A Physiologically Based Pharmacokinetic Drug–Disease Model to Predict Carvedilol Exposure in Adult and Paediatric Heart Failure Patients by Incorporating Pathophysiological Changes in Hepatic and Renal Blood Flows

Clinical Pharmacokinetics

Volumn 54, Issue 9, 2015, Pages 943-962

  Rasool, Muhammad Fawad ^a,b   Khalil, Feras ^a   Läer, Stephanie ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b BAHAUDDIN ZAKARIYA UNIVERSITY   (Pakistan)

Author keywords

[No Author keywords available]

Indexed keywords

CARVEDILOL; CARBAZOLE DERIVATIVE; CYTOCHROME P450; PROPANOLAMINE DERIVATIVE;

ADOLESCENT; ADULT; AREA UNDER THE CURVE; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG CLEARANCE; DRUG ELIMINATION; FEMALE; HEART FAILURE; HEPATIC CLEARANCE; HUMAN; KIDNEY BLOOD FLOW; LIVER BLOOD FLOW; MALE; MAXIMUM PLASMA CONCENTRATION; MICROSOME; NEW YORK HEART ASSOCIATION CLASS; NEWBORN; ORGAN BLOOD FLOW; PATHOPHYSIOLOGY; PHARMACOKINETIC PARAMETERS; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; AGE; BIOLOGICAL MODEL; COMORBIDITY; DRUG EFFECTS; KIDNEY; KIDNEY CIRCULATION; LIVER; LIVER CIRCULATION; METABOLISM; VASCULARIZATION; YOUNG ADULT;

ADOLESCENT; ADULT; AGE FACTORS; CARBAZOLES; CHILD; CHILD, PRESCHOOL; COMORBIDITY; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; HEART FAILURE; HUMANS; KIDNEY; LIVER; LIVER CIRCULATION; MALE; MODELS, BIOLOGICAL; PROPANOLAMINES; RENAL CIRCULATION; YOUNG ADULT;

EID: 84941188835     PISSN: 03125963     EISSN: 11791926     Source Type: Journal    
DOI: 10.1007/s40262-015-0253-7     Document Type: Article

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