al. Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4. J Biol Chem 2000;275:15482-9.
10. Padrissa-Altés S, Bachofner M, Bogorad RL, et al. Control of hepatocyte proliferation and survival by FGF receptors is essential for liver regeneration in mice. Gut 2014.
11. Steiling H, Wüstefeld T, Bugnon P, et al. Fibroblast growth factor receptor signalling is crucial for liver homeostasis and regeneration. Oncogene 2003;22:4380-8.
12. Böhm F, Speicher T, Hellerbrand C, et al. FGF receptors 1 and 2 control chemically induced injury and compound detoxification in regenerating livers of mice. Gastroenterology 2010;139:1385-96.
13. Ahn SM, Jang SJ, Shim JH, et al. Genomic portrait of resectable hepatocellular carcinomas: Implications of RB1 and FGF19 aberrations for patient stratification. Hepatology 2014;60:1972-82.