Nodding syndrome may be only the ears of the hippo

PLoS Neglected Tropical Diseases

Volumn 9, Issue 8, 2015, Pages

  Wamala, Joseph Francis ^a   Malimbo, Mugagga ^a   Tepage, Floribert ^b   Lukwago, Luswa ^a   Okot, Charles Lukoya ^c   Cannon, Robert O ^d   Laudisoit, Anne ^e,f   Colebunders, Robert ^e,g  

^a MINISTRY OF HEALTH   (Uganda)

^b Ministry of Health   (Congo)

^c WORLD HEALTH ORGANIZATION   (Switzerland)

^d ROC Consulting   (United States)

^e UNIVERSITY OF ANTWERP   (Belgium)

^f UNIVERSITY OF LIVERPOOL   (United Kingdom)

^g INSTITUTE OF TROPICAL MEDICINE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

DIETHYLCARBAMAZINE; IVERMECTIN;

ARTICLE; CLINICAL FEATURE; EPILEPSY; HUMAN; META ANALYSIS (TOPIC); NODDING SYNDROME; ONCHOCERCA VOLVULUS; ONCHOCERCIASIS; PUBLIC HEALTH; RISK FACTOR; TONIC CLONIC SEIZURE;

EID: 84940669337     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0003880     Document Type: Article

References (25)

1. Dowell SF, Sejvar JJ, Riek L, Vandemaele KA, Lamunu M, Kuesel AC et al. Nodding syndrome. Emerg Infect Dis 2013; 19(9):1374-84. doi: 10.3201/eid1909.130401 PMID: 23965548
2. Sejvar JJ, Kakooza AM, Foltz JL, Makumbi I, Atai-Omoruto AD, Malimbo M et al. Clinical, neurological, and electrophysiological features of nodding syndrome in Kitgum, Uganda: an observational case series. Lancet Neurol 2013 February; 12(2):166-74. doi: 10.1016/S1474-4422(12)70321-6 PMID: 23305742
3. Idro R, Namusoke H, Abbo C, Mutamba BB, Kakooza-Mwesige A, Opoka RO et al. Patients with nodding syndrome in Uganda improve with symptomatic treatment: a cross-sectional study. BMJ Open 2014; 4(11):e006476. doi: 10.1136/bmjopen-2014-006476 PMID: 25398677
4. Winkler AS, Wallner B, Friedrich K, Pfausler B, Unterberger I, Matuja W et al. A longitudinal study on nodding syndrome-a new African epilepsy disorder. Epilepsia 2014 January; 55(1):86-93. doi: 10. 1111/epi.12483 PMID: 24359274
5. Dietmann A, Wallner B, Konig R, Friedrich K, Pfausler B, F Deisenhammer et al. Nodding syndrome in Tanzania may not be associated with circulating anti-NMDA-and anti-VGKC receptor antibodies or decreased pyridoxal phosphate serum levels-a pilot study. Afr Health Sci 2014 June; 14(2):434-8. doi: 10.4314/ahs.v14i2.20 PMID: 25320594
6. Idro R, Opoka RO, Aanyu HT, Kakooza-Mwesige A, Piloya-Were T, Namusoke H et al. Nodding syndrome in Ugandan children-clinical features, brain imaging and complications: a case series. BMJ Open 2013; 3(5).
7. Winkler AS, Friedrich K, Velicheti S, Dharsee J, Konig R, Nassri A et al. MRI findings in people with epilepsy and nodding syndrome in an area endemic for onchocerciasis: an observational study. Afr Health Sci 2013 June; 13(2):529-40. doi: 10.4314/ahs.v13i2.51 PMID: 24235964
8. Foltz JL, Makumbi I, Sejvar JJ, Malimbo M, Ndyomugyenyi R, Atai-Omoruto AD et al. An Epidemiologic Investigation of Potential Risk Factors for Nodding Syndrome in Kitgum District, Uganda. PLoS One 2013; 8(6):e66419. PMID: 23823012
9. Kaiser C, Pion SD, Boussinesq M. Case-control studies on the relationship between onchocerciasis and epilepsy: systematic review and meta-analysis. PLoS Negl Trop Dis 2013; 7(3):e2147. doi: 10. 1371/journal.pntd.0002147 PMID: 23556028
10. Konig R, Nassri A, Meindl M, Matuja W, Kidunda AR, Siegmund V et al. The role of Onchocerca volvulus in the development of epilepsy in a rural area of Tanzania. Parasitology 2010 September; 137(10): 1559-68. doi: 10.1017/S0031182010000338 PMID: 20388236
11. Duke BO, Vincelette J, Moore PJ. Microfilariae in the cerebrospinal fluid, and neurological complications, during treatment of onchocerciasis with diethylcarbamazine. Tropenmed Parasitol 1976 June; 27(2):123-32. PMID: 941247
12. Winkler AS, Friedrich K, Konig R, Meindl M, Helbok R, Unterberger I et al. The head nodding syndrome-clinical classification and possible causes. Epilepsia 2008 December; 49(12):2008-15. doi: 10.1111/j.1528-1167.2008.01671.x PMID: 18503562
13. Kaiser C, Pion S, Preux PM, Kipp W, Dozie I, Boussinesq M. Onchocerciasis, cysticercosis, and epilepsy. Am J Trop Med Hyg 2008 November; 79(5):643-4. PMID: 18981494
14. Colebunders R, Post R, O'Neill S, Haesaert G, Opar B, Lakwo T et al. Nodding syndrome since 2012: recent progress, challenges and recommendations for future research. Trop Med Int Health 2014 October 28.
15. Iyengar PJ, Wamala J, Ratto J, Blanton C, Malimbo M, Lukwago L et al. Prevalence of nodding syndrome-Uganda, 2012-2013. MMWR Morb Mortal Wkly Rep 2014 July 18; 63(28):603-6. PMID: 25029112
16. World Health Organisation (2012) International Scientific Meeting on Nodding Syndrome, Kampala, Uganda. http://www.globalnurseinitiative.org/uploads/07-2012NS_Scientific_Meeting_Report_FINAL. pdf Accessed July 14, 2015
17. Ministry of Health Uganda (2014) Weekly epidemiological bulletin. Epidemiological week 41 of 2014 [6th October-12th October 2014.] http://health.go.ug/mohweb/node/83 Accessed April 7, 2015.
18. Pion SD, Kaiser C, Boutros-Toni F, Cournil A, Taylor MM, Meredith SE et al. Epilepsy in onchocerciasis endemic areas: systematic review and meta-analysis of population-based surveys. PLoS Negl Trop Dis 2009; 3(6):e461. doi: 10.1371/journal.pntd.0000461 PMID: 19529767
19. Colebunders R, Hendy A, Nanyunja M, Wamala JF, Van Oijen M (2014) Nodding syndrome-a new hypothesis and new direction for research. Int J Infect Dis 2014; 27: 74-77. S1201-9712(14)01579-3
20. Boussinesq M, Pion SD, Demanga N, Kamgno J. Relationship between onchocerciasis and epilepsy: a matched case-control study in the Mbam Valley, Republic of Cameroon. Trans R Soc Trop Med Hyg 2002 September; 96(5):537-41. PMID: 12474484
21. Colebunders R, Hendy A, Couderé K, Musinya G, Mandro M, Tepage F et al. Nodding Syndrome and epilepsy in onchocerciasis endemic regions: comparing the epidemiological situation in 3 different countries [abstract]. European conference on Clinical Microbiology and Infectious Diseases (ECCMID), Copenhagen 25-28 April 2015.
22. Ngugi AK, Bottomley C, Kleinschmidt I, Wagner RG, Kakooza-Mwesige A, Ae-Ngibise K et al. Prevalence of active convulsive epilepsy in sub-Saharan Africa and associated risk factors: cross-sectional and case-control studies. Lancet Neurol 2013 March; 12(3):253-63. doi: 10.1016/S1474-4422(13) 70003-6 PMID: 23375964
23. Johnson T, Tyagi R, Lee PR, Lee M, Johnson KR, Kowalak J et al. Detection of auto-antibodies to leiomodin-1 in patients with nodding syndrome [abstract]. Neuroimmunology 2014; 275(1):103.
24. Tumwine JK, Vandemaele K, Chungong S, Richer M, Anker M, Ayana Y et al. Clinical and epidemiologic characteristics of nodding syndrome in Mundri County, southern Sudan. Afr Health Sci. 2012 Sep; 12(3):242-8. PMID: 23382736
25. Zoure HG, Noma M, Tekle AH, Amazigo UV, Diggle PJ, Giorgi E et al. The geographic distribution of onchocerciasis in the 20 participating countries of the African Programme for Onchocerciasis Control: (2) pre-control endemicity levels and estimated number infected. Parasit Vectors 2014; 7(1):326.