Mechanism of thioridazine plus medroxyprogesterone in the treatment of endometrial cancer

National Medical Journal of China

Volumn 95, Issue 19, 2015, Pages 1540-1543

  Meng, Qiong ^a   Sun, Xiao ^a   Wang, Jing ^a   Wang, Yudong ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Endometrial cancer; Medroxyprogesterone; Thioridazine

Indexed keywords

CHOLECYSTOKININ OCTAPEPTIDE; DOPAMINE 2 RECEPTOR; MEDROXYPROGESTERONE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RETINOBLASTOMA PROTEIN; THIORIDAZINE; APOPTOSIS REGULATORY PROTEIN;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; COMPARATIVE STUDY; CONCENTRATION RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENDOMETRIAL CANCER CELL LINE; ENDOMETRIUM CANCER; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ENDOMETRIUM TUMOR;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; ENDOMETRIAL NEOPLASMS; FEMALE; FLOW CYTOMETRY; HUMANS; MEDROXYPROGESTERONE; PHOSPHATIDYLINOSITOL 3-KINASES; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; THIORIDAZINE;

EID: 84940517640     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0376-2491.2015.19.025     Document Type: Article

References (7)

1. Sachlos E, Risueiio RM, Earonde S, et al. Identification of drugs including a dopamine receptor antagonist that selectively targetcancer stem cells [J]. Cell, 2012, 149(6):1284-1297.
2. Kang S, Dong SM, Kim BR, et al. Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells [ J ]. Apoptosis, 2012, 17 (9): 989-997.
3. Martin-Liberal J, Benson C, Messiou C, et al. Reversion of Hormone Treatment Resistance with the Addition of an mTOR Inhibitor in Endometrial Stromal Sarcoma [J]. Case Rep Med, 2014, 2014:612496.
4. Chen X, Zhang Z, Eeng Y, et al. Aberrant survivin expression in endometrial hyperplasia; another mechanism of progestin resistance [J]. Mod Pathol, 2009, 22 (5):699-708.
5. Gu C, Zhang Z, Yu Y, et al. Inhibiting the PI3K/Akt pathway reversed progestin resistance in endometrial cancer [J]. Cancer Sci, 2011, 102(3):557-564.
6. Shao K. Progesterone receptor isoforms A and B: New insights into the mechanism of progesterone resistance for the treatment of endometrial carcinoma [J]. Ecaneermedicalscience, 2013, 18; 7:38
7. Eaton JE, Unno K, Caraveo M, et al. Increased AKT or MEK1/2 activity influences progesterone receptor levels and localization in endometriosis [J] J Clin Endocrinol Metab, 2013, 98 (12):El 871-1879.