Cleaved high-molecular-weight kininogen inhibits neointima formation following vascular injury

Thrombosis and Haemostasis

Volumn 114, Issue 3, 2015, Pages 603-613

  Daniel, Jan Marcus ^a,b   Reich, Fabian ^c   Dutzmann, Jochen ^a   Weisheit, Simona ^a   Teske, Rebecca ^c   Gündüz, Dursun ^c   Bauersachs, Johann ^a   Preissner, Klaus T ^b   Sedding, Daniel G ^a,b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

^c UNIVERSITY HOSPITAL GIESSEN   (Germany)

Author keywords

Cell adhesion; Cleaved high molecular weight kininogen (HKa); Inflammation; Neointimal formation; Smooth muscle cells

Indexed keywords

ENHANCED GREEN FLUORESCENT PROTEIN; HIGH MOLECULAR WEIGHT KININOGEN; VITRONECTIN; GREEN FLUORESCENT PROTEIN; HKA PROTEIN, HUMAN; INTEGRIN; PEPTIDE FRAGMENT;

ADULT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD ANALYSIS; BLOOD VESSEL INJURY; BONE MARROW TRANSPLANTATION; BRDU ASSAY; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMORAL ARTERY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; IRRADIATION; LEUKOCYTE ADHERENCE; MALE; MOUSE; NEOINTIMA; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; TUNEL ASSAY; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; GENETICS; INJURIES; METABOLISM; NEUTROPHIL CHEMOTAXIS; PATHOLOGY; PROTEIN TERTIARY STRUCTURE; REPORTER GENE; SMOOTH MUSCLE CELL; TIME FACTOR; TRANSGENIC MOUSE; U937 CELL LINE; VASCULAR SMOOTH MUSCLE; VASCULAR SYSTEM INJURIES;

ANIMALS; BONE MARROW TRANSPLANTATION; CELL PROLIFERATION; CHEMOTAXIS, LEUKOCYTE; DISEASE MODELS, ANIMAL; FEMORAL ARTERY; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HUMANS; INTEGRINS; KININOGEN, HIGH-MOLECULAR-WEIGHT; MALE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NEOINTIMA; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; TIME FACTORS; U937 CELLS; VASCULAR SYSTEM INJURIES; VITRONECTIN;

EID: 84940643165     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH15-01-0013     Document Type: Article

References (34)

1. McBride W, Lange RA, Hillis LD. Restenosis after successful coronary angioplasty. Pathophysiology and prevention. N Engl J Med 1988; 318: 1734–1737.
2. Mauri L, Silbaugh TS, Wolf RE, et al. Long-term clinical outcomes after drugeluting and bare-metal stenting in Massachusetts. Circulation 2008; 118: 1817–1827.
3. Forrester JS, Fishbein M, Helfant R, et al. A paradigm for restenosis based on cell biology: clues for the development of new preventive therapies. J Am Coll Cardiol 1991; 17: 758–769.
4. Weber C, Springer TA. Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factor. J Clin Invest 1997; 100: 2085–2093.
5. Dzau VJ, Braun-Dullaeus RC, Sedding DG. Vascular proliferation and atherosclerosis: New perspectives and therapeutic strategies. Nat Med 2002; 8: 1249–1256.
6. Welt FG, Tso C, Edelman ER, et al. Leukocyte recruitment and expression of chemokines following different forms of vascular injury. Vasc Med 2003; 8: 1–7.
7. Sata M, Saiura A, Kunisato A, et al. Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis. Nat Med 2002; 8: 403–409.
8. Yu H, Stoneman V, Clarke M, et al. Bone marrow-derived smooth muscle-like cells are infrequent in advanced primary atherosclerotic plaques but promote atherosclerosis. Arterioscl Thromb Vasc Biol 2011; 31: 1291–1299.
9. Sainz IM, Pixley RA, Colman RW. Fifty years of research on the plasma kallikrein- kinin system: from protein structure and function to cell biology and in-vivo pathophysiology. Thromb Haemost 2007; 98: 77–83.
10. Guo YL, Colman RW. Two faces of high-molecular-weight kininogen (HK) in angiogenesis: bradykinin turns it on and cleaved HK (HKa) turns it off. J Thromb Haemost 2005; 3: 670–676.
11. Chavakis T, Kanse SM, Lupu F, et al. Different mechanisms define the antiadhesive function of high molecular weight kininogen in integrin- and urokinase receptor-dependent interactions. Blood 2000; 96: 514–522.
12. Chavakis T, Kanse SM, Pixley RA, et al. Regulation of leukocyte recruitment by polypeptides derived from high molecular weight kininogen. FASEB J 2001; 15: 2365–2376.
13. Sheng N, Fairbanks MB, Heinrikson RL, et al. Cleaved high molecular weight kininogen binds directly to the integrin CD11b/CD18 (Mac-1) and blocks adhesion to fibrinogen and ICAM-1. Blood 2000; 95: 3788–3795.
14. Al-Fakhri N, Chavakis T, Schmidt-Woll T, et al. Induction of apoptosis in vascular cells by plasminogen activator inhibitor-1 and high molecular weight kininogen correlates with their anti-adhesive properties. Biol Chem 2003; 384: 423–435.
15. Kunapuli SP, DeLa Cadena RA, Colman RW. Deletion mutagenesis of high molecular weight kininogen light chain. Identification of two anionic surface binding subdomains. J Biol Chem 1993; 268: 2486–2492.
16. Chavakis T, May AE, Preissner KT, et al. Molecular mechanisms of zinc-dependent leukocyte adhesion involving the urokinase receptor and beta2-integrins. Blood 1999; 93: 2976–2983.
17. Stefansson S, Lawrence DA. The serpin PAI-1 inhibits cell migration by blocking integrin alpha V beta 3 binding to vitronectin. Nature 1996; 383: 441–443.
18. Sedding DG, Trobs M, Reich F, et al. 3-Deazaadenosine prevents smooth muscle cell proliferation and neointima formation by interfering with Ras signaling. Circ Res 2009; 104: 1192–1200.
19. Daniel JM, Bielenberg W, Stieger P, et al. Time-course analysis on the differentiation of bone marrow-derived progenitor cells into smooth muscle cells during neointima formation. Arterioscl Thromb Vasc Biol 2010; 30: 1890–1896.
20. Sedding D, Daniel JM, Muhl L, et al. The G534E polymorphism of the gene encoding the factor VII-activating protease is associated with cardiovascular risk due to increased neointima formation. J Exp Med 2006; 203: 2801–2807.
21. Welt FG, Rogers C. Inflammation and restenosis in the stent era. Arterioscl Thromb Vasc Biol 2002; 22: 1769–1776.
22. Agata J, Miao RQ, Yayama K, et al. Bradykinin B(1) receptor mediates inhibition of neointima formation in rat artery after balloon angioplasty. Hypertension 2000; 36: 364–370.
23. Massberg S, Gawaz M, Gruner S, et al. A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo. J Exp Med 2003; 197: 41–49.
24. Rogers C, Edelman ER, Simon DI. A mAb to the beta2-leukocyte integrin Mac-1 (CD11b/CD18) reduces intimal thickening after angioplasty or stent implantation in rabbits. Proc Natl Acad Sci USA 1998; 95: 10134–10139.
25. Inoue T, Uchida T, Yaguchi I, et al. Stent-induced expression and activation of the leukocyte integrin Mac-1 is associated with neointimal thickening and restenosis. Circulation 2003; 107: 1757–1763.
26. Dufourcq P, Louis H, Moreau C, et al. Vitronectin expression and interaction with receptors in smooth muscle cells from human atheromatous plaque. Arterioscl Thromb Vasc Biol 1998; 18: 168–176.
27. Daniel JM, Dutzmann J, Bielenberg W, et al. Inhibition of STAT3 signaling prevents vascular smooth muscle cell proliferation and neointima formation. Basic Res Cardiol 2012; 107: 1–12.
28. Psaltis PJ, Harbuzariu A, Delacroix S, et al. Identification of a monocyte-predisposed hierarchy of hematopoietic progenitor cells in the adventitia of postnatal murine aorta. Circulation 2012; 125: 592–603.
29. Psaltis PJ, Puranik AS, Spoon DB, et al. Characterisation of a resident population of adventitial macrophage progenitor cells in postnatal vasculature. Circ Res 2014; 115: 364–375.
30. Iwata H, Manabe I, Fujiu K, et al. Bone marrow-derived cells contribute to vascular inflammation but do not differentiate into smooth muscle cell lineages. Circulation 2010; 122: 2048–2057.
31. Daniel JM, Sedding DG. Circulating smooth muscle progenitor cells in arterial remodelling. J Mol Cell Cardiol 2011; 50: 273–279.
32. Colman RW, Wu Y, Liu Y. Mechanisms by which cleaved kininogen inhibits endothelial cell differentiation and signalling. Thromb Haemost 2010; 104: 875–885.
33. Rebuck JW. The skin window as a monitor of leukocytic functions in contact activation factor deficiencies in man. Am J Clin Pathol 1983; 79: 405–413.
34. Waldmann R, Abraham JP, Rebuck JW, et al. Fitzgerald factor: a hitherto unrecognised coagulation factor. Lancet 1975; 305: 949–951.