A prospective randomized cohort study evaluating 3 weeks vs 6 weeks of oral antibiotic treatment in the setting of "maximal medical therapy" for chronic rhinosinusitis

International Forum of Allergy and Rhinology

Volumn 5, Issue 9, 2015, Pages 820-828

  Sreenath, Satyan B ^a   Taylor, Robert J ^a   Miller, Justin D ^a   Ambrose, Emily C ^a   Rawal, Rounak B ^a   Ebert, Charles S ^a   Senior, Brent A ^a   Zanation, Adam M ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Chronic rhinosinusitis; Chronic sinusitis survey; Endoscopic sinus surgery; Maximal medical therapy; Rhinosinusitis disability index

Indexed keywords

AZITHROMYCIN; DOXYCYCLINE; MACROLIDE; METHYLPREDNISOLONE; STEROID; ANTIINFECTIVE AGENT;

ADULT; ANTIBIOTIC THERAPY; ARTICLE; CHRONIC RHINOSINUSITIS; CLINICAL ARTICLE; COHORT ANALYSIS; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DRUG EFFICACY; DRUG RESPONSE; DRUG TREATMENT FAILURE; ENDOSCOPIC SINUS SURGERY; FEMALE; HUMAN; MALE; NOSE POLYP; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; TREATMENT DURATION; TREATMENT OUTCOME; CHRONIC DISEASE; DRUG ADMINISTRATION; MIDDLE AGED; NASAL POLYPS; ORAL DRUG ADMINISTRATION; RADIOGRAPHY; RHINITIS; SINUSITIS;

ADMINISTRATION, ORAL; ANTI-BACTERIAL AGENTS; CHRONIC DISEASE; COHORT STUDIES; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; MALE; MIDDLE AGED; NASAL POLYPS; PROSPECTIVE STUDIES; QUALITY OF LIFE; RHINITIS; SINUSITIS; TREATMENT OUTCOME;

EID: 84940792824     PISSN: 20426976     EISSN: 20426984     Source Type: Journal    
DOI: 10.1002/alr.21542     Document Type: Article

References (21)

1. Lund VJ. Maximal medical therapy for chronic rhinosinusitis. Otolaryngol Clin North Am. 2005;38:1301-1310, x.
2. Dubin MG, Liu C, Lin SY, Senior BA. American Rhinologic Society member survey on "maximal medical therapy" for chronic rhinosinusitis. Am J Rhinol. 2007;21:483-488.
3. Sylvester DC, Carr S, Nix P. Maximal medical therapy for chronic rhinosinusitis: a survey of otolaryngology consultants in the United Kingdom. Int Forum Allergy Rhinol. 2013;3:129-132.
4. Lal D, Scianna JM, Stankiewicz JA. Efficacy of targeted medical therapy in chronic rhinosinusitis, and predictors of failure. Am J Rhinol Allergy. 2009;23:396-400.
5. Subramanian HN, Schechtman KB, Hamilos DL. A retrospective analysis of treatment outcomes and time to relapse after intensive medical treatment for chronic sinusitis. Am J Rhinol Allergy. 2002;16:303-312.
6. Van Zele T, Gevaert P, Holtappels G, et al. Oral steroids and doxycycline: two different approaches to treat nasal polyps. J Allergy Clin Immunol. 2010;125:1069-1076.e1064.
7. Soler ZM, Oyer SL, Kern RC, et al. Antimicrobials and chronic rhinosinusitis with or without polyposis in adults: an evidenced-based review with recommendations. Int Forum Allergy Rhinol. 2013;3:31-47.
8. Dubin MG, Kuhn FA, Melroy CT. Radiographic resolution of chronic rhinosinusitis without polyposis after 6 weeks vs 3 weeks of oral antibiotics. Ann Allergy Asthma Immunol. 2007;98:32-35.
9. Fokkens WJ, Lund VJ, Mullol J, et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2012. Rhinol Suppl. 2012;(23):3 p preceding table of contents, 1-298.
10. Rosenfeld RM, Andes D, Bhattacharyya N, et al. Clinical practice guideline: adult sinusitis. Otolaryngol Head Neck Surg. 2007;137(3 Suppl):S1-S31.
11. Harvey RJ, Wallwork BD, Lund VJ. Anti-inflammatory effects of macrolides: applications in chronic rhinosinusitis. Immunol Allergy Clin North Am. 2009;29:689-703.
12. Cervin A, Wallwork B. Macrolide therapy of chronic rhinosinusitis. Rhinology. 2007;45:259-267.
13. Fan Y, Xu R, Hong H, et al. High and low doses of clarithromycin treatment are associated with different clinical efficacies and immunomodulatory properties in chronic rhinosinusitis. J Laryngol Otol. 2014;128:236-241.
14. Wallwork B, Coman W, Mackay-Sim A, Greiff L, Cervin A. A double-blind, randomized, placebo-controlled trial of macrolide in the treatment of chronic rhinosinusitis. Laryngoscope. 2006;116:189-193.
15. Senior BA, Glaze C, Benninger MS. Use of the Rhinosinusitis Disability Index (RSDI) in rhinologic disease. Am J Rhinol. 2001;15:15-20.
16. Gliklich RE, Hilinski JM. Longitudinal sensitivity of generic and specific health measures in chronic sinusitis. Qual Life Res. 1995;4:27-32.
17. Lund VJ, Mackay IS. Staging in rhinosinusitus. Rhinology. 1993;31:183-184.
18. Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd ed. Hillsdale, NJ: Lawrence Erlbaum Associates; 1988.
19. Smith TL, Litvack JR, Hwang PH, et al. Determinants of outcomes of sinus surgery: a multi-institutional prospective cohort study. Otolaryngol Head Neck Surg. 2010;142:55-63.
20. Suberman TA, Zanation AM, Ewend MG, Senior BA, Ebert CS Jr. Sinonasal quality-of-life before and after endoscopic, endonasal, minimally invasive pituitary surgery. Int Forum Allergy Rhinol. 2011;1:161-166.
21. Tashima L, Piccirillo JF. Are antibiotics indicated for acute sinusitis? Laryngoscope. 2014;124:1979-1980.