Phosphoinositide signaling in cancer: INPP4B Akt(s) out

Trends in Molecular Medicine

Volumn 21, Issue 9, 2015, Pages 530-532

  Woolley, John F ^a,b   Dzneladze, Irakli ^b,c   Salmena, Leonardo ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Akt; INPP4B; Oncogene; Phosphoinositide; PI3K; Tumor suppressor

Indexed keywords

AKIN PROTEIN; INOSITOL POLYPHOSPHATE; INOSITOL POLYPHOSPHATE 4 PHOSPHATASE 2; PHOSPHATASE; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 2 PHOSPHATASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; SERUM GLUCOCORTICOID REGULATED KINASE 3; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL-3,4-BISPHOSPHATE 4-PHOSPHATASE;

ACUTE MYELOBLASTIC LEUKEMIA; ANCHORAGE INDEPENDENT GROWTH; APOPTOSIS; BREAST CANCER; BREAST CANCER CELL LINE; CANCER RECURRENCE; CANCER REGRESSION; CANCER RESISTANCE; CANCER SURVIVAL; CELL MOTILITY; CELL PROLIFERATION; CELL STIMULATION; CELL SURVIVAL; COLONY FORMATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; NEOPLASM; NONHUMAN; OVARY CANCER; OVERALL SURVIVAL; PHENOTYPE; PROSTATE CANCER; PROTEIN BINDING; PROTEIN DEPHOSPHORYLATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SHORT SURVEY; SIGNAL TRANSDUCTION; ENZYMOLOGY; GENETICS; METABOLISM;

HUMANS; NEOPLASMS; PHOSPHATIDYLINOSITOLS; PHOSPHORIC MONOESTER HYDROLASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84940592509     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2015.06.006     Document Type: Short Survey

References (10)

1. Bunney T.D., Katan M. Phosphoinositide signalling in cancer: beyond PI3K and PTEN. Nat. Rev. Cancer 2010, 10:342-352.
2. Westbrook T.F., et al. A genetic screen for candidate tumor suppressors identifies REST. Cell 2005, 121:837-848.
3. Gewinner C., et al. Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. Cancer Cell 2009, 16:115-125.
4. Fedele C.G., et al. Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:22231-22236.
5. Hodgson M.C., et al. Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer. Cancer Res. 2011, 71:572-582.
6. Kofuji S., et al. INPP4B is a PtdIns(3,4,5)P3 phosphatase that can act as a tumor suppressor. Cancer Discov. 2015, Published online April 16, 2015. 10.1158/2159-8290.CD-14-1329.
7. Chew C.L., et al. In vivo role of INPP4B in tumor and metastasis suppression through regulation of PI3K/AKT signaling at endosomes. Cancer Discov. 2015, Published online April 16, 2015. 10.1158/2159-8290.CD-14-1347.
8. Gasser J.a., et al. SGK3 Mediates INPP4B-Dependent PI3K Signaling in Breast Cancer. Mol. Cell 2014, 56:595-607.
9. Dzneladze I., et al. INPP4B overexpression is associated with poor clinical outcome and therapy resistance in acute myeloid leukemia. Leukemia 2015, Published online March 4, 2015. 10.1038/leu.2015.51.
10. Rijal S., et al. Inositol polyphosphate 4-phosphatase II (INPP4B) is associated with chemoresistance and poor outcome in AML. Blood 2015, 125:2815-2824.