Research on ursolic acid production of Eriobotrya japonica cell suspension culture in WAVE bioreactor

Zhongguo Zhongyao Zazhi

Volumn 40, Issue 9, 2015, Pages 1693-1698

  Li, Hui Hua ^a   Yao, De Heng ^a   Xu, Jian ^a   Wang, Wei ^a   Chang, Qiang ^a   Su, Ming Hua ^a  

^a Fujian Institute of Subtropical Botany   (China)

Author keywords

Bioreactor; Cell suspension culture; Loquat; Ursolic acid

Indexed keywords

URSOLIC ACID; CULTURE MEDIUM; TRITERPENE;

ARTICLE; BIOMASS; BIOREACTOR; CELL GROWTH; CELL SUSPENSION; CULTURE MEDIUM; DRY WEIGHT; LOQUAT; NONHUMAN; PLANT CELL CULTURE; WAVE BIOREACTOR; CHEMISTRY; CULTURE TECHNIQUE; DEVICES; ERIOBOTRYA; EVALUATION STUDY; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PROCEDURES;

BIOMASS; BIOREACTORS; CELL CULTURE TECHNIQUES; CULTURE MEDIA; ERIOBOTRYA; TRITERPENES;

EID: 84940662513     PISSN: 10015302     EISSN: None     Source Type: Journal    
DOI: 10.4268/cjcmm20150912     Document Type: Article

References (11)

1. Tsai S J, Yin M C. Antioxidative and anti-inflammatory protection of oleanolic acid and ursolic acid in PC12 cells[J]. J Food Sci, 2008, 73(7): H174.
2. Machado D G, Neis V B, Balen GO, et al. Antidepraesant-like eefect of ursolic acid isolated from Rossnaruus officinalis L. in mice: evidence for the involvement of the dopaminergic system [J]. Pharmacol Biochem Behav, 2012, 103(2): 204.
3. YU Yan-xia, GU Zhen-lun, YIN Jiang-lin, et al. Ursolic acid induces human hepatoma cell line SMMC-7721 apoptosis via p53-dependent pathway[J]. Chin Med J, 2010, 123: 1915.
4. Jang S M, Yee S T, Choi J, et al. Ursolic acid enhances the cel-lularimmunesystem and pancreatic beta-cell function in strepto-zotocin-induced diabetic mice fed a high-fat diet[J]. Intimmuno Pharma Col, 2009, 9(1): 113.
5. Lu J, Zheng Y L, Wu DM, et al. Ursolic acid ameliorates cognition deficitsand atenuatesoxidativedamagein the brain of senescent mice induced by D-galactose [J]. Biochem Pharmacol, 2007, 74(7): 1078.
6. Ho H Y, Liang K Y, Lin W C, et al. Regulation and improvement of triterpene formation in plant cultured cells of Eriobotrya Baponica Lindl[J]. J Biosci Bioeng, 2010, 110(5): 588.
7. Shih C C, Ciu J L, Lin CH, et al. Cell suspension culture of Eriobotrya Baponica regulats the diabetic and hyperlipidmic sign of high-fat-fed mic [J]. Molcules, 2013, 18: 2726.
8. Smetanska I. Production of secondary metabolites using plant cell cultures [J]. Adv Biochem Eng Biotechnol, 2008, 111: 187.
9. Verpoorte R, Contin A, Memelink J. Biotechnology for the production of plants secondary metabolites [J]. Phytochem Rev, 2002, 1: 13.
10. Raven N, Rasche S, Kuehn C. et al. Scaled-up manufacturing of recombinant antibodies produced by plant cells in a 200-L or-bitally-shaken disposable bioreactor [J] Biotechnol Bioeng, 2015, 112(2): 308
11. Boisson A M, Gout E, Bligny R, et al. A simple and efficient method for the long-term preservation of plant cell suspension cultures[J]. Plant Methods, 2012, 8: 4.