Human megakaryocytes confer tissue factor to a subset of shed platelets to stimulate thrombin generation

Thrombosis and Haemostasis

Volumn 114, Issue 3, 2015, Pages 579-592

  Brambilla, Marta ^a   Facchinetti, Laura ^a   Canzano, Paola ^a   Rossetti, Laura ^a   Ferri, Nicola ^b,c   Balduini, Alessandra ^d   Abbonante, Vittorio ^d   Boselli, Daniela ^a   De Marco, Luigi ^e   Di Minno, Matteo N D ^f   Toschi, Vincenzo ^g   Corsini, Alberto ^b,c   Tremoli, Elena ^a,b   Camera, Marina ^a,b  

^a CENTRO CARDIOLOGICO MONZINO   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c IRCCS MULTIMEDICA   (Italy)

^d UNIVERSITY OF PAVIA   (Italy)

^e CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^f UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^g SAN CARLO BORROMEO HOSPITAL   (Italy)

Author keywords

Megakaryocytes; Platelets; Thrombin generation; Tissue factor

Indexed keywords

BETA3 INTEGRIN; COLLAGEN; CYCLOOXYGENASE 1; GLYCOPROTEIN IB; GLYCOPROTEIN IIB; GLYCOPROTEIN IIIA; GLYCOPROTEIN VI; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; SHORT HAIRPIN RNA; THROMBIN; THROMBIN RECEPTOR ACTIVATING PEPTIDE 6; THROMBOPLASTIN; THROMBOPOIETIN; VALPROIC ACID; VERY LATE ACTIVATION ANTIGEN 2; VON WILLEBRAND FACTOR; BIOLOGICAL MARKER; CD34 ANTIGEN; MESSENGER RNA;

ARTICLE; BLOOD CLOTTING; CELL DIFFERENTIATION; CONTROLLED STUDY; ENDOGENOUS THROMBIN POTENTIAL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE SILENCING; HEMOSTASIS; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; MEGAKARYOBLAST; MEGAKARYOCYTE; MEMBRANE MICROPARTICLE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; THROMBOELASTOGRAPHY; TIME TO MAXIMUM PLASMA CONCENTRATION; UMBILICAL CORD BLOOD; BIOSYNTHESIS; CELL LINE; GENETIC TRANSFECTION; GENETICS; KINETICS; METABOLISM; PARACRINE SIGNALING; RNA INTERFERENCE; SIGNAL TRANSDUCTION; THROMBOCYTE;

ANTIGENS, CD34; BIOMARKERS; BLOOD PLATELETS; CELL LINE; HUMANS; KINETICS; MEGAKARYOCYTES; PARACRINE COMMUNICATION; RNA INTERFERENCE; RNA, MESSENGER; SIGNAL TRANSDUCTION; THROMBELASTOGRAPHY; THROMBIN; THROMBOPLASTIN; TRANSFECTION;

EID: 84940703481     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH14-10-0830     Document Type: Article

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