Novel thioviridamide derivative - JBIR-140: Heterologous expression of the gene cluster for thioviridamide biosynthesis

Journal of Antibiotics

Volumn 68, Issue 8, 2015, Pages 533-536

  Izumikawa, Miho ^a   Kozone, Ikuko ^a   Hashimoto, Junko ^a   Kagaya, Noritaka ^b   Takagi, Motoki ^a   Koiwai, Hanae ^c   Komatsu, Mamoru ^c   Fujie, Manabu ^d   Satoh, Noriyuki ^d   Ikeda, Haruo ^c   Shin ya, Kazuo ^b  

^a Japan Biological Informatics Consortium   (Japan)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^c KITASATO UNIVERSITY   (Japan)

^d OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY GRADUATE UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; ANTINEOPLASTIC AGENT; DNA FRAGMENT; MACROGOL; RIBOSOMAL PRECURSOR PEPTIDE; RIBOSOME PROTEIN; THIOVIRIDAMIDE DERIVATIVE; UNCLASSIFIED DRUG; CYCLOPEPTIDE; RECOMBINANT PROTEIN; THIOAMIDE; THIOVIRIDAMIDE;

CARBON NUCLEAR MAGNETIC RESONANCE; CELL VIABILITY; DRUG CYTOTOXICITY; DRUG SYNTHESIS; ELECTROPORATION; ELECTROSPRAY MASS SPECTROMETRY; ESCHERICHIA COLI; GENE CLUSTER; GENE LIBRARY; HETEROLOGOUS EXPRESSION; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HUMAN; HUMAN CELL; IC50; JURKAT CELL LINE; NOTE; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTON NUCLEAR MAGNETIC RESONANCE; STREPTOMYCES AVERMITILIS; STREPTOMYCES LIVIDANS; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MULTIGENE FAMILY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ANTINEOPLASTIC AGENTS; BIOSYNTHETIC PATHWAYS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; MULTIGENE FAMILY; PEPTIDES, CYCLIC; RECOMBINANT PROTEINS; STREPTOMYCES LIVIDANS; THIOAMIDES;

EID: 84940499806     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.1038/ja.2015.20     Document Type: Note

References (9)

1. Hayakawa,Y.et al. Thioviridamide, a novel apoptosis inducer in transformed cells from Streptomyces olivoviridis. J. Antibiot. 59, 1-5 (2006).
2. Hayakawa, Y., Sasaki, K., Nagai, K., Shin-ya, K. & Furihata, K. Structure of thioviridamide, a novel apoptosis inducer from Streptomyces olivoviridis. J. Antibiot. 59, 6-10 (2006).
3. Izawa, M., Kawasaki, T. & Hayakawa, Y. Cloning and heterologous expression of the thioviridamide biosynthesis gene cluster from Streptomyces olivoviridis. Appl. Environ. Microbiol. 79, 7110-7113 (2013).
4. Komatsu, M. et al. Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites. ACS Synth. Biol. 2, 384-396 (2013).
5. Komatsu, M., Uchiyama, T., Omura, S., Cane, D. E. & Ikeda, H. Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism. Proc. Natl Acad. Sci. USA 105, 2646-2651 (2010).
6. Furihata, K. & Seto, H. Constant time HMBC (CT-HMBC), a new HMBC technique useful for improving separation of cross peaks. Tetrahedron Lett. 39, 7337-7340 (1998).
7. Velásquez, J. E., Zhang, X. & van der Donk, W. A. Biosynthesis of the antimicrobial peptide epilancin 15X and its N-terminal lactate. Chem. Biol. 18, 857-867 (2011).
8. Freeman, M. F. et al. Metagenome mining reveals polytheonamides as posttranslationally modified ribosomal peptides. Science 338, 387-390 (2012).
9. Bhushan, R. & Brückner, H. Marfey's reagent for chiral amino acid analysis: A review. Amino Acids 27, 231-247 (2004).