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Volumn 59, Issue 9, 2015, Pages 5196-5202

Influenza A(H7N9) virus acquires resistance-related neuraminidase I222T substitution when infected mallards are exposed to low levels of oseltamivir in water

Author keywords

[No Author keywords available]

Indexed keywords

4 ACETAMIDO 5 AMINO 3 (1 ETHYLPROPOXY) 1 CYCLOHEXENE 1 CARBOXYLIC ACID; VIRUS RNA; VIRUS SIALIDASE; WATER; ZANAMIVIR; OSELTAMIVIR; SIALIDASE;

EID: 84940936073     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00886-15     Document Type: Article
Times cited : (22)

References (63)
  • 8
    • 78751493390 scopus 로고    scopus 로고
    • Perspectives on influenza evolution and the role of research
    • Forrest HL, Webster RG 2010. Perspectives on influenza evolution and the role of research. Anim Health Res Rev 11:3-18. http://dx.doi.org/10.1017/S1466252310000071.
    • (2010) Anim Health Res Rev , vol.11 , pp. 3-18
    • Forrest, H.L.1    Webster, R.G.2
  • 9
    • 84921328078 scopus 로고    scopus 로고
    • H7N9: Preparing for the unexpected in influenza
    • Jernigan DB, Cox NJ 2015. H7N9: preparing for the unexpected in influenza. Annu Rev Med 66:361-371. http://dx.doi.org/10.1146/annurev-med-010714-112311.
    • (2015) Annu Rev Med , vol.66 , pp. 361-371
    • Jernigan, D.B.1    Cox, N.J.2
  • 13
    • 84940926643 scopus 로고    scopus 로고
    • Disease outbreak news 11 March 2015
    • World Health Organization. 2015. Human infection with avian influenza A(H7N9) virus - China. Disease outbreak news 11 March 2015. http://www.who.int/csr/don/11-march-2015-avian-influenza-china/en/.
    • (2015) Human Infection with Avian Influenza A(H7N9) Virus - China
  • 14
    • 84906057785 scopus 로고    scopus 로고
    • Antivirals for influenza: Where now for clinical practice and pandemic preparedness?
    • Nguyen-Van-Tam JS, Openshaw PJ, Nicholson KG. 2014. Antivirals for influenza: where now for clinical practice and pandemic preparedness? Lancet 384:386-387. http://dx.doi.org/10.1016/S0140-6736(14)60726-1.
    • (2014) Lancet , vol.384 , pp. 386-387
    • Nguyen-Van-Tam, J.S.1    Openshaw, P.J.2    Nicholson, K.G.3
  • 15
    • 84907954836 scopus 로고    scopus 로고
    • Continuing challenges in influenza
    • Webster RG, Govorkova EA 2014. Continuing challenges in influenza. AnnN Y Acad Sci 1323:115-139. http://dx.doi.org/10.1111/nyas.12462.
    • (2014) AnnN y Acad Sci , vol.1323 , pp. 115-139
    • Webster, R.G.1    Govorkova, E.A.2
  • 16
    • 69449107690 scopus 로고    scopus 로고
    • Stockpiling antiviral drugs for the next influenza pandemic
    • Patel A, Gorman SE 2009. Stockpiling antiviral drugs for the next influenza pandemic. Clin Pharmacol Ther 86:241-243. http://dx.doi.org/10.1038/clpt.2009.142.
    • (2009) Clin Pharmacol Ther , vol.86 , pp. 241-243
    • Patel, A.1    Gorman, S.E.2
  • 17
    • 70349972794 scopus 로고    scopus 로고
    • Maximizing the value of drug stockpiles for pandemic influenza
    • Wan Po A.L., Farndon P, Palmer N. 2009. Maximizing the value of drug stockpiles for pandemic influenza. Emerg Infect Dis 15:1686-1687. http://dx.doi.org/10.3201/eid1510.090844.
    • (2009) Emerg Infect Dis , vol.15 , pp. 1686-1687
    • Wan Po, A.L.1    Farndon, P.2    Palmer, N.3
  • 18
    • 84898836342 scopus 로고    scopus 로고
    • The neuraminidase inhibitor oseltamivir is effective against A/Anhui/1/2013 (H7N9) influenza virus in a mouse model of acute respiratory distress syndrome
    • Baranovich T, Burnham AJ, Marathe B.M., Armstrong J., Guan Y, Shu Y, Peiris J.M., Webby RJ, Webster RG, Govorkova EA. 2014. The neuraminidase inhibitor oseltamivir is effective against A/Anhui/1/2013 (H7N9) influenza virus in a mouse model of acute respiratory distress syndrome. J Infect Dis 209:1343-1353. http://dx.doi.org/10.1093/infdis/jit554.
    • (2014) J Infect Dis , vol.209 , pp. 1343-1353
    • Baranovich, T.1    Burnham, A.J.2    Marathe, B.M.3    Armstrong, J.4    Guan, Y.5    Shu, Y.6    Peiris, J.M.7    Webby, R.J.8    Webster, R.G.9    Govorkova, E.A.10
  • 20
    • 84874690617 scopus 로고    scopus 로고
    • Oseltamivir (Tamiflu) in the environment, resistance development in influenza A viruses of dabbling ducks and the risk of transmissionofan oseltamivir-resistant virus tohumans - A review
    • Järhult JD. 2012. Oseltamivir (Tamiflu) in the environment, resistance development in influenza A viruses of dabbling ducks and the risk of transmissionofan oseltamivir-resistant virus tohumans - a review. Infect Ecol Epidemiol 2. http://dx.doi.org/10.3402/iee.v2i0.18385.
    • (2012) Infect Ecol Epidemiol , vol.2
    • Järhult, J.D.1
  • 21
    • 41549137835 scopus 로고    scopus 로고
    • Antiviral oseltamivir is not removed or degraded in normal sewage water treatment: Implications for development of resistance by influenza A virus
    • Fick J, Lindberg RH, Tysklind M, Haemig P.D., Waldenström J, Wallensten A., Olsen B. 2007. Antiviral oseltamivir is not removed or degraded in normal sewage water treatment: implications for development of resistance by influenza A virus. PLoS One 2:e986. http://dx.doi.org/10.1371/journal.pone.0000986.
    • (2007) PLoS One , vol.2 , pp. e986
    • Fick, J.1    Lindberg, R.H.2    Tysklind, M.3    Haemig, P.D.4    Waldenström, J.5    Wallensten, A.6    Olsen, B.7
  • 22
    • 77956060661 scopus 로고    scopus 로고
    • Occurrence and fate of oseltamivir carboxylate (Tamiflu) and amantadine in sewage treatment plants
    • Ghosh GC, Nakada N, Yamashita N., Tanaka H. 2010. Occurrence and fate of oseltamivir carboxylate (Tamiflu) and amantadine in sewage treatment plants. Chemosphere 81:13-17. http://dx.doi.org/10.1016/j.chemosphere.2010.07.023.
    • (2010) Chemosphere , vol.81 , pp. 13-17
    • Ghosh, G.C.1    Nakada, N.2    Yamashita, N.3    Tanaka, H.4
  • 23
    • 52949112247 scopus 로고    scopus 로고
    • The environmental fate of the antiviral drug oseltamivir carboxylate in different waters
    • Bartels P, von Tumpling W, Jr. 2008. The environmental fate of the antiviral drug oseltamivir carboxylate in different waters. Sci Total Environ 405:215-225. http://dx.doi.org/10.1016/j.scitotenv.2008.06.032.
    • (2008) Sci Total Environ , vol.405 , pp. 215-225
    • Bartels, P.1    Von Tumpling, W.2
  • 25
    • 84870554301 scopus 로고    scopus 로고
    • Detection of antiviral drugs oseltamivir phosphate and oseltamivir carboxylate in neya river, Osaka Japan
    • Takanami R, Ozaki H, Giri R.R., Taniguchi S., Hayashi S. 2010. Detection of antiviral drugs oseltamivir phosphate and oseltamivir carboxylate in Neya River, Osaka Japan. J Water Environ Technol 8:363-372. http://dx.doi.org/10.2965/jwet.2010.363.
    • (2010) J Water Environ Technol , vol.8 , pp. 363-372
    • Takanami, R.1    Ozaki, H.2    Giri, R.R.3    Taniguchi, S.4    Hayashi, S.5
  • 26
    • 84870547958 scopus 로고    scopus 로고
    • Synchronous dynamics of observed and predicted values of anti-influenza drugs in environmental waters during a seasonal influenza outbreak
    • Azuma T, Nakada N, Yamashita N., Tanaka H. 2012. Synchronous dynamics of observed and predicted values of anti-influenza drugs in environmental waters during a seasonal influenza outbreak. Environ Sci Technol 46:12873-12881. http://dx.doi.org/10.1021/es303203c.
    • (2012) Environ Sci Technol , vol.46 , pp. 12873-12881
    • Azuma, T.1    Nakada, N.2    Yamashita, N.3    Tanaka, H.4
  • 27
    • 77149160010 scopus 로고    scopus 로고
    • Oseltamivir carboxylate, the active metabolite of oseltamivir phosphate (Tamiflu), detected in sewage discharge and river water in Japan
    • Ghosh GC, Nakada N, Yamashita N., Tanaka H. 2010. Oseltamivir carboxylate, the active metabolite of oseltamivir phosphate (Tamiflu), detected in sewage discharge and river water in Japan. Environ Health Perspect 118:103-107. http://dx.doi.org/10.1289/ehp.0900930.
    • (2010) Environ Health Perspect , vol.118 , pp. 103-107
    • Ghosh, G.C.1    Nakada, N.2    Yamashita, N.3    Tanaka, H.4
  • 28
    • 77749261114 scopus 로고    scopus 로고
    • Antiviral drugs in wastewater and surface waters: A new pharmaceutical class of environmental relevance?
    • Prasse C, Schlusener MP, Schulz R, Ternes TA 2010. Antiviral drugs in wastewater and surface waters: a new pharmaceutical class of environmental relevance? Environ Sci Technol 44:1728-1735. http://dx.doi.org/10.1021/es903216p.
    • (2010) Environ Sci Technol , vol.44 , pp. 1728-1735
    • Prasse, C.1    Schlusener, M.P.2    Schulz, R.3    Ternes, T.A.4
  • 29
    • 79956015904 scopus 로고    scopus 로고
    • Photofate of oseltamivir (Tamiflu) and oseltamivir carboxylate under natural and simulated solar irradiation: Kinetics, identification of the transformation products, and environmental occurrence
    • Gonçalves C., Perez S, Osorio V., Petrovic M, Alpendurada MF, Barcelo D. 2011. Photofate of oseltamivir (Tamiflu) and oseltamivir carboxylate under natural and simulated solar irradiation: kinetics, identification of the transformation products, and environmental occurrence. Environ Sci Technol 45:4307-4314. http://dx.doi.org/10.1021/es1032629.
    • (2011) Environ Sci Technol , vol.45 , pp. 4307-4314
    • Gonçalves, C.1    Perez, S.2    Osorio, V.3    Petrovic, M.4    Alpendurada, M.F.5    Barcelo, D.6
  • 30
  • 33
    • 84876229065 scopus 로고    scopus 로고
    • Effect of oseltamivir carboxylate consumption on emergence of drug-resistant H5N2 avian influenza virus in mallard ducks
    • Achenbach JE, Bowen RA 2013. Effect of oseltamivir carboxylate consumption on emergence of drug-resistant H5N2 avian influenza virus in mallard ducks. Antimicrob Agents Chemother 57:2171-2181. http://dx.doi.org/10.1128/AAC.02126-12.
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 2171-2181
    • Achenbach, J.E.1    Bowen, R.A.2
  • 37
    • 0035559445 scopus 로고    scopus 로고
    • Universal primer set for the full-length amplification of all influenza A viruses
    • Hoffmann E, Stech J, Guan Y., Webster RG, Perez DR. 2001. Universal primer set for the full-length amplification of all influenza A viruses. Arch Virol 146:2275-2289. http://dx.doi.org/10.1007/s007050170002.
    • (2001) Arch Virol , vol.146 , pp. 2275-2289
    • Hoffmann, E.1    Stech, J.2    Guan, Y.3    Webster, R.G.4    Perez, D.R.5
  • 38
    • 84940906900 scopus 로고    scopus 로고
    • Standard operating procedure WHO-025: Fluorometric neuraminidase inhibition assay
    • World Health Organization Collaborating Centre for Reference & Research on Influenza Australia
    • Hurt A. 2007. Standard operating procedure WHO-025: Fluorometric neuraminidase inhibition assay. Official copy. World Health Organization Collaborating Centre for Reference & Research on Influenza Australia. http://www.nisn.org/documents/A.Hurt-Protocol-for-NA-fluorescence.pdf.
    • (2007) Official Copy
    • Hurt, A.1
  • 39
    • 84872322272 scopus 로고    scopus 로고
    • Pathobiology and virus shedding of low-pathogenic avian influenza virus (A/H1N1) infection in mallards exposed to oseltamivir
    • Bröjer C., Järhult JD, Muradrasoli S., Söderstrom H, Olsen B., Gavier-Widen D. 2013. Pathobiology and virus shedding of low-pathogenic avian influenza virus (A/H1N1) infection in mallards exposed to oseltamivir. J Wildl Dis 49:103-113. http://dx.doi.org/10.7589/2011-11-335.
    • (2013) J Wildl Dis , vol.49 , pp. 103-113
    • Bröjer, C.1    Järhult, J.D.2    Muradrasoli, S.3    Söderstrom, H.4    Olsen, B.5    Gavier-Widen, D.6
  • 40
    • 84934435117 scopus 로고    scopus 로고
    • Type A influenza virus detection and quantitation by real-time RT-PCR
    • Spackman E, Suarez DL 2008. Type A influenza virus detection and quantitation by real-time RT-PCR. Methods Mol Biol 436:19-26. http://dx.doi.org/10.1007/978-1-59745-279-3-4.
    • (2008) Methods Mol Biol , vol.436 , pp. 19-26
    • Spackman, E.1    Suarez, D.L.2
  • 41
    • 0018421350 scopus 로고
    • Fluorometric assay of neuraminidase with a sodium (4-methylumbelliferyl-alpha-D-N-acetylneuraminate) substrate
    • Potier M, Mameli L, Belisle M., Dallaire L, Melancon SB. 1979. Fluorometric assay of neuraminidase with a sodium (4-methylumbelliferyl-alpha-D-N-acetylneuraminate) substrate. Anal Biochem 94:287-296. http://dx.doi.org/10.1016/0003-2697(79)90362-2.
    • (1979) Anal Biochem , vol.94 , pp. 287-296
    • Potier, M.1    Mameli, L.2    Belisle, M.3    Dallaire, L.4    Melancon, S.B.5
  • 43
    • 84861225616 scopus 로고    scopus 로고
    • The development and application ofasystem for simultaneously determining anti-infectives and nasal decongestants using on-line solid-phase extraction and liquid chromatography-tandem mass spectrometry
    • Khan GA, Lindberg R, Grabic R., Fick J. 2012. The development and application ofasystem for simultaneously determining anti-infectives and nasal decongestants using on-line solid-phase extraction and liquid chromatography-tandem mass spectrometry. JPharm Biomed Anal 66:24-32. http://dx.doi.org/10.1016/j.jpba.2012.02.011.
    • (2012) JPharm Biomed Anal , vol.66 , pp. 24-32
    • Khan, G.A.1    Lindberg, R.2    Grabic, R.3    Fick, J.4
  • 45
    • 84884234449 scopus 로고    scopus 로고
    • Evolution of influenza A virus H7 and N9 subtypes, Eastern Asia
    • Lebarbenchon C, Brown JD, Stallknecht DE 2013. Evolution of influenza A virus H7 and N9 subtypes, Eastern Asia. Emerg Infect Dis 19:1635-1638. http://dx.doi.org/10.3201/eid1910.130609.
    • (2013) Emerg Infect Dis , vol.19 , pp. 1635-1638
    • Lebarbenchon, C.1    Brown, J.D.2    Stallknecht, D.E.3
  • 47
    • 84908610840 scopus 로고    scopus 로고
    • Evolution of oseltamivir resistance mutations in influenza A(H1N1) and A(H3N2) viruses during selection in experimentally infected mice
    • Pizzorno A, Abed Y, Plante P.L., Carbonneau J., Baz M, Hamelin ME, Corbeil J, Boivin G. 2014. Evolution of oseltamivir resistance mutations in influenza A(H1N1) and A(H3N2) viruses during selection in experimentally infected mice. Antimicrob Agents Chemother 58:6398-6405. http://dx.doi.org/10.1128/AAC.02956-14.
    • (2014) Antimicrob Agents Chemother , vol.58 , pp. 6398-6405
    • Pizzorno, A.1    Abed, Y.2    Plante, P.L.3    Carbonneau, J.4    Baz, M.5    Hamelin, M.E.6    Corbeil, J.7    Boivin, G.8
  • 48
    • 0026665418 scopus 로고
    • The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor
    • Varghese JN, McKimm-Breschkin JL, Caldwell J.B., Kortt AA, Colman PM. 1992. The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor. Proteins 14:327-332. http://dx.doi.org/10.1002/prot.340140302.
    • (1992) Proteins , vol.14 , pp. 327-332
    • Varghese, J.N.1    McKimm-Breschkin, J.L.2    Caldwell, J.B.3    Kortt, A.A.4    Colman, P.M.5
  • 51
    • 84961288106 scopus 로고    scopus 로고
    • Molecular surveillance of antiviral drug resistance of influenza A/H3N2 virus in Singapore, 2009-2013
    • Lee HK, Tang JW, Loh T.P., Hurt AC, Oon LL, Koay ES. 2015. Molecular surveillance of antiviral drug resistance of influenza A/H3N2 virus in Singapore, 2009-2013. PLoS One 10:e0117822. http://dx.doi.org/10.1371/journal.pone.0117822.
    • (2015) PLoS One , vol.10
    • Lee, H.K.1    Tang, J.W.2    Loh, T.P.3    Hurt, A.C.4    Oon, L.L.5    Koay, E.S.6
  • 52
    • 84884574122 scopus 로고    scopus 로고
    • Neuraminidase inhibitor susceptibility profile of pandemic and seasonal influenza viruses during the 2009-2010 and 2010-2011 influenza seasons in Japan
    • Dapat C, Kondo H, Dapat I.C., Baranovich T., Suzuki Y, Shobugawa Y, Saito K., Saito R, Suzuki H. 2013. Neuraminidase inhibitor susceptibility profile of pandemic and seasonal influenza viruses during the 2009-2010 and 2010-2011 influenza seasons in Japan. Antiviral Res 99:261-269. http://dx.doi.org/10.1016/j.antiviral.2013.06.003.
    • (2013) Antiviral Res , vol.99 , pp. 261-269
    • Dapat, C.1    Kondo, H.2    Dapat, I.C.3    Baranovich, T.4    Suzuki, Y.5    Shobugawa, Y.6    Saito, K.7    Saito, R.8    Suzuki, H.9
  • 53
    • 84871833125 scopus 로고    scopus 로고
    • Influenza neuraminidase inhibitors: Antiviral action and mechanisms of resistance
    • McKimm-Breschkin JL. 2012. Influenza neuraminidase inhibitors: antiviral action and mechanisms of resistance. Influenza Other Respir Viruses 7(Suppl 1):25-36. http://dx.doi.org/10.1111/irv.12047.
    • (2012) Influenza Other Respir Viruses , vol.7 , pp. 25-36
    • McKimm-Breschkin, J.L.1
  • 54
    • 84878919371 scopus 로고    scopus 로고
    • I222 neuraminidase mutations further reduce oseltamivir susceptibility of Indonesian clade 2.1 highly pathogenic avian influenza A(H5N1) viruses
    • McKimm-Breschkin J.L., Barrett S, Pudjiatmoko Azhar M, Wong FY, Selleck P, Mohr P.G., McGrane J., Kim M. 2013. I222 neuraminidase mutations further reduce oseltamivir susceptibility of Indonesian clade 2.1 highly pathogenic avian influenza A(H5N1) viruses. PLoS One 8:e66105. http://dx.doi.org/10.1371/journal.pone.0066105.
    • (2013) PLoS One , vol.8
    • McKimm-Breschkin, J.L.1    Barrett, S.2    Pudjiatmoko Azhar, M.3    Wong, F.Y.4    Selleck, P.5    Mohr, P.G.6    McGrane, J.7    Kim, M.8
  • 56
    • 84896878263 scopus 로고    scopus 로고
    • A conformational restriction in the influenza A virus neuraminidase binding site by R152 results in a combinational effect of I222T and H274Y on oseltamivir resistance
    • Huang L, Cao Y, Zhou J., Qin K, Zhu W, Zhu Y., Yang L, Wang D, Wei H., Shu Y. 2014. A conformational restriction in the influenza A virus neuraminidase binding site by R152 results in a combinational effect of I222T and H274Y on oseltamivir resistance. Antimicrob Agents Chemother 58:1639-1645. http://dx.doi.org/10.1128/AAC.01848-13.
    • (2014) Antimicrob Agents Chemother , vol.58 , pp. 1639-1645
    • Huang, L.1    Cao, Y.2    Zhou, J.3    Qin, K.4    Zhu, W.5    Zhu, Y.6    Yang, L.7    Wang, D.8    Wei, H.9    Shu, Y.10
  • 57
    • 84857159099 scopus 로고    scopus 로고
    • Impact of mutations at residue I223 of the neuraminidase protein on the resistance profile, replication level, and virulence of the 2009 pandemic influenza virus
    • Pizzorno A, Abed Y, Bouhy X., Beaulieu E, Mallett C, Russell R., Boivin G. 2012. Impact of mutations at residue I223 of the neuraminidase protein on the resistance profile, replication level, and virulence of the 2009 pandemic influenza virus. Antimicrob Agents Chemother 56:1208-1214. http://dx.doi.org/10.1128/AAC.05994-11.
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 1208-1214
    • Pizzorno, A.1    Abed, Y.2    Bouhy, X.3    Beaulieu, E.4    Mallett, C.5    Russell, R.6    Boivin, G.7
  • 58
    • 33845455661 scopus 로고    scopus 로고
    • Characterization of multidrug-resistant influenza A/H3N2 viruses shed during 1 year by an immunocompromised child
    • Baz M, Abed Y, McDonald J., Boivin G. 2006. Characterization of multidrug-resistant influenza A/H3N2 viruses shed during 1 year by an immunocompromised child. Clin Infect Dis 43:1555-1561. http://dx.doi.org/10.1086/508777.
    • (2006) Clin Infect Dis , vol.43 , pp. 1555-1561
    • Baz, M.1    Abed, Y.2    McDonald, J.3    Boivin, G.4
  • 59
    • 79951506684 scopus 로고    scopus 로고
    • The I222V neuraminidase mutation has a compensatory role in replication of an oseltamivir-resistant influenza virus A/H3N2 E119V mutant
    • Simon P, Holder BP, Bouhy X, Abed Y., Beauchemin CA, Boivin G. 2011. The I222V neuraminidase mutation has a compensatory role in replication of an oseltamivir-resistant influenza virus A/H3N2 E119V mutant. J Clin Microbiol 49:715-717. http://dx.doi.org/10.1128/JCM.01732-10.
    • (2011) J Clin Microbiol , vol.49 , pp. 715-717
    • Simon, P.1    Holder, B.P.2    Bouhy, X.3    Abed, Y.4    Beauchemin, C.A.5    Boivin, G.6
  • 60
    • 84923367482 scopus 로고    scopus 로고
    • Epistatic interactions between neuraminidase mutations facilitated the emergence of the oseltamivir-resistant H1N1 influenza viruses
    • Duan S, Govorkova EA, Bahl J, Zaraket H., Baranovich T, Seiler P, Prevost K., Webster RG, Webby RJ. 2014. Epistatic interactions between neuraminidase mutations facilitated the emergence of the oseltamivir-resistant H1N1 influenza viruses. Nat Commun 5:5029. http://dx.doi.org/10.1038/ncomms6029.
    • (2014) Nat Commun , vol.5 , pp. 5029
    • Duan, S.1    Govorkova, E.A.2    Bahl, J.3    Zaraket, H.4    Baranovich, T.5    Seiler, P.6    Prevost, K.7    Webster, R.G.8    Webby, R.J.9
  • 61
    • 84925438631 scopus 로고    scopus 로고
    • Competitive fitness of influenza B viruses with neuraminidase inhibitorresistant substitutions in a co-infection model of the human airway epithelium
    • Burnham AJ, Armstrong J, Lowen A.C., Webster RG, Govorkova EA. 2015. Competitive fitness of influenza B viruses with neuraminidase inhibitorresistant substitutions in a co-infection model of the human airway epithelium. J Virol 89:4575-4587. http://dx.doi.org/10.1128/JVI.02473-14.
    • (2015) J Virol , vol.89 , pp. 4575-4587
    • Burnham, A.J.1    Armstrong, J.2    Lowen, A.C.3    Webster, R.G.4    Govorkova, E.A.5
  • 62
    • 84898616627 scopus 로고    scopus 로고
    • Fitness costs for influenza B viruses carrying neuraminidase inhibitor-resistant substitutions: Underscoring the importance of E119A and H274Y
    • Burnham AJ, Baranovich T, Marathe B.M., Armstrong J., Webster RG, Govorkova EA. 2014. Fitness costs for influenza B viruses carrying neuraminidase inhibitor-resistant substitutions: underscoring the importance of E119A and H274Y. Antimicrob Agents Chemother 58:2718-2730. http://dx.doi.org/10.1128/AAC.02628-13.
    • (2014) Antimicrob Agents Chemother , vol.58 , pp. 2718-2730
    • Burnham, A.J.1    Baranovich, T.2    Marathe, B.M.3    Armstrong, J.4    Webster, R.G.5    Govorkova, E.A.6
  • 63
    • 84867469314 scopus 로고    scopus 로고
    • Meetings of the WHO working group on surveillance of influenza antiviral susceptibility - Geneva, November 2011 and June 2012
    • World Health Organization. 2012. Meetings of the WHO working group on surveillance of influenza antiviral susceptibility - Geneva, November 2011 and June 2012. Wkly Epidemiol Rec 87:369-374.
    • (2012) Wkly Epidemiol Rec , vol.87 , pp. 369-374
    • World Health Organization1


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