Microparticles containing Guaraná extract obtained by spray-drying technique: Development and characterization

Revista Brasileira de Farmacognosia

Volumn 25, Issue 3, 2015, Pages 292-300

  Klein, Traudi ^a   Longhini, Renata ^a   Bruschi, Marcos L ^a   De Mello, João C P ^a  

^a STATE UNIVERSITY OF MARINGÁ   (Brazil)

Author keywords

Antioxidant capacity; Guaran ; Microparticles; Paullinia cupana; Spray drying; Thermal analysis

Indexed keywords

GUARANA EXTRACT; GUARANA MICROPARTICLE; UNCLASSIFIED DRUG;

ANTIOXIDANT ASSAY; ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DPPH RADICAL SCAVENGING ASSAY; DRUG FORMULATION; DRUG SOLUBILITY; ENCAPSULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MODEL; MOISTURE; NONHUMAN; PARTICLE SIZE; SCANNING ELECTRON MICROSCOPY; SOLID PHASE EXTRACTION; SPRAY DRYING; THERMOGRAVIMETRY;

EID: 84940827554     PISSN: None     EISSN: 1981528X     Source Type: Journal    
DOI: 10.1016/j.bjp.2015.03.010     Document Type: Article

References (26)

1. Antonelli-Ushirobira, T.M., Kaneshima, E.N., Gabriel, M., Audi, E.A., Marques, L.C., Mello, J.C.P., 2010. Acute and subchronic toxicological evaluation of the semipurified extract of seeds of guaraná (Paullinia cupana) in rodents. Food Chem. Toxicol. 48, 1817-1820.
2. Audi, E.A., Mello, J.C.P., 2000. Efeito antidepressivo do extrato da droga vegetal guaraná (Paullinia cupana var. sorbilis (Martius) Ducke). Fundação Universidade Estadual de Maringá, BR Patent # PI00066389, Cl. Int. A61P 25/24; A61K 35/78.
3. Audi, E.A., Roncon, C.M., Almeida, C.B., Mello, J.C.P., 2010. Effect of semi-purified constituent from guaraná seeds on performance of rats in elevated T maze. Eur. Neuropsychopharmacol. 20, S274.
4. Aulton, M.E., 2007. Pharmaceutics: The Science of Dosage Form Design, 2nd ed. Churchill, Livingstone.
5. Borghetti, G.S., Costa, I.M., Petrovick, P.R., Ferreira, V.P., Bassani, V.L., 2006. Characterization of different samples of quercetin in solid state: indication of polymorphism occurrence. Pharmazie 61, 802-804.
6. Bruschi, M.L., Cardoso, M.L.C., Lucchesi, M.B., Gremião, M.P.D., 2003. Gelatin microparticles containing propolis obtained by spray-drying technique: preparation and characterization. Int. J. Pharm. 264, 45-55.
7. Chassot, J.M., Longhini, R., Gazarini, L., Mello, J.C.P., Oliveira, R.M.W., 2011. Preclinical evaluation of Trichilia catigua extracts on the central nervous system of mice. J. Ethnopharmacol. 137, 1143-1148.
8. Costa, P., Lobo, J.M.S., 2001. Modeling and comparison of dissolution profiles. Eur. J. Pharm. Sci. 13, 123-133.
9. Espinola, E.B., Dias, R.F., Mattei, R., Carlini, E., 1997. Pharmacological activity of Guarana (Paullinia cupana Mart) in laboratory animals. J. Ethnopharmacol. 55, 223-229.
10. Fu, N., Zhou, Z., Jones, T.B., Tan, T.T.Y., Wu, W.D., Lin, S.X., Chen, X.D., Chan, P.P.Y., 2011. Production of monodisperse epigallocatechin gallate (EGCG) microparticles by spray drying for high antioxidant activity retention. Int. J. Pharm. 413, 155-166.
11. Fukumasu, H., Silva, T.C., Avanzo, J.L., Lima, C.E., Mackowiak, I.I., Atroch, A., Spinosa, H.S., Moreno, F.S., Dagli, M.L.Z., 2006. Chemopreventive effects of Paullinia cupana Mart var. sorbilis, the guaraná, on mouse hepatocarcinogenesis. Cancer Lett. 233, 158-164.
12. Henman, A.R., 1982. Guaraná (Paullinia cupana var. sorbilis): ecological and social perspectives on an economic plant of the central Amazon basin. J. Ethnopharmacol. 6, 311-338.
13. Johnston, G.A.R., Beart, P.M., 2004. Flavonoids: some of the wisdom of sage? Br. J. Pharmacol. 142, 809-810.
14. Klein, T., Longhini, R., Bruschi, M.L., Mello, J.C.P., 2009. Fitoterápicos: um mercado promissor. J. Basic Appl. Pharm. Sci. 30, 241-248.
15. Klein, T., Longhini, R., Mello, J.C.P., 2012. Development of an analytical method using reversed-phase HPLC-PDA for a semipurified extract of Paullinia cupana var. sorbilis (guaraná). Talanta 88, 502-506.
16. Klein, T., Longhini, R., Bruschi, M.L., Mello, J.C.P., 2013. Development of tablets containing semipurified extract of guaraná (Paullinia cupana). Braz. J. Pharmacogn. 23, 186-193.
17. Manach, C., Williamson, G., Morand, C., Scalbert, A., Rémésy, C., 2005. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am. J. Clin. Nutr. 81, 230-242.
18. Mattei, R., Dias, R.F., Espinola, E.B., Carlini, E.A., Barros, S.B.M., 1998. Guarana (Paullinia cupana): toxic behavioral effects in laboratory animals and antioxidant activity in vitro. J. Ethnopharmacol. 60, 111-116.
19. Otobone, F.J., Sanches, A.C.C., Nagae, R.L., Martins, J.V.C., Obici, S., Mello, J.C.P., Audi, E.A., 2005. Effect of crude extract and its semi purified constituents from guaraná seeds [Paullinia cupana var. sorbilis (Mart.) Ducke] on cognitive performance in Morris water maze in rats. Braz. Arch. Biol. Technol. 48, 723-728.
20. Otobone, F.J., Sanches, A.C.C., Nagae, R.L., Martins, J.V.C., Sela, V.R., Mello, J.C.P., Audi, E.A., 2007. Effect of lyophilized extracts from Guaraná seeds [Paullinia cupana var. sorbilis (Mart.) Ducke] on behavioral profiles in rats. Phytother. Res. 21, 531-535.
21. Roncon, C.M., de Almeida, C.B., Klein, T., Mello, J.C.P., Audi, E.A., 2011. Anxiolytic effects of a semipurified constituent of guaraná seeds on rats in the elevated T-maze test. Planta Med. 77, 236-241.
22. Sansone, F., Picerno, P., Mencherini, T., Villeco, F., D’Ursi, A.M., Aquino, R.P., Lauro, M.R., 2011. Flavonoid microparticles by spray-drying: influence of enhancers of the dissolution rate properties and stability. J. Food Eng. 103, 188-196.
23. Ushirobira, T.M.A., Yamaguti, E., Uemura, L.M., Nakamura, C.V., Dias Filho, B.P., Mello, J.C.P., 2007. Chemical and microbiological study of extract from seeds of guarana (Paullinia cupana var. sorbilis). Latin Am. J. Pharm. 26, 5-9.
24. Weerakody, R., Fagan, P., Kosaraju, S., 2008. Chitosan microspheres for encapsulation of -lipoic acid. Int. J. Pharm. 357, 213-218.
25. Yamaguti-Sasaki, E., Ito, L.A., Canteli, V.C.D., Ushirobira, T.M.A., Ueda-Nakamura, T., Dias Filho, B.P., Nakamura, C.V., Mello, J.C.P., 2007. Antioxidant capacity and in vitro prevention of dental plaque formation by extracts and condensed tannins of Paullinia cupana. Molecules 12, 1950-1963.
26. Zhang, L., Mou, D., Du, Y., 2007. Procyanidins: extraction and microencapsulation. J. Sci. Food Agric. 87, 2192-2197.