Milk intolerance, beta-casein and lactose

Nutrients

Volumn 7, Issue 9, 2015, Pages 7285-7297

  Pal, Sebely ^a   Woodford, Keith ^b   Kukuljan, Sonja ^c   Ho, Suleen ^a  

^a CURTIN UNIVERSITY   (Australia)

^b LINCOLN UNIVERSITY   (New Zealand)

^c The a2 Milk Company (Australia) Pty Ltd   (Australia)

Author keywords

Beta casein; Lactose; Lactose intolerance; Milk consumption

Indexed keywords

BETA CASEIN; BETA CASOMORPHINE; LACTOSE; MYELOPEROXIDASE; NALOXONE; AUTACOID; CASEIN; MU OPIATE RECEPTOR;

ABDOMINAL PAIN; BLOATING; CONSTIPATION; FECES; GASTROINTESTINAL MOTILITY; IMMUNE RESPONSE; INTESTINE TRANSIT TIME; LACTOSE INTOLERANCE; MILK INTOLERANCE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN SECRETION; REVIEW; SIGNAL TRANSDUCTION; AGONISTS; ANIMAL; DEFECATION; DRUG EFFECTS; ENZYMOLOGY; GASTROINTESTINAL TRACT; GASTROINTESTINAL TRANSIT; HUMAN; METABOLISM; PATHOPHYSIOLOGY; TREATMENT OUTCOME;

ABDOMINAL PAIN; ANIMALS; CASEINS; DEFECATION; GASTROINTESTINAL TRACT; GASTROINTESTINAL TRANSIT; HUMANS; INFLAMMATION MEDIATORS; LACTOSE INTOLERANCE; RECEPTORS, OPIOID, MU; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

EID: 84940881456     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu7095339     Document Type: Review

References (60)

1. Suchy, F.J.; Brannon, P.M.; Carpenter, T.O.; Fernandez, J.R.; Gilsanz, V.; Gould, J.B.; Hall, K.; Hui, S.L.; Lupton, J.; Mennella, J.; et al. NIH consensus development conference statement: Lactose intolerance and health. NIH Consens. State Sci. Statements 2010, 27, 1-27. [PubMed]
2. Phelan, M.; Aherne, A.; FitzGerald, R.J.; O'Brien, N.M. Casein-derived bioactive peptides: Biological effects, industrial uses, safety aspects and regulatory status. Int. Dairy J. 2009, 19, 643-654. [CrossRef]
3. Formaggioni, P.; Summer, A.; Malacarne, M.; Mariani, P. Milk protein polymorphism: Detection and diffusion of the genetic variants in Bos genus. Ann. Fac. Med. Vet. Univ. Parma 1999, 19, 127-165.
4. Ng-Kwai-Hang, K.F.; Grosclaude, F. Genetic polymorphism of milk proteins. In Advanced Dairy Chemistry: Volume 1: Proteins, Parts A & B; Fox, P.F., McSweeney, P.L.H., Eds.; Kluwer Academic/Plenum Publishers: New York, NY, USA, 2002; pp. 739-816.
5. Boutrou, R.; Gaudichon, C.; Dupont, D.; Jardin, J.; Airinei, G.; Marsset-Baglieri, A.; Benamouzig, R.; Tomé, D.; Leonil, J. Sequential release of milk protein-derived bioactive peptides in the jejunum in healthy humans. Am. J. Clin. Nutr. 2013, 97, 1314-1323. [CrossRef] [PubMed]
6. De Noni, I.; Cattaneo, S. Occurrence of β-casomorphins 5 and 7 in commercial dairy products and in their digests following in vitro simulated gastro-intestinal digestion. Food Chem. 2010, 119, 560-566. [CrossRef]
7. De Noni, I. Release of β-casomorphins 5 and 7 during simulated gastro-intestinal digestion of bovine β-casein variants and milk-based infant formulas. Food Chem. 2008, 110, 897-903. [CrossRef] [PubMed]
8. Jinsmaa, Y.; Yoshikawa, M. Enzymatic release of neocasomorphin and β-casomorphin from bovine beta-casein. Peptides 1999, 20, 957-962. [CrossRef]
9. Ul Haq, M.R.; Kapila, R.; Kapila, S. Release of β-casomorphin-7/5 during simulated gastrointestinal digestion of milk β-casein variants from Indian crossbred cattle (Karan Fries). Food Chem. 2015, 168, 70-79. [CrossRef] [PubMed]
10. De Noni, R.J.; FitzGerald, H.J.T.; Korhonen, Y.; Le Roux, C.T.; Livesey, I.; Thorsdottir, D.; Tomé, R.W. Scientific Report of EFSA prepared by a DATEX Working Group on the potential health impact of β-casomorphins and related peptides. EFSA Sci. Rep. 2009, 231, 1-107.
11. Cielinkska, A.; Kostyra, E.B.; Kostyra, H.; Olenski, K.; Fiedorowicz, E.; Kaminski, S.A. Milk from cows of different β-casein genotypes as a source of β-casomorphin-7. Int. J. Food Sci. Nutr. 2012, 63, 426-430.
12. Woodford, K. Devil in the Milk: Illness, Health and Politics: A1 and A2 Milk; Craig Potton Publishing: Wellington, New Zealand, 2007.
13. Kaminski, S.; Cieslinska, A.; Kostyra, E. Polymorphism of bovine β-casein and its potential effect on human health. J. Appl. Genet. 2007, 48, 189-198. [CrossRef] [PubMed]
14. Mencarini, I.R.; Woodford, K.B.; Old, K.M. Comparing herd selection strategies for A2 beta-casein. Proc. N. Z. Soc. Anim. Prod. 2013, 73, 149-154.
15. Nguyen, D.D.; Solah, V.A.; Johnson, S.K.; Charrois, J.W.; Busetti, F. Isotope dilution liquid chromatography-tandem mass spectrometry for simultaneous identification and quantification of beta-casomorphin 5 and beta-casomorphin 7 in yoghurt. Food Chem. 2014, 146, 345-352. [CrossRef] [PubMed]
16. Janer, C.; Arigoni, F.; Lee, B.H.; Peláez, C.; Requena, T. Enzymatic ability of Bifidobacterium animalis subsp. lactis to hydrolyze milk proteins: Identification and characterization of endopeptidase O. Appl. Environ. Microbiol. 2005, 71, 8460-8465. [PubMed]
17. Hamosh, M.; Hong, H.; Hamosh, P. Beta-Casomorphins: Milk-β-casein derived opioid peptides. In Textbook of Gastroenterology and Nutrition in Infancy, 2nd ed.; Lebenthal, E., Ed.; Raven Press: New York, NY, USA, 1989; pp. 143-150.
18. Wada, Y.; Lonnerdal, B. Bioactive peptides released from in vitro digestion of human milk with or without pasteurization. Pediatr. Res. 2015, 77, 546-553. [CrossRef] [PubMed]
19. Koch, G.; Wiedemann, K.; Teschemacher, H. Opioid activities of human beta-casomorphins. Naunyn Schmiedebergs Arch. Pharmacol. 1985, 33, 351-354. [CrossRef]
20. Brantl, V. Novel opioid peptides derived from human beta-casein: Human beta-casomorphins. Eur. J. Pharmacol. 1984, 106, 213-214. [CrossRef]
21. Jarmolowska, B.; Sidor, K.; Iwan, M.; Bielikowicz, K.; Kaczmarski, M.; Kostyra, E.; Kostrya, H. Changes of β-casomorphin content in human milk during lactation. Peptides 2007, 28, 1982-1986. [CrossRef] [PubMed]
22. Brantl, V.; Teschemacher, H.; Henschen, A.; Lottspeich, F. Novel opioid peptides derived from casein (β-casomorphins). I. Isolation from bovine casein peptone. Hoppe Seylers Z. Physiol. Chem. 1979, 360, 1211-1216. [CrossRef] [PubMed]
23. Henschen, A.; Lottspeich, F.; Brantl, V.; Teschemacher, H. Novel opioid peptides derived from casein (β-casomorphins). II. Structure of active components from bovine casein peptone. Hoppe Seylers Z. Physiol. Chem. 1979, 360, 1217-1224. [PubMed]
24. Lottspeich, F.; Henschen, A.; Brantl, V.; Teschemacher, H. Novel opioid peptides derived from casein (β-casomorphins). III. Synthetic peptides corresponding to components from bovine casein peptone. Hoppe Seylers Z. Physiol. Chem. 1980, 361, 1835-1839. [CrossRef] [PubMed]
25. Brantl, V.; Teschemacher, H.; Blasig, J.; Henschen, A.; Lottspeich, F. Opioid activities of beta-casomorphins. Life Sci. 1981, 28, 1903-1909. [CrossRef]
26. Wasilewska, J.; Kaczmarski, M.; Kostyra, E.; Iwan, M. Cow's-milk-induced infant apnoea with increased serum content of bovine β-casomorphin-5. J. Pediatr. Gastroenterol. Nutr. 2011, 52, 772-775. [CrossRef] [PubMed]
27. Wasilewska, J.; Sienkiewicz-Szlapka, E.; Kuzbida, E.; Jarmolowska, B.; Kaczmarski, M.; Kostyra, E. The exogenous opioid peptides and DPPIV serum activity in infants with apnoea expressed as apparent life threatening events (ALTE). Neuropeptides 2011, 45, 189-195. [CrossRef] [PubMed]
28. Kost, N.V.; Sokolov, O.Y.; Kurasova, O.B.; Dmitriev, A.D.; Tarakanova, J.N.; Gabaeva, M.V.; Zolotarev, Y.A.; Dadayan, A.K.; Grachev, S.A.; Korneeva, E.V.; et al. β-casomorphins-7 in infants on different type of feeding and different levels of psychomotor development. Peptides 2009, 30, 1854-1860. [CrossRef] [PubMed]
29. Sokolov, O.; Kost, N.; Andreeva, O.; Korneeva, E.; Meshavkin, V.; Tarakanova, Y.; Dadayan, A.; Zolotarev, Y.; Grachev, S.; Mikheeva, I.; et al. Autistic children display elevated urine levels of bovine casomorphin-7 immunoreactivity. Peptides 2014, 56, 68-71. [CrossRef] [PubMed]
30. Barnett, M.P.; McNabb,W.C.; Roy, N.C.;Woodford, K.B.; Clarke, A.J. Dietary A1 β-casein affects gastrointestinal transit time, dipeptidyl peptidase-4 activity, and inflammatory status relative to A2 β-casein in Wistar rats. Int. J. Food Sci. Nutr. 2014, 65, 720-727. [CrossRef] [PubMed]
31. Saito, T.; Nakamura, T.; Kitazawa, H.; Kawai, Y.; Itoh, T. Isolation and structural analysis of antihypertensive peptides that exist naturally in Gouda cheese. J. Dairy Sci. 2000, 83, 1434-1440. [CrossRef]
32. Pleuvry, B.J. Opioid receptors and their ligands: Natural and unnatural. Br. J. Anaesth. 1991, 66, 370-380. [CrossRef] [PubMed]
33. Ward, S.J.; Takemori, A.E. Relative involvement of receptor subtypes in opioid-induced inhibition of gastrointestinal transit in mice. J. Pharmacol. Exp. Ther. 1983, 224, 359-363. [PubMed]
34. Zoghbi, S.; Trompette, A.; Claustre, J.; El Homsi, M.; Garzon, J.; Jourdan, G.; Scoazec, J.Y.; Plaisancié, P. β-Casomorphin-7 regulates the secretion and expression of gastrointestinal mucins through a μ-opioid pathway. Am. J. Physiol. Gastrointest. Liver Physiol. 2006, 290, G1105-G1113. [CrossRef] [PubMed]
35. Lang, M.E.; Davison, J.S.; Bates, S.L.; Meddings, J.B. Opioid receptors on guinea-pig intestinal crypt epithelial cells. J. Physiol. 1996, 497, 161-174. [CrossRef] [PubMed]
36. Greenwood-Van Meerveld, B.; Gardner, C.J.; Little, P.J.; Hicks, G.A.; Dehaven-Hudkins, D.L. Preclinical studies of opioids and opioid antagonists on gastrointestinal function. Neurogastroenterol. Motil. 2004, 16, 46-53. [CrossRef] [PubMed]
37. Gonenne, J.; Camilleri, M.; Ferber, I.; Burton, D.; Baxter, K.; Keyashian, K.; Foss, J.; Wallin, B.; Du, W.; Zinsmeister, A. Effect of alvimopan and codeine on gastrointestinal transit: A randomized controlled study. Clin. Gastroenterol. Hepatol. 2005, 3, 784-791. [CrossRef]
38. Stephen, A.M.;Wiggins, H.S.; Cummings, J.H. Effect of changing transit time on colonic microbial metabolism in man. Gut 1987, 28, 601-609. [CrossRef] [PubMed]
39. Becker, A.; Hempel, G.; Grecksch, G.; Matthies, H. Effects of beta-casomorphin derivatives on gastrointestinal transit in mice. Biomed. Biochim. Acta 1990, 49, 1203-1207. [PubMed]
40. Defilippi, C.; Gomez, E.; Charlin, V.; Silva, C. Inhibition of small intestinal motility by casein: A role of beta casomorphins? Nutrition 1995, 11, 751-754. [PubMed]
41. Mihatsch, W.A.; Franz, A.R.; Kuhnt, B.; Hogel, J.; Pohlandt, F. Hydrolysis of casein accelerates gastrointestinal transit via reduction of opioid receptor agonists released from casein in rats. Biol. Neonate 2005, 87, 160-163. [CrossRef] [PubMed]
42. Schulte-Frohlinde, E.; Schmid, R.; Brantl, V.; Schusdziarra, V. Effect of bovine β-casomorphin-4-amide on gastrointestinal transit and pancreatic endocrine function in man. In Beta-Casomorphins and Related Peptides: Recent Developments; Brantl, V., Teschemacher, H., Eds.; VCH Weinheim: New York, NY, USA, 1994; pp. 155-160.
43. Daniel, H.; Vohwinkel, M.; Rehner, G. Effect of casein and beta-casomorphins on gastrointestinal motility in rats. J. Nutr. 1990, 120, 252-257. [PubMed]
44. Ul Haq, M.R.; Kapila, R.; Sharma, R.; Saliganti, V.; Kapila, S. Comparative evaluation of cow β-casein variants (A1/A2) consumption on Th2-mediated inflammatory response in mouse gut. Eur. J. Nutr. 2014, 53, 1039-1049. [CrossRef] [PubMed]
45. Pol, O.; Sasaki, M.; Jimenez, N.; Dawson, V.L.; Dawson, T.M.; Puig, M.M. The involvement of nitric oxide in the enhanced expression of μ-opioid receptors during intestinal inflammation in mice. Br. J. Pharmacol. 2005, 145, 758-766. [CrossRef] [PubMed]
46. Drucker, D.J. The biology of incretin hormones. Cell Metab. 2006, 3, 153-165. [CrossRef] [PubMed]
47. Holst, J.J.; Gromada, J. Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans. Am. J. Physiol. Endocrinol. Metab. 2004, 287, E199-E206. [CrossRef] [PubMed]
48. Schirra, J.; Nicolaus, M.; Roggel, R.; Katschinski, M.; Storr, M.; Woerle, H.J.; Goke, B. Endogenous glucagon-like peptide 1 controls endocrine pancreatic secretion andantro-pyloro-duodenal motility in humans. Gut 2006, 55, 243-251. [CrossRef] [PubMed]
49. Claustre, J.; Toumi, F.; Trompette, A.; Jourdan, G.; Guignard, H.; Chayvialle, J.A.; Plaisancié, P. Effects of peptides derived from dietary proteins on mucus secretion in rat jejunum. Am. J. Physiol. Gastrointest Liver Physiol. 2002, 283, G521-G528. [CrossRef] [PubMed]
50. Elitsur, Y.; Luk, G.D. Beta-casomorphin (BCM) and human colonic lamina propria lymphocyte proliferation. Clin. Exp. Immunol. 1991, 85, 493-497. [CrossRef] [PubMed]
51. Kayser, H.; Meisel, H. Stimulation of human peripheral blood lymphocytes by bioactive peptides derived from bovine milk proteins. FEBS Lett. 1996, 383, 18-20. [CrossRef]
52. Ul Haq, M.R.; Kapila, R.; Saliganti, V. Consumption of β-casomorphins-7/5 induce inflammatory immune response in mice gut through Th2 pathway. J. Funct. Foods 2014, 8, 150-160. [CrossRef]
53. Crowley, E.T.; Williams, L.T.; Roberts, T.K.; Dunstan, R.H.; Jones, P.D. Does milk cause constipation? A crossover dietary trial. Nutrients 2013, 5, 253-266. [CrossRef] [PubMed]
54. Andiran, F.; Dayi, S.; Mete, E. Cows milk consumption in constipation and anal fissure in infants and young children. J. Paediatr. Child Health 2003, 39, 329-331. [CrossRef] [PubMed]
55. Iacono, G.; Cavataio, F.; Montalto, G.; Florena, A.; Tumminello, M.; Soresi, M.; Notarbartolo, A.; Carroccio, A. Intolerance of cow's milk and chronic constipation in children. N. Engl. J. Med. 1998, 339, 1100-1104. [CrossRef] [PubMed]
56. Ho, S.; Woodford, K.; Kukuljan, S.; Pal, S. Comparative effects of A1 versus A2 beta-casein on gastrointestinal measures: A blinded randomised cross-over pilot study. Eur. J. Clin. Nutr. 2014, 68, 994-1000. [CrossRef] [PubMed]
57. Mourad, F.H.; Barada, K.A.; Bou Rached, N.A.; Khoury, C.I.; Saade, N.E.; Nassar, C.F. Inhibitory effect of experimental colitis on fluid absorption in rat jejunum: Role of the enteric nervous system, VIP, and nitric oxide. Am. J. Physiol. Gastrointest Liver Physiol. 2006, 290, G262-G268. [CrossRef] [PubMed]
58. Sundaram, U.; Wisel, S.; Coon, S. Neutral Na-amino acid cotransport is differentially regulated by glucocorticoids in the normal and chronically inflamed rabbit small intestine. Am. J. Physiol. Gastrointest Liver Physiol. 2007, 292, G467-G474. [CrossRef] [PubMed]
59. Cani, P.D.; Bibiloni, R.; Knauf, C.; Waget, A.; Neyrinck, A.M.; Delzenne, N.M.; Burcelin, R. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 2008, 57, 1470-1481. [CrossRef] [PubMed]
60. Provot, C.; Persuy, M.A.; Mercier, J.C. Complete nucleotide sequence of ovine β-casein cDNA: Inter-species comparison. Biochimie 1989, 71, 827-832. [CrossRef]