New Strategies in the Prevention of Actinic Keratosis: A Critical Review

Skin Pharmacology and Physiology

Volumn 28, Issue 6, 2015, Pages 281-289

  Krutmann, Jean ^a,b   Berking, Carola ^c   Berneburg, Mark ^d   Diepgen, Thomas L ^e   Dirschka, Thomas ^f   Szeimies, Markus ^g  

^a IUF LEIBNIZ RESEARCH INSTITUTE FOR ENVIRONMENTAL MEDICINE   (Germany)

^b University of Dösseldorf   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

^d UNIVERSITY OF REGENSBURG   (Germany)

^e UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^f Dermatological Practice Center   (Germany)

^g Department of Dermatology and Allergology   (Germany)

Author keywords

Actinic keratosis; Medical device; Nonmelanoma skin cancer; Photolyase; Photoprotection; Photorepair

Indexed keywords

COSMETIC; DEOXYRIBODIPYRIMIDINE PHOTOLYASE; DEOXYRIBONUCLEASE (PYRIMIDINE DIMER); SUNSCREEN;

ACTINIC KERATOSIS; ADJUVANT THERAPY; CANCER GROWTH; DERMATOLOGIST; DNA DAMAGE; DNA MICROARRAY; DNA REPAIR; EPILUMINESCENCE MICROSCOPY; GENE EXPRESSION; HIGH RISK PATIENT; IMMUNOHISTOCHEMISTRY; MEDICAL DEVICE; MEDICAL DOCUMENTATION; MEDICAL PHOTOGRAPHY; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; PUNCH BIOPSY; REVIEW; SKIN BIOPSY; SKIN CARCINOGENESIS; SKIN DEFECT; SKIN PROTECTION; SOLAR RADIATION; SQUAMOUS CELL CARCINOMA; SUN EXPOSURE; TOPICAL TREATMENT; ULTRAVIOLET RADIATION; ANIMAL; DEVICES; GENETICS; HUMAN; KERATOSIS, ACTINIC;

ANIMALS; DNA DAMAGE; EQUIPMENT AND SUPPLIES; HUMANS; KERATOSIS, ACTINIC; SUNSCREENING AGENTS;

EID: 84940670053     PISSN: 16605527     EISSN: 16605535     Source Type: Journal    
DOI: 10.1159/000437272     Document Type: Review

References (42)

1. Marks R: Epidemiology of non-melanoma skin cancer and solar keratosis in Australia: A tale of self-immolation in Elysian fields. Australas J Dermatol 1997; 38:S26-S29.
2. Frost CA, Green AC: Epidemiology of solar keratoses. Br J Dermatol 1994; 131: 455-464.
3. Stockfleth E, Terhorst D, Braathen L, et al; Guideline Subcommittee of the European Dermatology Forum: Guidelines for the management of actinic keratosis-update 2011. http://bestpractice.bmj.com/best-practice/monograph/616/diagnosis/guidelines.html (accessed August 25, 2013).
4. Schaefer I, Augustin M, Spehr C, Reusch M, Kornek T: Prevalence and risk factors of actinic keratoses in Germany-Analysis of multisource data. J Eur Acad Dermatol Venereol 2014; 28: 309-313.
5. Berman B, Cockerell CJ: Pathobiology of actinic keratosis: ultraviolet-dependent keratinocyte proliferation. J Am Acad Dermatol 2013; 68:S10-S19.
6. Diepgen TL, Brandenburg S, Aberer W, Bauer A, Drexler H, Fartasch M, Malte John, S, Krohn S, Palfner S, Römer W, Schuhmacher-Stock U, Elsner P: Skin cancer induced by natural UV-radiation as an occupational disease-requirements for its notification and recognition. J Dtsch Dermatol Ges 2014; 12: 1102-1106.
7. Schmitt J, Seidler A, Diepgen TL, Bauer A: Occupational UV-light exposure increases the risk for the development of cutaneous squamous cell carcinoma: A systematic review and meta-Analysis. Br J Dermatol 2011; 164: 291-307.
8. Oppel T, Korting HC: Actinic keratosis: The key event in the evolution from photoaged skin to squamous cell carcinoma; therapy based on pathogenetic and clinical aspects. Skin Pharmacol Physiol 2004; 17: 67-76.
9. Segen JC: Field cancerization; in Medical Dictionary-The Free Dictionary. McGraw-Hill Concise Dictionary of Modern Medicine. New York, McGraw-Hill, 2002.
10. Braakhuis BJM, Tabor MP, Kummer JA, Leemans CR, Brakenhoff RH: A genetic explanation of Slaughters concept of field cancerization: evidence and clinical implications. Cancer Res 2003; 63: 1727-1730.
11. Brennan JA, Mao, L, Hruban, RH, Boyle, JO, Koch, WM, Sidransky D: Molecular assessment of histopathological staging in squamous cell carcinoma of the head and neck. N Engl J Med 1995; 332: 429-435.
12. Chen GJ, Feldman SR, Williford PM, Hester EJ, Kiang SH, Gill I, et al: Clinical diagnosis of actinic keratosis identifies an elderly population at high risk of developing skin cancer. Surg Dermatol 2005; 31: 43-47.
13. Mittelbronn MA, Mullins DL, Ramos-Caro FA, Flowers FP: Frequency of pre-existing actinic keratosis in cutaneous squamous cell carcinoma. Int J Dermatol 1998; 37: 677-681.
14. Czarnecki D, Meehan CJ, Bruce F, Culjak G: The majority of cutaneous squamous cell carcinomas arise in actinic keratoses. J Cutan Med Surg 2002; 6: 207-209.
15. Fernández-Figueras MT, Carrato C, Sáenz X, Puig L, Musulen E, Ferrándiz C, Ariza A: Actinic keratosis with atypical basal cells (AK I) is the most common lesion associated with invasive squamous cell carcinoma of the skin. J Eur Acad Dermatol Venereol 2015; 29: 991-997.
16. Dodson JM, DeSpain J, Hewett JE, Clark DP: Malignant potential of actinic keratoses and the controversy over treatment. A patientoriented perspective. Arch Dermatol 1991; 127: 1029-1031.
17. Glogau RG: The risk of progression to invasive disease. J Am Acad Dermatol 2000; 42: 23-24.
18. de Laat WL, Jaspers NGJ, Hoeijmakers JHJ: Molecular mechanism of nucleotide excision repair. Genes Dev 1999; 13: 768-785.
19. Kraemer KH, Levy DD, Parris CN, Gozukara EM, Moriwaki S, Adelberg S, Seidman MM: Xeroderma pigmentosum and related disorders: examining the linkage between defective DNA repair and cancer. J Invest Dermatol 1994; 103(suppl 5):96S-101S.
20. Ziegler A, Jonason AS, Leffell DJ, Simon JA, Sharma HW, Kimmelman J, Remington L, Jacks T, Brash DE: Sunburn and p53 in the onset of skin cancer. Nature 1994; 372: 773-776.
21. Raybaud-Diogène H, Tétu B, Morency R, Fortin A, Monteil RA: p53 overexpression in head and neck squamous cell carcinoma: review of the literature. Eur J Cancer B Oral Oncol 1996; 32B:143-149.
22. Schwarz T, Schwarz A: DNA repair and cytokine responses. J Investig Dermatol Symp Proc 2009; 14: 63-66.
23. Aubin F: Mechanisms involved in ultraviolet light-induced immunosuppression. Eur J Dermatol 2003; 13: 515-523.
24. Thompson SC, Jolley D, Marks R: Reduction of solar keratoses by regular sunscreen use. N Engl J Med 1993; 329: 1147-1151.
25. Naylor MF, Boyd A, Smith DW, Cameron GS, Hubbard D, Neldner KH: High sun protection factor sunscreens in the suppression of actinic neoplasia. Arch Dermatol 1995; 131: 170-175.
26. Ou-Yang H, Stanfield J, Cole C, Appa Y, Rigel D: High-SPF sunscreens (SPF ≥ 70) may provide ultraviolet protection above minimal recommended levels by adequately compensating for lower sunscreen user application amounts. J Am Acad Dermatol 2012; 67: 1220-1227.
27. Neale R, Williams G, Green A: Application patterns among participants randomized to daily sunscreen use in a skin cancer prevention trial. Arch Dermatol 2002; 138: 1319-1325.
28. Ulrich C, Jörgensen JS, Degen A, Hackethal M, Ulrich M, Patel MJ, Eberle J, Terhorst D, Sterry W, Stockfleth E: Prevention of nonmelanoma skin cancer in organ transplant patients by regular use of a sunscreen: A 24 months, prospective, case-control study. Br J Dermatol 2009; 161(suppl 3):78-84.
29. Holick MF: Sunlight, ultraviolet radiation, vitamin D and skin cancer: how much sunlight do we need? Adv Exp Med Biol 2014; 810: 1-16.
30. Terushkin V, Bender A, Psaty EL, Engelsen O, Wang SQ, Halpern AC: Estimated equivalency of vitamin D production from natural sun exposure versus oral vitamin D supplementation across seasons at two US latitudes. J Am Acad Dermatol 2010; 62: 929.e1-e9.
31. Yarosh D, Alas LG, Yee V, Oberyszyn A, Kibitel JT, Mitchell D, Rosenstein R, Spinowitz A: Pyrimidine dimer removal enhanced by DNA repair liposomes reduces the incidence of UV skin cancer in mice. Cancer Res 1992; 52: 4227-4231.
32. Yarosh D, Bucana C, Cox P, Alas L, Kibite, J, Kripke M: Localization of liposomes containing a DNA repair enzyme in murine skin. J Invest Dermatol 1994; 104: 461-468.
33. Yarosh D, Klein J, OConnor A, Hawk J, Rafal E, Wolf P: Effect of topically applied T4 endonuclease V in liposomes on skin cancer in xeroderma pigmentosum: A randomised study. Lancet 2001; 357: 926-929.
34. Stege H, Roza L, Vink AA, Grewe M, Ruzicka T, et al: Enzyme plus light therapy to repair DNA damage in ultraviolet-B-irradiated human skin. Proc Natl Acad Sci USA 2000; 97: 1790-1795.
35. Stege H: Effect of xenogenic repair enzymes on photoimmunology and photocarcinogenesis. J Photochem Photobiol B 2001; 65: 105-108.
36. Puviani M, Barcella A, Milani M: Eryfotona AK-NMSC in the treatment of cancerization field in patients with actinic keratosis or nonmelanoma skin cancer: A report of six cases. G Ital Dermatol Venereol 2013; 148(suppl 2):1-6.
37. Giustini S, Miraglia E, Berardesca E, Milani M, Calvieri S: Preventive long-Term effects of a topical film-forming medical device with ultra-high UV protection filters and DNA repair enzyme in xeroderma pigmentosum: A retrospective study of eight cases. Case Rep Dermatol 2014; 6: 222-226.
38. Puig S, Puig-Butillé JA, Díaz MA, Trullas C, Malvehy J: Field cancerisation improvement with topical application of a film-forming medical device containing photolyase and UV filters in patients with actinic keratosis, a pilot study. J Clin Exp Derm 2014; 5: 1-7.
39. Puig-Butille JM, Malvehy J, Potrony M, Trullas C, Joaquin Dopazo J, Puig S: Role of CPI-17 in restoring skin homoeostasis in cutaneous field of cancerization: effects of topical application of a film-forming medical device containing photolyase and UV filters. Exp Dermatol 2013; 22: 482-501.
40. Rstom SA, Martinez B, Abdalla Z, Rezze GG, Paschoal FM: Avaliação da ação de creme contendo fotolíase em lipossomas e filtro solar FPS 100 na queratose actínica da face: estudo clínico, dermatoscópico e por microscopia confocal. Surg Cosmet Dermatol 2014; 6: 226-231.
41. Shekelle PG, Woolf SH, Eccles M, Grimshaw J: Developing clinical guidelines. West J Med 1999; 170: 348-351.
42. Premi S, Wallisch S, Mano CM, Weiner AB, Bacchiocchi A, Wakamatsu K, Bechara EJ, Halaban R, Douki T, Brash DE: Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure. Science 2015; 347: 842-847.