Stress increases DNA methylation of the neuronal PAS domain 4 (Npas4) gene

NeuroReport

Volumn 26, Issue 14, 2015, Pages 827-832

  Furukawa Hibi, Yoko ^a   Nagai, Taku ^a   Yun, Jaesuk ^a   Yamada, Kiyofumi ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cyclic adenosine monophosphate response element; DNA methylation; Neuronal Per Arnt Sim domain 4; Stress

Indexed keywords

DECITABINE; MESSENGER RNA; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; DNA (CYTOSINE 5) METHYLTRANSFERASE; NPAS4 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DNA MODIFICATION; EPIGENETICS; GENE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HIPPOCAMPUS; IMMOBILIZATION STRESS; MALE; MOUSE; NEURONAL PER ARNT SIM DOMAIN 4 GENE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; ANIMAL; ANTAGONISTS AND INHIBITORS; DISEASE MODEL; DRUG EFFECTS; EXERCISE; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; MENTAL STRESS; METABOLISM; MUTATION; RANDOMIZATION; REAL TIME POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL LINE, TUMOR; CPG ISLANDS; DISEASE MODELS, ANIMAL; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; HIPPOCAMPUS; MALE; MICE, INBRED ICR; MUTATION; PROMOTER REGIONS, GENETIC; RANDOM ALLOCATION; REAL-TIME POLYMERASE CHAIN REACTION; RESTRAINT, PHYSICAL; RNA, MESSENGER; STRESS, PSYCHOLOGICAL;

EID: 84940947785     PISSN: 09594965     EISSN: 1473558X     Source Type: Journal    
DOI: 10.1097/WNR.0000000000000430     Document Type: Article

References (17)

1. de Kloet ER, Joels M, Holsboer F. Stress and the brain: from adaptation to disease. Nat Rev Neurosci 2005; 6:463-475.
2. Ibi D, Takuma K, Koike H, Mizoguchi H, Tsuritani K, Kuwahara Y, et al . Social isolation rearing-induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and behaviors in juvenile mice. J Neurochem 2008; 105:921-932.
3. Yun J, Koike H, Ibi D, Toth E, Mizoguchi H, Nitta A, et al . Chronic restraint stress impairs neurogenesis and hippocampus-dependent fear memory in mice: Possible involvement of a brain-specific transcription factor Npas4. J Neurochem 2010; 114:1840-1851.
4. Furukawa-Hibi Y, Yun J, Nagai T, Yamada K. Transcriptional suppression of the neuronal PAS domain 4 (Npas4) gene by stress via the binding of agonist-bound glucocorticoid receptor to its promoter. J Neurochem 2012; 123:866-875.
5. Lin Y, Bloodgood BL, Hauser JL, Lapan AD, Koon AC, Kim TK, et al . Activity-dependent regulation of inhibitory synapse development by Npas4. Nature 2008; 455:1198-1204.
6. Pruunsild P, Sepp M, Orav E, Koppel I, Timmusk T. Identification of cis-elements and transcription factors regulating neuronal activity-dependent transcription of human BDNF gene. J Neurosci 2011; 31:3295-3308.
7. Bloodgood BL, Sharma N, Browne HA, Trepman AZ, Greenberg ME. The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition. Nature 2013; 503:121-125.
8. Ramamoorthi K, Fropf R, Belfort GM, Fitzmaurice HL, McKinney RM, Neve RL, et al . Npas4 regulates a transcriptional program in CA3 required for contextual memory formation. Science 2011; 334:1669-1675.
9. Zhang SJ, Zou M, Lu L, Lau D, Ditzel DA, Delucinge-Vivier C, et al . Nuclear calcium signaling controls expression of a large gene pool: identification of a gene program for acquired neuroprotection induced by synaptic activity. PLoS Genet 2009; 5:e1000604.
10. Yun J, Nagai T, Furukawa-Hibi Y, Kuroda K, Kaibuchi K, Greenberg ME, et al . Neuronal Per Arnt Sim (PAS) domain protein 4 (NPAS4) regulates neurite outgrowth and phosphorylation of synapsin I. J Bio/ Chem 2013; 288:2655-2664.
11. Murgatroyd C, Patchev AV, Wu Y, Micale V, Bockmuhl Y, Fischer D, et al . Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat Neurosci 2009; 12:1559-1566.
12. Suzuki MM, Bird A. DNA methylation landscapes: Provocative insights from epigenomics. Nat Rev Genet 2008; 9:465-476.
13. Dupont JM, Tost J, Jammes H, Gut IG. De novo quantitative bisulfite sequencing using the pyrosequencing technology. Ana/ Biochem 2004; 333:119-127.
14. Roth TL, Lubin FD, Funk AJ, Sweatt JD. Lasting epigenetic influence ofearly-life adversity on the BDNF gene. Bio/ Psychiatry 2009; 65:760-769.
15. Uchida S, Hara K, Kobayashi A, Otsuki K, Yamagata H, Hobara T, et al . Epigenetic status of Gdnf in the ventral striatum determines susceptibility and adaptation to daily stressful events. Neuron 2011; 69:359-372.
16. Ebert DH, Greenberg ME. Activity-dependent neuronal signalling and autism spectrum disorder. Nature 2013; 493:327-337.
17. Rudenko A, Dawlaty MM, Seo J, Cheng AW, Meng J, Le T, et al . Tet1 is critical for neuronal activity-regulated gene expression and memory extinction. Neuron 2013; 79:1109-1122.