Body mass index and early CD4 T-cell recovery among adults initiating antiretroviral therapy in North America, 1998-2010

HIV Medicine

Volumn 16, Issue 9, 2015, Pages 572-577

  Koethe, J R ^a   Jenkins, C A ^a   Lau, B ^b   Shepherd, B E ^a   Silverberg, M J ^c   Brown, T T ^b   Blashill, A J ^d   Anema, A ^e   Willig, A ^f   Stinnette, S ^g   Napravnik, S ^g   Gill, J ^h   Crane, H M ⁱ   Sterling, T R ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c KAISER PERMANENTE   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e BRITISH COLUMBIA CENTRE FOR EXCELLENCE IN HIV AIDS   (Canada)

^f UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^g UNIVERSITY OF NORTH CAROLINA   (United States)

^h Sheldon M Chumir Health Centre   (Canada)

ⁱ UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Antiretroviral therapy; HIV; Immune reconsitition; Nutrition; Obesity

Indexed keywords

ANTIRETROVIRUS AGENT; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; VIRUS RNA; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ADIPOSE TISSUE; ADULT; ARTICLE; BODY COMPOSITION; BODY MASS; CANADA; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; COHORT ANALYSIS; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE SYSTEM; MAJOR CLINICAL STUDY; MALE; NORTH AMERICA; NUTRITION; OBESITY; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; TREATMENT OUTCOME; UNITED STATES; DRUG EFFECTS; HIV INFECTIONS; IMMUNOLOGY; INFORMATION PROCESSING; MIDDLE AGED; PATHOPHYSIOLOGY; REGRESSION ANALYSIS;

ADULT; ANTI-HIV AGENTS; BODY MASS INDEX; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; DATASETS AS TOPIC; FEMALE; HIV INFECTIONS; HUMANS; MALE; MIDDLE AGED; NORTH AMERICA; REGRESSION ANALYSIS; TREATMENT OUTCOME;

EID: 84940796485     PISSN: 14642662     EISSN: 14681293     Source Type: Journal    
DOI: 10.1111/hiv.12259     Document Type: Article

References (19)

1. Baker JV, Peng G, Rapkin J etal. Poor initial CD4+ recovery with antiretroviral therapy prolongs immune depletion and increases risk for AIDS and non-AIDS diseases. J Acquir Immune Defic Syndr 2008; 48: 541-546.
2. Lewden C, Chene G, Morlat P etal. HIV-infected adults with a CD4 cell count greater than 500 cells/mm3 on long-term combination antiretroviral therapy reach same mortality rates as the general population. J Acquir Immune Defic Syndr 2007; 46: 72-77.
3. Moore RD, Keruly JC. CD4+ cell count 6 years after commencement of highly active antiretroviral therapy in persons with sustained virologic suppression. Clin Infect Dis 2007; 44: 441-446.
4. Torti C, Prosperi M, Motta D etal. Factors influencing the normalization of CD4+ T-cell count, percentage and CD4+/CD8+ T-cell ratio in HIV-infected patients on long-term suppressive antiretroviral therapy. Clin Microbiol Infect 2012; 18: 449-458.
5. Crum-Cianflone NF, Roediger M, Eberly LE etal. Obesity among HIV-infected persons: impact of weight on CD4 cell count. AIDS 2010; 24: 1069-1072.
6. Crum-Cianflone NF, Roediger M, Eberly LE etal. Impact of weight on immune cell counts among HIV-infected persons. Clin Vaccine Immunol 2011; 18: 940-946.
7. Palermo B, Bosch RJ, Bennett K, Jacobson JM. Body mass index and CD4+ T-lymphocyte recovery in HIV-infected men with viral suppression on antiretroviral therapy. HIV Clin Trials 2010; 12: 222-227.
8. Koethe JR, Jenkins CA, Shepherd BE, Stinnette SE, Sterling TR. An optimal body mass index range associated with improved immune reconstitution among HIV-infected adults initiating antiretroviral therapy. Clin Infect Dis 2011; 53: 952-960.
9. Blashill AJ, Mayer KH, Crane HM, Grasso C, Safren SA. Body mass index, immune status, and virological control in HIV-infected men who have sex with men. J Int Assoc Provid AIDS Care 2013; 12: 319-324.
10. Gange SJ, Kitahata MM, Saag MS etal. Cohort profile: the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD). Int J Epidemiol 2007; 36: 294-301.
11. Crum-Cianflone N, Roediger MP, Eberly L etal. Increasing rates of obesity among HIV-infected persons during the HIV epidemic. PLoS ONE 2010; 5: e10106.
12. Amorosa V, Synnestvedt M, Gross R etal. A tale of 2 epidemics: the intersection between obesity and HIV infection in Philadelphia. J Acquir Immune Defic Syndr 2005; 39: 557-561.
13. Oral EA, Javor ED, Ding L etal. Leptin replacement therapy modulates circulating lymphocyte subsets and cytokine responsiveness in severe lipodystrophy. J Clin Endocrinol Metab 2006; 91: 621-628.
14. Farooqi IS, Matarese G, Lord GM etal. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 2002; 110: 1093-1103.
15. Salimonu L. Natural killer activity in protein-calorie malnutrition. In: Cunningham-Rundles S, ed. Nutrient Modulation of the Immune Response. New York, Marcel Dekker, Inc., 1993: 359-368.
16. Gershwin M, Beach R, Hurley L. Nutrition and Immunity. New York, Academic Press, 1984.
17. Womack J, Tien PC, Feldman J etal. Obesity and immune cell counts in women. Metabolism 2007; 56: 998-1004.
18. Viardot A, Heilbronn LK, Samocha-Bonet D, Mackay F, Campbell LV, Samaras K. Obesity is associated with activated and insulin resistant immune cells. Diabetes Metab Res Rev 2012; 28: 447-454.
19. Koethe JR, Hulgan T, Niswender K. Adipose tissue and immune function: a review of evidence relevant to HIV infection. J Infect Dis 2013; 208: 1194-1201.