메뉴 건너뛰기




Volumn 109, Issue 6, 2012, Pages 2138-2143

Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin

Author keywords

5 HT2A receptor; Default mode network; Depression; Hallucinogens; Serotonin

Indexed keywords

PLACEBO; PSILOCYBINE;

EID: 84857129869     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1119598109     Document Type: Article
Times cited : (725)

References (50)
  • 1
    • 0005084132 scopus 로고
    • Seeking the magic mushroom
    • May
    • Wasson GR (1957) Seeking the magic mushroom. Life Magazine, May 15:109-120.
    • (1957) Life Magazine , vol.15 , pp. 109-120
    • Wasson, G.R.1
  • 2
    • 78650913790 scopus 로고    scopus 로고
    • Pilot study of psilocybin treatment for anxiety in patients with advanced-stage cancer
    • Grob CS, et al. (2011) Pilot study of psilocybin treatment for anxiety in patients with advanced-stage cancer. Arch Gen Psychiatry 68:71-78.
    • (2011) Arch Gen Psychiatry , vol.68 , pp. 71-78
    • Grob, C.S.1
  • 3
    • 33746191808 scopus 로고    scopus 로고
    • Psilocybin can occasion mysticaltype experiences having substantial and sustained personal meaning and spiritual significance
    • discussion 284-292
    • Griffiths RR, Richards WA, McCann U, Jesse R (2006) Psilocybin can occasion mysticaltype experiences having substantial and sustained personal meaning and spiritual significance. Psychopharmacology (Berl) 187:268-283, discussion 284-292.
    • (2006) Psychopharmacology (Berl) , vol.187 , pp. 268-283
    • Griffiths, R.R.1    Richards, W.A.2    McCann, U.3    Jesse, R.4
  • 4
    • 50249103939 scopus 로고    scopus 로고
    • Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later
    • Griffiths R, Richards W, Johnson M, McCann U, Jesse R (2008) Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later. J Psychopharmacol 22:621-632.
    • (2008) J Psychopharmacol , vol.22 , pp. 621-632
    • Griffiths, R.1    Richards, W.2    Johnson, M.3    McCann, U.4    Jesse, R.5
  • 5
    • 83455162345 scopus 로고    scopus 로고
    • The administration of psilocybin to healthy, hallucinogen- experienced volunteers in a mock-functional magnetic resonance imaging environment: A preliminary investigation of tolerability
    • Carhart-Harris RL, et al. (2010) The administration of psilocybin to healthy, hallucinogen- experienced volunteers in a mock-functional magnetic resonance imaging environment: A preliminary investigation of tolerability. J Psychopharmacol 25:1562-1567.
    • (2010) J Psychopharmacol , vol.25 , pp. 1562-1567
    • Carhart-Harris, R.L.1
  • 6
    • 1642273671 scopus 로고    scopus 로고
    • Acute psychological and physiological affects of psilocybin in healthy humans: A double-blind, placebo-controlled dose-effect study
    • DOI 10.1007/s00213-003-1640-6
    • Hasler F, Grimberg U, Benz MA, Huber T, Vollenweider FX (2004) Acute psychological and physiological effects of psilocybin in healthy humans: A double-blind, placebocontrolled dose-effect study. Psychopharmacology (Berl) 172:145-156. (Pubitemid 38388763)
    • (2004) Psychopharmacology , vol.172 , Issue.2 , pp. 145-156
    • Hasler, F.1    Grimberg, U.2    Benz, M.A.3    Huber, T.4    Vollenweider, F.X.5
  • 7
    • 77957953386 scopus 로고    scopus 로고
    • Robustly measuring vascular reactivity differences with breath-hold: Normalising stimulus-evoked and resting state BOLD fMRI data
    • Murphy K, Harris AD, Wise RG (2011) Robustly measuring vascular reactivity differences with breath-hold: normalising stimulus-evoked and resting state BOLD fMRI data. Neuroimage 54:369-379.
    • (2011) Neuroimage , vol.54 , pp. 369-379
    • Murphy, K.1    Harris, A.D.2    Wise, R.G.3
  • 8
    • 0030916849 scopus 로고    scopus 로고
    • Positron emission tomography and fluorodeoxyglucose studies of metabolic hyperfrontality and psychopathology in the psilocybin model of psychosis
    • DOI 10.1016/S0893-133X(96)00246-1, PII S0893133X96002461
    • Vollenweider FX, et al. (1997) Positron emission tomography and fluorodeoxyglucose studies of metabolic hyperfrontality and psychopathology in the psilocybin model of psychosis. Neuropsychopharmacology 16:357-372. (Pubitemid 27211734)
    • (1997) Neuropsychopharmacology , vol.16 , Issue.5 , pp. 357-372
    • Vollenweider, F.X.1    Leenders, K.L.2    Scharfetter, C.3    Maguire, P.4    Stadelmann, O.5    Angst, J.6
  • 9
    • 84856097571 scopus 로고    scopus 로고
    • Comparison of the effects of hallucinogens psilocin and mescaline on quantitative EEG and sensorimotor gating - An animal model of psychosis
    • Páleníček T, et al. (2011) Comparison of the effects of hallucinogens psilocin and mescaline on quantitative EEG and sensorimotor gating - an animal model of psychosis. Psychiatrie 15:44-48.
    • (2011) Psychiatrie , vol.15 , pp. 44-48
    • Páleníček, T.1
  • 10
    • 44949148155 scopus 로고    scopus 로고
    • Neuronal correlates of spontaneous fluctuations in fMRI signals in monkey visual cortex: Implications for functional connectivity at rest
    • DOI 10.1002/hbm.20580
    • Shmuel A, Leopold DA (2008) Neuronal correlates of spontaneous fluctuations in fMRI signals in monkey visual cortex: Implications for functional connectivity at rest. Hum Brain Mapp 29:751-761. (Pubitemid 351813076)
    • (2008) Human Brain Mapping , vol.29 , Issue.7 , pp. 751-761
    • Shmuel, A.1    Leopold, D.A.2
  • 11
    • 0842324481 scopus 로고    scopus 로고
    • Hallucinogens
    • DOI 10.1016/j.pharmthera.2003.11.002
    • Nichols DE (2004) Hallucinogens. Pharmacol Ther 101:131-181. (Pubitemid 38167565)
    • (2004) Pharmacology and Therapeutics , vol.101 , Issue.2 , pp. 131-181
    • Nichols, D.E.1
  • 12
    • 0021646446 scopus 로고
    • 2 involvement in the mechanism of action of hallucinogenic agents
    • DOI 10.1016/0024-3205(84)90436-3
    • Glennon RA, Titeler M, McKenney JD (1984) Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents. Life Sci 35:2505-2511. (Pubitemid 15212191)
    • (1984) Life Sciences , vol.35 , Issue.25 , pp. 2505-2511
    • Glennon, R.A.1    Titeler, M.2    McKenney, J.D.3
  • 13
    • 0032430801 scopus 로고    scopus 로고
    • Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action
    • Vollenweider FX, Vollenweider-Scherpenhuyzen MF, Bäbler A, Vogel H, Hell D (1998) Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action. Neuroreport 9:3897-3902. (Pubitemid 29189323)
    • (1998) NeuroReport , vol.9 , Issue.17 , pp. 3897-3902
    • Vollenweider, F.X.1    Vollenweider-Scherpenhuyzen, M.F.I.2    Babler, A.3    Vogel, H.4    Hell, D.5
  • 14
    • 0031596783 scopus 로고    scopus 로고
    • 5-Hydroxytryptamine2 receptor facilitates GABAergic neurotransmission in rat hippocampus
    • Shen RY, Andrade R (1998) 5-Hydroxytryptamine2 receptor facilitates GABAergic neurotransmission in rat hippocampus. J Pharmacol Exp Ther 285:805-812.
    • (1998) J Pharmacol Exp Ther , vol.285 , pp. 805-812
    • Shen, R.Y.1    Andrade, R.2
  • 15
    • 0037630660 scopus 로고    scopus 로고
    • The hallucinogen 1-[2,5-dimethoxy-4-iodophenyl]-2-aminopropane (DOI) increases cortical extracellular glutamate levels in rats
    • DOI 10.1016/S0304-3940(03)00547-0
    • Scruggs JL, Schmidt D, Deutch AY (2003) The hallucinogen 1-[2,5-dimethoxy-4-iodophenyl]- 2-aminopropane (DOI) increases cortical extracellular glutamate levels in rats. Neurosci Lett 346:137-140. (Pubitemid 36829280)
    • (2003) Neuroscience Letters , vol.346 , Issue.3 , pp. 137-140
    • Scruggs, J.L.1    Schmidt, D.2    Deutch, A.Y.3
  • 16
    • 0032589812 scopus 로고    scopus 로고
    • 2 receptor regulation of extracellular GABA levels in the prefrontal cortex
    • DOI 10.1016/S0893-133X(98)00046-3, PII S0893133X98000463
    • Abi-Saab WM, Bubser M, Roth RH, Deutch AY (1999) 5-HT2 receptor regulation of extracellular GABA levels in the prefrontal cortex. Neuropsychopharmacology 20: 92-96. (Pubitemid 29010343)
    • (1999) Neuropsychopharmacology , vol.20 , Issue.1 , pp. 92-96
    • Abi-Saab, W.M.1    Bubser, M.2    Roth, R.H.3    Deutch, A.Y.4
  • 17
    • 73649110551 scopus 로고    scopus 로고
    • Unilateral lesion of the nigrostriatal pathway decreases the response of interneurons in medial prefrontal cortex to 5-HT 2A/2C receptor stimulation in the rat
    • Zhang QJ, et al. (2010) Unilateral lesion of the nigrostriatal pathway decreases the response of interneurons in medial prefrontal cortex to 5-HT 2A/2C receptor stimulation in the rat. Brain Res 1312:127-137.
    • (2010) Brain Res , vol.1312 , pp. 127-137
    • Zhang, Q.J.1
  • 19
    • 0030434487 scopus 로고    scopus 로고
    • LSD and the phenethylamine hallucinogen DOI are potent partial agonists at 5-HT2A receptors on interneurons in rat piriform cortex
    • Marek GJ, Aghajanian GK (1996) LSD and the phenethylamine hallucinogen DOI are potent partial agonists at 5-HT2A receptors on interneurons in rat piriform cortex. J Pharmacol Exp Ther 278:1373-1382.
    • (1996) J Pharmacol Exp Ther , vol.278 , pp. 1373-1382
    • Marek, G.J.1    Aghajanian, G.K.2
  • 20
    • 0030941213 scopus 로고    scopus 로고
    • In vivo electrophysiological characterization of 5-HT receptors in the guinea pig head of caudate nucleus and orbitofrontal cortex
    • el Mansari M, Blier P (1997) In vivo electrophysiological characterization of 5-HT receptors in the guinea pig head of caudate nucleus and orbitofrontal cortex. Neuropharmacology 36:577-588.
    • (1997) Neuropharmacology , vol.36 , pp. 577-588
    • El Mansari, M.1    Blier, P.2
  • 21
    • 0032935841 scopus 로고    scopus 로고
    • 2 receptors in the rat orbito-frontal cortex: An in vivo electrophysiological study
    • DOI 10.1007/s002130050923
    • Bergqvist PB, Dong J, Blier P (1999) Effect of atypical antipsychotic drugs on 5-HT2 receptors in the rat orbito-frontal cortex: An in vivo electrophysiological study. Psychopharmacology (Berl) 143:89-96. (Pubitemid 29189999)
    • (1999) Psychopharmacology , vol.143 , Issue.1 , pp. 89-96
    • Bergqvist, P.B.F.1    Dong, J.2    Blier, P.3
  • 24
    • 79953728262 scopus 로고    scopus 로고
    • Serotonergic regulation of neuronal excitability in the prefrontal cortex
    • Andrade R (2011) Serotonergic regulation of neuronal excitability in the prefrontal cortex. Neuropharmacology 61:382-386.
    • (2011) Neuropharmacology , vol.61 , pp. 382-386
    • Andrade, R.1
  • 25
    • 68349103200 scopus 로고    scopus 로고
    • Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors
    • Alexander GM, et al. (2009) Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors. Neuron 63:27-39.
    • (2009) Neuron , vol.63 , pp. 27-39
    • Alexander, G.M.1
  • 27
    • 41949121294 scopus 로고    scopus 로고
    • The brain's default network: Anatomy, function, and relevance to disease
    • DOI 10.1196/annals.1440.011, The Year in Cognitive Neuroscience 2008
    • Buckner RL, Andrews-Hanna JR, Schacter DL (2008) The brain's default network: Anatomy, function, and relevance to disease. Ann N Y Acad Sci 1124:1-38. (Pubitemid 351506788)
    • (2008) Annals of the New York Academy of Sciences , vol.1124 , pp. 1-38
    • Buckner, R.L.1    Andrews-Hanna, J.R.2    Schacter, D.L.3
  • 28
    • 0032578942 scopus 로고    scopus 로고
    • The neural correlates of consciousness: An analysis of cognitive skill learning
    • Raichle ME (1998) The neural correlates of consciousness: An analysis of cognitive skill learning. Philos Trans R Soc Lond B Biol Sci 353:1889-1901.
    • (1998) Philos Trans R Soc Lond B Biol Sci , vol.353 , pp. 1889-1901
    • Raichle, M.E.1
  • 30
    • 49749087507 scopus 로고    scopus 로고
    • Mourning and melancholia revisited: Correspondences between principles of Freudian metapsychology and empirical findings in neuropsychiatry
    • Carhart-Harris RL, Mayberg HS, Malizia AL, Nutt D (2008) Mourning and melancholia revisited: Correspondences between principles of Freudian metapsychology and empirical findings in neuropsychiatry. Ann Gen Psychiatry 7:9.
    • (2008) Ann Gen Psychiatry , vol.7 , pp. 9
    • Carhart-Harris, R.L.1    Mayberg, H.S.2    Malizia, A.L.3    Nutt, D.4
  • 31
    • 77950830684 scopus 로고    scopus 로고
    • The default-mode, ego-functions and free-energy: A neurobiological account of Freudian ideas
    • Carhart-Harris RL, Friston KJ (2010) The default-mode, ego-functions and free-energy: A neurobiological account of Freudian ideas. Brain 133:1265-1283.
    • (2010) Brain , vol.133 , pp. 1265-1283
    • Carhart-Harris, R.L.1    Friston, K.J.2
  • 32
    • 48349097292 scopus 로고    scopus 로고
    • Mapping the structural core of human cerebral cortex
    • Hagmann P, et al. (2008) Mapping the structural core of human cerebral cortex. PLoS Biol 6:e159.
    • (2008) PLoS Biol , vol.6
    • Hagmann, P.1
  • 33
    • 67651031684 scopus 로고    scopus 로고
    • Generic aspects of complexity in brain imaging data and other biological systems
    • Bullmore E, et al. (2009) Generic aspects of complexity in brain imaging data and other biological systems. Neuroimage 47:1125-1134.
    • (2009) Neuroimage , vol.47 , pp. 1125-1134
    • Bullmore, E.1
  • 35
    • 75549090229 scopus 로고    scopus 로고
    • The free-energy principle: A unified brain theory?
    • Friston K (2010) The free-energy principle: A unified brain theory? Nat Rev Neurosci 11:127-138.
    • (2010) Nat Rev Neurosci , vol.11 , pp. 127-138
    • Friston, K.1
  • 36
    • 20644439109 scopus 로고    scopus 로고
    • Can psychedelics have a role in psychiatry once again?
    • Sessa B (2005) Can psychedelics have a role in psychiatry once again? Br J Psychiatry 186:457-458.
    • (2005) Br J Psychiatry , vol.186 , pp. 457-458
    • Sessa, B.1
  • 37
    • 50249084453 scopus 로고    scopus 로고
    • Brain structural and functional abnormalities in mood disorders: Implications for neurocircuitry models of depression
    • Drevets WC, Price JL, Furey ML (2008) Brain structural and functional abnormalities in mood disorders: Implications for neurocircuitry models of depression. Brain Struct Funct 213:93-118.
    • (2008) Brain Struct Funct , vol.213 , pp. 93-118
    • Drevets, W.C.1    Price, J.L.2    Furey, M.L.3
  • 38
    • 77954649709 scopus 로고    scopus 로고
    • Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus
    • Sheline YI, Price JL, Yan Z, Mintun MA (2010) Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus. Proc Natl Acad Sci USA 107:11020-11025.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 11020-11025
    • Sheline, Y.I.1    Price, J.L.2    Yan, Z.3    Mintun, M.A.4
  • 39
    • 78650727581 scopus 로고    scopus 로고
    • Stuck in a rut: Rethinking depression and its treatment
    • Holtzheimer PE, Mayberg HS (2011) Stuck in a rut: Rethinking depression and its treatment. Trends Neurosci 34:1-9.
    • (2011) Trends Neurosci , vol.34 , pp. 1-9
    • Holtzheimer, P.E.1    Mayberg, H.S.2
  • 42
    • 79960841303 scopus 로고    scopus 로고
    • Mood-linked responses in medial prefrontal cortex predict relapse in patients with recurrent unipolar depression
    • Farb NA, Anderson AK, Bloch RT, Segal ZV (2011) Mood-linked responses in medial prefrontal cortex predict relapse in patients with recurrent unipolar depression. Biol Psychiatry 70:366-372.
    • (2011) Biol Psychiatry , vol.70 , pp. 366-372
    • Farb, N.A.1    Anderson, A.K.2    Bloch, R.T.3    Segal, Z.V.4
  • 43
    • 83455162410 scopus 로고    scopus 로고
    • Mystical experiences occasioned by the hallucinogen psilocybin lead to increases in the personality domain of openness
    • Griffiths RR, et al. (2011) Mystical experiences occasioned by the hallucinogen psilocybin lead to increases in the personality domain of openness. J Psychopharmacol 25: 1453-1461.
    • (2011) J Psychopharmacol , vol.25 , pp. 1453-1461
    • Griffiths, R.R.1
  • 44
    • 33745902205 scopus 로고    scopus 로고
    • Response of cluster headache to psilocybin and LSD
    • DOI 10.1212/01.wnl.0000219761.05466.43, PII 0000611420060627000029
    • Sewell RA, Halpern JH, Pope HG, Jr. (2006) Response of cluster headache to psilocybin and LSD. Neurology 66:1920-1922. (Pubitemid 44049828)
    • (2006) Neurology , vol.66 , Issue.12 , pp. 1920-1922
    • Sewell, R.A.1    Halpern, J.H.2    Pope Jr., H.G.3
  • 45
    • 0032566160 scopus 로고    scopus 로고
    • Hypothalamic activation in cluster headache attacks
    • DOI 10.1016/S0140-6736(98)02470-2
    • May A, Bahra A, Büchel C, Frackowiak RS, Goadsby PJ (1998) Hypothalamic activation in cluster headache attacks. Lancet 352:275-278. (Pubitemid 28340145)
    • (1998) Lancet , vol.352 , Issue.9124 , pp. 275-278
    • May, A.1    Bahra, A.2    Buchel, C.3    Frackowiak, R.S.J.4    Goadsby, P.J.5
  • 46
    • 77956205491 scopus 로고    scopus 로고
    • Deep brain stimulation of the posteromedial hypothalamus: Indications, long-term results, and neurophysiological considerations
    • Franzini A, Messina G, Cordella R, Marras C, Broggi G (2010) Deep brain stimulation of the posteromedial hypothalamus: Indications, long-term results, and neurophysiological considerations. Neurosurg Focus 29:E13.
    • (2010) Neurosurg Focus , vol.29
    • Franzini, A.1    Messina, G.2    Cordella, R.3    Marras, C.4    Broggi, G.5
  • 47
    • 0033934775 scopus 로고    scopus 로고
    • Image-based method for retrospective correction of physiological motion effects in fMRI: RETROICOR
    • DOI 10.1002/1522-2594(200007)44:1<162::AID-MRM23>3.0.CO;2-E
    • Glover GH, Li T-Q, Ress D (2000) Image-based method for retrospective correction of physiological motion effects in fMRI: RETROICOR. Magn Reson Med 44:162-167. (Pubitemid 30439852)
    • (2000) Magnetic Resonance in Medicine , vol.44 , Issue.1 , pp. 162-167
    • Glover, G.H.1    Li, T.-Q.2    Ress, D.3
  • 48
    • 35148820975 scopus 로고    scopus 로고
    • Low-frequency fluctuations in the cardiac rate as a source of variance in the resting-state fMRI BOLD signal
    • DOI 10.1016/j.neuroimage.2007.07.037, PII S1053811907006702
    • Shmueli K, et al. (2007) Low-frequency fluctuations in the cardiac rate as a source of variance in the resting-state fMRI BOLD signal. Neuroimage 38:306-320. (Pubitemid 47534282)
    • (2007) NeuroImage , vol.38 , Issue.2 , pp. 306-320
    • Shmueli, K.1    Van Gelderen, P.2    De Zwart, J.A.3    Horovitz, S.G.4    Fukunaga, M.5    Jansma, J.M.6    Duyn, J.H.7
  • 49
    • 33746852686 scopus 로고    scopus 로고
    • Separating respiratory-variation-related fluctuations from neuronal-activity-related fluctuations in fMRI
    • DOI 10.1016/j.neuroimage.2006.02.048, PII S1053811906001248
    • Birn RM, Diamond JB, Smith MA, Bandettini PA (2006) Separating respiratory-variation- related fluctuations from neuronal-activity-related fluctuations in fMRI. Neuroimage 31:1536-1548. (Pubitemid 44192499)
    • (2006) NeuroImage , vol.31 , Issue.4 , pp. 1536-1548
    • Birn, R.M.1    Diamond, J.B.2    Smith, M.A.3    Bandettini, P.A.4
  • 50
    • 1842609636 scopus 로고    scopus 로고
    • Resting fluctuations in arterial carbon dioxide induce significant low frequency variations in BOLD signal
    • DOI 10.1016/j.neuroimage.2003.11.025, PII S1053811903007663
    • Wise RG, Ide K, Poulin MJ, Tracey I (2004) Resting fluctuations in arterial carbon dioxide induce significant low frequency variations in BOLD signal. Neuroimage 21: 1652-1664. (Pubitemid 38446588)
    • (2004) NeuroImage , vol.21 , Issue.4 , pp. 1652-1664
    • Wise, R.G.1    Ide, K.2    Poulin, M.J.3    Tracey, I.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.