Deglucose chikusetsusaponin IVa isolated from Rhizoma Panacis Majoris induces apoptosis in human HepG2 hepatoma cells

Molecular Medicine Reports

Volumn 12, Issue 4, 2015, Pages 5494-5500

  Song, Xiaomei ^a   Wang, Wei ^a   Zhang, Xin ^a   Jiang, Yi ^a   Yang, Xinjie ^a   Deng, Chong ^a   Yue, Zhenggang ^a   Tang, Zhishu ^a  

^a SHAANXI UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Antitumor; Cell apoptosis; Cell cycle arrest; Cytotoxic Activity; Deglucose chikusetsusaponin IVa; Rhizoma Panacis Majoris

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; CHIKUSETSU SAPONIN; PROTEIN BCL 2; ANTINEOPLASTIC AGENT; CHIKUSETSU SAPONIN IVA; HERBACEOUS AGENT; OLEANOLIC ACID; SAPONIN;

APOPTOSIS; ARTICLE; CELL COUNT; CELL CYCLE M PHASE; CELL GROWTH; CELL STRUCTURE; CELL VIABILITY; CHROMATIN CONDENSATION; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; GROWTH INHIBITION; HEPG2 CELL LINE; HUMAN; HUMAN CELL; MTT ASSAY; PANACIS MAJORIS; PROTEIN EXPRESSION; RHIZOME; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; CELL CYCLE CHECKPOINT; CELL PROLIFERATION; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECTS; LIVER CELL CARCINOMA; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; HEP G2 CELLS; HUMANS; OLEANOLIC ACID; SAPONINS; SIGNAL TRANSDUCTION;

EID: 84940510748     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2015.4035     Document Type: Article

References (25)

1. Xu Q, Bauer R, Hendry BM, Fan TP, Zhao Z, Duez P, Simmonds MS, Witt CM, Lu A, Robinson N, et al: The quest for modernisation of traditional Chinese medicine. BMC Complement Altern Med 13: 132, 2013.
2. Wang L, Li Y, Li J, Zhang M, Xu L, Yuan W, Wang G and Hopewell S: Quality of reporting of trial abstracts needs to be improved: Using the CONSORT for abstracts to assess the four leading Chinese medical journals of traditional Chinese medicine. Trials 11: 75, 2010.
3. Zhao R, Zhao Y, Li D, Wang J and Zeng Y: Research progress of panax japonicus. Modern Chinese Medicine 10: 3-6, 2008.
4. Zou K, Liu Z, Zhu S, Cai S and Komatsu K: Research of ginsen-osides in kou zi qi using HPLC-MS-MS. Yao Xue Xue Bao 39: 385-388, 2004 (In Chinese).
5. Wang DQ, Feng BS, Wang XB, Yang CR and Zhou J: Further study on dammarane saponins of leaves of Panax japonicus var Major collected in Quinling Mountains China. Yao Xue Xue Bao 24: 633-636, 1989 (In Chinese).
6. Zhu XH, Hou WJ and Li CD: Study of effect of Panax Japonicus Saponin on spleen lymphocyte proliferous response. Academic Journal of Kunming Medical College 15: 65-67, 1994 (In Chinese).
7. He H, Shi M, Chen T, Lu X, Qin N and Chen S: Anti-infammatory and analgesic effect of water extractive of Panacis Majoris Rhizoma in mice. Acta Academiae Medicinae Militaris Tertiae 20: 20, 2010.
8. Mengqiong S, Haibo H, Ningling Q and Shuwei C: Effect of pretreatment with water extract from Rhizoma Panacis majoris on cerebral ischemia-reperfusion injury in mice. Acta Academiae Medicinae Militaris Tertiae 3: 023, 2011.
9. Chen T, Gong Z and Fu Y Rhizoma Panacis majori reduces toxicity of chemotherapy in S180-bearing mice. Zhong Xi Yi Jie He Xue Bao 6: 1255-1258, 2008 (In Chinese).
10. Chen C, Wu W, Xu X, Zhang L, Liu Y and Wang K: Chain conformation and anti-tumor activity of derivatives of polysac: charide from Rhizoma Panacis Japonici. Carbohydr Polym 105308-316, 2014
11. Huang Z, Ren H, Duan X and Zhang L Chain conformation and bioactivity of water-soluble polysaccharide extracted from Rhizoma Panacis Japonici. Biopolymers 93: 383-390, 2010.
12. Song X, Li L, Yang G and Cai B: HPLC determination of chiku-setsusaponin IVa in Rhizoma Panacis Majoris from different producing areas. Zhongguo Zhong Yao Za Zhi 35: 885-887, 2010 (In Chinese).
13. Sun GB, Xu HB, Wen FC, Ding T and Sun XB: Study of anti-experimental arrhythmia effect of deglucose Chikusetsu Saponin IVa. Chin J Pharmacol Toxicol 20: 377-380, 2006 (In Chinese).
14. Sun GB, Xu HB, Wen FC, Zhang W, Ding T and Sun XB: Protective Effects of Deglucose Chikusetsu Saponin IVa on Cultured Myocardial Cells Subjected to Anoxia Reoxygenation Injury. Chin J Pharmacol Toxicol 19: 424-427, 2005 (In Chinese).
15. Liu Y, Gao X, Deeb D and Gautam SC: Oleanane triterpenoid CDDO-Me inhibits Akt activity without affecting PDK1 kinase or PP2A phosphatase activity in cancer cells. Biochem Biophys Res Commun 417: 570-575, 2012.
16. Zhang H, Samadi AK, Rao KV, Cohen MS and Timmermann BN: Cytotoxic oleanane-type saponins from Albizia inundata. J Nat Prod 74: 477-482, 2011.
17. Gao X, Deeb D, Liu Y, Arbab AS, Divine GW, Dulchavsky SA and Gautam SC: Prevention of prostate cancer with oleanane synthetic triterpenoid CDDO-Me in the TRAMP mouse model of prostate cancer. Cancers (Basel) 3: 3353-3369, 2011.
18. Zhang W and Popovich DG: Group B oleanane triterpenoid extract containing soyasaponins I and III from soy four induces apoptosis in Hep-G2 cells. J Agric Food Chem 58: 5315-5319, 2010.
19. Antonsson B and Martinou JC: The Bcl-2 protein family. Exp Cell Res 256: 50-57, 2000.
20. Reed JC: Double identity for proteins of the Bcl-2 family. Nature 387: 773-776, 1997.
21. Paydar M, Kamalidehghan B, Wong YL, Wong WF, Looi CY and Mustafa MR: Evaluation of cytotoxic and chemotherapeutic properties of boldine in breast cancer using in vitro and in vivo models. Drug Des Devel Ther 8: 719-733, 2014.
22. Al-Fatlawi AA, Irshad M, Zafaryab M, Rizvi MM and Ahmad A: Rice bran phytic acid induced apoptosis through regulation of Bcl-2/Bax and p53 genes in HepG2 human hepatocellular carcinoma cells. Asian Pac J Cancer Prev 15: 3731-3736, 2014.
23. Narrima P, Paydar M, Looi CY, Wong YL, Taha H, Wong WF, Ali Mohd M and Hadi AH: Persea declinata (Bl.) Kosterm bark crude extract induces apoptosis in MCF-7 cells via G0/G1 cell cycle arrest, Bcl-2/Bax/Bcl-xl signaling pathways and ROS generation. Evid Based Complement Alternat Med 2014: 248103, 2014.
24. Bishayee A, Mandal A, Thoppil RJ, Darvesh AS and Bhatia D: Chemopreventive effect of a novel oleanane triterpenoid in a chemically induced rodent model of breast cancer. Int J Cancer 133: 1054-1063, 2013.
25. Hartwell LH and Weinert TA: Checkpoints: controls that ensure the order of cell cycle events. Science 246: 629-634, 1989.