Reduction of indoxyl sulfate by AST-120 attenuates monocyte inflammation related to chronic kidney disease

Journal of Leukocyte Biology

Volumn 93, Issue 6, 2013, Pages 837-845

  Ito, Shunsuke ^a,b   Higuchi, Yusuke ^b   Yagi, Yoko ^b   Nishijima, Fuyuhiko ^b   Yamato, Hideyuki ^b   Ishii, Hideto ^a   Osaka, Mizuko ^a   Yoshida, Masayuki ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b KUREHA CORPORATION   (Japan)

Author keywords

Adhesion molecule; Atherosclerosis; Leukocyte endothelial interactions; Oxidative stress; Uremic toxin

Indexed keywords

APOCYNIN; AST 120; CELL ADHESION MOLECULE; INDICAN; INTERLEUKIN 1BETA; JANUS KINASE; MAC 1 PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL ACTIVATION; CELL ADHESION; CHRONIC KIDNEY DISEASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR SIGNALING; MALE; MONOCYTE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; UMBILICAL VEIN ENDOTHELIAL CELL;

ADHESION MOLECULE; ATHEROSCLEROSIS; LEUKOCYTE-ENDOTHELIAL INTERACTIONS; OXIDATIVE STRESS; UREMIC TOXIN;

ANIMALS; CARBON; CARDIOVASCULAR DISEASES; CELL LINE; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; GASTROINTESTINAL AGENTS; HUMANS; IMMUNOBLOTTING; INDICAN; INFLAMMATION; MALE; MICE; MICE, INBRED C57BL; MONOCYTES; OXIDES; REACTIVE OXYGEN SPECIES; RENAL INSUFFICIENCY, CHRONIC;

MUS;

EID: 84878422338     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.0112023     Document Type: Article

References (45)

1. Wheeler, D. C. (1996) Cardiovascular disease in patients with chronic renal failure. Lancet 348, 1673-1674.
2. Amann, K., Gross, M. L., Ritz, E. (2004) Pathophysiology underlying accelerated atherogenesis in renal disease: closing in on the target. J. Am. Soc. Nephrol. 15, 1664-1666.
3. Go, A. S., Chertow, G. M., Fan, D., McCulloch, C. E., Hsu, C. Y. (2004) Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N. Engl. J. Med. 351, 1296-1305.
4. Ronco, C., Haapio, M., House, A. A., Anavekar, N., Bellomo, R. (2008) Cardiorenal syndrome. J. Am. Coll. Cardiol. 52, 1527-1539.
5. Ross, R. (1999) Atherosclerosis-an inflammatory disease. N. Engl. J. Med. 340, 115-126.
6. Pietersma, A., Kofflard, M., de Wit, L. E., Stijnen, T., Koster, J. F., Serruys, P. W., Sluiter, W. (1995) Late lumen loss after coronary angioplasty is associated with the activation status of circulating phagocytes before treatment. Circulation 91, 1320-1325.
7. Nageh, M. F., Sandberg, E. T., Marotti, K. R., Lin, A. H., Melchior, E. P., Bullard, D. C., Beaudet, A. L. (1997) Deficiency of inflammatory cell adhesion molecules protects against atherosclerosis in mice. Arterioscler. Thromb. Vasc. Biol. 17, 1517-1520.
8. Hynes, R. O. (1987) Integrins: a family of cell surface receptors. Cell 48, 549-554.
9. Hynes, R. O. (1992) Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69, 11-25.
10. Rogers, C., Edelman, E. R., Simon, D. I. (1998) A mAb to the 2-leukocyte integrin Mac-1 (CD11b/CD18) reduces intimal thickening after angioplasty or stent implantation in rabbits. Proc. Natl. Acad. Sci. USA 95, 10134-10139.
11. Simon, D. I., Dhen, Z., Seifert, P., Edelman, E. R., Ballantyne, C. M., Rogers, C. (2000) Decreased neointimal formation in Mac-1 mice reveals a role for inflammation in vascular repair after angioplasty. J. Clin. Invest. 105, 293-300.
12. Yoon, J. W., Pahl, M. V., Vaziri, N. D. (2007) Spontaneous leukocyte activation and oxygen-free radical generation in end-stage renal disease. Kidney Int. 71, 167-172.
13. Stenvinkel, P., Ketteler, M., Johnson, R. J., Lindholm, B., Pecoits-Filho, R., Riella, M., Heimburger, O., Cederholm, T., Girndt, M. (2005) IL-10, IL-6, and TNF-[1]: central factors in the altered cytokine network of uremia-the good, the bad, and the ugly. Kidney Int. 67, 1216-1233.
14. Anrather, J., Racchumi, G., Iadecola, C. (2006) NF-B regulates phagocytic NADPH oxidase by inducing the expression of gp91phox. J. Biol. Chem. 281, 5657-5667.
15. Kaul, N., Devaraj, S., Jialal, I. (2001) Tocopherol and atherosclerosis. Exp. Biol. Med. (Maywood) 226, 5-12.
16. Schulman, G., Agarwal, R., Acharya, M., Berl, T., Blumenthal, S., Kopyt, N. (2006) A multicenter, randomized, double-blind, placebo-controlled, dose-ranging study of AST-120 (Kremezin) in patients with moderate to severe CKD. Am. J. Kidney Dis. 47, 565-577.
17. Iida, S., Kohno, K., Yoshimura, J., Ueda, S., Usui, M., Miyazaki, H., Nishida, H., Tamaki, K., Okuda, S. (2006) Carbonic-adsorbent AST-120 reduces overload of IS and the plasma level of TGF-1 in patients with chronic renal failure. Clin. Exp. Nephrol. 10, 262-267.
18. Shoji, T., Wada, A., Inoue, K., Hayashi, D., Tomida, K., Furumatsu, Y., Kaneko, T., Okada, N., Fukuhara, Y., Imai, E., Tsubakihara, Y. (2007) Prospective randomized study evaluating the efficacy of the spherical adsorptive carbon AST-120 in chronic kidney disease patients with moderate decrease in renal function. Nephron. Clin. Pract. 105, c99-c107.
19. Namikoshi, T., Tomita, N., Satoh, M., Sakuta, T., Kuwabara, A., Kobayashi, S., Higuchi, Y., Nishijima, F., Kashihara, N. (2009) Oral adsorbent AST-120 ameliorates endothelial dysfunction independent of renal function in rats with subtotal nephrectomy. Hypertens. Res. 32, 194-200.
20. Kikuchi, K., Itoh, Y., Tateoka, R., Ezawa, A., Murakami, K., Niwa, T. (2010) Metabolomic search for uremic toxins as indicators of the effect of an oral sorbent AST-120 by liquid chromatography/tandem mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 878, 2997-3002.
21. Vanholder, R., De Smet, R. (1999) Pathophysiologic effects of uremic retention solutes. J. Am. Soc. Nephrol. 10, 1815-1823.
22. Vanholder, R., De Smet, R., Glorieux, G., Argiles, A., Baurmeister, U., Brunet, P., Clark, W., Cohen, G., De Deyn, P. P., Deppisch, R., Descamps-Latscha, B., Henle, T., Jorres, A., Lemke, H. D., Massy, Z. A., Passlick-Deetjen, J., Rodriguez, M., Stegmayr, B., Stenvinkel, P., Tetta, C., Wanner, C., Zidek, W. (2003) Review on uremic toxins: classification, concentration, and interindividual variability. Kidney Int. 63, 1934-1943.
23. Niwa, T. (2010) Indoxyl sulfate is a nephro-vascular toxin. J. Ren. Nutr. 20, S2-S6.
24. Niwa, T., Ise, M. (1994) Indoxyl sulfate, a circulating uremic toxin, stimulates the progression of glomerular sclerosis. J. Lab. Clin. Med. 124, 96-104.
25. Niwa, T., Ise, M., Miyazaki, T. (1994) Progression of glomerular sclerosis in experimental uremic rats by administration of indole, a precursor of indoxyl sulfate. Am. J. Nephrol. 14, 207-212.
26. Kobayashi, N., Maeda, A., Horikoshi, S., Shirato, I., Tomino, Y., Ise, M. (2002) Effects of oral adsorbent AST-120 (Kremezin) on renal function and glomerular injury in early-stage renal failure of subtotal nephrectomized rats. Nephron 91, 480-485.
27. Palm, F., Nangaku, M., Fasching, A., Tanaka, T., Nordquist, L., Hansell, P., Kawakami, T., Nishijima, F., Fujita, T. (2010) Uremia induces abnormal oxygen consumption in tubules and aggravates chronic hypoxia of the kidney via oxidative stress. Am. J. Physiol. Renal Physiol. 299, F380-F386.
28. Yu, M., Kim, Y. J., Kang, D. H. (2011) Indoxyl sulfate-induced endothelial dysfunction in patients with chronic kidney disease via an induction of oxidative stress. Clin. J. Am. Soc. Nephrol. 6, 30-39.
29. Yamamoto, H., Tsuruoka, S., Ioka, T., Ando, H., Ito, C., Akimoto, T., Fujimura, A., Asano, Y., Kusano, E. (2006) Indoxyl sulfate stimulates proliferation of rat vascular smooth muscle cells. Kidney Int. 69, 1780-1785.
30. Shimizu, H., Hirose, Y., Nishijima, F., Tsubakihara, Y., Miyazaki, H. (2009) ROS and PDGF- [corrected] receptors are critically involved in indoxyl sulfate actions that promote vascular smooth muscle cell proliferation and migration. Am. J. Physiol. Cell. Physiol. 297, C389-C396.
31. Muteliefu, G., Enomoto, A., Niwa, T. (2009) Indoxyl sulfate promotes proliferation of human aortic smooth muscle cells by inducing oxidative stress. J. Ren. Nutr. 19, 29-32.
32. Ito, S., Osaka, M., Higuchi, Y., Nishijima, F., Ishii, H., Yoshida, M. (2010) Indoxyl sulfate induces leukocyte-endothelial interactions through up-regulation of E-selectin. J. Biol. Chem. 285, 38869-38875.
33. Nakai, K., Fujii, H., Kono, K., Goto, S., Fukagawa, M., Nishi, S. (2011) Effects of AST-120 on left ventricular mass in predialysis patients. Am. J. Nephrol. 33, 218-223.
34. Shibahara, H., Shibahara, N. (2010) Cardiorenal protective effect of the oral uremic toxin absorbent AST-120 in chronic heart disease patients with moderate CKD. J. Nephrol. 23, 535-540.
35. Fujii, H., Nishijima, F., Goto, S., Sugano, M., Yamato, H., Kitazawa, R., Kitazawa, S., Fukagawa, M. (2009) Oral charcoal adsorbent (AST-120) prevents progression of cardiac damage in chronic kidney disease through suppression of oxidative stress. Nephrol. Dial. Transplant. 24, 2089-2095.
36. Prabhakar, S., Starnes, J., Shi, S., Lonis, B., Tran, R. (2007) Diabetic nephropathy is associated with oxidative stress and decreased renal nitric oxide production. J. Am. Soc. Nephrol. 18, 2945-2952.
37. Fujii, H., Kono, K., Nakai, K., Goto, S., Komaba, H., Hamada, Y., Shinohara, M., Kitazawa, R., Kitazawa, S., Fukagawa, M. (2010) Oxidative and nitrosative stress and progression of diabetic nephropathy in type 2 diabetes. Am. J. Nephrol. 31, 342-352.
38. Bolton, W. K., Innes D. J., Jr., Sturgill, B. C., Kaiser, D. L. (1987) T-cells and macrophages in rapidly progressive glomerulonephritis: clinicopathologic correlations. Kidney Int. 32, 869-876.
39. Nakatani, K., Fujii, H., Hasegawa, H., Terada, M., Arita, N., Ito, M. R., Ono, M., Takahashi, S., Saiga, K., Yoshimoto, S., Iwano, M., Shiiki, H., Saito, Y., Nose, M. (2004) Endothelial adhesion molecules in glomerular lesions: association with their severity and diversity in lupus models. Kidney Int. 65, 1290-1300.
40. Wu, Y. G., Lin, H., Qi, X. M., Wu, G. Z., Qian, H., Zhao, M., Shen, J. J., Lin, S. T. (2006) Prevention of early renal injury by mycophenolate mofetil and its mechanism in experimental diabetes. Int. Immunopharmacol. 6, 445-453.
41. Hagita, S., Osaka, M., Shimokado, K., Yoshida, M. (2008) Oxidative stress in mononuclear cells plays a dominant role in their adhesion to mouse femoral artery after injury. Hypertension 51, 797-802.
42. Barreto, F. C., Barreto, D. V., Liabeuf, S., Meert, N., Glorieux, G., Temmar, M., Choukroun, G., Vanholder, R., Massy, Z. A. (2009) Serum indoxyl sulfate is associated with vascular disease and mortality in chronic kidney disease patients. Clin. J. Am. Soc. Nephrol. 4, 1551-1558.
43. Mendez-Samperio, P., Perez, A., Alba, L. (2010) Reactive oxygen species- activated p38/ERK 1/2 MAPK signaling pathway in the Mycobacterium bovis bacillus Calmette Guerin (BCG)-induced CCL2 secretion in human monocytic cell line THP-1. Arch. Med. Res. 41, 579-585.
44. Ghori, K., O'Driscoll, J., Shorten, G. (2010) The effect of midazolam on neutrophil mitogen-activated protein kinase. Eur. J. Anaesthesiol. 27, 562-565.
45. Lekawanvijit, S., Adrahtas, A., Kelly, D. J., Kompa, A. R., Wang, B. H., Krum, H. (2010) Does indoxyl sulfate, a uraemic toxin, have direct effects on cardiac fibroblasts and myocytes? Eur. Heart. J. 31, 1771-1779.