Maternal and post-weaning high-fat, high-sucrose diet modulates glucose homeostasis and hypothalamic POMC promoter methylation in mouse offspring

Metabolic Brain Disease

Volumn 30, Issue 5, 2015, Pages 1129-1137

  Zheng, Jia ^a   Xiao, Xinhua ^a   Zhang, Qian ^a   Yu, Miao ^a   Xu, Jianping ^a   Wang, Zhixin ^a   Qi, Cuijuan ^a   Wang, Tong ^a  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

Author keywords

DNA methylation; Glucose homeostasis; High fat; High sucrose diet; Hypothalamus; Offspring

Indexed keywords

GLUCOSE; HORMONE; LEPTIN; MELANOCORTIN 4 RECEPTOR; PROOPIOMELANOCORTIN; SUCROSE; MC4R PROTEIN, MOUSE; SUGAR INTAKE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CLINICAL ASSESSMENT; COMPARATIVE STUDY; CONTROLLED STUDY; DIET THERAPY; DIETARY INTAKE; DISEASE ASSOCIATION; DNA METHYLATION; DNA MODIFICATION; FAT CONTENT; FEMALE; FOOD INTAKE; GENE EXPRESSION; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; GLUCOSE TOLERANCE TEST; HIGH SUCROSE DIET; HYPOTHALAMUS; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LACTATION; LIPID DIET; MALE; MATERNAL CARE; MATERNAL NUTRITION; METABOLIC DISORDER; MOUSE; NONHUMAN; OBESITY; PREGNANCY; PROGENY; PROMOTER REGION; WEANING; ADVERSE EFFECTS; ANIMAL; BIOSYNTHESIS; BLOOD; C57BL MOUSE; HOMEOSTASIS; METABOLISM; METHYLATION; PHYSIOLOGY; PRENATAL EXPOSURE; SECRETION (PROCESS); SUGAR INTAKE;

ANIMALS; BODY WEIGHT; DIET, HIGH-FAT; DIETARY SUCROSE; FEMALE; GLUCOSE; HOMEOSTASIS; HYPOTHALAMUS; MALE; METHYLATION; MICE; MICE, INBRED C57BL; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PRENATAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; PRO-OPIOMELANOCORTIN; RECEPTOR, MELANOCORTIN, TYPE 4; WEANING;

EID: 84941192226     PISSN: 08857490     EISSN: 15737365     Source Type: Journal    
DOI: 10.1007/s11011-015-9678-9     Document Type: Article

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