Prodromal Symptoms in Patients with Bisphosphonate-Associated Atypical Fractures of the Femur

Journal of Bone and Mineral Metabolism

Volumn 33, Issue 5, 2015, Pages 516-522

  Kharazmi, Mohammad ^a,b   Michaëlsson, Karl ^b   Hallberg, Pär ^b  

^a CENTRAL HOSPITAL   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Adverse drug reaction; Atypical fracture; Bisphosphonate; Osteoporosis; Prodromal symptom

Indexed keywords

ALENDRONIC ACID; RISEDRONIC ACID; ZOLEDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; BONE DENSITY CONSERVATION AGENT;

ADULT; ADVERSE DRUG REACTION; AGED; ARTICLE; CLINICAL ARTICLE; DIAGNOSTIC ACCURACY; EARLY DIAGNOSIS; FEMALE; FEMUR SHAFT ATYPICAL FRACTURE; FEMUR SHAFT FRACTURE; FREQUENCY ANALYSIS; HUMAN; MALE; MIDDLE AGED; PRIORITY JOURNAL; PRODROMAL SYMPTOM; SIDE EFFECT; SWEDISH CITIZEN; X RAY; CHEMICALLY INDUCED; DRUG EFFECTS; FEMORAL FRACTURES; FEMUR; OSTEOPOROSIS; PAIN; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BONE DENSITY CONSERVATION AGENTS; DIPHOSPHONATES; FEMALE; FEMORAL FRACTURES; FEMUR; HUMANS; MALE; MIDDLE AGED; OSTEOPOROSIS; PAIN; PRODROMAL SYMPTOMS;

EID: 84940796563     PISSN: 09148779     EISSN: 14355604     Source Type: Journal    
DOI: 10.1007/s00774-014-0611-9     Document Type: Article

References (25)

1. Odvina CV, Zerwekh JE, Rao DS, Maalouf N, Gottschalk FA, Pak CY (2005) Severely suppressed bone turnover: a potential complication of alendronate therapy. J Clin Endocrinol Metab 3:1294–1301
2. Shane E, American Society for Bone and Mineral Research et al (2010) Atypical subtrochanteric and diaphyseal femoral fractures: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res 11:2267–2294
3. Shane E et al. (2013) Atypical subtrochanteric and diaphyseal femoral fractures: Second report of a task force of the American society for bone and mineral research. J Bone Miner Res. doi:10.1002/jbmr
4. Schilcher J, Michaëlsson K, Aspenberg P (2011) Bisphosphonate use and atypical fractures of the femoral shaft. N Engl J Med 364:1728–1737
5. Shkolnikova J, Flynn J, Choong P (2013) Burden of bisphosphonate-associated femoral fractures. ANZ J Surg 3:175–181
6. Goh SK, Yang KY, Koh JS, Wong MK, Chua SY, Chua DT, Howe TS (2007) Subtrochanteric insufficiency fractures in patients on alendronate therapy: a caution. J Bone Joint Surg Br 3:349–353
7. Mashiba T, Turner CH, Hirano T, Forwood MR, Johnston CC, Burr DB (2001) Effects of suppressed bone turnover by bisphosphonates on microdamage accumulation and biomechanical properties in clinically relevant skeletal sites in beagles. Bone 5:524–531
8. Mashiba T, Hirano T, Turner CH, Forwood MR, Johnston CC, Burr DB (2000) Suppressed bone turnover by bisphosphonates increases microdamage accumulation and reduces some bio- mechanical properties in dog rib. J Bone Miner Res. 4:613–620
9. Li J, Mashiba T, Burr DB (2001) Bisphosphonate treatment suppresses not only stochastic remodeling but also the targeted repair of microdamage. Calcif Tissue Int 5:281–286
10. Schneider JP, Hinshaw WB, Su C, Solow P (2012) Atypical femur fractures: 81 individual personal histories. J Clin Endocrinol Metab 12:4324–4328
11. Kwek EB, Goh SK, Koh JS, Png MA, Howe TS (2008) An emerging pattern of subtrochanteric stress fractures: a long-term complication of alendronate therapy? Injury. 2:224–231
12. Isaacs JD, Shidiak L, Harris IA, Szomor ZL (2010) Femoral insufficiency fractures associated with prolonged bisphosphonate therapy. Clin Orthop Relat Res 12:3384–3392
13. Dell RM, Adams AL, Greene DF, Funahashi TT, Silverman SL, Eisemon EO, Zhou H, Burchette RJ, Ott SM (2012) Incidence of atypical nontraumatic diaphyseal fractures of the femur. J Bone Miner Res 12:2544–2550
14. Markman LH, Allison MB, Rosenberg ZS, Vieira RL, Babb JS, Tejwani NC, Im SA, Peck V (2013) A Retrospective Review of Patients with Atypical Femoral Fractures While on Long-Term Bisphosphonates: Including Pertinent Biochemical and Imaging Studies. Endocr Pract. 19:456–461. doi:10.4158/EP121791-23
15. Cakmak S, Mahiroğulları M, Keklikçi K, Sarı E, Erdik B, Rodop O (2013) Bilateral lowenergy sequential femoral shaft fractures in patients on long-term bisphosphonate therapy. Acta Orthop Traumatol Turc. 47:162–172
16. Capeci CM, Bilateral Tejwani NC (2009) Low-energy simultaneous or sequential femoral fractures in patients on long-term alendronate therapy. J Bone Joint Surg Am. 11:2556–2561
17. Koh JS, Goh SK, Png MA, Kwek EB, Howe TS (2010) Femoral cortical stress lesions in long-term bisphosphonate therapy: a herald of impending fracture? J Orthop Trauma 2:75–81
18. Gunawardena I, Baxter M, Rasekh Y (2011) Bisphosphonate-related subtrochanteric femoral fractures. Am J Geriatr Pharmacother 3:194–198
19. Gertz BJ, Holland SD, Kline WF, Matuszewski BK, Porras AG (1993) Clinical pharmacology of alendronate sodium. Osteoporos Int 3:S13–S16
20. Black DM, Schwartz AV, Ensrud KE, Cauley JA, Levis S, Quandt SA, Satterfield S, Wallace RB, Bauer DC, Palermo L, LE Wehren, Lombardi A, Cummings SR, Cummings SR, FLEX Research Group (2006) Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial. JAMA 296:2927–2938
21. Huang HT, Kang L, Huang PJ et al (2012) Successful teriparatide treatment of atypical fracture after long-term use of alendronate without surgical procedure in a postmenopausal woman: a case report. Menopause 19:1360–1363
22. Gomberg SJ, Wustrack RL, Napoli N, Arnaud CD, Black DM (2011) Teriparatide, vitamin D, and calcium healed bilateral subtrochanteric stress fractures in a postmenopausal woman with a 13-year history of continuous alendronate therapy. J Clin Endocrinol Metab 6:1627–1632
23. Carvalho NN, Voss LA, Almeida MO, Salgado CL, Bandeira F (2011) Atypical femoral fractures during prolonged use of bisphosphonates: short-term responses to strontium ranelate and teriparatide. J Clin Endocrinol Metab 96:2675–2680
24. Parrón Cambero R, Rey López A, Tomé-Bermejo F, Cibantos Martínez R (2012) Atypical bilateral femoral shaft fracture in patient treated with bisphosphonates. Eur J Orthop Surg Traumatol 2:S219–S223
25. Puah KL, Tan MH (2011) Bisphosphonate-associated atypical fracture of the femur: Spontaneous healing with drug holiday and re-appearance after resumed drug therapy with bilateral simultaneous displaced fractures: a case report. Acta Orthop 3:380–382