Antibiotic prescribing and associated diarrhoea: A prospective cohort study of care home residents

Age and Ageing

Volumn 44, Issue 5, 2015, Pages 853-860

  Gillespie, David ^a   Hood, Kerenza ^a   Bayer, Antony ^a   Carter, Ben ^a   Duncan, Donna ^b   Espinasse, Aude ^a   Evans, Meirion ^a   Nuttall, Jacqueline ^a   Stanton, Helen ^a   Acharjya, Arun ^c   Allen, Stephen ^d   Cohen, David ^e   Groves, Sam ^e   Francis, Nick ^a   Howe, Robin ^f   Johansen, Antony ^g   Mantzourani, Efi ^a   Thomas Jones, Emma ^a   Toghill, Alun ^a   Wood, Fiona ^a   Wigglesworth, Neil ^f   Wootton, Mandy ^f   Butler, Christopher C ^h   more..

^a CARDIFF UNIVERSITY   (United Kingdom)

^b ABERTAWE BRO MORGANNWG UNIVERSITY HEALTH BOARD   (United Kingdom)

^c PUBLIC HEALTH ENGLAND   (United Kingdom)

^d SWANSEA UNIVERSITY   (United Kingdom)

^e UNIVERSITY OF GLAMORGAN   (United Kingdom)

^f PUBLIC HEALTH WALES   (United Kingdom)

^g CARDIFF AND VALE UNIVERSITY HEALTH BOARD   (United Kingdom)

^h UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Antibiotic prescribing; Antibiotic associated diarrhoea; Care home residents; Clostridium difficile; Older people

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; ANTIINFECTIVE AGENT;

AGED; ANTIBIOTIC ASSOCIATED DIARRHEA; ANTIBIOTIC THERAPY; ARTICLE; CLINICAL FEATURE; CLOSTRIDIUM DIFFICILE INFECTION; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE DURATION; FECES INCONTINENCE; FEMALE; HIGH RISK POPULATION; HOME CARE; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; NURSING HOME; NUTRITIONAL STATUS; PRESCRIPTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RESIDENTIAL HOME; RISK ASSESSMENT; RISK FACTOR; UNITED KINGDOM; VERY ELDERLY; CHEMICALLY INDUCED; CLINICAL PRACTICE; CLINICAL TRIAL; COMPARATIVE STUDY; DIARRHEA; DRUG EFFECTS; DRUG USE; HOME FOR THE AGED; INTESTINE FLORA; MICROBIOLOGY; MULTICENTER STUDY; MULTIVARIATE ANALYSIS; ODDS RATIO; PROPORTIONAL HAZARDS MODEL; STATISTICAL MODEL; TIME FACTOR; WALES;

AGED; AGED, 80 AND OVER; AMOXICILLIN-POTASSIUM CLAVULANATE COMBINATION; ANTI-BACTERIAL AGENTS; DIARRHEA; DRUG PRESCRIPTIONS; DRUG UTILIZATION REVIEW; FEMALE; GASTROINTESTINAL MICROBIOME; HOMES FOR THE AGED; HUMANS; LOGISTIC MODELS; MALE; MULTIVARIATE ANALYSIS; NURSING HOMES; ODDS RATIO; PRACTICE PATTERNS, PHYSICIANS'; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RISK FACTORS; TIME FACTORS; WALES;

EID: 84940670737     PISSN: 00020729     EISSN: 14682834     Source Type: Journal    
DOI: 10.1093/ageing/afv072     Document Type: Article

References (32)

1. Office of Fair Trading. Care Homes for Older People in the UK-A Market Study. Office of Fair Trading, 2005.
2. Bajekal M. Consumer Behaviour and Care Homes-A Literature Assessment. London: The Stationary Office, 2002.
3. Wittenberg R, Comas-Herrera A, Pickard L, Hancock R. Future Demand for Long-Term Care in the UK. A Summary of Projections of Long-Term Care Finance for Older People to 2051. London: Joseph Rowntree Foundation, 2004.
4. Suetens C. Healthcare-associated infections in European longterm care facilities: how big is the challenge. Euro Surveill 2012; 17: 20259.
5. Williams D. Prevalence Survey of Healthcare Associated Infections in Long Term Care Facilities (HALT Study). Wales: Public Health Wales, 2012.
6. Brookes-Howell L, Hood K, Cooper L et al. Clinical influences on antibiotic prescribing decisions for lower respiratory tract infection: a nine country qualitative study of variation in care. BMJ Open 2012; 2: e000795.
7. van Buul L, van der Steen J, Veenhuizen R et al. Antibiotic use and resistance in long term care facilities. J Am Med Dir Assoc 2012; 13: 568.e1-e13.
8. Warren J, Palumbo F, Fitterman L, Speedie S. Incidence and characteristics of antibiotic use in aged nursing home patients. J Am Geriatr Soc 1991; 39: 963-72.
9. Nicolle L, Bentley D, Garibaldi R, Neuhaus E, Smith P. Antimicrobial use in long-term-care facilities. SHEA Long-Term-Care Committee. Infect Control Hosp Epidemiol 2000; 21: 537-45.
10. Benoit S, Nsa W, Richards C et al. Factors associated with antimicrobial use in nursing homes: a multilevel model. J Am Geriatr Soc 2008; 56: 2039-44.
11. Beaugerie L, Petit J. Microbial-gut interactions in health and disease. Antibiotic-associated diarrhoea. Best Pract Res Clin Gastroenterol 2004; 18: 337-52.
12. McFarland LV. Epidemiology, risk factors and treatments for antibiotic-associated diarrhea. Digest Dis 1999; 16: 292-307.
13. Fletcher KR, Cinalli M. Identification, optimal management, and infection control measures for Clostridium difficile-associated disease in long-term care. Geriatr Nurs 2007; 28: 171-81.
14. Monaghan T, Boswell T, Mahida YR. Recent advances in Clostridium difficile-associated disease. Gut 2008; 57: 850-60.
15. Berrington AW. National Clostridium difficile standards group: report to the Department of Health. J Hosp Infect 2004; 56: 1-38.
16. Hood K, Nuttall J, Gillespie D et al. Probiotics for Antibiotic-Associated Diarrhoea (PAAD): a prospective observational study of antibiotic-associated diarrhoea (including Clostridium difficile-associated diarrhoea) in care homes. Health Technology Assessment 2004; 18: 1.
17. Mental Capacity Act 2005. Code of Practice. London: TSO, 2007.
18. Rockwood K, Song X, MacKnight C et al. A global clinical measure of fitness and frailty in elderly people. CMAJ 2005; 173: 489-95.
19. Elia M. Screening for Malnutrition: A Multidisciplinary Responsibility. Development and Use of the 'Malnutrition Universal Screening Tool' ('MUST') for Adults. MAG, a Standing Committee of BAPEN. British Association for Parenteral and Enteral Nutrition (BAPEN), 2003.
20. Lewis SJ, Heaton KW. Stool form scale as a useful guide to intestinal transit time. Scand J Gastroenterol 1997; 32: 920-4.
21. Lewis SJ, Potts LF, Barry RE. The lack of therapeutic effect of Saccharomyces boulardii in the prevention of antibiotic-related diarrhoea in elderly patients. J Infect 1998; 36: 171-4.
22. Hall S, Longhurst S, Higginson IJ. Challenges to conducting research with older people living in nursing homes. BMC Geriatr 2009; 9: 1471-2318.
23. Zermansky AG. Including care home residents in clinical research is fraught. BMJ 2005; 331: 1271-2.
24. Higgins JPT, Green S, Collaboration C. Cochrane Handbook for Systematic Reviews of Interventions. Chichester, UK: Wiley Online Library, 2008.
25. Lievesley N, Crosby G, Bowman C. The Changing Role of Care Homes. London: Centre for Policy on Ageing, 2011.
26. Goodman C, Baron NL, Machen I et al. Culture, consent, costs and care homes: enabling older people with dementia to participate in research. Aging Mental Health 2011; 15: 475-81.
27. Russell CA, Elia M. Nutrition Screening Survey in the UK and Republic of Ireland in 2010. A Report by the British Association for Parenteral and Enteral Nutrition (BAPEN) BAPEN, Redditch. 2011.
28. Health Protection Agency. Voluntary Surveillance of Clostridium difficile associated disease in England, Wales, Northern Ireland, 2012, 2013. http://www.hpa.org.uk/webc/ HPAwebFile/HPAweb_C/1317138039648 (6th March 2013, date last accessed).
29. Roberts C, Roberts J, Roberts RJ. Survey of healthcareassociated infection rates in a nursing home resident population. J Infect Prev 2010; 11: 82-6.
30. Eklund Å, Hartvig P, Tverin I, Palm M, Sylvan S. Prevalence and management of infections in nursing homes in Uppsala County, Sweden. Open Longev Sci 2008; 2: 96-9.
31. Butler CC, Duncan D, Hood K. Does taking probiotics routinely with antibiotics prevent antibiotic associated diarrhoea? BMJ 2012; 344: e682.
32. Allen SJ, Wareham K, Wang D et al. Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): a randomised, double-blind, placebo-controlled, multicentre trial. Lancet 2013; 382: 1249-57.