An Epidemiologic Investigation of Potential Risk Factors for Nodding Syndrome in Kitgum District, Uganda

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Foltz, Jennifer L ^a   Makumbi, Issa ^b   Sejvar, James J ^c   Malimbo, Mugagga ^b   Ndyomugyenyi, Richard ^b   Atai Omoruto, Anne Deborah ^b   Alexander, Lorraine N ^d   Abang, Betty ^d   Melstrom, Paul ^e   Kakooza, Angelina M ^f   Olara, Dennis ^d   Downing, Robert G ^d   Nutman, Thomas B ^g   Dowell, Scott F ^d   Lwamafa, D K W ^b  

^a NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION   (United States)

^b MINISTRY OF HEALTH   (Uganda)

^c NATIONAL CENTER FOR EMERGING AND ZOONOTIC INFECTIOUS DISEASES   (United States)

^d CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^e NATIONAL CENTER FOR ENVIRONMENTAL HEALTH   (United States)

^f MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES   (Uganda)

^g NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PYRIDOXINE;

ADOLESCENT; ARTICLE; BLOOD ANALYSIS; CASE CONTROL STUDY; CHILD; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SURVEILLANCE; ENVIRONMENTAL EXPOSURE; FEMALE; FOOD INTAKE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEASLES; NEUROLOGIC DISEASE; NODDING SYNDROME; NUTRITIONAL DEFICIENCY; ONCHOCERCIASIS; PLANT ROOT; PRESCHOOL CHILD; PREVALENCE; PYRIDOXINE DEFICIENCY; RISK FACTOR; SCHOOL CHILD; SORGHUM; TREND STUDY; UGANDA;

ADOLESCENT; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; MALE; NODDING SYNDROME; RISK FACTORS; UGANDA;

EID: 84879163722     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066419     Document Type: Article

References (27)

1. Aall-Jilek L, (1965) Epilepsy in the Wapogoro Tribe in Tanganyika. Acta psychiatrica scandinavica 41: 57-86.
2. van der Waals F, Goudsmit J, Gajdusek DC, (1983) See-ee:Clinical characteristics of highly prevalent seizure disorders in the Gbawein and Wroughbarh Clan region of Grand Bassa County, Liberia. Neuroepidemiology 2: 35-44.
3. Gerrits C, (1983) A West African epilepsy focus. Lancet 1: 358.
4. Kaiser C, Benninger C, Asaba G, Mugisa C, Kabagambe G, et al. (2000) Clinical and electro-clinical classification of epileptic seizure in west Uganda. Bulletin de la Societe de pathologie exotique 93: 255-259.
5. Lacey M, (2003) Nodding disease: mystery of southern Sudan. Lancet Neurol 2: 714.
6. Tumwine J, Vandemaele K, Chungong S, Richer M, Anker M, et al. (2012) Clinical and epidemiologic characteristics of nodding syndrome in Mundri County, South Sudan. African Health Sciences 12: 242-248.
7. Winkler AS, Friedrich K, Konig R, Meindl M, Helbok R, et al. (2008) The head nodding syndrome-clinical classification and possible causes. Epilepsia 49: 2008-2015.
8. Winkler AS, Friedrich K, Meindl M, Kidunda A, Nassri A, et al. (2010) Clinical characteristics of people with head nodding in southern Tanzania. Tropical doctor 40: 173-175.
9. Government of South Sudan WHO, United Nations Children's Fund, (2012) U.S. Centers for Disease Control and Prevention (2012) Nodding Syndrome - South Sudan, 2011. MMWR 61: 52-54.
10. Sejvar JJ, Kakooza A, Foltz JL, Makumbi I, Atai-Omoruto AD, et al. (2013) Clinical, neurological, and electrophysiological features of Nodding Syndrome in Kitgum, Uganda: An observational case series. Lancet Neurology 12: 166-174.
11. Prost A, Prod'hon J, (1978) Parasitological diagnosis of onchocerciasis. A critical review of present methods. Med Trop 38: 519-532.
12. Rybak ME, Pfeiffer CM, (2004) Clinical analysis of vitamin B6: Determination of pyridoxal 5'-phosphate and 4-pyridoxic acid in human serum by reversed-phase high-performance liquid chromatography with chlorite postcolumn derivatization. Anal Biochem 333: 336-344.
13. Nyungura JL, Akim T, Lako A, Gordon A, Lejeng L, et al. (2010) Investigation into nodding syndrome in Witto Payam, Western Equatoria State, 2010. Southern Sudan Medical Journal 4: 3-6.
14. Burbelo PD, Leahy HP, Iadarola MJ, Nutman TB, (2009) A Four-Antigen Mixture for Rapid Assessment of Onchocerca volvulus Infection. PLoS Negl Trop Dis 3: e438.
15. Pion SD, Kaiser C, Boutros-Toni F, Cournil A, Taylor MM, et al. (2009) Epilepsy in onchocerciasis endemic areas: systematic review and meta-analysis of population-based surveys. PLoS Negl Trop Dis 3: e461.
16. Konig R, Nassri A, Meindl M, Matuja W, Kidunda AR, et al. (2010) The role of Onchocerca volvulus in the development of epilepsy in a rural area of Tanzania. Parasitology 137: 1559-1568.
17. Kaiser C, (2009) Head nodding syndrome and river blindness: a parasitologic perspective [Letter]. Epilepsia 50: 2325.
18. Pearlman E, Gillette-Ferguson I (2007) Onchocerca volvulus, Wolbachia and River Blindness. In: Niederkorn J, Kaplan HJ, editors. Immune Response and the Eye Chem Immunol Allergy, Basel, Karger. 254-265.
19. Institute of Medicine, Food and Nutrition Board (1998) Vitamin B6, Chapter 7. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline: National Academy of Sciences. pp. 150-195.
20. Coursin DB, (1954) Convulsive seizures in infants with pyridoxine-deficient diet. JAMA 154: 406-408.
21. Grabow J, Linkswiler H, (1969) Electroencephalographic and nerve-conduction studies in experimental vitamin B6 deficiency in adults. Am J Clin Nutr 22: 1429-1434.
22. Kretsch M, Sauberlich HE, Newbrun E, (1991) Electroencephalographic changes and periodontal status during short- term vitamin B-6 depletion of young, nonpregnant women. Am J Clin Nutr 53: 1266-1274.
23. Baxter P, (2001) Pyridoxine-dependent and pyridoxine-responsive seizures. Dev Med Child Neurol 43: 416-420.
24. Harvey P, Rambeloson Z, Dary O. (2010) The 2008 Uganda Food Consumption Survey: Determining the dietary patterns of Ugandan women and children. A2Z: The USAID Micronutrient and Child Blindness Project, AED. Washington D.C.
25. Bauernfeind J, Miller ON (1978) Vitamin B6: Nutritional and Pharmaceutical Usage, Stability, Bioavailability, Antagonists, and Safety. In: The National Research Council, editor. Human Vitamin B6 Requirements. Washington, DC: National Academy of Sciences.
26. Beg M, Fistein JL, Storey DM, (1995) The host-parasite relationships in pyridoxine (vitamin B6) deficient cotton rats infected with Litomosoides carinii (Nematoda: Filaroidea). Parasitology 111: 111-118.
27. Agresti A (2002) Categorical data analysis. Hoboken, NJ: John Wiley & Sons.