A Food-Grade Approach to Isolate Crocetin from Saffron (Crocus sativus L.) Extracts

Food Analytical Methods

Volumn 8, Issue 9, 2015, Pages 2261-2272

  Kyriakoudi, Anastasia ^a   Tsimidou, Maria Z ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Crocetin; Crocins; Deoxycholic acid; Inclusion complex; Response surface methodology; Saffron

Indexed keywords

DICHLOROACETIC ACID; ENCAPSULATION; FOOD ADDITIVES; FOURIER TRANSFORM INFRARED SPECTROSCOPY; SCANNING ELECTRON MICROSCOPY; SURFACE PROPERTIES; X RAY DIFFRACTION;

CROCETIN; CROCINS; DEOXYCHOLIC ACID; INCLUSION COMPLEX; RESPONSE SURFACE METHODOLOGY; SAFFRON;

THERMOGRAVIMETRIC ANALYSIS;

EID: 84940796113     PISSN: 19369751     EISSN: 1936976X     Source Type: Journal    
DOI: 10.1007/s12161-015-0111-0     Document Type: Article

References (31)

1. Ahmad AS, Ansari MA, Ahmad M, Saleem S, Yousuf S, Hoda MN, Islam F (2005) Neuroprotection by crocetin in a hemi-parkinsonian rat model. Pharmacol Biochem Behav 81:805–813
2. Aigner Z, Berkesi O, Farkas G, Szabo-Revesz P (2012) DSC, X-Ray and FT-IR studies of a gemfibrozil/dimethyl-β-cyclodextrin inclusion complex produced by co-grinding. J Pharm Biomed Anal 57:62–67
3. Asai A, Nakano T, Takahashi M, Nagao A (2005) Orally administered crocetin and crocins are absorbed into blood plasma as crocetin and its glucuronide conjugates in mice. J Agric Food Chem 53:7302–7306
4. Bortolini O, Fantin G, Fogagnolo M (2005) Bile acid derivatives as enantiodifferentiating host molecules in inclusion processes. Chirality 17:121–130
5. Carmona M, Zalacain A, Sánchez AM, Novella JL, Alonso GL (2006) Crocetin esters, picrocrocin and its related compounds present in Crocus sativus stigmas and Gardenia jasminoides fruits. Tentative identification of seven new compounds by LC-ESI-MS. J Agric Food Chem 54:973–979
6. Chryssanthi DG, Lamari FN, Iatrou G, Pylara A, Karamanos NK, Cordopatis P (2007) Inhibition of breast cancer cell proliferation by style constituents of different Crocus species. Anticancer Res 27:357–362
7. Chryssanthi DG, Dedes PG, Karamanos NK, Cordopatis P, Lamari FN (2011) Crocetin inhibits invasiveness of MDA-MB-231 breast cancer cells via downregulation of matrix metalloproteinases. Planta Med 77:146–151
8. Cormier F, Dufresne C, Dorion S (1995) Enhanced crocetin glucosylation by means of maltosyl-β-cyclodextrin encapsulation. Biotechnol Tech 9:553–556
9. Desai KGH, Park HJ (2005) Recent developments in microencapsulation of food ingredients. Dry Technol 23:1361–1394
10. Fantin G, Fogagnolo M, Medici A, Perrone D (2007) Isolation of lycopene from crude tomato extract via selective inclusion in deoxycholic acid. Tetrahedron Lett 48:9148–9150
11. Fantin G, Fogagnolo M, Maietti S, Rossetti S (2010) Selective removal of monoterpenes from bergamot oil by inclusion in deoxycholic acid. J Agric Food Chem 58:5438–5443
12. Fogagnolo M, Fantin G, Bortolini O (2007) Inclusion compounds of dehydrocholic acid with solvents. Int J Mol Sci 8:662–669
13. Francescutto A, Ciuti P, Iernetti G, Dezhkunov NV (1999) Clarification of the cavitation zone by pulse modulation of the ultrasound field. Europhys Lett 47:49–55
14. Hancock BC, Parks M (2000) What is the true solubility advantage for amorphous pharmaceuticals? Pharm Res 17:397–404
15. ISO 3632-2 (2010) Saffron (Crocus sativus Linneaus). Part 2: test methods. International Organization for Standardization, Geneva
16. Karrer P, Jucker E (1948) Carotinoide. Birkhäuser, Basel
17. Kyriakoudi A, Chrysanthou A, Mantzouridou F, Tsimidou MZ (2012) Revisiting extraction of bioactive apocarotenoids from Crocus sativus L. dry stigmas (saffron). Anal Chim Acta 755:77–85
18. Marcolino VA, Zanin GM, Durrant LR, Benassi MDT, Matioli G (2011) Interaction of curcumin and bixin with β-cyclodextrin: complexation methods, stability and applications in food. J Agric Food Chem 59:3348–3357
19. Neter J, Kutner MH, Nachtsheim CJ, Waaerman W (1996) Applied linear statistical models. McGraw-Hill Companies, London
20. Oguchi T, Tozuka Y, Hanawa T, Mizutani M, Sasaki N, Limmatvapirat S, Yamamoto K (2002) Elucidation of solid-state complexation in ground mixtures of cholic acid and guest compounds. Chem Pharm Bull 50:887–891
21. Ordoudi SA, Befani CD, Nenadis N, Koliakos GG, Tsimidou MZ (2009) Further examination of antiradical properties of Crocus sativus stigmas extract rich in crocins. J Agric Food Chem 57:3080–3086
22. Sampathu SR, Shivashankar S, Lewis YS, Wood AB (1984) Saffron (Crocus sativus Linn.)—cultivation, processing, chemistry and standardization. C R C Crit Rev Food Sci Nutr 20:123–157
23. Schlenk H, Sand DM, Tillotson JA (1955) Stabilization of autoxidizable materials by means of inclusion. J Am Chem Soc 77:3587–3590
24. Selim K, Tsimidou M, Biliaderis CG (2000) Kinetic studies of degradation of saffron carotenoids encapsulated in amorphous polymer matrices. Food Chem 71:199–206
25. Singh R, Bharti N, Madan J, Hiremath SN, Singh R (2010) Characterization of cyclodextrin inclusion complexes—a review. J Pharm Sci Technol 2:171–183
26. Tanaka T, Okemoto H, Kuwahara, N (1995) Crocetin-containing coloring. United States patent, patent number 5:424–407
27. Tarantilis PA, Beljebbar A, Manfait M, Polissiou M (1998) FT-IR, FT-Raman spectroscopic study of carotenoids from saffron (Crocus sativus L.) and some derivatives. Spectrochim Acta Part A 54:651–657
28. Tseng TH, Chu CY, Huang JM, Shiow SJ, Wang CJ (1995) Crocetin protects against oxidative damage in rat primary hepatocytes. Cancer Lett 97:61–67
29. Ulbricht C, Conquer J, Costa D, Hollands W, Iannuzzi C, Isaac R, Jordan JK, Ledesma N, Ostroff C, Serrano JMG, Shaffer MD, Varghese M (2011) An evidence-based systematic review of saffron (Crocus sativus) by the natural standard research collaboration. J Diet Suppl 8:58–114
30. Zalacain A, Ordoudi SA, Blázquez I, Ma Diáz-Plaza E, Carmona M, Tsimidou MZ, Alonso GL (2005) Screening method for the detection of artificial colours in saffron using derivative UV-Vis spectrometry after precipitation of crocetin. Food Addit Contam 22:607–615
31. Zhou H, Yuan X, Zhao Q, Zhao B, Wang X (2013) Determination of oxygen transmission barrier of microcapsule wall by crocetin deterioration kinetics. Eur Food Res Technol 237:639–646