2015 Infectious Diseases Society of America (IDSA) Clinical Practice Guidelines for the Diagnosis and Treatment of Native Vertebral Osteomyelitis in Adults

Clinical Infectious Diseases

Volumn 61, Issue 6, 2015, Pages e26-e46

  Berbari, Elie F ^a   Kanj, Souha S ^b   Kowalski, Todd J ^c   Darouiche, Rabih O ^d   Widmer, Andreas F ^e   Schmitt, Steven K ^f   Hendershot, Edward F ^g   Holtom, Paul D ^h   Huddleston, Paul M ⁱ   Petermann, Gregory W ^j   Osmon, Douglas R ⁱ  

^a Mayo Clinic College of Medicine   (United States)

^b AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

^c Gundersen Health System   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

^e UNIVERSITY HOSPITAL BASEL   (Switzerland)

^f LERNER RESEARCH INSTITUTE   (United States)

^g DUKE UNIVERSITY   (United States)

^h UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

ⁱ MAYO CLINIC   (United States)

^j MARSHFIELD CLINIC   (United States)

more..

Author keywords

discitis; osteomyelitis; spine infection; spondylodiscitis; Staphylococcus aureus

Indexed keywords

CARBAPENEM; CEFEPIME; DAPTOMYCIN; QUINOLONE; VANCOMYCIN; ANTIINFECTIVE AGENT;

ADULT; ANTIMICROBIAL THERAPY; BACTERIUM CULTURE; BLOODSTREAM INFECTION; CLINICAL ASSESSMENT; CLINICAL TRIAL (TOPIC); DEBRIDEMENT; FINE NEEDLE ASPIRATION BIOPSY; FOLLOW UP; HUMAN; IMAGE GUIDED BIOPSY; MEDICAL SPECIALIST; NATIVE VERTEBRAL OSTEOMYELITIS; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; ORTHOPEDIC SURGEON; PHYSICAL EXAMINATION; PRACTICE GUIDELINE; PRIORITY JOURNAL; RADIOLOGIST; REVIEW; SEROLOGY; SPONDYLITIS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS LUGDUNENSIS; SURGEON; TREATMENT FAILURE; OSTEOMYELITIS;

ADULT; ANTI-BACTERIAL AGENTS; DEBRIDEMENT; HUMANS; OSTEOMYELITIS; SPONDYLITIS;

EID: 84940640240     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/civ482     Document Type: Review

References (154)

1. Zimmerli W. Clinical practice. Vertebral osteomyelitis. N Engl J Med 2010; 362:1022-9.
2. Ablin G, Erickson TC. Osteomyelitis of cervical vertebrae (and quadriparesis) secondary to urinary tract infection: case report and review of literature. J Neurosurg 1958; 15:455-9.
3. Abram SR, Tedeschi AA, Partain CL, Blumenkopf B. Differential diagnosis of severe back pain using MRI. South Med J 1988; 81:1487-92.
4. Gupta A, Kowalski TJ, Osmon DR, et al. Long-term outcome of pyogenic vertebral osteomyelitis: a cohort study of 260 patients. Open Forum Infect Dis 2014; 1:8.
5. Chew FS, Kline MJ. Diagnostic yield of CT-guided percutaneous aspiration procedures in suspected spontaneous infectious diskitis. Radiology 2001; 218:211-4.
6. McHenry MC, Easley KA, Locker GA. Vertebral osteomyelitis: longterm outcome for 253 patients from 7 Cleveland-area hospitals. Clin Infect Dis 2002; 34:1342-50.
7. Bettini N, Girardo M, Dema E, Cervellati S. Evaluation of conservative treatment of non specific spondylodiscitis. Eur Spine J 2009; 18(suppl 1):143-50.
8. Jensen AG, Espersen F, Skinhoj P, Rosdahl VT, Frimodt-Moller N. Increasing frequency of vertebral osteomyelitis following Staphylococcus aureus bacteraemia in Denmark 1980-1990. J Infect 1997; 34:113-8.
9. Mylona E, Samarkos M, Kakalou E, Fanourgiakis P, Skoutelis A. Pyogenic vertebral osteomyelitis: a systematic review of clinical characteristics. Semin Arthritis Rheum 2009; 39:10-7.
10. Corrah TW, Enoch DA, Aliyu SH, Lever AM. Bacteraemia and subsequent vertebral osteomyelitis: a retrospective review of 125 patients. QJM 2011; 104:201-7.
11. Livorsi DJ, Daver NG, Atmar RL, Shelburne SA, White AC Jr, Musher DM. Outcomes of treatment for hematogenous Staphylococcus aureus vertebral osteomyelitis in the MRSA era. J Infect 2008; 57:128-31.
12. Bhavan KP, Kirmani N. Hematogenous vertebral osteomyelitis. Mo Med 2009; 106:277-82.
13. Chelsom J, Solberg CO. Vertebral osteomyelitis at a Norwegian university hospital 1987-97: clinical features, laboratory findings and outcome. Scand J Infect Dis 1998; 30:147-51.
14. Carragee EJ, Kim D, van der Vlugt T, Vittum D. The clinical use of erythrocyte sedimentation rate in pyogenic vertebral osteomyelitis. Spine 1997; 22:2089-93.
15. Kowalski TJ, Berbari EF, Huddleston PM, Steckelberg JM, Osmon DR. Do follow-up imaging examinations provide useful prognostic information in patients with spine infection? Clin Infect Dis 2006; 43:172-9.
16. Kowalski TJ, Berbari EF, Huddleston PM, Steckelberg JM, Osmon DR. Propionibacterium acnes vertebral osteomyelitis: seek and ye shall find? Clin Orthop Relat Res 2007; 461:25-30.
17. Brozek JL, Akl EA, Jaeschke R, et al. Grading quality of evidence and strength of recommendations in clinical practice guidelines: part 2 of 3. The GRADE approach to grading quality of evidence about diagnostic tests and strategies. Allergy 2009; 64:1109-16.
18. Guyatt GH, Oxman AD, Kunz R, et al. Going from evidence to recommendations. BMJ 2008; 336:1049-51.
19. Guyatt GH, Oxman AD, Vist GE, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2008; 336:924-6.
20. Schunemann HJ, Oxman AD, Brozek J, et al. Grading quality of evidence and strength of recommendations for diagnostic tests and strategies. BMJ 2008; 336:1106-10.
21. Grammatico L, Baron S, Rusch E, et al. Epidemiology of vertebral osteomyelitis (VO) in France: analysis of hospital-discharge data 2002-2003. Epidemiol Infect 2008; 136:653-60.
22. Case records of the Massachusetts General Hospital; weekly clinicopathological exercises; case 44012. N Engl J Med 1958; 258:42-5.
23. Sharma SK, Jones JO, Zeballos PP, Irwin SA, Martin TW. The prevention of discitis during discography. Spine J 2009; 9:936-43.
24. Field M, Kathleen N. Institute of Medicine Committee to Advise the Public Health Service on Clinical Practice Guidelines (1990). Washington, DC: National Academy Press, 1990:52-77.
25. Gasbarrini AL, Bertoldi E, Mazzetti M, et al. Clinical features, diagnostic and therapeutic approaches to haematogenous vertebral osteomyelitis. Eur Rev Med Pharmacol Sci 2005; 9:53-66.
26. Buranapanitkit B, Lim A, Geater A. Misdiagnosis in vertebral osteomyelitis: problems and factors. J Med Assoc Thai 2001; 84:1743-50.
27. Hsiao MY, Liang HW. Delayed diagnosis of vertebral osteomyelitis in a paraplegic patient. Spinal Cord 2011; 49:1020-2.
28. Siemionow K, Lieberman IH. Surgical approaches to metastatic spine disease. Curr Opin Support Palliat Care 2008; 2:192-6.
29. Torda AJ, Gottlieb T, Bradbury R. Pyogenic vertebral osteomyelitis: analysis of 20 cases and review. Clin Infect Dis 1995; 20:320-8.
30. Skaf GS, Domloj NT, Fehlings MG, et al. Pyogenic spondylodiscitis: an overview. J Infect Public Health 2010; 3:5-16.
31. Oztekin O, Calli C, Adibelli Z, Kitis O, Eren C, Altinok T. Brucellar spondylodiscitis: magnetic resonance imaging features with conventional sequences and diffusion-weighted imaging. Radiol Med 2010; 115:794-803.
32. Goertz CE, Frasca S Jr, Bohach GA, et al. Brucella sp. vertebral osteomyelitis with intercurrent fatal Staphylococcus aureus toxigenic enteritis in a bottlenose dolphin (Tursiops truncatus). J Vet Diagn Invest 2011; 23:845-51.
33. Kraniotis P, Marangos M, Lekkou A, Romanos O, Solomou E. Brucellosis presenting as piriformis myositis: a case report. J Med Case Reports 2011; 5:125.
34. Mrabet D, Mizouni H, Khiari H, et al. Brucellar spondylodiscitis affecting non-contiguous spine levels. BMJ Case Rep 2011; 2011.
35. Song KJ, Yoon SJ, Lee KB. Cervical spinal brucellosis with epidural abscess causing neurologic deficit with negative serologic tests. World Neurosurg 2012; 78:375.e15-9.
36. Wong-Chung JK, Naseeb SA, Kaneker SG, Aradi AJ. Anterior disc protrusion as a cause for abdominal symptoms in childhood discitis. A case report. Spine 1999; 24:918-20.
37. Siemionow K, Steinmetz M, Bell G, Ilaslan H, McLain RF. Identifying serious causes of back pain: cancer, infection, fracture. Cleve Clin J Med 2008; 75:557-66.
38. Jensen AG, Espersen F, Skinhoj P, Frimodt-Moller N. Bacteremic Staphylococcus aureus spondylitis. Arch Intern Med 1998; 158:509-17.
39. Schinina V, Rizzi EB, Rovighi L, de Carli G, David V, Bibbolino C. Infectious spondylodiscitis: magnetic resonance imaging in HIV-infected and HIV-uninfected patients. Clin Imaging 2001; 25:362-7.
40. Bozgeyik Z, Ozdemir H, Demirdag K, Ozden M, Sonmezgoz F, Ozgocmen S. Clinical and MRI findings of brucellar spondylodiscitis. Eur J Radiol 2008; 67:153-8.
41. Ledermann HP, Schweitzer ME, Morrison WB, Carrino JA. MR imaging findings in spinal infections: rules or myths? Radiology 2003; 228:506-14.
42. Dagirmanjian A, Schils J, McHenry M, Modic MT. MR imaging of vertebral osteomyelitis revisited. AJR Am J Roentgenol 1996; 167:1539-43.
43. Ozaksoy D, Yucesoy K, Yucesoy M, Kovanlikaya I, Yuce A, Naderi S. Brucellar spondylitis: MRI findings. Eur Spine J 2001; 10:529-33.
44. Dunbar JA, Sandoe JA, Rao AS, Crimmins DW, Baig W, Rankine JJ. The MRI appearances of early vertebral osteomyelitis and discitis. Clin Radiol 2010; 65:974-81.
45. Love C, Patel M, Lonner BS, Tomas MB, Palestro CJ. Diagnosing spinal osteomyelitis: a comparison of bone and Ga-67 scintigraphy and magnetic resonance imaging. Clin Nucl Med 2000; 25:963-77.
46. Palestro CJ, Torres MA. Radionuclide imaging in orthopedic infections. Semin Nucl Med 1997; 27:334-45.
47. Datz FL. Indium-111-labeled leukocytes for the detection of infection: current status. Semin Nucl Med 1994; 24:92-109.
48. Ohtori S, Suzuki M, Koshi T, et al. 18F-fluorodeoxyglucose-PET for patients with suspected spondylitis showing Modic change. Spine 2010; 35:E1599-603.
49. Lee A, Mirrett S, Reller LB, Weinstein MP. Detection of bloodstream infections in adults: how many blood cultures are needed? J Clin Microbiol 2007; 45:3546-8.
50. Patel R, Vetter EA, Harmsen WS, Schleck CD, Fadel HJ, Cockerill FR 3rd. Optimized pathogen detection with 30-compared to 20-milliliter blood culture draws. J Clin Microbiol 2011; 49:4047-51.
51. Araj GF, Kattar MM, Fattouh LG, Bajakian KO, Kobeissi SA. Evaluation of the PANBIO Brucella immunoglobulin G (IgG) and IgM enzyme-linked immunosorbent assays for diagnosis of human brucellosis. Clin Diagn Lab Immunol 2005; 12:1334-5.
52. Skaf GS, Kanafani ZA, Araj GF, Kanj SS. Non-pyogenic infections of the spine. Int J Antimicrob Agents 2010; 36:99-105.
53. Herron LD, Kissel P, Smilovitz D. Treatment of coccidioidal spinal infection: experience in 16 cases. J Spinal Disord 1997; 10:215-22.
54. Sapico FL, Montgomerie JZ. Vertebral osteomyelitis. Infect Dis Clin North Am 1990; 4:539-50.
55. Theodoros K, Sotirios T. Successful treatment of azole-resistant Candida spondylodiscitis with high-dose caspofungin monotherapy. Rheumatol Int 2012; 32:2957-8.
56. Joshi TN. Candida albicans spondylodiscitis in an immunocompetent patient. J Neurosci Rural Pract 2012; 3:221-2.
57. Jorge VC, Cardoso C, Noronha C, Simoes J, Riso N, Vaz Riscado M. Fungal spondylodiscitis in a non-immunocompromised patient. BMJ Case Rep 2012; doi:10.1136/bcr.12.2011.5337.
58. Werner BC, Hogan MV, Shen FH. Candida lusitaniae discitis after discogram in an immunocompetent patient. Spine J 2011; 11:e1-6.
59. Rachapalli SM, Malaiya R, Mohd TA, Hughes RA. Successful treatment of Candida discitis with 5-flucytosine and fluconazole. Rheumatol Int 2010; 30:1543-4.
60. Cho K, Lee SH, Kim ES, EohW. Candida parapsilosis spondylodiscitis after lumbar discectomy. J Korean Neurosurg Soc 2010; 47:295-7.
61. Moon HH, Kim JH, Moon BG, Kim JS. Cervical spondylodiscitis caused by Candida albicans in non-immunocompromised patient. J Korean Neurosurg Soc 2008; 43:45-7.
62. Walsh TJ, Anaissie EJ, Denning DW, et al. Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis 2008; 46:327-60.
63. Chapman SW, Dismukes WE, Proia LA, et al. Clinical practice guidelines for the management of blastomycosis: 2008 update by the Infectious Diseases Society of America. Clin Infect Dis 2008; 46:1801-12.
64. Galgiani JN, Ampel NM, Blair JE, et al. Coccidioidomycosis. Clin Infect Dis 2005; 41:1217-23.
65. Pappas PG, Kauffman CA, Andes D, et al. Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis 2009; 48:503-35.
66. Wheat LJ, Freifeld AG, Kleiman MB, et al. Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the Infectious Diseases Society of America. Clin Infect Dis 2007; 45:807-25.
67. Ramos A, Huddleston PM, Patel R, Vetter E, Berbari EF. Vertebral osteomyelitis due to Candida species: a cohort study and review of the literature. Open J Orthop 2013; 3:81-9.
68. De Backer AI, Mortele KJ, Vanschoubroeck IJ, et al. Tuberculosis of the spine: CT and MR imaging features. JBR-BTR 2005; 88:92-7.
69. Menzies D, Pai M, Comstock G. Meta-analysis: new tests for the diagnosis of latent tuberculosis infection: areas of uncertainty and recommendations for research. Ann Intern Med 2007; 146:340-54.
70. Yuan K, Zhong ZM, Zhang Q, Xu SC, Chen JT. Evaluation of an enzyme-linked immunospot assay for the immunodiagnosis of atypical spinal tuberculosis (atypical clinical presentation/atypical radiographic presentation) in China. Braz J Infect Dis 2013; 17:529-37.
71. Michel SC, Pfirrmann CW, Boos N, Hodler J. CT-guided core biopsy of subchondral bone and intervertebral space in suspected spondylodiskitis. AJR Am J Roentgenol 2006; 186:977-80.
72. de Lucas EM, Gonzalez Mandly A, Gutierrez A, et al. CT-guided fineneedle aspiration in vertebral osteomyelitis: true usefulness of a common practice. Clin Rheumatol 2009; 28:315-20.
73. Kornblum MB, Wesolowski DP, Fischgrund JS, Herkowitz HN. Computed tomography-guided biopsy of the spine. A review of 103 patients. Spine 1998; 23:81-5.
74. Sehn JK, Gilula LA. Percutaneous needle biopsy in diagnosis and identification of causative organisms in cases of suspected vertebral osteomyelitis. Eur J Radiol 2012; 81:940-6.
75. Fouquet B, Goupille P, Gobert F, Cotty P, Roulot B, Valat JP. Infectious discitis diagnostic contribution of laboratory tests and percutaneous discovertebral biopsy. Rev Rhum 1996; 63:24-9.
76. Olscamp A, Rollins J, Tao SS, Ebraheim NA. Complications of CTguided biopsy of the spine and sacrum. Orthopedics 1997; 20:1149-52.
77. Jensen AG. Staphylococcus aureus bacteremia. Dan Med Bull 2003; 50:423-38.
78. Greig JM, Wood MJ. Staphylococcus lugdunensis vertebral osteomyelitis. Clin Microbiol Infect 2003; 9:1139-41.
79. Murdoch DR, Everts RJ, Chambers ST, Cowan IA. Vertebral osteomyelitis due to Staphylococcus lugdunensis. J Clin Microbiol 1996; 34:993-4.
80. Cervan AM, Colmenero Jde D, Del Arco A, Villanueva F, Guerado E. Spondylodiscitis in patients under haemodialysis. Int Orthop 2012; 36:421-6.
81. Faria B, Canto Moreira N, Sousa TC, et al. Spondylodiscitis in hemodialysis patients: a case series. Clin Nephrol 2011; 76:380-7.
82. Solera J, Lozano E, Martinez-Alfaro E, Espinosa A, Castillejos ML, Abad L. Brucellar spondylitis: review of 35 cases and literature survey. Clin Infect Dis 1999; 29:1440-9.
83. Binnicker MJ, Theel ES, Larsen SM, Patel R. A high percentage of serum samples that test reactive by enzyme immunoassay for anti-Brucella antibodies are not confirmed by the standard tube agglutination test. Clin Vaccine Immunol 2012; 19:1332-4.
84. Rankine JJ, Barron DA, Robinson P, Millner PA, Dickson RA. Therapeutic impact of percutaneous spinal biopsy in spinal infection. Postgrad Med J 2004; 80:607-9.
85. Hassoun A, Taur Y, Singer C. Evaluation of thin needle aspiration biopsy in the diagnosis and management of vertebral osteomyelitis (VO). Int J Infect Dis 2006; 10:486-7.
86. Kim CJ, Song KH, Park WB, et al. Microbiologically and clinically diagnosed vertebral osteomyelitis: impact of prior antibiotic exposure. Antimicrob Agents Chemother 2012; 56:2122-4.
87. Marschall J, Bhavan KP, Olsen MA, Fraser VJ, Wright NM, Warren DK. The impact of prebiopsy antibiotics on pathogen recovery in hematogenous vertebral osteomyelitis. Clin Infect Dis 2011; 52:867-72.
88. Trampuz A, Piper KE, Jacobson MJ, et al. Sonication of removed hip and knee prostheses for diagnosis of infection. N Engl J Med 2007; 357:654-63.
89. Grados F, Lescure FX, Senneville E, Flipo RM, Schmit JL, Fardellone P. Suggestions for managing pyogenic (non-tuberculous) discitis in adults. Joint Bone Spine 2007; 74:133-9.
90. Mete B, Kurt C, Yilmaz MH, et al. Vertebral osteomyelitis: eight years' experience of 100 cases. Rheumatol Int 2012; 32:3591-7.
91. Sakkas LI, Davas EM, Kapsalaki E, et al. Hematogenous spinal infection in central Greece. Spine 2009; 34:E513-8.
92. Memish ZA, Balkhy HH. Brucellosis and international travel. J Travel Med 2004; 11:49-55.
93. Colmenero JD, Ruiz-Mesa JD, Plata A, et al. Clinical findings, therapeutic approach, and outcome of brucellar vertebral osteomyelitis. Clin Infect Dis 2008; 46:426-33.
94. Froissart A, Pagnoux C, Cherin P. Lymph node paradoxical enlargement during treatment for tuberculous spondylodiscitis (Pott's disease). Joint Bone Spine 2007; 74:292-5.
95. Gouliouris T, Aliyu SH, Brown NM. Spondylodiscitis: update on diagnosis and management. J Antimicrob Chemother 2010; 65(suppl 3): iii11-24.
96. Lifeso R. Atlanto-axial tuberculosis in adults. J Bone Joint Surg Br 1987; 69:183-7.
97. Berk RH, Yazici M, Atabey N, Ozdamar OS, Pabuccuoglu U, Alici E. Detection of Mycobacterium tuberculosis in formaldehyde solutionfixed, paraffin-embedded tissue by polymerase chain reaction in Pott's disease. Spine 1996; 21:1991-5.
98. Kim CJ, Song KH, Jeon JH, et al. A comparative study of pyogenic and tuberculous spondylodiscitis. Spine 2010; 35:E1096-100.
99. Colmenero JD, Jimenez-Mejias ME, Sanchez-Lora FJ, et al. Pyogenic, tuberculous, and brucellar vertebral osteomyelitis: a descriptive and comparative study of 219 cases. Ann Rheum Dis 1997; 56:709-15.
100. Arizono T, Oga M, Shiota E, Honda K, Sugioka Y. Differentiation of vertebral osteomyelitis and tuberculous spondylitis by magnetic resonance imaging. Int Orthop 1995; 19:319-22.
101. Petitjean G, Fluckiger U, Scharen S, Laifer G. Vertebral osteomyelitis caused by non-tuberculous mycobacteria. Clin Microbiol Infect 2004; 10:951-3.
102. Josephson CB, Al-Azri S, Smyth DJ, Haase D, Johnston BL. A case of Pott's disease with epidural abscess and probable cerebral tuberculoma following bacillus Calmette-Guerin therapy for superficial bladder cancer. Can J Infect Dis Med Microbiol 2010; 21:e75-8.
103. Bhavan KP, Marschall J, Olsen MA, Fraser VJ, Wright NM, Warren DK. The epidemiology of hematogenous vertebral osteomyelitis: a cohort study in a tertiary care hospital. BMC Infect Dis 2010; 10:158.
104. Turunc T, Demiroglu YZ, Uncu H, Colakoglu S, Arslan H. A comparative analysis of tuberculous, brucellar and pyogenic spontaneous spondylodiscitis patients. J Infect 2007; 55:158-63.
105. Fuursted K, Arpi M, Lindblad BE, Pedersen LN. Broad-range PCR as a supplement to culture for detection of bacterial pathogens in patients with a clinically diagnosed spinal infection. Scand J Infect Dis 2008; 40:772-7.
106. Navarro E, Segura JC, Castano MJ, Solera J. Use of real-time quantitative polymerase chain reaction to monitor the evolution of Brucella melitensis DNA load during therapy and post-therapy follow-up in patients with brucellosis. Clin Infect Dis 2006; 42:1266-73.
107. Navarro-Martinez A, Navarro E, Castano MJ, Solera J. Rapid diagnosis of human brucellosis by quantitative real-time PCR: a case report of brucellar spondylitis. J Clin Microbiol 2008; 46:385-7.
108. Chen SCA, Halliday CL, Meyer W. A review of nucleic acid-based diagnostic tests for systemic mycoses with an emphasis on polymerase chain reaction-based assays. Med Mycol 2002; 40:333-57.
109. Lis E, Bilsky MH, Pisinski L, et al. Percutaneous CT-guided biopsy of osseous lesion of the spine in patients with known or suspected malignancy. Am J Neuroradiol 2004; 25:1583-8.
110. Wu JS, Gorbachova T, Morrison WB, Haims AH. Imaging-guided bone biopsy for osteomyelitis: are there factors associated with positive or negative cultures? Am J Roentgenol 2007; 188:1529-34.
111. Babu NV, Titus VT, Chittaranjan S, Abraham G, Prem H, Korula RJ. Computed tomographically guided biopsy of the spine. Spine 1994; 19:2436-42.
112. Peh W. CT-guided percutaneous biopsy of spinal lesions. Biomed Imaging Interv J 2006; 2:e25.
113. Priest DH, Peacock JE Jr. Hematogenous vertebral osteomyelitis due to Staphylococcus aureus in the adult: clinical features and therapeutic outcomes. South Med J 2005; 98:854-62.
114. Yang SC, Fu TS, Chen LH, Niu CC, Lai PL, Chen WJ. Percutaneous endoscopic discectomy and drainage for infectious spondylitis. Int Orthop 2007; 31:367-73.
115. Cotty P, Fouquet B, Pleskof L, et al. Vertebral osteomyelitis: value of percutaneous biopsy. 30 cases. J Neuroradiol 1988; 15:13-21.
116. Parker LM, McAfee PC, Fedder IL, Weis JC, Geis WP. Minimally invasive surgical techniques to treat spine infections. Orthop Clin North Am 1996; 27:183-99.
117. Staatz G, Adam GB, Keulers P, Vorwerk D, Gunther RW. Spondylodiskitic abscesses: CT-guided percutaneous catheter drainage. Radiology 1998; 208:363-7.
118. Vinicoff PG, Gutschik E, Hansen SE, Karle A, Rieneck K. CT-guided spinal biopsy in spondylodiscitis [in Danish]. Ugeskr Laeger 1998; 160:5931-4.
119. Haaker RG, Senkal M, Kielich T, Kramer J. Percutaneous lumbar discectomy in the treatment of lumbar discitis. Eur Spine J 1997; 6:98-101.
120. Ito M, Abumi K, Kotani Y, Kadoya K, Minami A. Clinical outcome of posterolateral endoscopic surgery for pyogenic spondylodiscitis: results of 15 patients with serious comorbid conditions. Spine 2007; 32:200-6.
121. Yang SC, Fu TS, Chen LH, Chen WJ, Tu YK. Identifying pathogens of spondylodiscitis: percutaneous endoscopy or CT-guided biopsy. Clin Orthop Relat Res 2008; 466:3086-92.
122. Viale P, Furlanut M, Scudeller L, et al. Treatment of pyogenic (nontuberculous) spondylodiscitis with tailored high-dose levofloxacin plus rifampicin. Int J Antimicrob Agents 2009; 33:379-82.
123. Liu C, Bayer A, Cosgrove SE, et al. Clinical practice guidelines by the Infectious Diseases Society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children: executive summary. Clin Infect Dis 2011; 52:285-92.
124. Baddour LM,Wilson WR, Bayer AS, et al. Infective endocarditis: Diagnosis, antimicrobial therapy, and management of complications: a statement for healthcare professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, and the Councils on Clinical Cardiology, Stroke, and Cardiovascular Surgery and Anesthesia, American Heart Association: endorsed by the Infectious Diseases Society of America. Circulation 2005; 111:e394-434.
125. Graninger W, Ragette R. Nosocomial bacteremia due to Enterococcus faecalis without endocarditis. Clin Infect Dis 1992; 15:49-57.
126. Tice AD, Rehm SJ, Dalovisio JR, et al. Practice guidelines for outpatient parenteral antimicrobial therapy. IDSA guidelines. Clin Infect Dis 2004; 38:1651-72.
127. Bernard L, Dinh A, Ghout I, et al. Antibiotic treatment for 6 weeks versus 12 weeks in patients with pyogenic vertebral osteomyelitis: an open-label, non-inferiority, randomised, controlled trial. Lancet 2015; 385:875-82.
128. Legrand E, Flipo RM, Guggenbuhl P, et al. Management of nontuberculous infectious discitis. treatments used in 110 patients admitted to 12 teaching hospitals in France. Joint Bone Spine 2001; 68:504-9.
129. Roblot F, Besnier JM, Juhel L, et al. Optimal duration of antibiotic therapy in vertebral osteomyelitis. Semin Arthritis Rheum 2007; 36:269-77.
130. Flury BB, Elzi L, Kolbe M, et al. Is switching to an oral antibiotic regimen safe after 2 weeks of intravenous treatment for primary bacterial vertebral osteomyelitis? BMC Infect Dis 2014; 14:226.
131. Lazzarini L, Lipsky BA, Mader JT. Antibiotic treatment of osteomyelitis: what have we learned from 30 years of clinical trials? Int J Infect Dis 2005; 9:127-38.
132. Lazzarini L, De Lalla F, Mader JT. Long bone osteomyelitis. Curr Infect Dis Rep 2002; 4:439-45.
133. Gentry LO. Antibiotic therapy for osteomyelitis. Infect Dis Clin North Am 1990; 4:485-99.
134. Carek PJ, Dickerson LM, Sack JL. Diagnosis and management of osteomyelitis. Am Fam Physician 2001; 63:2413-20.
135. Daver NG, Shelburne SA, Atmar RL, et al. Oral step-down therapy is comparable to intravenous therapy for Staphylococcus aureus osteomyelitis. J Infect 2007; 54:539-44.
136. Rissing JP. Antimicrobial therapy for chronic osteomyelitis in adults: role of the quinolones. Clin Infect Dis 1997; 25:1327-33.
137. Swiontkowski MF, Hanel DP, Vedder NB, Schwappach JR. A comparison of short-and long-term intravenous antibiotic therapy in the postoperative management of adult osteomyelitis. J Bone Joint Surg Br 1999; 81:1046-50.
138. American Thoracic Society, Centers for Disease Control and Prevention, Infectious Diseases Society of America. Treatment of tuberculosis. MMWR Recomm Rep 2003; 52(RR-11):1-77.
139. Chen WH, Jiang LS, Dai LY. Surgical treatment of pyogenic vertebral osteomyelitis with spinal instrumentation. Eur Spine J 2007; 16: 1307-16.
140. Valancius K, Hansen ES, Hoy K, Helmig P, Niedermann B, Bunger C. Failure modes in conservative and surgical management of infectious spondylodiscitis. Eur Spine J 2013; 22:1837-44.
141. Kulowski J. The Orr treatment of pyogenic osteomyelitis. Ann Surg 1936; 103:613-24.
142. Carragee EJ. Pyogenic vertebral osteomyelitis. J Bone Joint Surg Am 1997; 79:874-80.
143. Nolla JM, Ariza J, Gomez-Vaquero C, et al. Spontaneous pyogenic vertebral osteomyelitis in nondrug users. Semin Arthritis Rheum 2002; 31:271-8.
144. Wang Q, Babyn P, Branson H, Tran D, Davila J, Mueller EL. Utility of MRI in the follow-up of pyogenic spinal infection in children. Pediatr Radiol 2010; 40:118-30.
145. Carragee EJ. Instrumentation of the infected and unstable spine: a review of 17 cases from the thoracic and lumbar spine with pyogenic infections. J Spinal Disord 1997; 10:317-24.
146. Solis Garcia del Pozo J, Vives Soto M, Solera J. Vertebral osteomyelitis: long-term disability assessment and prognostic factors. J Infect 2007; 54:129-34.
147. O'Daly BJ, Morris SF, O'Rourke SK. Long-term functional outcome in pyogenic spinal infection. Spine 2008; 33:E246-53.
148. Kowalski TJ, Layton KF, Berbari EF, et al. Follow-up MR imaging in patients with pyogenic spine infections: lack of correlation with clinical features. AJNR Am J Neuroradiol 2007; 28:693-9.
149. Carragee EJ. The clinical use of magnetic resonance imaging in pyogenic vertebral osteomyelitis. Spine 1997; 22:780-5.
150. Khan MH, Smith PN, Rao N, Donaldson WF. Serum C-reactive protein levels correlate with clinical response in patients treated with antibiotics for wound infections after spinal surgery. Spine J 2006; 6:311-5.
151. Yoon SH, Chung SK, Kim KJ, Kim HJ, Jin YJ, Kim HB. Pyogenic vertebral osteomyelitis: identification of microorganism and laboratory markers used to predict clinical outcome. Eur Spine J 2010; 19:575-82.
152. Veillard E, Guggenbuhl P, Morcet N, et al. Prompt regression of paravertebral and epidural abscesses in patients with pyogenic discitis. Sixteen cases evaluated using magnetic resonance imaging. Joint Bone Spine 2000; 67:219-27.
153. Euba G, Narvaez JA, Nolla JM, et al. Long-term clinical and radiological magnetic resonance imaging outcome of abscess-associated spontaneous pyogenic vertebral osteomyelitis under conservative management. Semin Arthritis Rheum 2008; 38:28-40.
154. Zarrouk V, Feydy A, Salles F, et al. Imaging does not predict the clinical outcome of bacterial vertebral osteomyelitis. Rheumatology 2007; 46:292-5.