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Volumn 4, Issue , 2015, Pages

FOXO1 inhibits osteosarcoma oncogenesis via Wntβ-catenin pathway suppression

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; TRANSCRIPTION FACTOR FKHR; WNT PROTEIN;

EID: 84941061222     PISSN: None     EISSN: 21579024     Source Type: Journal    
DOI: 10.1038/oncsis.2015.25     Document Type: Article
Times cited : (56)

References (47)
  • 3
    • 79955964176 scopus 로고    scopus 로고
    • High-frequency canonical Wnt activation in multiple sarcoma subtypes drives proliferation through a TCF/β-catenin target gene, CDC25A
    • Vijayakumar S, Liu G, Rus IA, Yao S, Chen Y, Akiri G et al. High-frequency canonical Wnt activation in multiple sarcoma subtypes drives proliferation through a TCF/β-catenin target gene, CDC25A. Cancer Cell 2011; 19: 601-612.
    • (2011) Cancer Cell , vol.19 , pp. 601-612
    • Vijayakumar, S.1    Liu, G.2    Rus, I.A.3    Yao, S.4    Chen, Y.5    Akiri, G.6
  • 4
    • 0036888309 scopus 로고    scopus 로고
    • Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma
    • Haydon RC, Deyrup A, Ishikawa A, Heck R, Jiang W, Zhou L et al. Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma. Int J Cancer 2002; 102: 338-342.
    • (2002) Int J Cancer , vol.102 , pp. 338-342
    • Haydon, R.C.1    Deyrup, A.2    Ishikawa, A.3    Heck, R.4    Jiang, W.5    Zhou, L.6
  • 5
    • 0142029993 scopus 로고    scopus 로고
    • Cytoplasmic and/or nuclear staining of beta-catenin is associated with lung metastasis
    • Iwaya K, Ogawa H, Kuroda M, Izumi M, Ishida T, Mukai K. Cytoplasmic and/or nuclear staining of beta-catenin is associated with lung metastasis. Clin Exp Metastasis 2003; 20: 525-529.
    • (2003) Clin Exp Metastasis , vol.20 , pp. 525-529
    • Iwaya, K.1    Ogawa, H.2    Kuroda, M.3    Izumi, M.4    Ishida, T.5    Mukai, K.6
  • 7
    • 80053237717 scopus 로고    scopus 로고
    • Genetic amplification of the vascular endothelial growth factor (VEGF) pathway genes, including VEGFA, in human osteosarcoma
    • Yang J, Yang D, Sun Y, Sun B, Wang G, Trent JC et al. Genetic amplification of the vascular endothelial growth factor (VEGF) pathway genes, including VEGFA, in human osteosarcoma. Cancer 2011; 117: 4925-4938.
    • (2011) Cancer , vol.117 , pp. 4925-4938
    • Yang, J.1    Yang, D.2    Sun, Y.3    Sun, B.4    Wang, G.5    Trent, J.C.6
  • 8
    • 18844467502 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression in untreated osteosarcoma is predictive of pulmonary metastasis and poor prognosis
    • Kaya M, Wada T, Akatsuka T, Kawaguchi S, Nagoya S, Shindoh M et al. Vascular endothelial growth factor expression in untreated osteosarcoma is predictive of pulmonary metastasis and poor prognosis. Clin Cancer Res 2000; 6: 572-577.
    • (2000) Clin Cancer Res , vol.6 , pp. 572-577
    • Kaya, M.1    Wada, T.2    Akatsuka, T.3    Kawaguchi, S.4    Nagoya, S.5    Shindoh, M.6
  • 9
    • 43049095679 scopus 로고    scopus 로고
    • Platelet-derived growth factor receptor as a prognostic marker and a therapeutic target for imatinib mesylate therapy in osteosarcoma
    • Kubo T, Piperdi S, Rosenblum J, Antonescu CR, Chen W, Kim HS et al. Platelet-derived growth factor receptor as a prognostic marker and a therapeutic target for imatinib mesylate therapy in osteosarcoma. Cancer 2008; 112: 2119-2129.
    • (2008) Cancer , vol.112 , pp. 2119-2129
    • Kubo, T.1    Piperdi, S.2    Rosenblum, J.3    Antonescu, C.R.4    Chen, W.5    Kim, H.S.6
  • 10
    • 67449100489 scopus 로고    scopus 로고
    • The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors
    • Essaghir A, Dif N, Marbehant CY, Coffer PJ, Demoulin JB. The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors. J Biol Chem 2009; 284: 10334-10342.
    • (2009) J Biol Chem , vol.284 , pp. 10334-10342
    • Essaghir, A.1    Dif, N.2    Marbehant, C.Y.3    Coffer, P.J.4    Demoulin, J.B.5
  • 12
    • 84880508618 scopus 로고    scopus 로고
    • A novel permutation test for case-only analysis identifies epistatic effects on human longevity in the FOXO gene family
    • Tan Q, Soerensen M, Kruse TA, Christensen K, Christiansen L. A novel permutation test for case-only analysis identifies epistatic effects on human longevity in the FOXO gene family. Aging Cell 2013; 12: 690-694.
    • (2013) Aging Cell , vol.12 , pp. 690-694
    • Tan, Q.1    Soerensen, M.2    Kruse, T.A.3    Christensen, K.4    Christiansen, L.5
  • 13
    • 78249280592 scopus 로고    scopus 로고
    • Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data
    • Soerensen M, Dato S, Christensen K, McGue M, Stevnsner T, Bohr VA et al. Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data. Aging Cell 2010; 9: 1010-1017.
    • (2010) Aging Cell , vol.9 , pp. 1010-1017
    • Soerensen, M.1    Dato, S.2    Christensen, K.3    McGue, M.4    Stevnsner, T.5    Bohr, V.A.6
  • 14
    • 84887441485 scopus 로고    scopus 로고
    • Antagonism between FOXO and MYC regulates cellular powerhouse
    • Peck B, Ferber EC, Schulze A. Antagonism between FOXO and MYC regulates cellular powerhouse. Front Oncol 2013; 3: 96.
    • (2013) Front Oncol , vol.3 , pp. 96
    • Peck, B.1    Ferber, E.C.2    Schulze, A.3
  • 15
    • 81255195809 scopus 로고    scopus 로고
    • FoxO3A promotes metabolic adaptation to hypoxia by antagonizing Myc function
    • Jensen KS, Binderup T, Jensen KT, Therkelsen I, Borup R, Nilsson E et al. FoxO3A promotes metabolic adaptation to hypoxia by antagonizing Myc function. EMBO J 2011; 30: 4554-4570.
    • (2011) EMBO J , vol.30 , pp. 4554-4570
    • Jensen, K.S.1    Binderup, T.2    Jensen, K.T.3    Therkelsen, I.4    Borup, R.5    Nilsson, E.6
  • 16
    • 84860709659 scopus 로고    scopus 로고
    • FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression
    • Ferber EC, Peck B, Delpuech O, Bell GP, East P, Schulze A. FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression. Cell Death Differ 2012; 19: 968-979.
    • (2012) Cell Death Differ , vol.19 , pp. 968-979
    • Ferber, E.C.1    Peck, B.2    Delpuech, O.3    Bell, G.P.4    East, P.5    Schulze, A.6
  • 17
    • 75149115329 scopus 로고    scopus 로고
    • FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts
    • Rached MT, Kode A, Xu L, Yoshikawa Y, Paik JH, Depinho RA et al. FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts. Cell Metab 2010; 11: 147-160.
    • (2010) Cell Metab , vol.11 , pp. 147-160
    • Rached, M.T.1    Kode, A.2    Xu, L.3    Yoshikawa, Y.4    Paik, J.H.5    Depinho, R.A.6
  • 18
    • 79955594241 scopus 로고    scopus 로고
    • FoxO1: A molecule for all seasons
    • Kousteni S. FoxO1: a molecule for all seasons. J Bone Miner Res 2011; 26: 912-917.
    • (2011) J Bone Miner Res , vol.26 , pp. 912-917
    • Kousteni, S.1
  • 19
    • 84855868834 scopus 로고    scopus 로고
    • FoxO1, the transcriptional chief of staff of energy metabolism
    • Kousteni S. FoxO1, the transcriptional chief of staff of energy metabolism. Bone 2012; 50: 437-443.
    • (2012) Bone , vol.50 , pp. 437-443
    • Kousteni, S.1
  • 20
    • 75149146587 scopus 로고    scopus 로고
    • FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice
    • Ambrogini E, Almeida M, Martin-Millan M, Paik JH, Depinho RA, Han L et al. FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice. Cell Metab 2010; 11: 136-146.
    • (2010) Cell Metab , vol.11 , pp. 136-146
    • Ambrogini, E.1    Almeida, M.2    Martin-Millan, M.3    Paik, J.H.4    Depinho, R.A.5    Han, L.6
  • 21
    • 74949089660 scopus 로고    scopus 로고
    • FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice
    • Rached MT, Kode A, Silva BC, Jung DY, Gray S, Ong H et al. FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice. J Clin Invest 2010; 120: 357-368.
    • (2010) J Clin Invest , vol.120 , pp. 357-368
    • Rached, M.T.1    Kode, A.2    Silva, B.C.3    Jung, D.Y.4    Gray, S.5    Ong, H.6
  • 22
    • 84864115273 scopus 로고    scopus 로고
    • miR-182 is a negative regulator of osteoblast proliferation, differentiation, and skeletogenesis through targeting FoxO1
    • Kim KM, Park SJ, Jung SH, Kim EJ, Jogeswar G, Ajita J et al. miR-182 is a negative regulator of osteoblast proliferation, differentiation, and skeletogenesis through targeting FoxO1. J Bone Miner Res 2012; 27: 1669-1679.
    • (2012) J Bone Miner Res , vol.27 , pp. 1669-1679
    • Kim, K.M.1    Park, S.J.2    Jung, S.H.3    Kim, E.J.4    Jogeswar, G.5    Ajita, J.6
  • 23
    • 84880183633 scopus 로고    scopus 로고
    • Liver X receptor alpha inhibits osteosarcoma cell proliferation through up-regulation of FoxO1
    • Chang YW, Zhao YF, Cao YL, Gu XF, Li ZQ, Wang SQ et al. Liver X receptor alpha inhibits osteosarcoma cell proliferation through up-regulation of FoxO1. Cell Physiol Biochem 2013; 32: 180-186.
    • (2013) Cell Physiol Biochem , vol.32 , pp. 180-186
    • Chang, Y.W.1    Zhao, Y.F.2    Cao, Y.L.3    Gu, X.F.4    Li, Z.Q.5    Wang, S.Q.6
  • 24
    • 34250030269 scopus 로고    scopus 로고
    • Grifolin induces apoptosis via inhibition of PI3K/AKT signalling pathway in human osteosarcoma cells
    • Jin S, Pang RP, Shen JN, Huang G, Wang J, Zhou JG. Grifolin induces apoptosis via inhibition of PI3K/AKT signalling pathway in human osteosarcoma cells. Apoptosis 2007; 12: 1317-1326.
    • (2007) Apoptosis , vol.12 , pp. 1317-1326
    • Jin, S.1    Pang, R.P.2    Shen, J.N.3    Huang, G.4    Wang, J.5    Zhou, J.G.6
  • 25
    • 84922102197 scopus 로고    scopus 로고
    • MiR-135b promotes proliferation and invasion of osteosarcoma cells via targeting FOXO1
    • Pei H, Jin Z, Chen S, Sun X, Yu J, Guo W. MiR-135b promotes proliferation and invasion of osteosarcoma cells via targeting FOXO1. Mol Cell Biochem 2015; 400: 245-252.
    • (2015) Mol Cell Biochem , vol.400 , pp. 245-252
    • Pei, H.1    Jin, Z.2    Chen, S.3    Sun, X.4    Yu, J.5    Guo, W.6
  • 26
    • 27144523169 scopus 로고    scopus 로고
    • Gene expression profiling of human sarcomas: Insights into sarcoma biology
    • Baird K, Davis S, Antonescu CR, Harper UL, Walker RL, Chen Y et al. Gene expression profiling of human sarcomas: insights into sarcoma biology. Cancer Res 2005; 65: 9226-9235.
    • (2005) Cancer Res , vol.65 , pp. 9226-9235
    • Baird, K.1    Davis, S.2    Antonescu, C.R.3    Harper, U.L.4    Walker, R.L.5    Chen, Y.6
  • 27
    • 67650465624 scopus 로고    scopus 로고
    • LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas, identified by array comparative genomic hybridization
    • Kresse SH, Ohnstad HO, Paulsen EB, Bjerkehagen B, Szuhai K, Serra M et al. LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas, identified by array comparative genomic hybridization. Genes Chromosomes Cancer 2009; 48: 679-693.
    • (2009) Genes Chromosomes Cancer , vol.48 , pp. 679-693
    • Kresse, S.H.1    Ohnstad, H.O.2    Paulsen, E.B.3    Bjerkehagen, B.4    Szuhai, K.5    Serra, M.6
  • 28
    • 0036888453 scopus 로고    scopus 로고
    • Genetic imbalances revealed by comparative genomic hybridization in osteosarcomas
    • Ozaki T, Schaefer KL, Wai D, Buerger H, Flege S, Lindner N et al. Genetic imbalances revealed by comparative genomic hybridization in osteosarcomas. Int J Cancer 2002; 102: 355-365.
    • (2002) Int J Cancer , vol.102 , pp. 355-365
    • Ozaki, T.1    Schaefer, K.L.2    Wai, D.3    Buerger, H.4    Flege, S.5    Lindner, N.6
  • 30
    • 84898027965 scopus 로고    scopus 로고
    • Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma
    • Chen X, Bahrami A, Pappo A, Easton J, Dalton J, Hedlund E et al. Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma. Cell Rep 2014; 7: 104-112.
    • (2014) Cell Rep , vol.7 , pp. 104-112
    • Chen, X.1    Bahrami, A.2    Pappo, A.3    Easton, J.4    Dalton, J.5    Hedlund, E.6
  • 32
    • 77958127193 scopus 로고    scopus 로고
    • Discovery of novel forkhead box O1 inhibitors for treating type 2 diabetes: Improvement of fasting glycemia in diabetic db/db mice
    • Nagashima T, Shigematsu N, Maruki R, Urano Y, Tanaka H, Shimaya A et al. Discovery of novel forkhead box O1 inhibitors for treating type 2 diabetes: improvement of fasting glycemia in diabetic db/db mice. Mol Pharmacol 2010; 78: 961-970.
    • (2010) Mol Pharmacol , vol.78 , pp. 961-970
    • Nagashima, T.1    Shigematsu, N.2    Maruki, R.3    Urano, Y.4    Tanaka, H.5    Shimaya, A.6
  • 33
    • 77956375914 scopus 로고    scopus 로고
    • Activation of FOXO1 is critical for the anticancer effect of methylseleninic acid in prostate cancer cells
    • Zhang H, Fang J, Yao D, Wu Y, Ip C, Dong Y. Activation of FOXO1 is critical for the anticancer effect of methylseleninic acid in prostate cancer cells. Prostate 2010; 70: 1265-1273.
    • (2010) Prostate , vol.70 , pp. 1265-1273
    • Zhang, H.1    Fang, J.2    Yao, D.3    Wu, Y.4    Ip, C.5    Dong, Y.6
  • 34
    • 84905051881 scopus 로고    scopus 로고
    • Suppression of FOXO1 is responsible for a growth regulatory repressive transcriptional sub-signature of EWS-FLI1 in Ewing sarcoma
    • Niedan S, Kauer M, Aryee DN, Kofler R, Schwentner R, Meier A et al. Suppression of FOXO1 is responsible for a growth regulatory repressive transcriptional sub-signature of EWS-FLI1 in Ewing sarcoma. Oncogene 2014; 33: 3927-3938.
    • (2014) Oncogene , vol.33 , pp. 3927-3938
    • Niedan, S.1    Kauer, M.2    Aryee, D.N.3    Kofler, R.4    Schwentner, R.5    Meier, A.6
  • 35
    • 84867883377 scopus 로고    scopus 로고
    • Mammary and vaginal myofibroblastomas are genetically related lesions: Fluorescence in situ hybridization analysis shows deletion of 13q14 region
    • Magro G, Righi A, Casorzo L, Antonietta T, Salvatorelli L, Kacerovska D et al. Mammary and vaginal myofibroblastomas are genetically related lesions: fluorescence in situ hybridization analysis shows deletion of 13q14 region. Hum Pathol 2012; 43: 1887-1893.
    • (2012) Hum Pathol , vol.43 , pp. 1887-1893
    • Magro, G.1    Righi, A.2    Casorzo, L.3    Antonietta, T.4    Salvatorelli, L.5    Kacerovska, D.6
  • 36
    • 33947522360 scopus 로고    scopus 로고
    • Extramammary myofibroblastoma is genetically related to spindle cell lipoma
    • Maggiani F, Debiec-Rychter M, Verbeeck G, Sciot R. Extramammary myofibroblastoma is genetically related to spindle cell lipoma. Virchows Arch 2006; 449: 244-247.
    • (2006) Virchows Arch , vol.449 , pp. 244-247
    • Maggiani, F.1    Debiec-Rychter, M.2    Verbeeck, G.3    Sciot, R.4
  • 37
    • 33746930170 scopus 로고    scopus 로고
    • FOXO1A is a candidate for the 13q14 tumor suppressor gene inhibiting androgen receptor signaling in prostate cancer
    • Dong XY, Chen C, Sun X, Guo P, Vessella RL, Wang RX et al. FOXO1A is a candidate for the 13q14 tumor suppressor gene inhibiting androgen receptor signaling in prostate cancer. Cancer Res 2006; 66: 6998-7006.
    • (2006) Cancer Res , vol.66 , pp. 6998-7006
    • Dong, X.Y.1    Chen, C.2    Sun, X.3    Guo, P.4    Vessella, R.L.5    Wang, R.X.6
  • 38
    • 84906273693 scopus 로고    scopus 로고
    • FOXO1 down-regulation contributes to the oncogenic program of primary mediastinal B-cell lymphoma
    • Xie L, Ritz O, Leithauser F, Guan H, Farbinger J, Weitzer CD et al. FOXO1 down-regulation contributes to the oncogenic program of primary mediastinal B-cell lymphoma. Oncotarget 2014; 5: 5392-5402.
    • (2014) Oncotarget , vol.5 , pp. 5392-5402
    • Xie, L.1    Ritz, O.2    Leithauser, F.3    Guan, H.4    Farbinger, J.5    Weitzer, C.D.6
  • 39
    • 33846419112 scopus 로고    scopus 로고
    • FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
    • Tothova Z, Kollipara R, Huntly BJ, Lee BH, Castrillon DH, Cullen DE et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 2007; 128: 325-339.
    • (2007) Cell , vol.128 , pp. 325-339
    • Tothova, Z.1    Kollipara, R.2    Huntly, B.J.3    Lee, B.H.4    Castrillon, D.H.5    Cullen, D.E.6
  • 40
    • 80052276420 scopus 로고    scopus 로고
    • AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias
    • Sykes SM, Lane SW, Bullinger L, Kalaitzidis D, Yusuf R, Saez B et al. AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias. Cell 2011; 146: 697-708.
    • (2011) Cell , vol.146 , pp. 697-708
    • Sykes, S.M.1    Lane, S.W.2    Bullinger, L.3    Kalaitzidis, D.4    Yusuf, R.5    Saez, B.6
  • 41
    • 33846295218 scopus 로고    scopus 로고
    • FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
    • Paik JH, Kollipara R, Chu G, Ji H, Xiao Y, Ding Z et al. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 2007; 128: 309-323.
    • (2007) Cell , vol.128 , pp. 309-323
    • Paik, J.H.1    Kollipara, R.2    Chu, G.3    Ji, H.4    Xiao, Y.5    Ding, Z.6
  • 43
    • 0037059328 scopus 로고    scopus 로고
    • The IKK-2/Ikappa Balpha/NF-kappa B pathway plays a key role in the regulation of CCR3 and eotaxin-1 in fibroblasts. A critical link to dermatitis in Ikappa Balpha-deficient mice
    • Huber MA, Denk A, Peter RU, Weber L, Kraut N, Wirth T. The IKK-2/Ikappa Balpha/NF-kappa B pathway plays a key role in the regulation of CCR3 and eotaxin-1 in fibroblasts. A critical link to dermatitis in Ikappa Balpha-deficient mice. J Biol Chem 2002; 277: 1268-1275.
    • (2002) J Biol Chem , vol.277 , pp. 1268-1275
    • Huber, M.A.1    Denk, A.2    Peter, R.U.3    Weber, L.4    Kraut, N.5    Wirth, T.6
  • 44
    • 34547101264 scopus 로고    scopus 로고
    • FOXO1 regulates the expression of 4E-BP1 and inhibits mTOR signaling in mammalian skeletal muscle
    • Southgate RJ, Neill B, Prelovsek O, El-Osta A, Kamei Y, Miura S et al. FOXO1 regulates the expression of 4E-BP1 and inhibits mTOR signaling in mammalian skeletal muscle. J Biol Chem 2007; 282: 21176-21186.
    • (2007) J Biol Chem , vol.282 , pp. 21176-21186
    • Southgate, R.J.1    Neill, B.2    Prelovsek, O.3    El-Osta, A.4    Kamei, Y.5    Miura, S.6
  • 46
    • 77956579875 scopus 로고    scopus 로고
    • KLF4 is a tumor suppressor in B-cell non-Hodgkin lymphoma and in classic Hodgkin lymphoma
    • Guan H, Xie L, Leithauser F, Flossbach L, Moller P, Wirth T et al. KLF4 is a tumor suppressor in B-cell non-Hodgkin lymphoma and in classic Hodgkin lymphoma. Blood 2010; 116: 1469-1478.
    • (2010) Blood , vol.116 , pp. 1469-1478
    • Guan, H.1    Xie, L.2    Leithauser, F.3    Flossbach, L.4    Moller, P.5    Wirth, T.6
  • 47
    • 84937421430 scopus 로고    scopus 로고
    • Epoxyeicosanoids suppress osteoclastogenesis and prevent ovariectomy-induced bone loss
    • Guan H, Zhao L, Cao H, Chen A, Xiao J. Epoxyeicosanoids suppress osteoclastogenesis and prevent ovariectomy-induced bone loss. FASEB J 2015; 29: 1092-1101.
    • (2015) FASEB J , vol.29 , pp. 1092-1101
    • Guan, H.1    Zhao, L.2    Cao, H.3    Chen, A.4    Xiao, J.5


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