LSD enhances the emotional response to music

Psychopharmacology

Volumn 232, Issue 19, 2015, Pages 3607-3614

  Kaelen, M ^a   Barrett, F S ^b   Roseman, L ^a   Lorenz, R ^a   Family, N ^c   Bolstridge, M ^a   Curran, H V ^d   Feilding, A ^e   Nutt, D J ^a   Carhart Harris, R L ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Rheinland Pfälzische Technische Universität Kaiserslautern Landau   (Germany)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e THE BECKLEY FOUNDATION   (United Kingdom)

Author keywords

Emotion; LSD; Music; Psychedelic; Psychotherapy; Serotonin 2A receptor

Indexed keywords

LYSERGIDE; PLACEBO; PSYCHEDELIC AGENT;

ADULT; AROUSAL; ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATIONAL STUDY; DRUG EFFECT; EMOTION; EMOTION ASSESSMENT; FEMALE; GENEVA EMOTIONAL MUSIC SCALE; HUMAN; HUMAN EXPERIMENT; MALE; MUSIC; NORMAL HUMAN; PILOT STUDY; POWER; PRIORITY JOURNAL; SELF REPORT; SYSTOLIC BLOOD PRESSURE; TENDERNESS; TRANSCENDENCE; VISUAL ANALOG SCALE; WONDER; BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; DRUG EFFECTS; HEART RATE; MIDDLE AGED; PHYSIOLOGY; PSYCHOLOGY;

ADULT; BLOOD PRESSURE; DOUBLE-BLIND METHOD; EMOTIONS; FEMALE; HALLUCINOGENS; HEART RATE; HUMANS; LYSERGIC ACID DIETHYLAMIDE; MALE; MIDDLE AGED; MUSIC; PILOT PROJECTS;

EID: 84941259082     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-015-4014-y     Document Type: Article

References (41)

1. Barrett FS, Grimm KJ, Robins RW, Wildschut T, Sedikides C, Janata P (2010) Music-evoked nostalgia: affect, memory, and personality. Emotion 10:390-403
2. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J (1961) An inventory for measuring depression. Arch Gen Psychiatry 4:561-71
3. Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate - a practical and powerful approach to multiple testing. J R Stat Soc Ser B Methodol 57:289-300
4. Bogenschutz MP, Forcehimes AA, Pommy JA, Wilcox CE, Barbosa PCR, Strassman RJ (2015) Psilocybin-assisted treatment for alcohol dependence: a proof-of-concept study. J Psychopharmacol. doi: 10.1177/0269881114565144. http://www.ncbi.nlm.nih.gov/pubmed/25586396
5. Bonny HL, Pahnke WN (1972) The use of music in psychedelic (LSD) psychotherapy. J Music Ther 9:64-87
6. Busch AK, Johnson WC (1950) L.S.D. 25 as an aid in psychotherapy; preliminary report of a new drug. Dis Nerv Syst 11:241-3
7. Carhart-Harris RL, Erritzoe D, Williams T, Stone JM, Reed LJ, Colasanti A, Tyacke RJ, Leech R, Malizia AL, Murphey K, Hobden P, Evans J, Feilding A, Wise RG, Nutt DJ (2012) Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin. Proc Natl Acad Sci U S A 109:2138-43
8. Carhart-Harris RL, Kaelen M, Whalley MG, Bolstridge M, Feilding A, Nutt DJ (2014) LSD enhances suggestibility in healthy volunteers. Psychopharmacology 232(4):785-794
9. Cohen S (1970) Drugs of hallucination: the LSD story. Harper Collins, New York
10. Eagle CT (1972) Music and LSD: an empirical study. J Music Ther IX:23-38
11. Garcia-Romeu A, Griffith RR, Johnson MW (2014) Psilocybin-occasioned mystical experiences in the treatment of tobacco addiction. Curr Drug Abuse Rev 7:157-164
12. Gasser P, Holstein D, Michel Y, Doblin R, Yazar-Klosinski B, Passie T, Brenneisen R (2014a) Safety and efficacy of lysergic acid diethylamide-assisted psychotherapy for anxiety associated with life-threatening diseases. J Nerv Ment Dis 202(7):513-20
13. Gasser P, Kirchner K, Passie T (2014b) LSD-assisted psychotherapy for anxiety associated with a life-threatening disease: a qualitative study of acute and sustained subjective effects. J Psychopharmacol 1:57-68
14. Gaston ET, Eagle CT (1970) The function of music in LSD therapy for alcoholic patients. J Music Ther VII:3-19
15. Griffiths RR, Richards WA, McCann U, Jesse R (2006) Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance. Psychopharmacology 187:268-83, discussion 84-92
16. Griffiths RR, Richards W, Johnson MW, McCann U, Jesse R (2008) Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later. J Psychopharmacol 22:621-32
17. Griffiths RR, Johnson MW, Richards WA, Richards BD, McCann U, Jesse R (2011) Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects. Psychopharmacology 218:649-65
18. Grob CS, Danforth AL, Chopra GS, Hagerty M, McKay CR, Halberstadt AL et al (2011) Pilot study of psilocybin treatment for anxiety in patients with advanced-stage cancer. Arch Gen Psychiatry 68:71-8
19. Grof S (1980) LSD psychotherapy. Hunter House Publishers, Alameda
20. Hasler F, Grimberg U, Benz MA, Huber T, Vollenweider FX (2004) Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose-effect study. Psychopharmacology 172(2):145-56
21. Johnson MW, Richards W, Griffiths R (2008) Human hallucinogen research: guidelines for safety. J Psychopharmacol 22:603-20
22. Johnson MW, Garcia-Romeu A, Cosimano MP, Griffiths RR (2014) Pilot study of the 5-HT2AR agonist psilocybin in the treatment of tobacco addiction. J Psychopharmacol 28:983-92
23. Juslin PN, Vastfjall D (2008) Emotional responses to music: the need to consider underlying mechanisms. Behav Brain Sci 31:559-75, discussion 75-621
24. Koelsch S (2014) Brain correlates of music-evoked emotions. Nature reviews. Neuroscience 15:170-80
25. Leuner HC (1983) Psycholytic therapy: hallucinogenics as an aid in psychodynamically oriented psychotherapy. In: Grinspoon J, Bakalar JB (eds) Psychedelic reflections. Human Science Press, Oxford, pp 177-92
26. MacLean KA, Johnson MW, Griffiths RR (2011) Mystical experiences occasioned by the hallucinogen psilocybin lead to increases in the personality domain of openness. J Psychopharmacol 25:1453-61
27. Maslow AH (1993) The farther reaches of human nature. Arkana, New York
28. McCrae RR, Costa PT (1987) Validation of the five-factor model of personality across instruments and observers. J Pers Soc Psychol 52:81-90
29. Middlefell R (1967) The effects of LSD on body sway suggestibility in a group of hospital patients. Br J Psychiatry J Ment Sci 113:277-80
30. Moore KS (2013) A systematic review on the neural effects of music on emotion regulation: implications for music therapy practice. J Music Ther 50:198-242
31. Nettl B (1956) Music in primitive culture. Harvard University Press, Cambridge
32. Nichols DE (2004) Hallucinogens. Pharmacol Ther 101(2):131-81
33. Pahnke W (1963) Drugs and mysticism: an analysis of the relationship between psychedelic drugs and the mystical consciousness. A thesis completed for the degree of Doctor of Philosophy, Harvard University, Cambridge, Mass
34. Passie T, Halpern JH, Stichtenoth DO, Emrich HM, Hintzen A (2008) The pharmacology of lysergic acid diethylamide: a review. CNS Neurosci Ther 14(4):295-314
35. Peirce JW (2008) Generating stimuli for neuroscience using PsychoPy. Front Neuroinform 2:10
36. Richards WA (2009) The rebirth of resarch with entheogens: lessons from the past and hypotheses for the future. J Transpers Psychol 41:139-50
37. Schmid Y, Enzler F, Gasser P, Grouzmann E, Preller KH, Vollenweider, FX, Liechti, M. E. (2015) Acute effects of lysergic acid diethylamide in healthy subjects. Biol Psychiatry. doi: 10.1016/j.biopsych.2014.11.015. http://www.ncbi.nlm.nih.gov/pubmed/25575620
38. Solursh LP, Rae JM (1966) LSD, suggestion and hypnosis. Int J Neuropsychiatry 2:60-4
39. Studerus E, Gamma A, Kometer M, Vollenweider FX (2012) Prediction of psilocybin response in healthy volunteers. PLoS One 7(2), e30800
40. Turek IS, Soskin RA, Kurland AA (1974) Methylenedioxyamphetamine (MDA) - subjective effects. J Psychoactive Drugs 6(1):7-14
41. Zentner M, Grandjean D, Scherer KR (2008) Emotions evoked by the sound of music: characterization, classification, and measurement. Emotion 8:494-521