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Volumn 17, Issue 9, 2015, Pages 1183-1184

PI3K pathway inhibition in GBM - Is there a signal?

Author keywords

[No Author keywords available]

Indexed keywords

3' FLUOROTHYMIDINE F 18; EVEROLIMUS; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; RAPAMYCIN; SONOLISIB; TEMOZOLOMIDE; ANTINEOPLASTIC AGENT; DACARBAZINE; GONANE DERIVATIVE;

EID: 84940761007     PISSN: 15228517     EISSN: 15235866     Source Type: Journal    
DOI: 10.1093/neuonc/nov124     Document Type: Editorial
Times cited : (7)

References (17)
  • 1
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • Parsons DW, Jones S, Zhang X, et al. An integrated genomic analysis of human glioblastoma multiforme. Science. 2008; 321(5897):1807-1812.
    • (2008) Science , vol.321 , Issue.5897 , pp. 1807-1812
    • Parsons, D.W.1    Jones, S.2    Zhang, X.3
  • 2
    • 84885074034 scopus 로고    scopus 로고
    • The somatic genomic landscape of glioblastoma
    • Brennan CW, Verhaak RG, McKenna A, et al. The somatic genomic landscape of glioblastoma. Cell. 2013;155(2):462-477.
    • (2013) Cell , vol.155 , Issue.2 , pp. 462-477
    • Brennan, C.W.1    Verhaak, R.G.2    McKenna, A.3
  • 3
    • 84874650275 scopus 로고    scopus 로고
    • Development of PI3K inhibitors: Lessons learned from early clinical trials
    • Rodon J, Dienstmann R, Serra V, et al. Development of PI3K inhibitors: lessons learned from early clinical trials. Nat Rev Clin Oncol. 2013;10(3):143-153.
    • (2013) Nat Rev Clin Oncol. , vol.10 , Issue.3 , pp. 143-153
    • Rodon, J.1    Dienstmann, R.2    Serra, V.3
  • 4
    • 84940775359 scopus 로고    scopus 로고
    • A phase II trial of everolimus, temozolomide, and radiotherapy in patients with newly diagnosed glioblastoma: NCCTG N057K
    • [Epub ahead of print]
    • Ma DJ, Galanis E, Anderson SK, et al. A phase II trial of everolimus, temozolomide, and radiotherapy in patients with newly diagnosed glioblastoma: NCCTG N057K. Neuro Oncol. 2014; [Epub ahead of print].
    • (2014) Neuro Oncol.
    • Ma, D.J.1    Galanis, E.2    Anderson, S.K.3
  • 5
    • 0037115523 scopus 로고    scopus 로고
    • Inhibition of the mammalian target of rapamycin sensitizes U87 xenografts to fractionated radiation therapy
    • Eshleman JS, Carlson BL, Mladek AC, et al. Inhibition of the mammalian target of rapamycin sensitizes U87 xenografts to fractionated radiation therapy. Cancer Res. 2002;62(24):7291-7297.
    • (2002) Cancer Res. , vol.62 , Issue.24 , pp. 7291-7297
    • Eshleman, J.S.1    Carlson, B.L.2    Mladek, A.C.3
  • 6
    • 84940778136 scopus 로고    scopus 로고
    • Phase II study of PX-866 in recurrent glioblastoma
    • Pitz MW, Eisenhauer EA, MacNeil MV, et al. Phase II study of PX-866 in recurrent glioblastoma. Neuro Oncol. 2015;17(9): 1270-1274.
    • (2015) Neuro Oncol. , vol.17 , Issue.9 , pp. 1270-1274
    • Pitz, M.W.1    Eisenhauer, E.A.2    MacNeil, M.V.3
  • 7
    • 58249120506 scopus 로고    scopus 로고
    • Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance
    • Ihle NT, Lemos R Jr, Wipf P, et al. Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance. Cancer Res. 2009;69(1): 143-150.
    • (2009) Cancer Res. , vol.69 , Issue.1 , pp. 143-150
    • Ihle, N.T.1    Lemos, R.2    Wipf, P.3
  • 8
    • 77956004085 scopus 로고    scopus 로고
    • Cellular and in vivo activity of a novel PI3K inhibitor, PX-866, against human glioblastoma
    • Koul D, Shen R, Kim YW, et al. Cellular and in vivo activity of a novel PI3K inhibitor, PX-866, against human glioblastoma. Neuro Oncol. 2010;12(6):559-569.
    • (2010) Neuro Oncol. , vol.12 , Issue.6 , pp. 559-569
    • Koul, D.1    Shen, R.2    Kim, Y.W.3
  • 9
    • 15044347137 scopus 로고    scopus 로고
    • Monitoring antiproliferative responses to kinase inhibitor therapy in mice with 3′-deoxy-3′-18F-fluorothymidine PET
    • Waldherr C, Mellinghoff IK, Tran C, et al. Monitoring antiproliferative responses to kinase inhibitor therapy in mice with 3′-deoxy-3′-18F-fluorothymidine PET. J Nucl Med. 2005;46(1):114-120.
    • (2005) J Nucl Med. , vol.46 , Issue.1 , pp. 114-120
    • Waldherr, C.1    Mellinghoff, I.K.2    Tran, C.3
  • 10
    • 84907993131 scopus 로고    scopus 로고
    • Molecular imaging for early prediction of response to Sorafenib treatment in sarcoma
    • Li Z, Herrmann K, Pirsig S, et al. Molecular imaging for early prediction of response to Sorafenib treatment in sarcoma. Am J Nucl Med Mol Imaging. 2013;4(1):70-79.
    • (2013) Am J Nucl Med Mol Imaging , vol.4 , Issue.1 , pp. 70-79
    • Li, Z.1    Herrmann, K.2    Pirsig, S.3
  • 11
    • 84877685163 scopus 로고    scopus 로고
    • [18F]-FLT positron emission tomography can be used to image the response of sensitive tumors to PI3-kinase inhibition with the novel agent GDC-0941
    • Cawthorne C, Burrows N, Gieling RG, et al. [18F]-FLT positron emission tomography can be used to image the response of sensitive tumors to PI3-kinase inhibition with the novel agent GDC-0941. Mol Cancer Ther. 2013;12(5):819-828.
    • (2013) Mol Cancer Ther. , vol.12 , Issue.5 , pp. 819-828
    • Cawthorne, C.1    Burrows, N.2    Gieling, R.G.3
  • 12
    • 38849208347 scopus 로고    scopus 로고
    • Antitumor activity of rapamycin in a phase I trial for patients with recurrent PTEN-deficient glioblastoma
    • Cloughesy TF, Yoshimoto K, Nghiemphu P, et al. Antitumor activity of rapamycin in a phase I trial for patients with recurrent PTEN-deficient glioblastoma. PLoS Med. 2008;5(1):e8.
    • (2008) PLoS Med. , vol.5 , Issue.1 , pp. e8
    • Cloughesy, T.F.1    Yoshimoto, K.2    Nghiemphu, P.3
  • 13
    • 23944453425 scopus 로고    scopus 로고
    • Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: A North central cancer treatment group study
    • Galanis E, Buckner JC, Maurer MJ, et al. Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group Study. J Clin Oncol. 2005; 23(23):5294-5304.
    • (2005) J Clin Oncol. , vol.23 , Issue.23 , pp. 5294-5304
    • Galanis, E.1    Buckner, J.C.2    Maurer, M.J.3
  • 14
    • 84925545317 scopus 로고    scopus 로고
    • PI3K in cancer: Divergent roles of isoforms, modes of activation and therapeutic targeting
    • Thorpe LM, Yuzugullu H, Zhao JJ. PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting. Nat Rev Cancer. 2015;15(1):7-24.
    • (2015) Nat Rev Cancer , vol.15 , Issue.1 , pp. 7-24
    • Thorpe, L.M.1    Yuzugullu, H.2    Zhao, J.J.3
  • 15
    • 84883624766 scopus 로고    scopus 로고
    • MTORC1 inhibition is required for sensitivity to PI3K p110alpha inhibitors in PIK3CA-mutant breast cancer
    • Elkabets M, Vora S, Juric D, et al. mTORC1 inhibition is required for sensitivity to PI3K p110alpha inhibitors in PIK3CA-mutant breast cancer. Sci Transl Med. 2013;5(196):196ra99.
    • (2013) Sci Transl Med. , vol.5 , Issue.196 , pp. 196ra99
    • Elkabets, M.1    Vora, S.2    Juric, D.3
  • 16
    • 84883644630 scopus 로고    scopus 로고
    • TORC1 suppression predicts responsiveness to RAF and MEK inhibition in BRAF-mutant melanoma
    • Corcoran RB, Rothenberg SM, Hata AN, et al. TORC1 suppression predicts responsiveness to RAF and MEK inhibition in BRAF-mutant melanoma. Sci Transl Med. 2013;5(196):196ra98.
    • (2013) Sci Transl Med. , vol.5 , Issue.196 , pp. 196ra98
    • Corcoran, R.B.1    Rothenberg, S.M.2    Hata, A.N.3
  • 17
    • 84890056861 scopus 로고    scopus 로고
    • What a tangled web we weave: Emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathway
    • Klempner SJ, Myers AP, Cantley LC. What a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathway. Cancer Discov. 2013;3(12): 1345-1354.
    • (2013) Cancer Discov. , vol.3 , Issue.12 , pp. 1345-1354
    • Klempner, S.J.1    Myers, A.P.2    Cantley, L.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.