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Volumn 18, Issue 4, 2014, Pages 381-388

Defining phenotypes in COPD: An aid to personalized healthcare

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BIOLOGICAL MARKER; BRONCHODILATING AGENT; CORTICOSTEROID; MUSCARINIC RECEPTOR BLOCKING AGENT; TIOTROPIUM BROMIDE;

EID: 84905676087     PISSN: 11771062     EISSN: 11792000     Source Type: Journal    
DOI: 10.1007/s40291-014-0100-9     Document Type: Review
Times cited : (50)

References (67)
  • 1
    • 85047695734 scopus 로고    scopus 로고
    • Clinical phenotypes of COPD: Identification, definition and implications for guidelines
    • doi:10.1016/j.arbres.2011.10.007
    • Miravitlles M, Calle M, Soler-Cataluna JJ. Clinical phenotypes of COPD: identification, definition and implications for guidelines. Arch Bronconeumol. 2012;48(3):86-98. doi:10.1016/j.arbres.2011.10.007.
    • (2012) Arch Bronconeumol , vol.48 , Issue.3 , pp. 86-98
    • Miravitlles, M.1    Calle, M.2    Soler-Cataluna, J.J.3
  • 2
    • 84905685893 scopus 로고    scopus 로고
    • Global Initiative for Chronic Obstructive Pulmonary Disease. http://www.goldcopd.org/uploads/users/files/GOLD-Report-2014.pdf.
  • 4
    • 77956689733 scopus 로고    scopus 로고
    • Susceptibility to exacerbation in chronic obstructive pulmonary disease
    • doi:10.1056/NEJMoa0909883
    • Hurst JR, Vestbo J, Anzueto A, Locantore N, Mullerova H, Tal-Singer R, et al. Susceptibility to exacerbation in chronic obstructive pulmonary disease. N Engl J Med. 2010;363(12):1128-38. doi:10.1056/NEJMoa0909883.
    • (2010) N Engl J Med , vol.363 , Issue.12 , pp. 1128-1138
    • Hurst, J.R.1    Vestbo, J.2    Anzueto, A.3    Locantore, N.4    Mullerova, H.5    Tal-Singer, R.6
  • 5
    • 0000225183 scopus 로고
    • Chronic bronchitis, asthma and pulmonary emphysema: A statement by the Committee on Diagnostic Standards for Nontuberculous Respiratory Diseases
    • American Thoracic Society
    • American Thoracic Society. Chronic bronchitis, asthma and pulmonary emphysema: a statement by the Committee on Diagnostic Standards for Nontuberculous Respiratory Diseases. Am Rev Respir Dis. 1962;85:762-8.
    • (1962) Am Rev Respir Dis , vol.85 , pp. 762-768
  • 6
    • 0022100360 scopus 로고
    • The definition of emphysema. Report of a National Heart, Lung, and Blood Institute, Division of Lung Diseases workshop
    • The definition of emphysema. Report of a National Heart, Lung, and Blood Institute, Division of Lung Diseases workshop. Am Rev Respir Dis. 1985;132(1):182-5.
    • (1985) Am Rev Respir Dis , vol.132 , Issue.1 , pp. 182-185
  • 7
    • 68049084752 scopus 로고    scopus 로고
    • The overlap syndrome of asthma and COPD: What are its features and how important is it?
    • doi:10.1136/thx.2008.108027
    • Gibson PG, Simpson JL. The overlap syndrome of asthma and COPD: what are its features and how important is it? Thorax. 2009;64(8):728-35. doi:10.1136/thx.2008.108027.
    • (2009) Thorax , vol.64 , Issue.8 , pp. 728-735
    • Gibson, P.G.1    Simpson, J.L.2
  • 8
    • 33750092225 scopus 로고    scopus 로고
    • Clinical analysis of chronic obstructive pulmonary disease phenotypes classified using high-resolution computed tomography
    • DOI 10.1111/j.1440-1843.2006.00930.x
    • Fujimoto K, Kitaguchi Y, Kubo K, Honda T. Clinical analysis of chronic obstructive pulmonary disease phenotypes classified using high-resolution computed tomography. Respirology. 2006;11(6):731-40. doi:10.1111/j.1440-1843. 2006.00930.x. (Pubitemid 44581437)
    • (2006) Respirology , vol.11 , Issue.6 , pp. 731-740
    • Fujimoto, K.1    Kitaguchi, Y.2    Kubo, K.3    Honda, T.4
  • 9
    • 33747828166 scopus 로고    scopus 로고
    • Characteristics of COPD phenotypes classified according to the findings of HRCT
    • DOI 10.1016/j.rmed.2006.02.003, PII S0954611106000643
    • Kitaguchi Y, Fujimoto K, Kubo K, Honda T. Characteristics of COPD phenotypes classified according to the findings of HRCT. Respir Med. 2006;100(10):1742-52. doi:10.1016/j.rmed.2006.02.003. (Pubitemid 44283760)
    • (2006) Respiratory Medicine , vol.100 , Issue.10 , pp. 1742-1752
    • Kitaguchi, Y.1    Fujimoto, K.2    Kubo, K.3    Honda, T.4
  • 10
    • 0034064973 scopus 로고    scopus 로고
    • Toward a consensus definition for COPD exacerbations
    • Rodriguez-Roisin R. Toward a consensus definition for COPD exacerbations. Chest. 2000;117(5 Suppl 2):398S-401S. (Pubitemid 30314474)
    • (2000) Chest , vol.117 , Issue.5 SUPPL. 2
    • Rodriguez-Roisin, R.1
  • 11
    • 33645053487 scopus 로고    scopus 로고
    • COPD exacerbations. 2: Aetiology
    • doi:10.1136/thx.2005.041822
    • Sapey E, Stockley RA. COPD exacerbations. 2: aetiology. Thorax. 2006;61(3):250-8. doi:10.1136/thx.2005.041822.
    • (2006) Thorax , vol.61 , Issue.3 , pp. 250-258
    • Sapey, E.1    Stockley, R.A.2
  • 12
    • 84887909801 scopus 로고    scopus 로고
    • Mechanisms and impact of the frequent exacerbator phenotype in chronic obstructive pulmonary disease
    • doi:10.1186/1741-7015-11-181
    • Wedzicha JA, Brill SE, Allinson JP, Donaldson GC. Mechanisms and impact of the frequent exacerbator phenotype in chronic obstructive pulmonary disease. BMC Med. 2013;11:181. doi:10.1186/1741-7015-11-181.
    • (2013) BMC Med , vol.11 , pp. 181
    • Wedzicha, J.A.1    Brill, S.E.2    Allinson, J.P.3    Donaldson, G.C.4
  • 13
    • 84886406587 scopus 로고    scopus 로고
    • Characterisation of exacerbation risk and exacerbator phenotypes in the POET-COPD trial
    • doi:10.1186/1465-9921-14-116
    • Beeh KM, Glaab T, Stowasser S, Schmidt H, Fabbri LM, Rabe KF, et al. Characterisation of exacerbation risk and exacerbator phenotypes in the POET-COPD trial. Respir Res. 2013;14:116. doi:10.1186/1465-9921-14-116.
    • (2013) Respir Res , vol.14 , pp. 116
    • Beeh, K.M.1    Glaab, T.2    Stowasser, S.3    Schmidt, H.4    Fabbri, L.M.5    Rabe, K.F.6
  • 14
    • 43449117521 scopus 로고    scopus 로고
    • Inhaled and systemic corticosteroids in chronic obstructive pulmonary disease
    • doi:10.1513/pats.200707-096ET
    • Falk JA, Minai OA, Mosenifar Z. Inhaled and systemic corticosteroids in chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2008;5(4):506-12. doi:10.1513/pats.200707-096ET.
    • (2008) Proc Am Thorac Soc , vol.5 , Issue.4 , pp. 506-512
    • Falk, J.A.1    Minai, O.A.2    Mosenifar, Z.3
  • 15
    • 84871253503 scopus 로고    scopus 로고
    • The role of bronchodilator treatment in the prevention of exacerbations of COPD
    • doi:10.1183/09031936.00048912
    • Wedzicha JA, Decramer M, Seemungal TA. The role of bronchodilator treatment in the prevention of exacerbations of COPD. Eur Respir J. 2012;40(6):1545-54. doi:10.1183/09031936.00048912.
    • (2012) Eur Respir J , vol.40 , Issue.6 , pp. 1545-1554
    • Wedzicha, J.A.1    Decramer, M.2    Seemungal, T.A.3
  • 16
    • 79953700575 scopus 로고    scopus 로고
    • Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease
    • doi:10.1111/j.1476-5381.2011.01218.x
    • Rabe KF. Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease. Brit J Pharmacol. 2011;163(1):53-67. doi:10.1111/j.1476-5381.2011.01218.x.
    • (2011) Brit J Pharmacol , vol.163 , Issue.1 , pp. 53-67
    • Rabe, K.F.1
  • 17
    • 69149103642 scopus 로고    scopus 로고
    • Roflumilast in symptomatic chronic obstructive pulmonary disease: Two randomised clinical trials
    • doi:10.1016/S0140-6736(09)61255-1
    • Calverley PM, Rabe KF, Goehring UM, Kristiansen S, Fabbri LM, Martinez FJ. Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials. Lancet. 2009;374(9691):685-94. doi:10.1016/S0140- 6736(09)61255-1.
    • (2009) Lancet , vol.374 , Issue.9691 , pp. 685-694
    • Calverley, P.M.1    Rabe, K.F.2    Goehring, U.M.3    Kristiansen, S.4    Fabbri, L.M.5    Martinez, F.J.6
  • 18
    • 84877589288 scopus 로고    scopus 로고
    • Efficacy of roflumilast in the COPD frequent exacerbator phenotype
    • doi:10.1378/chest.12-1489
    • Wedzicha JA, Rabe KF, Martinez FJ, Bredenbroker D, Brose M, Goehring UM, et al. Efficacy of roflumilast in the COPD frequent exacerbator phenotype. Chest. 2013;143(5):1302-11. doi:10.1378/chest.12-1489.
    • (2013) Chest , vol.143 , Issue.5 , pp. 1302-1311
    • Wedzicha, J.A.1    Rabe, K.F.2    Martinez, F.J.3    Bredenbroker, D.4    Brose, M.5    Goehring, U.M.6
  • 19
    • 0036727140 scopus 로고    scopus 로고
    • Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations
    • DOI 10.1136/thorax.57.9.759
    • Patel IS, Seemungal TA, Wilks M, Lloyd-Owen SJ, Donaldson GC, Wedzicha JA. Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations. Thorax. 2002;57(9):759-64. (Pubitemid 34984972)
    • (2002) Thorax , vol.57 , Issue.9 , pp. 759-764
    • Patel, I.S.1    Seemungal, T.A.R.2    Wilks, M.3    Lloyd-Owen, S.J.4    Donaldson, G.C.5    Wedzicha, J.A.6
  • 20
    • 71049148969 scopus 로고    scopus 로고
    • Efficacy of moxifloxacin in the treatment of bronchial colonisation in COPD
    • doi:10.1183/09031936.00195608
    • Miravitlles M, Marin A, Monso E, Vila S, de la Roza C, Hervas R, et al. Efficacy of moxifloxacin in the treatment of bronchial colonisation in COPD. Eur Respir J. 2009;34(5):1066-71. doi:10.1183/09031936.00195608.
    • (2009) Eur Respir J , vol.34 , Issue.5 , pp. 1066-1071
    • Miravitlles, M.1    Marin, A.2    Monso, E.3    Vila, S.4    De La Roza, C.5    Hervas, R.6
  • 21
    • 56749157688 scopus 로고    scopus 로고
    • Long-term erythromycin therapy is associated with decreased chronic obstructive pulmonary disease exacerbations
    • doi:10.1164/rccm.200801-145OC
    • Seemungal TA, Wilkinson TM, Hurst JR, Perera WR, Sapsford RJ, Wedzicha JA. Long-term erythromycin therapy is associated with decreased chronic obstructive pulmonary disease exacerbations. Am J Respir Crit Care Med. 2008;178(11):1139-47. doi:10.1164/rccm.200801-145OC.
    • (2008) Am J Respir Crit Care Med , vol.178 , Issue.11 , pp. 1139-1147
    • Seemungal, T.A.1    Wilkinson, T.M.2    Hurst, J.R.3    Perera, W.R.4    Sapsford, R.J.5    Wedzicha, J.A.6
  • 23
    • 77952490797 scopus 로고    scopus 로고
    • Pulsed moxifloxacin for the prevention of exacerbations of chronic obstructive pulmonary disease: A randomized controlled trial
    • doi:10.1186/1465-9921-11-10
    • Sethi S, Jones PW, Theron MS, Miravitlles M, Rubinstein E, Wedzicha JA, et al. Pulsed moxifloxacin for the prevention of exacerbations of chronic obstructive pulmonary disease: a randomized controlled trial. Respir Res. 2010;11:10. doi:10.1186/1465-9921-11-10.
    • (2010) Respir Res , vol.11 , pp. 10
    • Sethi, S.1    Jones, P.W.2    Theron, M.S.3    Miravitlles, M.4    Rubinstein, E.5    Wedzicha, J.A.6
  • 24
    • 61749103937 scopus 로고    scopus 로고
    • Tobramycin Nebulizer Solution in severe COPD patients colonized with Pseudomonas aeruginosa: Effects on bronchial inflammation
    • doi:10.1007/s12325-008-0105-2
    • Dal Negro R, Micheletto C, Tognella S, Visconti M, Turati C. Tobramycin Nebulizer Solution in severe COPD patients colonized with Pseudomonas aeruginosa: effects on bronchial inflammation. Adv Therapy. 2008;25(10):1019-30. doi:10.1007/s12325-008-0105-2.
    • (2008) Adv Therapy , vol.25 , Issue.10 , pp. 1019-1030
    • Dal Negro, R.1    Micheletto, C.2    Tognella, S.3    Visconti, M.4    Turati, C.5
  • 25
    • 84872660131 scopus 로고    scopus 로고
    • COPD exacerbations: Causes, prevention, and treatment
    • doi:10.1016/j.iac.2012.10.006
    • Mackay AJ, Hurst JR. COPD exacerbations: causes, prevention, and treatment. Immunol Allergy Clin N Am. 2013;33(1):95-115. doi:10.1016/j.iac.2012. 10.006.
    • (2013) Immunol Allergy Clin N Am , vol.33 , Issue.1 , pp. 95-115
    • Mackay, A.J.1    Hurst, J.R.2
  • 26
    • 84862282452 scopus 로고    scopus 로고
    • Bacterial lysates as a potentially effective approach in preventing acute exacerbation of COPD
    • doi:10.1016/j.coph.2012.01.019
    • Cazzola M, Capuano A, Rogliani P, Matera MG. Bacterial lysates as a potentially effective approach in preventing acute exacerbation of COPD. Current Opin Pharmacol. 2012;12(3):300-8. doi:10.1016/j.coph.2012.01.019.
    • (2012) Current Opin Pharmacol , vol.12 , Issue.3 , pp. 300-308
    • Cazzola, M.1    Capuano, A.2    Rogliani, P.3    Matera, M.G.4
  • 28
    • 33645515247 scopus 로고    scopus 로고
    • Why does the lung hyperinflate?
    • doi:10.1513/pats.200508-094DO
    • Ferguson GT. Why does the lung hyperinflate? Proc Am Thorac Soc. 2006;3(2):176-9. doi:10.1513/pats.200508-094DO.
    • (2006) Proc Am Thorac Soc , vol.3 , Issue.2 , pp. 176-179
    • Ferguson, G.T.1
  • 29
    • 80054874700 scopus 로고    scopus 로고
    • Dynamic pulmonary hyperinflation and low grade systemic inflammation in stable COPD patients
    • Gatta D, Aliprandi G, Pini L, Zanardini A, Fredi M, Tantucci C. Dynamic pulmonary hyperinflation and low grade systemic inflammation in stable COPD patients. Eur Rev Med Pharmacol Sci. 2011;15(9):1068-73.
    • (2011) Eur Rev Med Pharmacol Sci , vol.15 , Issue.9 , pp. 1068-1073
    • Gatta, D.1    Aliprandi, G.2    Pini, L.3    Zanardini, A.4    Fredi, M.5    Tantucci, C.6
  • 30
  • 31
    • 1642493871 scopus 로고    scopus 로고
    • The Role of Long-Acting Bronchodilators in the Management of Stable COPD
    • DOI 10.1378/chest.125.1.249
    • Tashkin DP, Cooper CB. The role of long-acting bronchodilators in the management of stable COPD. Chest. 2004;125(1):249-59. (Pubitemid 38114590)
    • (2004) Chest , vol.125 , Issue.1 , pp. 249-259
    • Tashkin, D.P.1    Cooper, C.B.2
  • 32
    • 84895058605 scopus 로고    scopus 로고
    • Exercise performance after standard rehabilitation in COPD patients with lung hyperinflation
    • doi:10.1007/s11739-011-0727-z
    • Crisafulli E, Venturelli E, Biscione G, Vagheggini G, Iattoni A, Lucic S, et al. Exercise performance after standard rehabilitation in COPD patients with lung hyperinflation. Intern Emerg Med. 2011;. doi:10.1007/s11739-011-0727-z.
    • (2011) Intern Emerg Med
    • Crisafulli, E.1    Venturelli, E.2    Biscione, G.3    Vagheggini, G.4    Iattoni, A.5    Lucic, S.6
  • 33
    • 49449094831 scopus 로고    scopus 로고
    • Comparison of a combination of tiotropium plus formoterol to salmeterol plus fluticasone in moderate COPD
    • doi:10.1378/chest.07-2138
    • Rabe KF, Timmer W, Sagkriotis A, Viel K. Comparison of a combination of tiotropium plus formoterol to salmeterol plus fluticasone in moderate COPD. Chest. 2008;134(2):255-62. doi:10.1378/chest.07-2138.
    • (2008) Chest , vol.134 , Issue.2 , pp. 255-262
    • Rabe, K.F.1    Timmer, W.2    Sagkriotis, A.3    Viel, K.4
  • 34
    • 79251588730 scopus 로고    scopus 로고
    • Reduction of exacerbations by the PDE4 inhibitor roflumilast - The importance of defining different subsets of patients with COPD
    • doi:10.1186/1465-9921-12-18
    • Rennard SI, Calverley PM, Goehring UM, Bredenbroker D, Martinez FJ. Reduction of exacerbations by the PDE4 inhibitor roflumilast - the importance of defining different subsets of patients with COPD. Respir Res. 2011;12:18. doi:10.1186/1465-9921-12-18.
    • (2011) Respir Res , vol.12 , pp. 18
    • Rennard, S.I.1    Calverley, P.M.2    Goehring, U.M.3    Bredenbroker, D.4    Martinez, F.J.5
  • 35
    • 77649179376 scopus 로고    scopus 로고
    • Responses to inhaled long-acting beta-agonist and corticosteroid according to COPD subtype
    • doi:10.1016/j.rmed.2009.10.024
    • Lee JH, Lee YK, Kim EK, Kim TH, Huh JW, Kim WJ, et al. Responses to inhaled long-acting beta-agonist and corticosteroid according to COPD subtype. Respir Med. 2010;104(4):542-9. doi:10.1016/j.rmed.2009.10.024.
    • (2010) Respir Med , vol.104 , Issue.4 , pp. 542-549
    • Lee, J.H.1    Lee, Y.K.2    Kim, E.K.3    Kim, T.H.4    Huh, J.W.5    Kim, W.J.6
  • 36
    • 80054700549 scopus 로고    scopus 로고
    • The National Emphysema Treatment Trial (NETT) Part II: Lessons learned about lung volume reduction surgery
    • doi:10.1164/rccm.201103-0455CI
    • Criner GJ, Cordova F, Sternberg AL, Martinez FJ. The National Emphysema Treatment Trial (NETT) Part II: Lessons learned about lung volume reduction surgery. Am J Respir Crit Care Med. 2011;184(8):881-93. doi:10.1164/rccm.201103- 0455CI.
    • (2011) Am J Respir Crit Care Med , vol.184 , Issue.8 , pp. 881-893
    • Criner, G.J.1    Cordova, F.2    Sternberg, A.L.3    Martinez, F.J.4
  • 37
    • 43449135929 scopus 로고    scopus 로고
    • Pulmonary rehabilitation in emphysema
    • doi:10.1513/pats.200707-093ET
    • Ries AL, Make BJ, Reilly JJ. Pulmonary rehabilitation in emphysema. Proc Am Thorac Soc. 2008;5(4):524-9. doi:10.1513/pats.200707-093ET.
    • (2008) Proc Am Thorac Soc , vol.5 , Issue.4 , pp. 524-529
    • Ries, A.L.1    Make, B.J.2    Reilly, J.J.3
  • 38
    • 84872923830 scopus 로고    scopus 로고
    • The asthma-COPD overlap syndrome: A common clinical problem in the elderly
    • doi:10.1155/2011/861926
    • Zeki AA, Schivo M, Chan A, Albertson TE, Louie S. The asthma-COPD overlap syndrome: a common clinical problem in the elderly. J Allergy. 2011;2011:861926. doi:10.1155/2011/861926.
    • (2011) J Allergy , vol.2011 , pp. 861926
    • Zeki, A.A.1    Schivo, M.2    Chan, A.3    Albertson, T.E.4    Louie, S.5
  • 39
    • 3242656252 scopus 로고    scopus 로고
    • Clinical application of a simple questionnaire for the differentiation of asthma and chronic obstructive pulmonary disease
    • DOI 10.1016/j.rmed.2004.01.004, PII S0954611104000381
    • Beeh KM, Kornmann O, Beier J, Ksoll M, Buhl R. Clinical application of a simple questionnaire for the differentiation of asthma and chronic obstructive pulmonary disease. Respir Med. 2004;98(7):591-7. (Pubitemid 38949921)
    • (2004) Respiratory Medicine , vol.98 , Issue.7 , pp. 591-597
    • Beeh, K.M.1    Kornmann, O.2    Beier, J.3    Ksoll, M.4    Buhl, R.5
  • 41
    • 84860314088 scopus 로고    scopus 로고
    • Sputum eosinophilia can predict responsiveness to inhaled corticosteroid treatment in patients with overlap syndrome of COPD and asthma
    • doi:10.2147/COPD.S30651
    • Kitaguchi Y, Komatsu Y, Fujimoto K, Hanaoka M, Kubo K. Sputum eosinophilia can predict responsiveness to inhaled corticosteroid treatment in patients with overlap syndrome of COPD and asthma. Int J Chron Obstr Pulm Dis. 2012;7:283-9. doi:10.2147/COPD.S30651.
    • (2012) Int J Chron Obstr Pulm Dis , vol.7 , pp. 283-289
    • Kitaguchi, Y.1    Komatsu, Y.2    Fujimoto, K.3    Hanaoka, M.4    Kubo, K.5
  • 42
    • 40049104892 scopus 로고    scopus 로고
    • Immunology of asthma and chronic obstructive pulmonary disease
    • DOI 10.1038/nri2254, PII NRI2254
    • Barnes PJ. Immunology of asthma and chronic obstructive pulmonary disease. Nat Rev Immunol. 2008;8(3):183-92. doi:10.1038/nri2254. (Pubitemid 351323287)
    • (2008) Nature Reviews Immunology , vol.8 , Issue.3 , pp. 183-192
    • Barnes, P.J.1
  • 43
    • 0034727453 scopus 로고    scopus 로고
    • Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: A randomised controlled trial
    • doi:10.1016/S0140-6736(00)02872-5
    • Brightling CE, Monteiro W, Ward R, Parker D, Morgan MD, Wardlaw AJ, et al. Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trial. Lancet. 2000;356(9240):1480-5. doi:10.1016/S0140-6736(00)02872-5.
    • (2000) Lancet , vol.356 , Issue.9240 , pp. 1480-1485
    • Brightling, C.E.1    Monteiro, W.2    Ward, R.3    Parker, D.4    Morgan, M.D.5    Wardlaw, A.J.6
  • 45
    • 40649117704 scopus 로고    scopus 로고
    • Outcomes for COPD pharmacological trials: From lung function to biomarkers
    • doi:10.1183/09031936.00099306
    • Cazzola M, MacNee W, Martinez FJ, Rabe KF, Franciosi LG, Barnes PJ, et al. Outcomes for COPD pharmacological trials: from lung function to biomarkers. Eur Respir J. 2008;31(2):416-69. doi:10.1183/09031936.00099306.
    • (2008) Eur Respir J , vol.31 , Issue.2 , pp. 416-469
    • Cazzola, M.1    MacNee, W.2    Martinez, F.J.3    Rabe, K.F.4    Franciosi, L.G.5    Barnes, P.J.6
  • 46
    • 34547781171 scopus 로고    scopus 로고
    • Biomarkers in COPD: Time for a deep breath
    • DOI 10.1136/thx.2007.084228
    • Stockley RA. Biomarkers in COPD: time for a deep breath. Thorax. 2007;62(8):657-60. doi:10.1136/thx.2007.084228. (Pubitemid 47235002)
    • (2007) Thorax , vol.62 , Issue.8 , pp. 657-660
    • Stockley, R.A.1
  • 47
    • 84873192609 scopus 로고    scopus 로고
    • Systemic biomarkers in the evaluation and management of COPD patients: Are we getting closer to clinical application?
    • Kostikas K, Bakakos P, Papiris S, Stolz D, Celli BR. Systemic biomarkers in the evaluation and management of COPD patients: are we getting closer to clinical application? Current Drug Targets. 2013;14(2):177-91.
    • (2013) Current Drug Targets , vol.14 , Issue.2 , pp. 177-191
    • Kostikas, K.1    Bakakos, P.2    Papiris, S.3    Stolz, D.4    Celli, B.R.5
  • 48
    • 78649333247 scopus 로고    scopus 로고
    • Biomarkers in COPD
    • doi:10.1016/j.pupt.2010.05.001
    • Cazzola M, Novelli G. Biomarkers in COPD. Pulm Pharmacol Ther. 2010;23(6):493-500. doi:10.1016/j.pupt.2010.05.001.
    • (2010) Pulm Pharmacol Ther , vol.23 , Issue.6 , pp. 493-500
    • Cazzola, M.1    Novelli, G.2
  • 49
    • 84879896693 scopus 로고    scopus 로고
    • The mitochondrial Italian Human Proteome Project initiative (mt-HPP)
    • doi:10.1039/c3mb70065h
    • Urbani A, De Canio M, Palmieri F, Sechi S, Bini L, Castagnola M, et al. The mitochondrial Italian Human Proteome Project initiative (mt-HPP). Mol Biosystems. 2013;9(8):1984-92. doi:10.1039/c3mb70065h.
    • (2013) Mol Biosystems , vol.9 , Issue.8 , pp. 1984-1992
    • Urbani, A.1    De Canio, M.2    Palmieri, F.3    Sechi, S.4    Bini, L.5    Castagnola, M.6
  • 50
    • 84867346308 scopus 로고    scopus 로고
    • Application of metabolomics approaches to the study of respiratory diseases
    • doi:10.4155/bio.12.218
    • Snowden S, Dahlen SE, Wheelock CE. Application of metabolomics approaches to the study of respiratory diseases. Bioanalysis. 2012;4(18):2265-90. doi:10.4155/bio.12.218.
    • (2012) Bioanalysis , vol.4 , Issue.18 , pp. 2265-2290
    • Snowden, S.1    Dahlen, S.E.2    Wheelock, C.E.3
  • 51
    • 84871675721 scopus 로고    scopus 로고
    • DNA damage due to oxidative stress in chronic obstructive pulmonary disease (COPD)
    • doi:10.3390/ijms131216853
    • Neofytou E, Tzortzaki EG, Chatziantoniou A, Siafakas NM. DNA damage due to oxidative stress in chronic obstructive pulmonary disease (COPD). Int J Mol Sci. 2012;13(12):16853-64. doi:10.3390/ijms131216853.
    • (2012) Int J Mol Sci , vol.13 , Issue.12 , pp. 16853-16864
    • Neofytou, E.1    Tzortzaki, E.G.2    Chatziantoniou, A.3    Siafakas, N.M.4
  • 52
    • 84879520955 scopus 로고    scopus 로고
    • Exhaled breath analysis by electronic nose in airways disease. Established issues and key questions
    • doi:10.1111/cea.12052
    • Fens N, van der Schee MP, Brinkman P, Sterk PJ. Exhaled breath analysis by electronic nose in airways disease. Established issues and key questions. Clin Exp Allergy J Brit Soc Allergy Clin Immunol. 2013;43(7):705-15. doi:10.1111/cea.12052.
    • (2013) Clin Exp Allergy J Brit Soc Allergy Clin Immunol , vol.43 , Issue.7 , pp. 705-715
    • Fens, N.1    Van Der Schee, M.P.2    Brinkman, P.3    Sterk, P.J.4
  • 53
    • 80053586178 scopus 로고    scopus 로고
    • Pilot analysis of the plasma metabolite profiles associated with emphysematous chronic obstructive pulmonary disease phenotype
    • doi:10.1016/j.bbrc.2011.09.006
    • Paige M, Burdick MD, Kim S, Xu J, Lee JK, Michael Shim Y. Pilot analysis of the plasma metabolite profiles associated with emphysematous chronic obstructive pulmonary disease phenotype. Biochem Biophys Res Commun. 2011;413(4):588-93. doi:10.1016/j.bbrc.2011.09.006.
    • (2011) Biochem Biophys Res Commun , vol.413 , Issue.4 , pp. 588-593
    • Paige, M.1    Burdick, M.D.2    Kim, S.3    Xu, J.4    Lee, J.K.5    Michael Shim, Y.6
  • 54
    • 69949189204 scopus 로고    scopus 로고
    • The influence of radiographic phenotype and smoking status on peripheral blood biomarker patterns in chronic obstructive pulmonary disease
    • doi:10.1371/journal.pone.0006865
    • Bon JM, Leader JK, Weissfeld JL, Coxson HO, Zheng B, Branch RA, et al. The influence of radiographic phenotype and smoking status on peripheral blood biomarker patterns in chronic obstructive pulmonary disease. PloS one. 2009;4(8):e6865. doi:10.1371/journal.pone.0006865.
    • (2009) PloS One , vol.4 , Issue.8
    • Bon, J.M.1    Leader, J.K.2    Weissfeld, J.L.3    Coxson, H.O.4    Zheng, B.5    Branch, R.A.6
  • 56
    • 73749084965 scopus 로고    scopus 로고
    • Systemic and airway inflammation and the presence of emphysema in patients with COPD
    • doi:10.1016/j.rmed.2009.09.016
    • Papaioannou AI, Mazioti A, Kiropoulos T, Tsilioni I, Koutsokera A, Tanou K, et al. Systemic and airway inflammation and the presence of emphysema in patients with COPD. Respir Med. 2010;104(2):275-82. doi:10.1016/j.rmed.2009.09. 016.
    • (2010) Respir Med , vol.104 , Issue.2 , pp. 275-282
    • Papaioannou, A.I.1    Mazioti, A.2    Kiropoulos, T.3    Tsilioni, I.4    Koutsokera, A.5    Tanou, K.6
  • 57
    • 84861410475 scopus 로고    scopus 로고
    • Inflammatory biomarkers improve clinical prediction of mortality in chronic obstructive pulmonary disease
    • doi:10.1164/rccm.201110-1792OC
    • Celli BR, Locantore N, Yates J, Tal-Singer R, Miller BE, Bakke P, et al. Inflammatory biomarkers improve clinical prediction of mortality in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2012;185(10):1065-72. doi:10.1164/rccm.201110-1792OC.
    • (2012) Am J Respir Crit Care Med , vol.185 , Issue.10 , pp. 1065-1072
    • Celli, B.R.1    Locantore, N.2    Yates, J.3    Tal-Singer, R.4    Miller, B.E.5    Bakke, P.6
  • 58
    • 84878927718 scopus 로고    scopus 로고
    • Characterisation of the overlap COPDasthma phenotype. Focus on physical activity and health status
    • doi:10.1016/j.rmed.2013.03.007
    • Miravitlles M, Soriano JB, Ancochea J, Munoz L, Duran-Tauleria E, Sanchez G, et al. Characterisation of the overlap COPDasthma phenotype. Focus on physical activity and health status. Respir Med. 2013;107(7):1053-60. doi:10.1016/j.rmed.2013.03.007.
    • (2013) Respir Med , vol.107 , Issue.7 , pp. 1053-1060
    • Miravitlles, M.1    Soriano, J.B.2    Ancochea, J.3    Munoz, L.4    Duran-Tauleria, E.5    Sanchez, G.6
  • 59
    • 70349955002 scopus 로고    scopus 로고
    • Sputum IL-5 concentration is associated with a sputum eosinophilia and attenuated by corticosteroid therapy in COPD
    • doi:10.1159/000221902
    • Bafadhel M, Saha S, Siva R, McCormick M, Monteiro W, Rugman P, et al. Sputum IL-5 concentration is associated with a sputum eosinophilia and attenuated by corticosteroid therapy in COPD. Respir Int Rev Thorac Dis. 2009;78(3):256-62. doi:10.1159/000221902.
    • (2009) Respir Int Rev Thorac Dis , vol.78 , Issue.3 , pp. 256-262
    • Bafadhel, M.1    Saha, S.2    Siva, R.3    McCormick, M.4    Monteiro, W.5    Rugman, P.6
  • 60
    • 61649107441 scopus 로고    scopus 로고
    • TORCH and UPLIFT: What has been learned from the COPD "mega-trials"?
    • doi:10.1080/15412550902723984
    • Niewoehner DE. TORCH and UPLIFT: what has been learned from the COPD "mega-trials"? Copd. 2009;6(1):1-3. doi:10.1080/15412550902723984.
    • (2009) Copd , vol.6 , Issue.1 , pp. 1-3
    • Niewoehner, D.E.1
  • 61
    • 84905685889 scopus 로고    scopus 로고
    • National Institute for Health and Care Excellence. http://www.nice.org. uk/nicemedia/live/13029/49397/49397.pdf.
  • 62
    • 75649102186 scopus 로고    scopus 로고
    • Targeted treatment in COPD: A multisystem approach for a multi-system disease
    • Anderson D, Macnee W. Targeted treatment in COPD: a multisystem approach for a multi-system disease. Int J Chron Obstr Pulmon Dis. 2009;4:321-35.
    • (2009) Int J Chron Obstr Pulmon Dis , vol.4 , pp. 321-335
    • Anderson, D.1    Macnee, W.2
  • 63
    • 80053058518 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease exacerbations in the COPDGene study: Associated radiologic phenotypes
    • doi:10.1148/radiol.11110173
    • Han MK, Kazerooni EA, Lynch DA, Liu LX, Murray S, Curtis JL, et al. Chronic obstructive pulmonary disease exacerbations in the COPDGene study: associated radiologic phenotypes. Radiology. 2011;261(1):274-82. doi:10.1148/radiol.11110173.
    • (2011) Radiology , vol.261 , Issue.1 , pp. 274-282
    • Han, M.K.1    Kazerooni, E.A.2    Lynch, D.A.3    Liu, L.X.4    Murray, S.5    Curtis, J.L.6
  • 64
    • 84871589418 scopus 로고    scopus 로고
    • Comparative effectiveness of drugs for chronic obstructive pulmonary disease
    • doi:10.1358/dot.2012.48.12.1860770
    • Cazzola M, Segreti A, Rogliani P. Comparative effectiveness of drugs for chronic obstructive pulmonary disease. Drugs Today (Barc). 2012;48(12):785-94. doi:10.1358/dot.2012.48.12.1860770.
    • (2012) Drugs Today (Barc) , vol.48 , Issue.12 , pp. 785-794
    • Cazzola, M.1    Segreti, A.2    Rogliani, P.3
  • 65
    • 79955498646 scopus 로고    scopus 로고
    • Addressing the complexity of chronic obstructive pulmonary disease: From phenotypes and biomarkers to scale-free networks, systems biology, and P4 medicine
    • doi:10.1164/rccm.201009-1414PP
    • Agusti A, Sobradillo P, Celli B. Addressing the complexity of chronic obstructive pulmonary disease: from phenotypes and biomarkers to scale-free networks, systems biology, and P4 medicine. Am J Respir Crit Care Med. 2011;183(9):1129-37. doi:10.1164/rccm.201009-1414PP.
    • (2011) Am J Respir Crit Care Med , vol.183 , Issue.9 , pp. 1129-1137
    • Agusti, A.1    Sobradillo, P.2    Celli, B.3
  • 66
    • 84875229819 scopus 로고    scopus 로고
    • Clinical phenotypes of chronic obstructive pulmonary disease and asthma: Recent advances
    • quiz 35. doi:10.1016/j.jaci.2013.01.010
    • Carolan BJ, Sutherland ER. Clinical phenotypes of chronic obstructive pulmonary disease and asthma: recent advances. J Allergy Clin Immunol. 2013;131(3):627-34; quiz 35. doi:10.1016/j.jaci.2013.01.010.
    • (2013) J Allergy Clin Immunol , vol.131 , Issue.3 , pp. 627-634
    • Carolan, B.J.1    Sutherland, E.R.2


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