Brain Uptake of Tetrahydrohyperforin and Potential Metabolites after Repeated Dosing in Mice

Journal of Natural Products

Volumn 78, Issue 8, 2015, Pages 2029-2035

  Fracasso, Claudia ^a   Bagnati, Renzo ^a   Passoni, Alice ^a   Guiso, Giovanna ^a   Cantoni, Lavinia ^a   Riva, Antonella ^b   Morazzoni, Paolo ^b   Gobbi, Marco ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b INDENA S P A   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; HYPERFORIN; NOOTROPIC AGENT; TETRAHYDROHYPERFORIN; UNCLASSIFIED DRUG; PHLOROGLUCINOL; TERPENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN METABOLISM; BRAIN UPTAKE; CHRONOTHERAPY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEHYDROGENATION; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG HYDROXYLATION; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG UPTAKE; HIPPOCAMPUS; IN VITRO STUDY; LIVER MICROSOME METABOLISM; MALE; MOUSE; NONHUMAN; QUANTITATIVE ANALYSIS; REPEATED DRUG DOSE; SYNAPTIC EFFICACY; ALZHEIMER DISEASE; ANALOGS AND DERIVATIVES; ANIMAL; BRAIN; CHEMICAL STRUCTURE; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPERICUM; LIVER MICROSOME; METABOLISM;

ALZHEIMER DISEASE; ANIMALS; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; HYPERICUM; MICE; MICROSOMES, LIVER; MOLECULAR STRUCTURE; PHLOROGLUCINOL; TERPENES;

EID: 84940542943     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/acs.jnatprod.5b00302     Document Type: Article

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